from genetics to neuroethics: is imaging “visualizing” human thought?
DESCRIPTION
From Genetics to Neuroethics: Is Imaging “Visualizing” Human Thought?. Program in Neuroethics Stanford Center for Biomedical Ethics and Department of Pediatrics, Medical Genetics Stanford University. Judy Illes, Ph.D. EMBO/EMBL Heidelberg, Germany November 2006. Outline. - PowerPoint PPT PresentationTRANSCRIPT
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EMBO/EMBLHeidelberg, Germany
November 2006
From Genetics to Neuroethics:Is Imaging “Visualizing”
Human Thought?
Judy Illes, Ph.D.
Program in Neuroethics Stanford Center for Biomedical Ethics
andDepartment of Pediatrics, Medical Genetics
Stanford University
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Outline
• Definitions and key questions
• Imaging capabilities and state of the art
• Tackling some key questions
• Conclusions
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NeuroethicsAdina Roskies, Neuron, 2002
• Ethics of neuroscience; neuroscience of ethics
William Safire, The Dana Foundation, 2002: • “… the examination of what is right and wrong and good and bad about
the treatment of, perfection of, or unwelcome invasion of and worrisome manipulation of the human brain […] It deals with our consciousness – our sense of self – and as such is central to our being.”
Michael Gazzaniga, The Ethical Brain, 2005: • “… the examination of how we want to deal with the social issues of
disease, normality, mortality, lifestyle, and the philosophy of living informed by our understanding of underlying brain mechanisms.”
Judy Illes, Society for Neuroscience, 2006:• A discipline that aligns the exploration and discovery of neurobiological
knowledge with human value systems.
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Key Questions
Does imaging visualize human thought?
Why is neuroethics interested in the question of thought visualization?
How does neuroethics interact with this question?
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Outline
• Definition and key questions
• Imaging capabilities and the state of the art
• Tackling the key questions
• Conclusions
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NEURO-TECHNOLOGY DESCRIPTION THERAPEUTIC POTENTIAL
Neuro-Engineering; Neuro-nanotechnology
Functional interfaces
Restore motor function.Relieve major psychiatric illnesses.Enable better drug delivery
Neuro-pharmacology; Neuro-nanotechnology
Targeted molecules
Treat psychiatric illnesses. Improve outcome in acute neurological disease.Slow neurodegeneration.
Neurogenetics Neurogenetic testsInform life planning.Make lifestyle choices.Inform healthcare decisions.
Neuroimaging Structural and functional imaging
Advance the neurobiology ofhuman cognition. Improve diagnosis of neurological diseases. Plan for and monitor neurosurgical intervention.
Frontier Neurotechnology
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From Antiquity to Present
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CLINICAL PRACTICE• Diagnosis
• Medical screening and prediction• Self referral
• Safety• Technology transfer
• Therapy• Image guided neurosurgery
SELF• Responsibility
• Free will• Consciousness
• Reasoning
SOCIAL POLICY• Lie detection
• Non-medical screening• Surveillance
• Cognitive enhancement
DISSEMINATION• Scientists as disseminators as well as
citizens of scientific information• Self-referral (advertising and marketing)
• Interfacing with the media and public• Data sharing
• Training the next generation of neuroscientists
Imaging Imaging
NeurosciencesNeurosciences
Critical Pillars in Neuroethics
Mapping the Field, The Dana Foundation, 2002; Illes et al., Neuroscience Imaging,2005
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EEG: Electrical signals
PET and SPECT:Blood flow and metabolic activity
MEG: Current sources and sinks
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Functional MRI
ActivationMap
IncreasedNeuronalActivity
IncreasedOxygenatedBlood Flow
HbO2 Hbarterial venous
Performa Task
Non-invasive, small clinical risk
BehaviorFunctional
Brain Anatomy
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The fMRI Experiment
Stimulus
Response
A A A AB B B
- =
"A" state images Activation map”B" state images
Courtesy of Gary Glover, PhD
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Year
1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001
% o
f A
rtic
les
0.0
20.0
40.0
60.0
80.0
100.0 motor sensory1 sensory2 cognition1 cognition2 emotion
Illes et al., Nat. Neuroscience, 2003
Trends in Research with fMRI
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Trends in Research with fMRI
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“The brain can’t lie: Brain scans reveal how you think
and even how you might behave.”
--The Guardian, 2003
Racine, Bar-Ilan, Illes, fMRI in the Public Eye, NRN, 2005
0
5
10
15
20
25
30
35
40
45
92 93 94 95 96 97 98 99 0 1 2 3 4*
Coverage of fMRI in theInternational Print Press
#
Year
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De Martino et al., Science, 2006
Rational Decision-making
Moral Judgement
Greene et al., Science, 2001
Superior Temporal Sulcus
Posterior Cingulate/Precuneus
Impersonal Moral Dilemmas
Non-moral Dilemmas
Personal Moral Dilemmas
Bra
in A
ctiv
ity%
ch
ang
e M
R s
igna
l
Medial Frontal Cortex
Dorsolateral Prefrontal Cortex (PFC)
Emotional/Social Cognition Areas
“Cognitive” Areas
Personality
Canli et al., Science, 2002
Mean Correlation
Scatterplot
-1
0
1
2
3
r = .20
p = .24
T S
core
-1
0
1
2
3
30 40 50
r = .71
p < .002
T S
core
Extraversion Score
Fear
Happy
Activation Correlation with Extraversion
T Value
L R
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“Eventually we’ll be able to know a lot more about people through understanding more about how their brains work…
This is a domain that offers enough that’s novel in the area of information about one’s own persona, that we ought to be thinking very seriously about it.”
- Participant 201NS/M/AA
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Patient
Schiff et al., Neurology, 2005
Control
Owen et al., Science 2006
A Picture is Worth 100 Words: Disorders of Consciousness
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“These results confirm that despite fulfilling the clinical criteria for a diagnosis of vegetative state, this patient retained the ability to understand spoken commands and to respond to them through her brain activity rather than through speech or movement. Moreover, her decision to cooperate with the authors by imagining particular tasks when asked to do so represents a clear act of intention.”
Owen et al., Science, 2006
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Structural Fetal MRI
(Courtesy of D. Levine, BIDMC)
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Real-Time fMRI Decoding
グー
チョキ
パー
Image Data
Feature Vectors
Pattern recognition analysis
Commands to Robot
Brain activity measurement every second by fMRI
Robot hand moves
Extraction of brain areas related to movement control
Pattern Extraction of Brain Activity Pattern Recognition
Anterior
Posterior
RightLeft
f MRI
PaperScissors
Rock
Courtesy of M. Kawato and Y. Kamitani, ATR Computational Neurosci. Labs and Masahiro Kumura, Honda Res. Inst., Japan
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Outline
• Definitions and key questions
• Imaging capabilities and state of the art
• Tackling the key questions
• Conclusions
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Does imaging visualize human thought?
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No: Thought is a composite of cognitive functions involving - information processing,- the disposition of an individual to information,
and - individual methods of integrating information
into an internal schema and responding to it.
Imaging does, however, visualize correlates of the cognitive functions that humans harness to create thought.
Visualizing Human Thought
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Why is neuroethics interested in the question of thought visualization?
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“Far more than our genomes, our brains are us, collectively defining us as human, and individually marking out the special character of our personal capacities, emotions and convictions.”
- Kennedy, Society for Neuroscience, 2003
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Lessons from ELSI Genetics
• Discrimination, stigma, coercion
• Medical privacy
• Secondary and extended uses of data
• Distributive justice
• Commercial potential
• Public perception
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Lessons from ELSI Genetics(cont’d)
• Diagnostic potential
• Predictive potential
Benefits for life planning Incidental findings Risks of false positives and negatives
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ELSI Unique to Neuroimaging
• Physiologic variability due to day-to-day variation in physiology, gender
• Paradigmatic variability due to design issues (protocols for data acquisition, statistics for data interpretation)
• Interpretative variability due to investigator-subject bias, values and culture
True bridging of technique and technology. Imaging genomics may be one of most powerful new tools.
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ELSI Unique to Neuroimaging (cont’d)
• Decision and discovery in that brain is both the seat of ethical decision-making and the target of ethics discovery
• Experience of brain health and brain disease is different than the experience of health and disease of other organ systems Chimeras Tissue engineering
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Source of Neuroethics Interest in Neuroimaging
Unique neuro ethical, legal and social implications.
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How does neuroethics interact with the question of thought visualization with imaging?
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Interaction of Neuroethics and Neuroimaging
• Identify pragmatic starting points for imaging and alternatives for resolution of difficult ethical challenges through a negotiated scientific-social process
• Empower, not encumber the scientific process
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IntegrationEvaluation
DiscoveryEthics analysisTools
DiscoveryEthics analysis
Discovery/Pre-discovery
Commercialization Stakeholder engagement Regen. Med., Mol. Imaging
Incidental findings
Surrogate and bio markers
20062001
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Illes, Kirschen, Edwards, Stanford et al., SfN 2005 and based on Science 2006
Research protocol anticipates incidental findings A
IRB protocol & informed consent articulate plan for managing incidental findingsIRB protocol & informed consent articulate plan for managing incidental findings
Incidental findings are managed
Subjectoption to decline to be informed
Incidental findings are not managed
B
Research Study
Principal Investigator or Designee
Physician qualified to read scans
Incidental finding is detectedAll scansreviewed
C
Principal Investigator or Designee
Research subject or surrogate is encouraged to initiate clinical follow-up
Incidental finding is evaluated
Incidental finding is communicated
No action taken
D
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Interaction of Neuroethics and Neuroimaging
(cont’d)
Proactively engage deliberation from multiple stakeholders at multiple junctures
Improve science literacy and communication
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Scientists and scholars seeking standards of
practice and a common voice and language
Critical voice of caregivers, stakeholders, and the public in matters
of neuroscience discovery
Knowledge Cycle
Engaged world press dedicated to a close partnership between
science and journalism
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International Neuroethics
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International Neuroethics Networkan arm of the
Neuroethics Society
To foster international collaboration in neuroethics through the identification of common priorities and joint funding opportunities.
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Outline
• Definitions and key questions
• Imaging capabilities and the state-of-the-
art
• Tackling the key questions
• Conclusions
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Conclusions
There are compelling reasons for anticipating neuroethical issues at the bench, at the bedside, and in the public domain.
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Adapted from Illes, Racine, Kirschen, in Neuroethics: Defining the Issues in Theory, Practice and Policy,Oxford University Press, 2006
Expanded Roles in Neuroscience and Neurotechnology
Responsiveness Pursue a duty of care within the research setting and extended roles outside
Democratic and civic involvement
Participate in a partnership that promotes public understanding of the brain, and democratic debate
Prospective responsibility Proactively manage real and imagined future uses of neurotechnology
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Roles for Neuroethicists
• Draw upon history of bioethics, genetics and other disciplines to inform the unique challenges that are raised by the opportunity to study and probe the brain.
• Keep up with the pulse of neuroscience and pursue an ethically coherent agenda based on the needs of the neuroscience community and its interface with society.
• Bridge cultural, linguistic and disciplinary barriers
• Develop capacity on an internationally relevant scale.
• Develop research, resource and reference tools that are flexible, practical and useful.
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Bruce Arnow
Vivian Chin
Mildred Cho
Pamela S.-Desmond
Ray De Vries
Margaret Eaton
Martha Farah
Agnieszka Jaworska
Gary Glover
Mike Grecius
Henry T. (Hank) Greely
Katrina Karkazis
Matthew P. Kirschen
Sophia Lombera
Allyson Mackey
Gladys Maestre
David Magnus
Eric Racine
Allyson Rosen
Jennifer Singh
Jane Stewart
HFM Van der Loos
Adri, Kiah Van der Loos
RO1 Advisory Board
Many others collaborators
NIH RO1 #NS 045831 & #CSI 8-17-04The National Science FoundationThe Dana FoundationThe Greenwall FoundationThe Henry J. Kaiser FoundationThe New York Academy of SciencesThe Children’s Health Initiative at Stanford
Acknowledgements
http://neuroethics.stanford.edu