hc place cells
DESCRIPTION
HC Place cells. taxi drivers enlarged CA1 region Rat place cells How was this diagram obtained? How reliable is it?. rat running in triangular path. McNaughton et al (1996) J Exp Biol 199 , 173–185. Colours represent different neurons. recordings separated by 1 hr in home cage - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: HC Place cells](https://reader035.vdocument.in/reader035/viewer/2022070400/56813550550346895d9cafd8/html5/thumbnails/1.jpg)
HC Place cells taxi drivers
enlarged CA1 region
Rat place cells
How was this diagram obtained?
How reliable is it?
rat running in triangular path
McNaughton et al (1996) J Exp Biol 199, 173–185
![Page 2: HC Place cells](https://reader035.vdocument.in/reader035/viewer/2022070400/56813550550346895d9cafd8/html5/thumbnails/2.jpg)
Colours represent different neurons
![Page 3: HC Place cells](https://reader035.vdocument.in/reader035/viewer/2022070400/56813550550346895d9cafd8/html5/thumbnails/3.jpg)
recordings separated by 1 hr in home cage
recordings separated by 6 hours of novel environments
![Page 4: HC Place cells](https://reader035.vdocument.in/reader035/viewer/2022070400/56813550550346895d9cafd8/html5/thumbnails/4.jpg)
The recording environment consisted of a moderately illuminated room, with a raised triangular track located in the middle. The rat’s task was to move continuously in one direction around the track to receive food reinforcement at the mid-point of each side
![Page 5: HC Place cells](https://reader035.vdocument.in/reader035/viewer/2022070400/56813550550346895d9cafd8/html5/thumbnails/5.jpg)
It all began…
Note this is actually a restrained rat, being gently moved around
400 ms
O'Keefe J, Dostrovsky J. Brain Res. 1971 Nov;34(1):171-5. [on VLE]
![Page 6: HC Place cells](https://reader035.vdocument.in/reader035/viewer/2022070400/56813550550346895d9cafd8/html5/thumbnails/6.jpg)
Multiple electrodes
O'Keefe &. Recce (1993) Hippocampus 3, 317–330
Use a computer to do spike recognition
![Page 7: HC Place cells](https://reader035.vdocument.in/reader035/viewer/2022070400/56813550550346895d9cafd8/html5/thumbnails/7.jpg)
Gothard et al (1996) J Neurosci: 16:823-835
LEDs to track head position and direction
Inbuilt FET amplifier, 14 x 4
![Page 8: HC Place cells](https://reader035.vdocument.in/reader035/viewer/2022070400/56813550550346895d9cafd8/html5/thumbnails/8.jpg)
![Page 9: HC Place cells](https://reader035.vdocument.in/reader035/viewer/2022070400/56813550550346895d9cafd8/html5/thumbnails/9.jpg)
Freely moving rat
O’Keefe (1976) Experimental neurol 51, 78-109 (1976)
![Page 10: HC Place cells](https://reader035.vdocument.in/reader035/viewer/2022070400/56813550550346895d9cafd8/html5/thumbnails/10.jpg)
Place unit 202-2. There is a smaller high-frequency displace unit in the background
O’Keefe (1976) Experimental neurol 51, 78-109 (1976)
![Page 11: HC Place cells](https://reader035.vdocument.in/reader035/viewer/2022070400/56813550550346895d9cafd8/html5/thumbnails/11.jpg)
O'Keefe Conway (1978) Exp. Brain Res. 31,573-590
light, buzzer, fan, white card,
trained to forage in T-maze
![Page 12: HC Place cells](https://reader035.vdocument.in/reader035/viewer/2022070400/56813550550346895d9cafd8/html5/thumbnails/12.jpg)
O'Keefe &. Recce (1993) Hippocampus 3, 317–330
place cells [2 and 3] firing as rat ran along runway
theta rhythm of EEG
speed of rat
![Page 13: HC Place cells](https://reader035.vdocument.in/reader035/viewer/2022070400/56813550550346895d9cafd8/html5/thumbnails/13.jpg)
Precession
at end of rhythm at start of rhythm
![Page 14: HC Place cells](https://reader035.vdocument.in/reader035/viewer/2022070400/56813550550346895d9cafd8/html5/thumbnails/14.jpg)
rats foraging over platform
record CA1 pyramidal cells in theta θ rhythm
Skaggs et al (1996) Hippocampus 6:149-172
![Page 15: HC Place cells](https://reader035.vdocument.in/reader035/viewer/2022070400/56813550550346895d9cafd8/html5/thumbnails/15.jpg)
Place cells fire out of θ phase
Skaggs et al (1996) Hippocampus 6:149-172
where was rat when θ was max? where was the max firing of this pyramidal cell?
![Page 16: HC Place cells](https://reader035.vdocument.in/reader035/viewer/2022070400/56813550550346895d9cafd8/html5/thumbnails/16.jpg)
Review Are the CA1 cells firing at random? Are the CA1 neurons firing to
place some other activity motivation?
http://biolpc22.york.ac.uk/750/mem/place_cells.ppt