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GGGNNNIIIPPPSSSTTT BBBUUULLLLLLEEETTTIIINNN 222000111555 24th April, 2015 Volume No.: 44 Issue No.: 03

Vision

TO REACH THE PINNACLE OF GLORY AS A CENTRE OF EXCELLENCE IN THE FIELD OF PHARMACEUTICAL AND BIOLOGICAL SCIENCES BY KNOWLEDGE

BASED LEARNING AND PRACTICE

Contents • Message from PRINCIPAL• Editorial board• Historical article• News Update• Knowledge based Article• Disease Related Breaking

News• Upcoming Events• Drugs Update• Campus News• Student’s Section• Editor’s Note• Archive

GNIPST Photo Gallery For your comments/contribution OR For Back-Issues, mailto:gnipstbulletin@gmail.com

GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY

W e bs i t e : ht t p: / / gni ps t. a c. i n

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MESSAGE FROM PRINCIPAL

"It can happen. It does happen. But it can't happen if you quit." Lauren Dane.

‘We are what we repeatedly do. Excellence then is not an act, but a habit.’ Aristotle

It gives me immense pleasure to pen a few words for our e-bulletin. At the onset I would like to thank the last year’s editors and congratulate the newly selected editors for the current year.

Our first consideration is always in the best interest of the students. Our goal is to promote academic excellence and continuous improvement.

I believe that excellence in education is aided by creating a learning environment in which all learners are supported in maximizing their potential and talents. Education needs to focus on personalized learning and instruction, while promoting an education system that is impartial, universally accessible, and meeting the needs of all students.

It is of paramount importance that our learners have sufficient motivation and encouragement in order to achieve their aims. We are all very proud of you, our students, and your accomplishments and look forward to watching as you put your mark on the profession in the years ahead.

The call of the time is to progress, not merely to move ahead. Our progressive Management is looking forward and wants our Institute to flourish as a Post Graduate Institute of Excellence. Steps are taken in this direction and fruits of these efforts will be received by our students in the near future. Our Teachers are committed and dedicated for the development of the institution by imparting their knowledge and play the role of facilitator as well as role model to our students.

The Pharmacy profession is thriving with a multitude of possibilities, opportunities and positive challenges. At Guru Nanak Institute of Pharmaceutical Science and Technology, our focus is on holistic needs of our students.

I am confident that the students of GNIPST will recognize all the possibilities, take full advantage of the opportunities and meet the challenges with purpose and determination.

Excellence in Education is not a final destination, it is a continuous walk. I welcome you to join us on this path.

My best wishes to all.

Dr. A. Sengupta

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EDITORIAL BOARD

CHIEF EDITOR DR. ABHIJIT SENGUPTA EDITOR MS. JEENATARA BEGUM ASSOCIATE EDITOR MR. DIPANJAN MANDAL

HISTORICAL ARTICLE Wresting the Jungle’s Secrets: Expeditions in search of new medicinal plants probably are as old as Pharmacy. Scientific adventurers, such as Henry Hurd Rusby (1855-1940), opened vast new horizons for the advancement of Pharmacy and Medicine, late in the nineteenth century. Sent by Parke, Davis & Company in 1884 to Peru for supplies of coca leaves, Dr. Rusby crossed the Andes and journeyed down the Amazon to the Atlantic amid incredible hardships. He returned with 45,000 botanical specimens. Among them were many new drug plants, including cocillana bark, pharmaceutical preparations of which are still important to Medicine. Dr. Rusby later became Dean of the College of Pharmacy of Columbia University.

NEWS UPDATE Delayed diagnosis of Celiac disease may put lives

at risk: (24th April, 2015) Celiac disease is one of the most common life-long conditions in Europe, yet many people remain undiagnosed and lengthy diagnostic delays may be putting lives at risk. Today, doctors are being urged to consider testing for celiac disease in anyone showing signs and symptoms of the condition and to consider screening everyone in high-risk groups.

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World's first genetic modification of human embryos reported: Experts consider ethics: (24th April, 2015) Chinese scientists say they've genetically modified human embryos for the very first time. The team attempted to modify the gene responsible for beta-thalassaemia, a potentially fatal blood disorder, using a gene-editing technique known as CRISPR/Cas9. Gene editing is a recently developed type of genetic engineering in which DNA is inserted, replaced, or removed. Here, experts weigh-in with ethical questions and considerations.

Discovery may open door for treating fragile X carriers: (24th April, 2015) Fragile X syndrome, an inherited cause of autism and intellectual disability, can have consequences even for carriers of the disorder who don't have full-blown symptoms.

New light shed on brain's source of power: (24th April, 2015) New research represents a potentially fundamental shift in our understanding of how nerve cells in the brain generate the energy needed to function. The study shows neurons are more independent than previously believed and this research has implications for a range of neurological disorders.

New insight into how brain makes memories: (24th April, 2015) Researchers have identified the role that a key protein associated with autism and the co-occurrence of alcohol dependency and depression plays in forming the spines that create new connections in the brain.

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Long lasting anti-hemophilia factor safe in kids, experts say: (24th April, 2015) Children with hemophilia A require three to four infusions each week to prevent bleeding episodes, chronic pain and joint damage. The effect on quality of life can be significant, due to time and discomfort associated with infusions. For these reasons, under dosing is common, leaving children at increased risk for bleeding episodes and even death.

Non-Alcoholic Fatty Liver Disease, Steatohepatitis: NASH linked to 50% higher death rate compared with NAFLD: (24th April, 2015) Results from a large population-based cohort of almost a million people in the UK found that the chances of dying from non-alcoholic steatohepatitis, over a 14-year period, was approximately 50 percent higher than for those with non-alcoholic fatty liver disease.

Cancer rates among patients with hepatitis C are increased compared to those not infected: (24th April, 2015) New results show that cancer rates in patients with the hepatitis C virus (HCV) were significantly increased compared to the non-HCV cohort. The researchers suggest an extrahepatic manifestation of HCV may be an increased risk of cancer.

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Novel therapeutic candidate targets key driver of HCC in genomically defined subset of patients: (24th April, 2015) Findings on a novel therapeutic candidate for a genomically defined subset of hepatocellular carcinoma (HCC) patients with an aberrant fibroblast growth factor receptor 4 (FGFR4) pathway have been presented. BLU-554, a small molecule inhibitor of FGFR4, has been identified as a potential treatment option for up to 30 percent of HCC patients.

Discovery of a protein capable of regulating DNA repair during sperm formation: (24th April, 2015) Researchers have discovered that the signalling route - a cascade activation of several molecules - triggered by the ATM protein regulates DNA repair during the production of spermatocytes by meiosis, the cell division process which yields spermatozoa. For detail mail to editor

KNOWLEDGE BASED ARTICLE Combined brachytherapy techniques should be 'benchmark' for cervical cancer treatment

The first large international study to investigate the late side-effects of a combination of two forms of brachytherapy to treat cervical cancer has shown that the technique successfully delivers higher radiation doses to the tumour without an increase in treatment-related problems afterwards. Brachytherapy is a type of internal radiotherapy that involves putting a radioactive source close to, or in the tumour. It is often performed after a CT or MRI scan has pinpointed the exact

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position of the cancer, so that the radiation treatment can be targeted precisely; this is called image-guided brachytherapy (IGBT). During intracavitary (IC) brachytherapy, the radioactive applicator is placed in the uterus and the vagina, while interstitial (IS) brachytherapy involves inserting needles directly into the tumour to deliver the radiation. In a presentation to the 3rd ESTRO Forum in Barcelona, Spain, on Saturday, Dr Lars Fokdal (MD, PhD), a consultant at the Aarhus University Hospital, Denmark, will say: "Image-guided brachytherapy has transformed treatment for cervical cancer considerably, and dose adaptation and a combination of intracavitary and interstitial brachytherapy enable us to deliver radiation that is targeted at the tumour while avoiding other organs. However, although some centres are using IC/IS brachytherapy, there are concerns that the technique might increase the likelihood of adverse side-effects occurring three months or more after the end of radiation treatment." Dr Fokdal and colleagues in Austria, France, UK, Slovenia, The Netherlands and Ireland, enrolled 731 women with cervical cancer that had started to spread into nearby tissues (locally advanced) into the "retroEMBRACE" study -- a study that collected retrospective data on the use of IGBT to treat cervical cancer in nearly 800 women in 12 different countries. The researchers analysed data from a group of 300 patients from institutions that systematically used combined IC and IS brachytherapy on more than 20% of women, and a group of 310 patients from institutions where the most common treatment used was IC brachytherapy alone. "We found that combined IC/IS brachytherapy enabled us to deliver higher doses to the tumour without delivering more radiation to the bladder and the bowel. This meant that there was no increased risk in severe adverse side-effects three or more months later, but there is a better chance of a cure," he will tell the conference.

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"These results show that combined IC/IS brachytherapy is a good treatment and should serve as a benchmark for future brachytherapy in cervical cancer." Problems (morbidity) caused by radiotherapy for cervical cancer can include bladder and bowel dysfunction; in rare cases they can include the narrowing, loss of flexibility or drying of the vagina or bowel (known as stenosis) or holes forming in the wall of the vagina, bowel or bladder (fistulas). These are graded from 0 for no problems to 5 for death related to radiation treatment. After a median follow-up of 40 months, ranging from three to 163 months, the researchers found there was no significant difference in late bladder, gastro-intestinal or vaginal grade 2-5 morbidities between the two groups of patients. Among the patients in the group more likely to receive IC/IS brachytherapy, 66% (versus 52% in the other group) received high-dose rate brachytherapy, and 47% versus 4% received the combined IC/IS treatment. In addition, 97% (versus 66%) of patients in the IC/IS group benefited from their radiation doses being planned with the aid of MRI scans. Compared to the group least likely to receive IC/IS brachytherapy, the radiation dose in the IC/IS group of patients reached more of the targeted tumour area, with at least 90% of the tumours receiving a dose that was 9Gy higher than in the non-IC-IS patients. However, these higher, targeted doses in the IC/IS group of patients did not result in higher doses of radiation to the bowel, and radiation doses to the bladder was an average of 4Gy lower. Professor Philip Poortmans, President of ESTRO, commented: "Dr Fokdal and colleagues show again that intensive close collaboration between high-level departments from several countries can help to extend our knowledge of how to further improve the outcome of our patients. This specific study of the EMBRACE network shows how the best results may be obtained by properly using the newest technical developments in the field of brachytherapy. Now, the next step is to teach these optimised techniques to all our other colleagues who treat locally advanced

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cervical cancer but do not yet use interstitial techniques as an addition to intracavitary ones."

Jeenatara Begum Assistant Professor

GNIPST

DISEASE RELATED BREAKING NEWS Middle East respiratory syndrome coronavirus

(MERS-CoV) – Saudi Arabia: (16th April, 2015) Between 2 and 12 April 2015, the National IHR Focal Point for the Kingdom of Saudi Arabia notified WHO of 4 additional cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection, including 2 deaths. Cases are listed by date of reporting, with the most recent case listed first. Read more

UPCOMING EVENTS 1st IIMA International Conference on Advances in Healthcare

Management Services is going to held at Ahmedabad, Gujrat, India on 6th to 7th June, 2015.

DRUGS UPDATES Medicure Announces Approval of Expanded Dosing

Time For Aggrastat: (23rd April, 2015) Medicure Inc. ("Medicure" or the "Company") (TSXV:MPH, OTC:MCUJF), a specialty pharmaceutical company, is pleased to announce that the United States Food and Drug Administration (FDA) has approved a revision to the duration of the bolus delivery for the Aggrastat (tirofiban HCl) high-dose bolus (HDB) regimen. Read more

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CAMPUS NEWS SPIRIT JIS 2015

On 03 to 05th April, 2015 JIS organised SPIRIT JIS 2015.

GPAT 2015 Result: The following B.Pharm. final year students have qualified, GPAT-2015. We congratulate them all. Diksha Kumari Rupanjay Bhattacharya Avik Paul

Xtasy 2015: GNIPST is going to organize the Tech Fest ‘Xtasy 2015’ from 30th March, 2015 to 1st April, 2015.

FINISHING SCHOOL TRAINING PROGRAMME: The FINISHING SCHOOL TRAINING PROGRAMME is going to organize by the Entrepreneurship Development Cell and Training & Placement Cell, GNIPST in collaboration with Indian Pharmacy Graduates’ Association (IPGA), Bengal Branch from 21st February to 11th April, 2015 at GNIPST Auditorium.

On 21st February, 2015 the Finishing School Training Programme of GNIPST was inaugurated by Sri Soumen Mukhopadhyay, Deputy Director, Drug Control Office, Goutam Kr. Sen, President, IPGA, Mr. Subroto Saha, Asst. Directorate, Drug Control Office, Mr. Ranendra Chakraborty, Sales Manager and Associate Director Dr. Reddys Laboratory.

On 28th February, 2015 Dr. D. Roy, Former Deputy Drug Controller, Mr. Sujoy Chakraborty, divisional Therapy Manager, Cipla and Mr. Vikranjit Biswas, Senior Manager, Learning & Development, Cipla delivered their valuable lectures in the 2nd day FINISHING SCHOOL TRAINING PROGRAMME of GNIPST.

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On 14th March, 2015 Mr. Milindra Bhattacharya, Senior Manager, QA & QC, Emami Ltd. and Mr. Joydev Bhoumik, Manager, Operation, Ranbaxy Laboratory Limited delivered their valuable lectures in the 3rd day FINISHING SCHOOL TRAINING PROGRAMME of GNIPST.

On 21st March, 2015 Mr. Tridib Neogi, Associate Vice-President (Quality Assurance), Albert David Ltd. delivered his valuable lectures in the 4th FINISHING SCHOOL TRAINING PROGRAMME of GNIPST.

On 28th March, 2015 Dr. Gautam Chaterjee, an Alumni of Jadavpur University and presently associated with NIPER delivered his valuable lectures in the 5th FINISHING SCHOOL TRAINING PROGRAMME of GNIPST. On 11th April, 2015 the closing ceremony of the FINISHING SCHOOL TRAINING PROGRAMME was held in GNIPST Auditorium.

JOBS: All the students of Final Year B. Pharm and M. Pharm are hereby informed that an interview will be conducted by GSK for sales and marketing job. Details given below:

Date : 27.03.2015 Time : 09:45 am Venue : GSK Consumer Healthcare Limited, Unit No. 208,

2nd Floor, Ecospace Campus B (3 B), New Town, Rajarhat, 24 Pgs (N). Kolkata-700156.

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THYROCARE provisionally selected 15 students from JIS Group. Amongst these, 3 students of B. Sc (H) Biotechnology and M. Sc Biotechnology have been selected.

Ipsita Mondal (M. Sc Biotechnology) Debriti Paul (M. Sc Biotechnology) Debopriya Chatterjee {B. Sc (H) Biotechnology}

The final year students of B.Pharm (31 students) and B.Sc (11 students) attended the pooled campus drive of Abbott India Ltd. on 10th March, 2015 at Jadavpur University. Among them 17 students have gone through to the final round of this pooled campus drive and short listed for final selection.

ACHIEVEMENT: Congratulations to Anurag Chanda, student of B.Pharm final year who have got the 1st prize in poster presentation event in Prakriti 2015 at Department of Agricultural and Food engineering, IIT, Kharagpur.

OTHERS:

On 24th and 25th February, 2015 Swamiji of Gourio Math wasdelivered some motivational lectuers in GNIPST.

The students of GNIPST participated in the 4th

Sardar Jodh SinghTrophy organised by NIT on 20th February, 2015.

On 8th February, 2015 Gnipst celebrated the Reunion programme“Reminiscence Reloaded 2015”.

The 2nd Annual Sports of GNIPST was held on 28th and 29thJanuary,2015 in College campus ground.

Congratulations to all the winner of Annual Sports of GNIPST, 2015.

100 meter flat race (Girls):

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Priya Roy Nirmita Gupta Joyoti Ghosh 100 meter flat race (Boys): Arijit Mitra Thakur Deep Chakraborty Arindam Ganguly Three legged race (Girls):

Nayana Sinha Anjali Mondal Saheli Mukherjee Arjita Biswas Aindrila Bhowmick Archita Basu

200 meter flat race (Girls): Priya Roy Nirmita Gupta Anjali Mondal Long Jump (Boys): Dipankar Kamila Arindam Ganguly Rohan Datta Skipping (Girls): Saheli Mukherjee Indira Saha Jayita Roy Shotput (Girls): Chandrika Saha Priya Roy Sneha Paul Shotput (Boys): Arijit Mitra Thakur Arindam Ganguly Rohan Datta Musical Chair (Staff): Mr. Abir Koley Ms. Priyanka Ray Mr. Debabrata Ghoshdastidar Discuss Throw(Girls): Priya Roy Arjita Biswas Varsha Shrivastava 50 meter female flat race (staff): Ms. Aparupa Bhattacharya Ms. Priyanka Ray Ms. Anuranjita

Kundu

100 meter male flat race (staff): Mr. Debabrata Ghoshdastidar Mr. Mrinal Datta Mr. Ranjit

Ghosh Walking race female (staff): Ms. Aparupa Bhattacharya Ms. Anuranjita Kundu Ms. Sumana Roy Balance race female (staff): Ms. Aparupa Bhattacharya Dr. Sriparna KunduSen Ms. Priyanka Ray

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Tug of war (Female staff): Ms. Priyanka Ray Ms. Aparupa Bhattacharya Ms. Prathama SenGupta Dr. Sriparna KunduSen Ms. Sumana Roy Tug of war (Male staff): Mr. Debabrata Ghoshdastidar Mr. Abir Koley Sk. Ziaur Rahman Mr. Ranjit Ghosh Mr. Koushik Dhar Balance race (Girls): Indira Saha Aindrila Bhowmick Pamolita Paul Long Jump (Girls): Aindrila Bhowmick Nirmita Gupta Krishnakali Basu 200 meter flat race (Boys): Dipankar Kamila Arijit Mitra Thakur Kaustav Sakar Sack race (Girls): Aindrila Bhowmick Nirmita Gupta Sayani Banerjee Sack race (Boys): Rohan Datta Souvik Debnath Sayantan Das Relay race (Boys): Dipankar Kamila

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Arijit Mitra Thakur Soumyajit Sinha Sneham Sen Relay race (Girls): Joyoti Ghosh Aindrila Bhowmick Anjali Mondal Poulami Sarkar Go for Goal (Boys): Abhijit Kumar Mondal Arkajyoti Hazra Abhinandan Mondal Tug of war (Boys): Dipu Roy Vishal Singh Sk Minhaz Uddin Ahmed Ritobroto Paul Rohan Dutta Tug of war (Girls): Krishnakali Basu Indira Saha Chandrika Saha Maitryee Banerjee Kajal Nagpal

The male faculties and staffs of GNIPST participated in the 4th

Sardar Jodh Singh Trophy organised by NIT on 15th January, 2015. An industrial tour and biodiversity tour was conducted in Sikkim

for B.Pharm, B.Sc. and M.Sc. students under the supervision of Mr. Dipanjan Mandal, Mr. Samrat Bose and Ms. Aparupa Bhattacharya from 5th January to 12th January, 2015.

GNIPST commemorated the Birth Anniversary of Swami Vivekananda on Monday, 12th January, 2015 & served Oldages and Orphanages.

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STUDENTS’ SECTION WHO CAN ANSWER FIRST????

Who is the first Chief Election Commissioner of India? Answer of Previous Issue’s Questions:

A) Indian Army

Identify the person

Answer of Previous Issue’s Image:

Yuvraj Walmiki

Send your thoughts/ Quiz/Puzzles/games/write-ups or any other contributions for Students’ Section& answers of this Section at gnipstbulletin@gmail.com

EDITOR’S NOTE

It is a great pleasure for me to publish the 3rd issue of 44th Volume of GNIPST BULLETIN. All the followers of GNIPST BULLETIN are able to avail the bulletin through facebook account ‘GNIPST bulletin’ I am very much thankful to all the GNIPST members and readers who are giving their valuable comments, encouragements and supports. I am also thankful to Dr. Abhijit Sengupta, Director

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of GNIPST for his valuable advice and encouragement. Special thanks to Dr. Prerona Saha, Mr. Debabrata Ghosh Dastidar and Mr. Soumya Bhattacharya for their kind co-operation and technical supports. Thank you Mr. Soumya Bhattacharya for the questionnaires of the student section. An important part of the improvement of the bulletin is the contribution of the readers. You are invited to send in your write ups, notes, critiques or any kind of contribution for the forthcoming special and regular issue. ARCHIVE

AICTE has sanctioned a release of grant under Research Promotion Scheme (RPS) during the financial year 2012-13to GNIPST as per the details below: a. Beneficiary Institution: Guru Nanak Institution of Pharmaceutical Science & Technology. b. Principal Investigator: Dr. LopamudraDutta.

c. Grant-in-aid sanctioned:Rs. 16,25000/- only d. Approved duration: 3 years

e. Title of the project: Screening and identification of potential medicinal plant of Purulia & Bankura districts of West Bengal with respect to diseases such as diabetes, rheumatism, Jaundice, hypertension and developing biotechnological tools for enhancing bioactive molecules in these plants.

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Activity Clubs of GNIPST: Name of Club Member Faculty SPORTS Mr. Debabrata GhoshDastidar LITERARY AND PAINTING Ms. Jeenatara Begum SCIENCE AND INNOVATIVE MODELLING

Mr. Samrat Bose

ECO Ms. Sumana Roy SOCIAL SERVICES Dr. Asis Bala PHOTOGRAPHY Ms. Sanchari Bhattacharya CULTURAL Ms. Priyanka Ray DEBATE AND EXTEMPORE Mr. Soumya Bhattacharya

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