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30th May , 2014 Volume No.: 34 Issue No.: 01

Contents • Message from GNIPST • Letter to the Editor • News Update • Health awareness • Disease Outbreak News • Forth Coming Events • Drugs Update • Campus News • Student’s Section • Editor’s Note • Archive •

Vision

TO GROW AS A CENTRE OF EXCELLENCE IN THE FIELD OF PHARMACEUTICAL AND BIOLOGICAL SCIENCE

EDITOR: Soumya Bhattacharya GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND

TECHNOLOGY

GNIPST Photo Gallery For your comments/contributionOR

For Back-Issues, mailto:gnipstbulletin@gmail.com

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MESSAGE FROM GNIPST

GNIPST BULLETIN is the official publication of Guru Nanak Institute of Pharmaceutical Science & Technology. All the members of GNIPST are proud to publish the 34th Volume of “GNIPST BULLETIN”. Over the last three years this bulletin updating readers with different scientific, cultural or sports activities of this prestigious institute and promoting knowledge of recent development in Pharmaceutical and Biological Sciences. Student’s section is informing readers about some curious facts of drug discovery, science, sports and other relevant fields. We look forward to seeing your submission and welcome comments and ideas you may have.

NEWS UPDATE

Learning early in life may help keep brain cells alive (27th May, 2014)

Researchers report that the massive proliferation of new brain cells most likely helps young animals leave the protectiveness of their mothers and face dangers, challenges and opportunities of adulthood. "It's not that learning makes more cells," "It's that the process of learning keeps new cells alive that are already present at the time of the learning experience." Since the process of producing new brain cells on a cellular level is similar in animals, including humans, ensuring that adolescent children learn at optimal levels is critical.

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Physical activity helps maintain mobility in older adults (27th May, 2014)

Results from a new University of Florida study shows daily moderate physical activity may mean the difference between seniors being able to keep up everyday activities or becoming housebound. In fact, moderate physical activity helped aging adults maintain their ability to walk at a rate 18 percent higher than older adults who did not exercise.

'Virtual human' shows that stiff arteries can explain cause of high blood pressure (20th May, 2014)

High blood pressure is highly age-related and affects more than 1 billion people worldwide. But doctors can't fully explain the cause of 90 per cent of all cases. A computer model of a "virtual human" suggests that stiff arteries alone are enough to cause high blood pressure. High blood pressure is a major source of morbidity and mortality, because it makes individuals more prone to heart failure, stroke and kidney disease. When blood pressure travels down the aorta from the heart, a special group of cells in the aortic wall, called baroreceptors, sense the pressure in this stretch of the aortic wall and send signals with this information to the nervous system. If the blood pressure is too high, these cells send stronger signals and the body is able to lower blood pressure. However, if the aorta gets stiffer, as typically happens with age, this stretch of the aorta is not as sensitive as it once was in measuring blood pressure. Thus, although a person's blood pressure may have increased, the baroreceptors do not signal as intensively as they should and the body does not get the message to lower blood pressure. With the stiffening of the wall that follows aging, these

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sensors become less able to send signals that reflect the actual blood pressure. With the use of existing experimental data and models of the aging human aorta, the researchers were able to show quantitatively how the stiffening of the aorta with age causes the baroreceptors to misinform the central nervous system about blood pressure, thus preventing the system from downregulating blood pressure. The model predictions were compared with data from the Nord-Trøndelag Health Study (HUNT2), which is composed of information on the health history of 74,000 people, including blood sample collection from 65,000 people.

Clinical trial reaffirms diet beverages play positive role in weight loss (27th May, 2014) A new study confirms that drinking diet beverages can help people lose weight. "This study clearly demonstrates that diet beverages can in fact help people lose weight, directly countering myths in recent years that suggest the opposite effect -- weight gain." The 12-week clinical study of 303 participants is the first prospective, randomized clinical trial to directly compare the effects of water and diet beverages on weight loss within a behavioral weight loss program. Conducted simultaneously by researchers at the University of Colorado Anschutz Center for Health and Wellness in Aurora and Temple University's Center for Obesity Research and Education in Philadelphia, the study shows that subjects who consumed diet beverages lost an average of 13 pounds -- 44 percent more than the control group, which lost an average of 9 pounds. More than half of the participants in the diet beverage group -- 64 percent -- lost at least five percent of their body weight, compared

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with only 43 percent of the control group. Losing just five percent of body weight has been shown to significantly improve health, including lowering the risk of heart disease, high blood pressure and type 2 diabetes.

Sylvant is First FDA-Approved Drug for Multicentric Castleman’s Disease (April, 2014) The U.S. Food and Drug Administration (FDA) has approved Janssen Biotech’s Sylvant(siltuximab), an orphan drug for patients with multicentric Castleman’s disease (MCD). MCD is a rare disorder resembling cancer of the lymph nodes (lymphoma). Sylvant is an interleukin-6 (IL-6) antagonist that blocks a protein to help slow abnormal growth of immune cells. In clinical trials, a tumor response was seen in 34 percent of 79 participants treated with Sylvant and best supportive care (BSC), but no participant treated with placebo and BSC had a tumor response. Sylvant is used in patients who do not have HIV or human herpes virus 8.

Pfizer Announces Approval of Over-the-Counter Nexium 24HR (April, 2014) The mega-blockbuster Nexium (esomeprazole magnesium) has been approved for over-the-counter (OTC) use by the U.S. Food and Drug Administration (FDA). The newly marketed OTC - Nexium 24HR - is a proton pump inhibitor used for gastroesophageal reflux disease (GERD), otherwise known as heartburn. The prescription product Nexium is indicated for treatment of erosive esophagitis, gastroesophageal reflux disease (GERD) and for use in eradication of H. pylori to reduce the risk of duodenal (intestinal) ulcer recurrence. Nexium reaped in over $6

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billion in 2013 and has long been ranked in the top 5 drugs by sales.

GSK’s Tanzeum Approved: A Once-Weekly Injection for Type 2 Diabetes (April, 2014) Tanzeum (albiglutide) is a newly approved glucagon-like peptide-1 (GLP-1) receptor agonist, a hormone that helps normalize blood sugar levels in patients with type 2 diabetes. Tanzeum is given by subcutaneous (under the skin) injection, and, as with most diabetes treatments, is to be used alongside diet and exercise. The safety and effectiveness of Tanzeum was shown in eight clinical trials involving over 2,000 participants with type 2 diabetes. Tanzeum was studied alone and in use with other type 2 diabetes treatments, including metformin, glimepiride, pioglitazone, and insulin. Byetta and Victoza are other drugs in the same class as Tanzeum.

Low-Power Laser May Trigger Tooth Repair (28th May,

2014) Researchers report that a low-power laser can trigger stem cells in the body to repair teeth in mice. The laser prompted dental stem cells to form dentin, the hard material that is similar to bone and provides most of a tooth's structure. This type of laser therapy may also prove useful in other cases that require tissue regeneration, such as wound healing and bone repair, according to the researchers.

For detail mail to editor

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HEALTH AWARENESS

SECONDHAND SMOKE –A SERIOUS PROBLEM

Secondhand smoke is a mixture of gases and fine particles that includes:

• Smoke from a burning tobacco product such as a cigarette, cigar, or pipe

• Smoke that has been exhaled or breathed out by the person or people smoking

• More than 7,000 chemicals, including hundreds that are toxic and about 70 that can cause cancer. Most exposure to secondhand smoke occurs in homes and workplaces. Secondhand smoke exposure also continues to occur in public places such as restaurants, bars, and casinos, as well as multiunit housing and vehicles. Eliminating smoking in indoor spaces is the only way to fully protect nonsmokers from secondhand smoke exposure. Separating smokers from nonsmokers within the same air space, cleaning the air, opening windows, and ventilating buildings does not eliminate secondhand smoke exposure. Since 1964, 2.5 million nonsmokers have died from exposure to secondhand smoke.

Health effect on children

• Ear infections

• More frequent and severe asthma attacks

• Respiratory symptoms (e.g., coughing, sneezing, shortness of breath)

• Respiratory infections (i.e., bronchitis, pneumonia)

• A greater risk for sudden infant death syndrome (SIDS)

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In U.S. children aged 18 months or younger, secondhand smoke exposure is responsible for:

• An estimated 150,000–300,000 new cases of bronchitis and pneumonia annually

• Approximately 7,500–15,000 hospitalizations annually

Health effect on adults In adults who have never smoked, secondhand smoke can cause cardiovascular disease and lung cancer.

Cardiovascular Disease

• For nonsmokers, breathing secondhand smoke has immediate harmful effects on the cardiovascular system that can increase the risk for heart attack. People who already have heart disease are at especially high risk.

• Nonsmokers who are exposed to secondhand smoke increase their heart disease risk by 25–30%.

• It is estimated that secondhand smoke exposure caused nearly 34,000 heart disease deaths annually (during 2005–2009) among adult nonsmokers in the United States.

• Stroke is caused by exposure to secondhand smoke.

Cancer

• Secondhand smoke (SHS) is classified as a “known human carcinogen” (cancer-causing agent) by the US Environmental Protection Agency (EPA), the US National Toxicology Program, and the International Agency for Research on Cancer (IARC – a branch of the World Health Organization).

• Tobacco smoke is a mixture of gases and particles. It contains more than 7,000 chemical compounds. More than 250 of these

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chemicals are known to be harmful, and at least 69 are known to cause cancer.

• SHS has been linked to lung cancer. There is also some evidence suggesting it might be linked to lymphoma, leukemia, and brain tumors in children, and cancers of the larynx (voice box), pharynx (throat), nasal sinuses, brain, bladder, rectum, stomach, and breast in adults.

• IARC reported in 2009 that parents who smoked before and during pregnancy were more likely to have a child with hepatoblastoma. This rare liver cancer is thought to start while the child is still in the uterus. Compared with non-smoking parents, the risk was about twice as high if only one parent smoked, but nearly 5 times higher when both parents smoked.

• Nonsmokers who are exposed to secondhand smoke at home or work increase their lung cancer risk by 20–30%.

• Secondhand smoke exposure causes an estimated more than 7,300 lung cancer deaths annually (for 2005–2009) among adult nonsmokers in the United States. Secondhand smoke and breast cancer

• Whether SHS increases the risk of breast cancer is an issue that’s still being studied. Both mainstream and SHS have about 20 chemicals that, in high concentrations, cause breast cancer in rodents. And we know that in humans, chemicals from tobacco smoke reach breast tissue and can be found in breast milk.

• One reason the link between SHS and breast cancer risk in human studies is uncertain is because breast cancer risk has not clearly been shown to be increased in active smokers. One possible explanation for this is that tobacco smoke might have different effects on breast cancer risk in smokers compared to those who are exposed to SHS.

• A report from the California Environmental Protection Agency in 2005 concluded that the evidence regarding SHS and breast cancer is “consistent with a causal association” in younger women. This

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means SHS acts as if it could be a cause of breast cancer in these women. The 2006 US Surgeon General’s report, The Health Consequences of Involuntary Exposure to Tobacco Smoke, sums it up by saying that there is “suggestive but not sufficient” evidence of a link.

• Research is still being done, but women should be told that this possible link to breast cancer is yet another reason to avoid being around SHS.

There is no risk-free level of secondhand smoke exposure; even brief exposure can be harmful to health. Smoke-free laws can reduce the risk of heart disease and lung cancer among nonsmokers. When a nonsmoker breathes in secondhand smoke, the body begins to metabolize or break down the nicotine that was in the smoke. During this process, a nicotine byproduct called cotinine is created. Exposure to nicotine and secondhand smoke can be measured by testing saliva, urine, or blood for the presence of cotinine.

Many in the United States Continue to be Exposed to Secondhand Smoke

• An estimated 88 million nonsmokers in the United States were exposed to secondhand smoke in 2007–2008.

• Children are at particular risk for exposure to secondhand smoke: 53.6% of young children (aged 3–11 years) were exposed to secondhand smoke in 2007–2008.

• While only 5.4% of adult nonsmokers in the United States lived with someone who smoked inside their home, 18.2% of children (aged 3–11 years) lived with someone who smoked inside their home in 2007–2008.

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• Among children who live in homes in which no one smokes inside, those who live in multiunit housing have 45% higher cotinine levels compared to those who live in detached homes.

• Today about half of the children between ages 3 and 18 in the U.S. are exposed to cigarette smoke regularly, either at home or in places such as restaurants that still allow smoking. (Based on CDC facts)

DISEASE OUTBREAK NEWS Human infection with avian influenza A(H7N9)

virus

(28th May, 2014)

On 26 May 2014, the National Health and Family Planning Commission (NHFPC) of China notified WHO of 3 additional laboratory-confirmed cases of human infection with avian influenza A(H7N9) virus. Read more

FORTHCOMING EVENTS ∆ 5th International Conference on Stem Cells and Cancer

,2014,JNU Convention Centre, New Delhi,India from 8-10 November.2014

∆ World no tobacco day,2014 on 31st May,2014

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DRUGS UPDATES

FDA approves Dalvance to treat skin infections (23rd May, 2014) The U.S. Food and Drug Administration approved Dalvance (dalbavancin), a new antibacterial drug used to treat adults with skin infections. Dalvance is intended to treat acute bacterial skin and skin structure infections (ABSSSI) caused by certain susceptible bacteria like Staphylococcus aureus(including methicillin-susceptible and methicillin-resistant strains) andStreptococcus pyogenes. The treatment is administered

intravenously. Read more

CAMPUS NEWS

Reminiscence, 2014(GNIPST Reunion) was held in College campus on 2nd February,2014.

1st Annual Sports of GNIPST was held on 3rd February,2014 in College campus ground.

An industrial tour and biodiversity tour was conducted in Sikkim for B.Pharm and B.Sc. students under the supervision of Mr. Asis Bala, Ms. Jeentara Begum and Ms. Moumita Chowdhury.

B.Pharm 3rd year won the GNIPST Football Champions trophy, 2013. B.Pharm 3rd year won the final match 1-0 against B.Pharm 2nd year. Deep Chakraborty was the only scorer of the final.

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Students of GNIPST organized pre puja celebration programme, ‘Saaranya’ on 7th October, 2013 in college Auditorium.

GNIPST organized a garment distribution programme on 28th September, 2013 at Dakshineswar Kali Temple and Adyapith, Kolkata. On this remarkable event about hundred people have received garments. More than hundred students and most of the faculties participated on that day with lot of enthusiasm.

GNIPST celebrated World Heart Day (29th September) and Pharmacist’s Day (25th September) on 25th and 26th September, 2013 in GNIPST Auditorium. A seminar on ‘Violence against woman’ and ‘female foeticide’ was held on GNIPST Auditorium on 25th September organized by JABALA Action Research Organization. On 26th September an intra-college Oral and Poster presentation competition related to World Pharmacist’s day and Heart day was held in GNIPST. Ms. Purbali Chakraborty of B.Pharm 4th year won the first prize in Oral Presentation. The winner of Poster presentation was the group of Ms. Utsa Sinha, Mr. Koushik Saha and Mr. Niladri Banerjee (B.Pharm 4th year). A good number of students have participated in both the competition with their valuable views.

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STUDENTS’ SECTION

WHO CAN ANSWER FIRST????

Which consumer product was invented by T.T.Pond in 1846?

Which FMCG product was introduced by Lever Brothers in 1895?

Answer of Previous Issue’s Questions: A) Lakmé Cosmetics B) L'Oréal

Identify the famous brothers

Answer of Previous Issue’s Image: Chhanda Gayen

Congratulation

Subhodeep Sengupta(2013 Pass Out) for your right answer of the previous issue’s student’s section questions

Send your thoughts/ Quiz/Puzzles/games/write-ups or any other

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contributions for Students’ Section& answers of this Section at gnipstbulletin@gmail.com

EDITOR’S NOTE

I am proud to publish the 1st issue of 34th Volume of GNIPST BULLETIN. GNIPST BULLETIN now connected globally through facebook account ‘GNIPST bulletin’

I want to convey my thanks to all the GNIPST members and the readers for their valuable comments, encouragement and supports.

I am thankful to Dr. Abhijit Sengupta, Director of GNIPST for his valuable advice and encouragement. Special thanks to Dr. Prerona Saha , Mr. Debabrata Ghosh Dastidar and Mrs. Jeenatara Begum for their kind co-operation and technical supports. An important part of the improvement of the bulletin is the contribution of the readers. You are invited to send in your write ups, notes, critiques or any kind of contribution for the forthcoming special and regular issue.

ARCHIVE

Teacher’s day was celebrated on 5th September, 2013 by the students of GNIPST in GNIPST Auditorium.

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Azalea (exotic flower ) , the fresher welcome programme for newcomers of GNIPST in the session 2013-14 was held on 8th August in GNIPST Auditorium.

One day seminar cum teachers’ development programme for school teachers on the theme of “Recent Trends of Life Sciences in Higher Education” organized by GNIPST held on 29th June, 2013 at GNIPST auditorium. The programme was inaugurated by Prof . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, Dy Director of JIS Group and Dr. Abhijit Sengupta, Director cum Principal of GNIPST with lamp lighting. The programme started with an opening song performed by the B.Pharm students of this institute. The seminar consists of a series of lectures, video presentations and poster session. On the pre lunch session 4 lectures were given by Dr. Lopamudra Dutta, Mr. Debabrata Ghosh Dastidar, Ms. Swati Nandy and Ms. Tamalika Chakraborty respectively. On their presentation the speakers enlighten the recent development of Pharmacy, Genetics and Microbiology and their correlation with Life Sciences. On the post lunch session, Ms. Saini Setua and Ms. Sanchari Bhattacharjee explained the recent development and career opportunities in Biotechnology and Hospital Management. The programme was concluded with valedictory session and certificate distribution. About 50 Higher secondary school teachers from different schools of Kolkata and North& South 24 Parganas district of West Bengal participated in this programme. A good interactive session between participants and speakers was observed in the seminar. The seminar was a great success with the effort of faculties, staffs and students of our Institute. It was a unique discussion platform for school teachers and professional of the emerging and newer branches of Life Science.

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The general body meeting of APTI, Bengal Branch has been conducted at GNIPST on 15th June, 2012. The program started with a nice presentation by Dr. Pulok Kr. Mukherjee, School of Natural Products, JU on the skill to write a good manuscript for publication in impact journals. It was followed by nearly two hour long discussion among more than thirty participants on different aspects of pharmacy education. Five nonmember participants applied for membership on that very day.

GNIPST is now approved by AICTE and affiliated to WBUT for conducting the two years’ post graduate course (M.Pharm) in PHARMACOLOGY. The approved number of seat is 18.

The number of seats in B.Pharm. has been increased from 60 to 120.

AICTE has sanctioned a release of grant under Research Promotion Scheme (RPS) during the financial year 2012-13to GNIPST as per the details below: a. Beneficiary Institution: Guru Nanak Institution of Pharmaceutical Science & Technology. b. Principal Investigator: Dr. LopamudraDutta.

c. Grant-in-aid sanctioned:Rs. 16,25000/- only

d. Approved duration: 3 years

e. Title of the project: Screening and identification of potential medicinal plant of Purulia & Bankura districts of West Bengal with respect to diseases such as diabetes, rheumatism, Jaundice, hypertension and developing biotechnological tools for enhancing bioactive molecules in these plants.

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