neuroethics, neurochallenges: a needs-based research agenda
TRANSCRIPT
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Judy Illes, Ph.D. Judicial Seminar on Emerging Issues in Neuroscience
Stanford University2006
Brain Imaging and Lie Detection:Avoiding a Collision between
Neuroscience and the Justice System
Center for Biomedical Ethics, Program in NeuroethicsDepartment of Pediatrics, Medical Genetics
Stanford University
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A Return to the Fish Story
The fish I caught was this big …
Dana Press, 2004
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Outline
• Baseline Technology and experimental models Neural circuitry
• Ethical obstacles and challenges Conceptual and behavioral Technical Policy
• Lessons from the history of neuroscience, admissibility, varying scenarios, conclusions
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From Antiquity to Present
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EEG: Electrical signals
PET and SPECT:Blood flow and metabolic activity
MEG: Current sources and sinks
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ActivationMap
IncreasedNeuronalActivity
IncreasedOxygenatedBlood Flow
HbO2 Hbarterial venous
Performa Task
Non-invasive, small clinical risk
Behavior FunctionalBrain Anatomy
Functional MRI
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Stimulus
Response
A A A AB B B
- =
"A" state images Activation map”B" state images
Courtesy of Gary Glover, PhD
The fMRI Experiment
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Trends in Research with fMRI
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Year
1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001
% of Articles
0.0
20.0
40.0
60.0
80.0
100.0 motor sensory1 sensory2 cognition1 cognition2 emotion
Illes et al., Nat. Neuroscience, 2003
Trends in Research with fMRI
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De Martino et al., Science, 2006
Rational Decision-making
Moral Judgement
Greene et al., Science, 2001
Superior Temporal Sulcus
Posterior Cingulate/Precuneus
Impersonal Moral Dilemmas
Non-moral Dilemmas
Personal Moral Dilemmas
Bra
in A
ctiv
ity%
ch
ang
e M
R s
igna
l
Medial Frontal Cortex
Dorsolateral Prefrontal Cortex (PFC)
Emotional/Social Cognition Areas
“Cognitive” Areas
Personality
Canli et al., Science, 2002
Mean Correlation
Scatterplot
-1
0
1
2
3
r = .20
p = .24
T S
core
-1
0
1
2
3
30 40 50
r = .71
p < .002
T S
core
Extraversion Score
Fear
Happy
Activation Correlation with Extraversion
T Value
L R
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Lying and Deception(of ~20 in Research Articles in PubMed)
• Spence et al., 2001 True/false about subject’s daily activities
• Langleben et al., 2002; Davatzikos et al., 2005 True/false about playing card in subject’s possession
• Lee et al. 2002 True/false about autobiographical information
• Ganis et al., 2003 True/false about life narrative
• Kozel et al. 2005; Mohamed et al. 2006 True/false mock crime
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Critical Nodes in Neural Circuitry
Anterior prefrontal areaVentromedial prefrontal areaDorsolateral prefrontal areaParahippocampal areasAnterior cingulate, left posterior cingulateTemporal and subcortical caudateRight precuneousLeft cerebellumInsulaPutamen, caudate, thalamusRegions of temporal cortex
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Entrepreneurial Efforts
• No Lie MRI
• Cephos
• Human Bionics
• N=? Supported by the military and intelligence community
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Outline
• Technology and experimental models
• Neural circuitry
• Ethical obstacles and challenges Conceptual and behavioral Technical Policy
• Lessons from the history of neuroscience, admissibility, varying scenarios, conclusions
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Does imaging visualize human thought?
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No: Thought is a composite of cognitive functions involving - information processing,- the disposition of an individual to information,
and - individual methods of integrating information
into an internal schema and responding to it.
Imaging does, however, visualize correlates of the cognitive functions that humans harness to create thought.
Visualizing Human Thought
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Conceptual and Behavioral Issues
• Human behavior is complex, involving:memory, intention, motivation, planning and executive function, monitoring, mood, daily physiology
+ consciousness, will and language
• Lying and deception require all of the above, +Inferences about:
another person’s intent or positiongullibility
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Conceptual and Behavioral Issues, cont’d
• Lying and deception are different:
Lying: Frank misinformation that states an erroneous conclusion.
Deception: Misleading information, omission, distortion that leads to an erroneous conclusion.
• There are good and bad liars (and deceivers).
• There are everyday liars and there are pathologic liars.
• There are dark lies and white lies.
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It is not a lie, it's a terminological inexactitude. Also, a tactical misrepresentation.
Alexander Haig
Of course I lie to people. But I lie altruistically–for our mutual good. The lie is the basic building block of good manners.
Quentin Crisp
No man has a good enough memory to make a successful liar.Abraham Lincoln
I never had sex with that woman.Bill Clinton
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Technical Issues• Paradigmatic (Standards of practice, quality
control) Instrumentation Study design Experimental parameters; internal/external validity Socioculturally-appropriate stimuli Subject N’s and relevance Data geography (ROIs) SNR /statistical approach(es)
• Analytic Localization vs. networks Repeat scanning and learning effects Motivation-mitigated neural signatures
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Ethics & Policy Issues• Privacy
• Context Autonomy, Coercion
•Accused, victims (false memories)
•Children and adults (stigma, profiling)
• Justice What goal? What uses?
•Proximate
Definitive or adjunctive information? Degree? Motivation? Intent? Screening/prediction?
•Long-range
• Nonmalficence False positives/false negatives Unexpected clinical finding
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Courtesy of The Lucas MR Imaging Center, Stanford University
The Case of SH
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Ethics & Policy Issues
• Countermeasures (internal and external [e.g, beta blockers, TMS])
• Allocation of scarce resources for research
• Oversight - By whom and how
• Moral culpability (Kulynych 2002)
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Risks and Troubling Concerns
• Premature adoption of technology
• Misuse, mischievous covert use• Technically incorrect use (equipment, personnel)
• Outcome of false positives• Outcomes of true positives
• Conflict of interest (overzealous “lie catchers”; quotas)
• Public perception
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Kozel et al., Neuropsychiatry Clin Neurosci. 2004.
Brain Fingerprinting, Polygraphy, MRI
• What’s new? Technical sophistication (but consider cost and
availability) Power of the image Type of measure (emotional [physiologic vs.
cognitive]) Promise of new technology may be considerable
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http://www.brainwavescience.com/HarringtonSummary.php
Brain Fingerprinting, Polygraphy, MRI
• Reflecting on the past Similarities are conceptual,
ethical & technical• Experimental paradigms • Meaning• Interpretation• Autonomy• Use and outcomes (how and by
whom)• Countermeasures• Sensitivity/specificity metric…
only the If, not the What
FORENSIC TECHNOLOGIES, INC.When the truth really matters... count on us
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Outline
• Technology and experimental models • Neural circuitry• Ethical obstacles and challenges
Conceptual and behavioral Technical Policy
• Lessons from the history of neuroscience, admissibility, varying scenarios, conclusions
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“The brain can’t lie: Brain scans reveal how you think and even how you might behave.”
--The Guardian, 2003
Racine, Bar-Ilan, Illes, fMRI in the Public Eye, NRN, 2005
0
5
10
15
20
25
30
35
40
45
92 93 94 95 96 97 98 99 0 1 2 3 4*
#
Year
Coverage of fMRI in theInternational Print Press
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Lessons from the History of Neuroscience
• Prefrontal lobotomies (1935)
• Bovine Spongiform Encephalopathy (1986)
• Mozart Effect (1993)
• Measles, mumps, rubella vaccine/autism (1998)
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• Convicted facing sentencing• Accused• Screening
Different Scenarios
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AdmissibilityDaubert, 509 U.S. at 592 n.10
• Has the theory or technique can be or has been tested?
• Has it been subjected to peer review and publication?
• Does the technique have a known or potential rate of error and are there are standards controlling its operation?
• Does the theory or technique enjoys general acceptance within a relevant scientific community?
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Scientists and legal scholars
seeking standards of practice and a common
voice and language
Critical voice of caregivers, stakeholders, and the public in matters
of neuroscience discovery
Knowledge Cycle
Engaged world press dedicated to a close partnership between
science and journalism
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Responsibility: Scholars in Neuroscience,
the Humanities and Law• Moral efficacy
Ensure the right questions are asked.
• Observation Provide impartial observation.
• Linkage Provide guidance in linking moral beliefs to moral theory and
tradition.
• Bridges Introduce new approaches that facilitate and support improved
science literacy, and wise acceptance and measured introduction of new technology.
Adapted from Illes, Racine, Kirschen, in Neuroethics: Defining the Issues in Theory, Practice and Policy,Oxford University Press, 2006
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Get involved
Conclusions
Contribute
Impart
knowledge
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Acknowledgments
Program in Neuroethics
http://neuroethics.stanford.edu
The Greenwall Foundation
The Dana Foundation
NIH/NINDS #NS045831