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FDA-MANDATED ALTERNATIVE TO BISPHENOL-A Kristina Lenn Kevin Miles Gregory Jackett Isaac Norton August 5, 2010

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Foreshadow Introduction Effects of BPA on Human Physiology Possible Alternative Plastics to BPA Manufacturing Analysis Conclusion/Recommendation Questions

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Introduction Nalgene water bottles BPA usage FDA regulations

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Meet the Team Kristina Lenn Project Manager Bachelor of Science in chemical engineering with an emphasis in biological engineering Research on molecular modeling and computer simulation Worked with Nalgene for one year

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Meet the Team Kevin Miles Team Leader during the Project Proposal Bachelor of Science in chemical engineering with an emphasis in biological engineering Research on tissue engineering Worked with Nalgene for one year

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Meet the Team Gregory Jackett Team Leader during the Final Presentation Bachelor of Science degree in chemical engineering with emphasis in molecular engineering and nanotechnology Research on fatigue-induced muscle injury Worked with Nalgene for one year

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Meet the Team Isaac Norton Team Leader during the Final Report Bachelor of Science in chemical engineering with an emphasis in product and process design Work experience in quality control Worked with Nalgene for one year

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Background BPA=Bisphenol-A Polycarbonate Chemical in water bottles and pop cans

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Problem Recognized by the human body as estrogen Absorbed by breast tumor cells Promote breast and prostate tumor growths

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Task BPA effects Harmless Alternatives Manufacturing Techniques

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BPA EFFECTS ON HUMAN PHYSIOLOGY Kevin Miles

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A Look Ahead Previous Statements Enviornmental exposure to BPA BPA Leeching The Endocrine system BPA linked to cancer Conclusion

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~ 25 ng/kg/day 50,000 ng/kg/day http://www.google.com/imgres?imgurl=http:// onwardstate.com/wp- content/uploads/2008/12/water_bottle- 300x300.jpg&imgrefurl=http://onwardstate.com /2008/12/20/water-water-everywhere-but-a- storage- dilemma/&usg=__qNetutbQEJVjtGWRfq72AO1L wVU=&h=300&w=300&sz=11&hl=en&start=0&t bnid=WsPcp- pgT6AipM:&tbnh=115&tbnw=114&prev=/imag es%3Fq%3DWater%2BBottle%26um%3D1%26hl %3Den%26sa%3DN%26rlz%3D1G1GGLQ_ENUS 367%26biw%3D740%26bih%3D411%26tbs%3Di sch:1&um=1&itbs=1&iact=rc&dur=244&ei=xTV PTOe5HZKlnQemi6CQBw&page=1&ndsp=10&ve d=1t:429,r:6,s:0 Human Exposure: 52-74ng/kg/day

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How does the endocrine system work?

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BPA increased the level of hormone receptors produced by a prostate gland cell Some dosages of BPA were environmentally relevant

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An increase in cell receptors fuels growth of the cell Cells can proliferate out of control, resulting in cancerous tumor cells.

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Conclusions BPA is harmful in lower doses BPA can leech into food/beverages at relevant levels BPA exposure increases risk of cancer

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ALTERNATIVE POLYMERS Gregory Jackett

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The Line up The Candidates Strength Toughness Liquid Stability UV Stability Thermal Stability The Ranking

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PETE(Polyethylene terephthalate)

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Atactic Polystyrene(PS)

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Eastman Tritan Copolyester

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Strength

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Toughness

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Liquid Stability

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UV Stability Copolyester?

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Thermal Stability

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The Ranking Copolyester PETE Polystyrene

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MANUFACTURING ANALYSIS Isaac Norton

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Forecast Polymerization Method Safety Quality Retooling Ranking

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Method

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Safety

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Reaction Heat Runaway

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Quality

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The Ranking Copolyester PETE Polystyrene

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Conclusions Hazardous in small concentrations Carcinogenic developmental changes Copolyesters better material properties PETEs better safety and quality properties

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Our Solution Is PETE

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Just a Reminder The Problem BPA Effects Possible Alternatives Manufacturing Comparison The Solution

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References http://www.intuitive-recruitment.co.uk/ http://fondnessforreading.blogspot.com/2008/12/melting.html http://jalopnik.com/276775/wrecking-ball-on-the-loose http://www.better-leadership.com/great-offices.html http://www.greenerist.com/2009/02/green-tip-get-a-bpa-free-water-bottle/ http://health.allrefer.com/health/cancer-ovarian-cancer-metastasis.html http://www.tuxedoranch.com/images/featured/bpa-free-1.png http://www.sitnews.us/MacDougall/111207_PETE.jpg http://www.extension.iastate.edu/newsrel/reiman/PolystyrenePot.jpg http://www.innovationlab.eastman.com/NR/rdonlyres/4C99D9B3-B19A-4FD5-A60F- 8115B0DF5064/0/example_lrg_camelbak1.jpg http://www.eastman.com/Brands/Eastman_Tritan/PublishingImages/TritanWater.jpg

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References http://i1.treklens.com/photos/5947/dscn0425c.jpg http://grail.cs.washington.edu/projects/office/dewey/china/photos/yunnan/hutiaoxia /middle/middle14.jpg http://www.jcu.edu/Philosophy/gensler/nc/images/10.jpg http://faculty.uscupstate.edu/llever/Polymer%20Resources/Isomerism.htm http://en.wikipedia.org/wiki/File:Ester-general.svg Taylor & Francis Group. (2010) Polymers, a property database. Retrieved from http://poly.chemnetbase.com http://poly.chemnetbase.com

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QUESTIONS?