gastrointestinal system instructor: ge shun office: 0850 physiological sciences email:...
TRANSCRIPT
Gastrointestinal System
Instructor: Ge Shun
Office: 0850 physiological sciencesEmail: [email protected]
Jining medical collegeDepartment of Physiology
Gastrointestinal System
1. G.I. Physiology: general organization of G.I. tract
2. Mastication and deglutition3. Gastric secretion4. Regulation of gastric secretion5. Pathophysiology of peptic ulcer6. Biliary and pancreatic secretions7. Physiology of colon8. Pathophysiology of diarrhea disease
Digestive secretions from the liver and the pancreas are delivered into the duodenum of the small intestine through
the sphincter of Oddi.
Functions of small intenstine movements
• Mixes the luminal contents with secretions
• Brings the contents nto contact with the epithelial surface
• Slowly advances the luminal material toward the large intenstine
(I) Physiological properties of gastrointestinal smooth muscle
(1) General properties
- Low excitability - High extensibility - Tonic contraction - Autorhythmicity
- High sensitivity to temperature, stretch & chemical stimulation
(2) Electrophysiological properties
(a) Resting potential: - between -50 and -60 Mv
- Ionic basis -Em (selective membrane permeability to K+)
-Electrogenic Na+-K+ pump
(b) Slow wave (basic electrical rhythm,BER)
- The spontaneous rhythmic, subthreshold depolarizations of the cell membrane (slow wave) of the gastrointestinal tract
- Initiated in the interstitial cells of Cajal (ICC) (pacemaker cell)
Slow wave (basic electrical rhythm)
- Intensity: 5~15 mV
- Frequency: 3~12 cpm - Ionic mechanism
spontaneous rhythmic changes in Na+-K+ pump activity
Spike potential (Action potential)
-Duration: 10~20 ms
-Ionic mechanism:
• Depolarization: Ca2+ influx
• Repolarization: K+ efflux
Myenteric plexus : control over GI motility Submucous plexus: regulate gastrointestinal blood flow and control GI secretion
(III) Hormonal Regulation --GI hormones
The hormones synthesized by a large number of
endocrine cells within the gastrointestinal tract
Brain-gut peptides: a number of the classical GI hormones are also synthesized in the brai
n
(IV) Phases of Gastrointenstinal Control
• Cephalic phase
• Gastric phase
• Intenstinal phase
• Three phase of gastric secretion.swf
Summary
• Terms:
- Basic electrical rhythm (BER) or slow waves - Gastrointestinal (GI) hormones
• Three phase of gastric secretion
Mouth, Pharynx, and Esophagus
Secretion of saliva
The Salivary Glands • Parotid gland • Mandibular gland • Sublingual gland
Saliva
1000 ml/d pH 6.0~7.0 Composition of saliva -H2O -Na+, Cl-, K+, HCO3
-
-Mucus (containing mucin) -Amylase, lysozyme, …
Chief cells synthesize and secrete the protease precursor known as pepsinogen.
Parietal cells synthesize and secrete the hydrochloric acid responsible for the acidic pH in the gastric lumen.
(I) Gastric juice
(1) Hydrochloric acid
Secreted by the parietal cells
Output
- Basal: 0~5 mmol/h
- Maximal: 20~25 mmol/h
Acid production by the parietal cells in the stomach depends on the generation of carbonic acid; subsequent movement of hydrogen ions into the gastric lumen results from primary active transport.
Role of HCl
- Acid sterilization
- Activation of pepsinogen
- Promotion of secretin secretion
- Assisted effect of iron and calcium absorption
(4) Intrinsic factor
A high molecular weight glycoprotein, synthesized and secreted by the parietal cells
•The intrinsic factor binds to Vit B12 and facilitates its absorption
(II) Regulation of gastric secretion
(1) Basic factors that stimulate gastric secretion
- Acetylcholine (+ all secretory cells) - Gastrin (+ parietal cells)
- Histamine (+ parietal cells)
Motor Function of the Stomach
• Receptive relaxation - Storage function (1.0~1.5 L) - Vago-vagal reflex • Peristalsis - BER in the stomach
Emptying of the stomach
Emptying rate
- Fluid > viscous
- Small particle > large particle
- Isosmotic > hyper- & hypo-osmotic - Carbohydrates > Protein > Fat - Regular meal 4~ 6 hrs
Summary
Terms:
- Receptive relaxation (Storage function of the stomach)
- Mucus-HCO3- barrier - Intrinsic factor
Gastric secretion (including the composition and physiological function of the gastric juice, the regulation of gastric secretion)
(I) Pancreatic juice
• pH 7.8~8.4 • ~1500 ml/day• Isosmotic • Components: - Pancreatic digestive enzymes: secreted by pancreatic
acini - Sodium bicarbonate: secreted by small ductules and
larger ducts
(II) Regulation of pancreatic secretion
Basic stimuli that cause pancreatic secretion - Ach - Cholecystokinin: • Secreted by I cells • Stimulates the acinar cells to secrete large amounts o
f enzymes - Secretin: • Released by S cells • Acts primarily on the duct cells to stimulate the secreti
on of a large volume of solution with a high HCO3- concentration
4. Fats
(1) Absorption through lymph duct to the circulatory blood
(2) Direct absorption into the portal blood
Summary
• Pancreatic secretion (including the composition and physiological function of the pancreatic juice, the regulation of pancreatic secretion)
• Biliary secretion (including the composition andphysiological function of the bile)• Absorption in the small intestine• Describe the digestion of carbohydrates, proteins andfat