giving effective presentations, oct. 2016
TRANSCRIPT
WhatIwillcover
1. Howtopresentanengagingstory2. Designingslides:TheAsser9on–Evidencetemplate3. Claus'petpeevesaboutpresenta9ons
Ketogenic diet as supporting treatment option in glioblastoma multiformae
Onaketogenicdiet,theliverproducesketonebodies,inpar9cularβ-hydroxybuturate(BHB)
Ketogenic diet as supporting treatment option in glioblastoma multiformae
BHBcancrosstheblood-brainbarrierandserveasanalterna9vefuelforbraincells,replacingglucose
Ketogenic diet as supporting treatment option in glioblastoma multiformae
Adietisketogenicwhencarbohydrateintakefallsbelow20-50gram/daywhilefatcomprises~80%ofcaloricintake
Ketogenic diet as supporting treatment option in glioblastoma multiformae
Glioblastomamul9formae(GBM)needsglucoseforgrowth,andseemsinhibitedbythepresenceofBHB
Ketogenic diet as supporting treatment option in glioblastoma multiformae
SeveralclinicaltrialsarecurrentlyongoingtodeterminewhetherketogenicdietscansloworinhibitGBMgrowth
Why eating eggs and bacon may cure brain cancer
Despitemedicaladvances,mostcancertreatmentsaregruesomeyetonlymoderatelysuccessful
Why eating eggs and bacon may cure brain cancer
Ifwecouldpreventortreatcancerbyasimplechangeindiet,thatwouldbeawesome
Why eating eggs and bacon may cure brain cancer
Increasingevidencelinkscancertohigh-carbohydratediets(inpar9cularsugarandstarches)
Why eating eggs and bacon may cure brain cancer
Ea9ngahigh-fat,low-carbdiet(liketheAtkinsdiet)maystarvetumorsofnecessaryglucose
Why eating eggs and bacon may cure brain cancer
Ini9altrialswithbrain-cancerpa9entshavebeenpromising,andfurthertrialsareongoing
Formaximumimpact,useapproximately
equalamountsoftimeforeachlayer
Why? ~30%oftalk
What? ~30%oftalk
How? ~30%oftalk(atmost)
Ketogenic diet as supporting treatment option in glioblastoma multiformae
• Onaketogenicdiet,theliverproducesketonebodies,inpar9cularβ-hydroxybuturate(BHB)
• BHBcancrosstheblood-brainbarrierandserveasanalterna9vefuelforbraincells,replacingglucose
• Adietisketogenicwhencarbohydrateintakefallsbelow20-50gram/daywhilefatcomprises~80%ofcaloricintake
• Glioblastomamul9formae(GBM)needsglucoseforgrowth,andseemsinhibitedbythepresenceofBHB
• SeveralclinicaltrialsarecurrentlyongoingtodeterminewhetherketogenicdietscansloworinhibitGBMgrowth
Why eating eggs and bacon may cure brain cancer
• Canceristheleadingcauseofdeathindevelopedcountries
• Despitemedicaladvances,mostcancertreatmentsaregruesomeyetonlymoderatelysuccessful
• Ifwecouldpreventortreatcancerbyasimplechangeindiet,thatwouldbeawesome
• Increasingevidencelinkscancertohigh-carbohydratediets(inpar9cularsugarandstarches)
• Ea9ngahigh-fat,low-carbdiet(liketheAtkinsdiet)maystarvetumorsofnecessaryglucose
• Ini9altrialswithbrain-cancerpa9entshavebeenpromising,andfurthertrialsareongoing
Sequencingcostshavedeclined1000-fold
from2007to2010C
ost p
er g
enom
e
Year
Sep. 2007: $10,000,000
Sep. 2010: $10,000
Source: genome.gov/sequencingcosts
Violentcrimeisatanall-timelowH
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Year Source: http://blogs.berkeley.edu/2010/06/16/a-crime-puzzle-violent-crime-declines-in-america/
WhatIwillcover
1. Howtopresentanengagingstory2. Designingslides:TheAsser9on–Evidencetemplate3. Claus'petpeevesaboutpresenta9ons
Claus'1stlawofpresentations:
Alltextonslidesneedstobereadaloud
WhileIgenerallyprefergraphicalvisualiza9ons,insomecasestextispreferred.Forexample,summaryslidesoaenrequiresomeamountoftext.Textisfineaslongasyoureaditwordforword.Ifyoustartparaphrasingortalkingoveratext-heavyslide,however,youraudiencewillgetconfused.Theycannotatthesame9mereadthetextandlistentoyou.Someaudiencememberswillreadthetextandstoplistening.Otherswilllistenbutnotread.Allwillworrythattheymadethewrongchoiceandmissedsomethingimportant.
Nowanexampleofhownottodoit.
Thisslideisfulloftext.Likely,noneofthetextma\ers,butyoucan'tknowforsureunlessyoureaditall.Butifyouwanttoreadit,youcan'tlistentomeblatheringonaboutsomethingcompletelydifferent.Thatisbecausehumanscannotprocesstwoseparatecontentstreams(visualandoral)atthesame9me.Nextweek'swinninglo\erynumberswillbe5,13,28,33,34,36,41.IknowbecauseI'ma9metravelerfromthefuture.
Violentcrimeisatanall-timelowH
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Year Source: http://blogs.berkeley.edu/2010/06/16/a-crime-puzzle-violent-crime-declines-in-america/
The Department in numbers
• We have 36 faculty members • Annual grant funding: $5M
– Funding agencies: NSF, NIH, ARO, ONR, DARPA, DTRA, USDA
• Our faculty members supervise 112 graduate students – 69 EEB, 23 Plant Biology, 10 CMB, 10 other
• 20% of our graduate students receive external fellowships – 14 NSF GRFP, 1 NIH F31, 10 other
The Department in numbers
36 faculty members
112 graduate students
69 EEB 23 PB 10 CMB 10 Other
20% students on external fellowships
14 NSF GRFP 1 NIH F31 10 Other
$5M annual grant funding
NSF, NIH, ARO, ONR, DARPA, DTRA, USDA
Evenwithsubstantialdivergenceininterface
sites,evolvedproteinsbindancestors
Kachrooetal.,Science2015
divergenceininterfacesites
divergenceinnon-interfacesites
Advantagesofdarkbackgrounds
• Moreelegant• Easierontheeye• Goodwithphotos
SassodellaCroce,ValBadia,Italy