Grace Health Care Overseas Division

Grace Health Care (Pvt) Limited Pakistan

joint venture with

Kunming Dihon Pharmaceutical Co, Ltd.. For

GCC, Middle-East , Afghanistan.

Knowledge of

Skineal & Haicneal

Grace Health Care Overseas Division

What is Skineal?

History of Skineal

Skineal is in great demand during the last twenty years;

Cumulative sales reached five hundred million bottles;

SKINEAL has an annual revenue exceeding RMB 300 million;

Professional sales team and complete marketing network are located throughout RPC and overseas markets;

The best sold brand of enepidermic drug in Vietnam and Indonesia.

Composition of SKINEALCompound Ketoconazole Cream

Description：A white to off-white cream with an emulsive base.Composition：Ketoconazole（1%）

Clobetasol Propionate（0.025%）Neomycin Sulfate（5000IU each gram)

Usage & Dosage: For external use; Twice per day

What can Skineal cure?

The first indication of Skineal

Skin Pruritus

Pruritus is the most common symptom showed on 90% of skin diseases.

Cause of Skin Disease

Fungus Infection

Clinical Manifestation

Tinea Manus

Tinea Cruris

Tinea Pedis

Tinea Corporis

Skineal Pharmacological Actions

Mycelium

Regular transform

Clobetasol Propionate

Accelerate transform

effective

Ketoconazole

Pityrosporum

invalid

Ketoconazole:A broad-spectrum anti- fungal agent that acts on the cell membranes of fungi by changing its permeability.Kill Fungus 、Eliminate Pathogeny、High Effect、Quick and Thorough

Clobetasol Propionate:Highly effective as an anti-inflammatory 、anti-allergic and anti-pruritic agent with

few side-effects.Stop itching promptly; Relieve symptom apparently; Eliminate discomfort effectively.

Neomycin Sulfate:After skin is infected by fungus，superficial cells are destroyed and resistance descend，accompanied by itching, Thus, bacterial re-infection will easily occur。Effectively cure bacterial re-infection.Ketoconazole + Clobetasol propionate ---

Synergistic effectCompletely killing fungi, treatment for both manifestation and root cause

Clinical Test

The clinical tests by Chinese Academy of Medical Sciences & Peking Union Medical College indicated that

Skineal has a high effect on anti-fungus and anti-pruritic

With few side effects

No stimulation and no allergic reaction to the skin.

Why choose Skineal?

Skineal is a product that…

New compound used as anti-fungus medicine;

Cooperative effect from three ingredients: definite effect,

quick, few side effect;

Widely accepted by doctors and patients through clinic

applications over 20 years;

First choice for the treatment of superficial skin disease.

Anti-Fungus,

Anti-Bacteria,

Anti-Inflammatory

Relieve itching

Quick and Thorough

Skineal can give Patient…

Recover immediately after using the drug;

Cure the obstinate disease completely;

No side-effect;

Low price.

Haicneal

Scalp Problems…

The Pathology of dandruff

Physiologic Dandruff•Appears on everybody•Product of metabolism on scalp•Do not influence people's daily life•No treatment is necessary

Pathological Dandruff•Medical term•Pityriasis capitis •Due to the Malassezia furfur overgrowth•Belonging to the skin disease•Requires medical care.

Without treatment, in the severe cases:

Damage hair follicle ， cause permanent Baldness

FungiPityrosporum

furfur

Reasons of overgrowth of

the Pityrosporum :

1. insufficient rinsing of shampoo .

2. using a harsh shampoo

3. excessive sebum

4. vitamin imbalance ，lack of Vitamin A, B-6,B-2

5. reversal of season

2/3 of people in China have dandruff problem ， the

ratio of males and females is nearly 1:1Dandruff is recurrent and persistent. According to the research, 95% of patient suffer a relapse.

The Pathology of dandruff

Dandruff

Pruritus

HELP!!!

Tinea versicolor

Seborrheic dermatitis

Alopecia seborrheica

Follicle papula

What is Haicneal?

Haicneal Compound Ketoconazole Lotion for Scalp

History of Brand Haicneal

HAICNEAL has an annual revenue exceeding RMB 500 million.

Mycelium

Regular transform

Clobetasol Propionate

Accelerate transform

effective

Ketoconazole

Pityrosporum

invalid

Composition: Ketoconazole, Clobetasol propionate

Ketoconazole:A broad-spectrum anti- fungal agent that acts on the cell membranes of fungi by changing its permeability.Kill Fungus 、Eliminate Pathogeny、High Effect、Quick and Thorough

Clobetasol Propionate:Highly effective as an anti-inflammatory 、anti-allergic and anti-pruritic agent with

few side-effects.Stop itching promptly; Relieve symptom apparently; Eliminate discomfort effectively.

Haicneal Pharmacological Actions

Ketoconazole + Clobetasol propionate ---Synergistic effectCompletely killing fungi, treatment for both manifestation and root cause

Dosage and administration

External use only. Apply about 5 ml of this lotion to the moist hair or effected scalp; massage it gently to let the lotion contact with the scalp thoroughly. After 2-5 minutes, rinse cleanly with water. For the treatment of seborrheic dermatitis and tinea versicolor, the lotion should be used twice a week continuously for 2-4 weeks, and it should be used once every one or two weeks for strengthen effect; the lotion should be used once daily continuously for 5 days for tinea versicolor.

Why Choose Haicneal?

Present Therapeutic Situation

Therapeutic results comparing of antidandruff drugs

Active ingredient

Minimum bacteriostat

concentration（ppm）

Antibacterial ability( Taking the Coal tar as

standard)

Ketoconazole 0.5 200 times

Hydroxy-pyridinethione（ZPT）

4 25 times

Climbazole 4 25 times

Selenium sulfide 10 10 times

Sulphur 12.5 8 times

Coal tar >1 00 Standard

API

Antidandruff Drugs

Cytostatics agent: Piroctone olamine------Malassezia are still exist

Destratum corneum agent : Salicylic acid:------Malassezia are still

exist with scalp thinning

Compare Haicneal with other shampoo

Products HaicnealKetoconazole single-agent

shampoo

Daily antidandruff shampoo

Compounding Variations

Ketoconazole and Clobetasol propionate

Ketoconazole single-agent

ZPT

Sterilization Effect for Pityrosporum

Completely killing (Synergistic effect)

Partly killingPreventing but not killing

Anti-pruritic Effect Quick Anti-itching None None

Anti-dandruff Strong Weak Weak

Hair Care Yes None Yes

Non-dandruff lasting time

Long Short Short

Recurrence possibility Small Big Big

Rising by advertising Necessary and Reasonable Advertisement

--- ---

Market Position The first anti-dandruff band in OTC in China, Vietnam, Burma…

--- ---

Conclusion

Dandruff is a skin disease caused by fungus, killing fungus is the key factor.

Using common shampoo can not kill the fungus, just wash scurf out temporarily but not eliminate scurf. To completely eliminate dandruff, the antimycotic drugs are necessary.

Haicneal contains various of high effective antimycotic compounds, which can quickly and completely destroys fungi, fundamentally treatment for dandruff.

Dandruff always companies with itching on scalp and other symptoms. Haicneal is Compound preparations, destroying fungi and anti-inflammatory, anti-itching simultaneously.

Haicneal specially adds new-style hair conditioner ,which can nourish and protect your hair whilst leaving it more smooth.

Why choose Dihon?

Grace Health Care (Pvt) Limited Pakistan

joint venture with

Kunming Dihon Pharmaceutical Co, Ltd.. For

GCC, Middle-East , Afghanistan.

About DIHON

Dihon Pharmaceutical Group Co.,Ltd. is a Sino-American joint venture founded in 1997 by Great Eastern Enterprises Inc. of US and the majority shareholder Yunnan Dihon Pharmaceutical Group Co., Ltd. of China.

In 2012, Dihon has eight branch companies, which successfully developed itself as a professional pharmaceutical company into a multiple group company in the area of healthcare products.

Currently it is approved with eight national GMP certified dosage forms (including lotion, cream, ointment, tincture, mixture, concentrated decoction, capsule and liniment) and 11 products categories all possessing independent intellectual property rights.

Dihon has over 2,000 staff of R&D, production, marketing and management, and became the second largest pharmaceutical company in Yunnan Province of China in terms of comprehensive strength.

We can provide

Visiting and Training in DIHON Headquarter

We can provide

Compressed towel PVC Board Handbag

Promotional Materials

We can provide

Necessary and Reasonable Advertisement

Grace House, 4,F-9/10, Nazmiabad Karachi, Pakistan, Tel: 00922136609531-8, Fax: 00922136680511, Email, roofi740@yahoo.com,

info@graceinternational.com.pk

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