BASF CorporationFungicide Update

IR 4 Food Use WorkshopIR-4 Food Use WorkshopCleveland, OH

Sept. 16, 2009

Ted Bardinelli

MetrafenoneMetrafenone(BAS 560F)( )

A New Powdery Mildew Fungicide from BASFFungicide from BASF

Metrafenone is not registered by the US EPA and is not available for sale. This presentation is for informational purposes only and is notintended to promote the sale of the product. Any sale of this product after registration is obtained shall be solely on the basis of the EPA-approved product label, and any claims regarding product safety and efficacy shall be addressed solely by the label.app o ed p oduct abe , a d a y c a s ega d g p oduct sa ety a d e cacy s a be add essed so e y by t e abe

Metrafenone FungicideCh i l Ch t i tiChemical Characteristics

Totally unique chemistry and mode of actionTotally unique chemistry and mode of action

Benzophenone chemical class

N k i tNo known cross-resistance

FRAC MoA Group U8

Biochemical site of action is not known

Actin disruption has been proposed.

Actins are structural proteins critical to cell division and function.

Favorable Toxicity and Environmental Profile

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MetrafenoneProposed Directions for Use on GrapesProposed Directions for Use on Grapes

Use Rate InformationUse Rate Information10.3 -15.4 fl oz/A rate range (224 – 337 g ai/ha)

Spray intervals of 14-21 days

Maximum of 6 applications per season

No more than 2 consecutive applications

Restricted-entry interval (REI) = 12 hoursRestricted entry interval (REI) 12 hours

Application TimingApply preventively for best performance

Any time after bud break to 14 day PHI

Adjuvants

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Performance may be improved by adding non-phytotoxic adjuvants

– e.g. organo-silicone adjuvants commonly used in grapes

Metrafenone FungicideP d t I t d tiProduct Introduction

Anticipated registration with EPA and California in June of 2010Anticipated registration with EPA and California in June of 2010 for use in grapes.

Proposed commercial name will be VivandoTMProposed commercial name will be VivandoTM.

300 g ai/L SC formulation.

Label will be for powdery mildew (Uncinula necator) only.

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Initium®Initium®

(BAS 650F)

An innovative fungicidegof a new chemical class

for the control offor the control of oomycetes

Initium is not registered by the US EPA and is not available for sale. This presentation is for informational purposes only and is notintended to promote the sale of the product. Any sale of this product after registration is obtained shall be solely on the basis of the EPA-approved product label, and any claims regarding product safety and efficacy shall be addressed solely by the label.app o ed p oduct abe , a d a y c a s ega d g p oduct sa ety a d e cacy s a be add essed so e y by t e abe

Reliable & highly active against oomycete diseases

Initium® – The key benefitsReliable & highly active against oomycete diseases with excellent selectivity

Innovative complex III inhibitor of a new chemical classInnovative complex III inhibitor of a new chemical class and a new tool in resistance management

Very favorable regulatory profileVery favorable regulatory profile

Premium preventive action

Excellent grape cluster efficacy

W ld id i t ti d i t t l

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World-wide registrations and import tolerances

Reliable & highly active against oomycete diseases with excellent selectivity

Proposed uses of Initium®

Application rates

200 – 300 g/ha in combination with other fungicides of a different mode of action

SSpray interval 7 - 14 days

F iFungi controlled Downy mildew & late blight diseases

Grapes potatoes tomatoes & otherCrops

Grapes, potatoes, tomatoes & other Solanaceae,

cucurbits, leafy & fruiting vegetables,bulb vegetables brassicas hops ornamentals

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bulb vegetables, brassicas, hops, ornamentals

Spectrum of activity

Reliable & highly active against oomycete diseases with excellent selectivity

p y

P t t Ph t hth i f tPotatoes Phytophthora infestansTomatoes Phytophthora infestansGrapes Plasmopara viticolaGrapes Plasmopara viticolaVegetables Peronospora spp.Vegetables Phytophthora spp.Vegetables Phytophthora spp.Cucurbits Pseudoperonospora cubensisLettuce Bremia lactucaeHops Pseudoperonospora humuliOrnamentals Phytophthora spp.

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Innovative complex III inhibitor of a new chemical class and a new tool in resistance management

A new choice in resistance managementInitium® displays no cross resistance to fungicide classes ofInitium® displays no cross-resistance to fungicide classes of

phenylamides (e.g. metalaxyl)

Q i hibit ( t bil i )Qo inhibitors (e.g. strobilurins)

carboxylic acid amides (e.g. dimethomorph)

benzimidazoles, SDH inhibitors, triazoles and imidazoles

As a pro-active measure Initium will be marketed only as ready mixes inAs a pro active measure, Initium will be marketed only as ready mixes incombination with other fungicidal active ingredients of a different mode of action.The partners will complement the activity spectrum and deliver built-in resistancemanagement for Initium and vice versa.

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– a new tool for resistance management

Innovative complex III inhibitor of a new chemical class and a new tool in resistance management

New proprietary chemical class: pyrimidylamines

The mode of action of Initium® – summaryNew proprietary chemical class: pyrimidylamines

Initium inhibits respiration at complex III

Exact binding site at complex III is not yet known

No cross-resistance to important oomycete fungicide classes detected,

including complex III Qo inhibitors

Cross-resistance to QiI fungicides cyazofamid and amisulbrom cannot

be excluded

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be excluded

is the innovative complex III inhibitor of a new chemical class

World-wide registrations and import tolerances

Initium® registration

A II I iti i t ti d i b itt d f i i EAnnex II Initium registration dossier submitted for review in Europe

in September 2008.

MRL dossier submitted as an application for EU MRLs for all European

uses developed up to now.

World-wide registration campaign for Initium products in progress.

First registration expected in 2010.

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is on track for world-wide registration