healthy scaffolding - traditional chinese medicine

HEALTHY

SCAFFOLDING

LIFESTYLE

EXERCISE/DIET/STRESS

MANAGEMENT

PATHOGEN LOAD

MICROBIOME

NEUROTRANSMITTERS

TELOMERES

GENES

ANTI AGING

STRATEGIES

LIFESTYLE

THE KIDNEY

QI

YIN

YANG

JING

“In order to grasp clinical advances

towards longevity, we must understand

metabolic health, insulin resistance and,

Type 2 Diabetes Mellitus.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814170/

Sugar

&

The Other Sugar

CYCLIN

• Atorvastatin Calcium (generic Lipitor)

• Levothyroxine (generic Synthroid)

• Lisinopril (generic Prinivil)

• Omeprazole (generic Prilosec)

• Metformin (generic Glucophage)

• Amlodipine (generic Norvasc)

• Simvastatin (generic Zocor)

29 million Type 2 DM

80 million undiagnosed Type 2 DM

Type 2 DM costs US

$

300B annually

1 of every 3 Medicare $ spent on

Type 2 DM

Four Diabetic Patients

• #1: 26 yo male. Jogs 6 miles a day, eats 1000 calories a day and

meditates. His glucose and early onset heart disease resist treatment.

• #2: 61 yo female. Osteoporosis, Cardiovascular Dx. and her Hgb A1c

is 12.5. She is taking 11 medications and it is difficult to discern which

of her many health complaints are her disease or her medications?

• #3: 42 yo male. Must exercise, eat a stringent diet - NO cheating -

and still has uncontrollable blood sugar.

• #4. 49 yo female. Exercises 6 days a week. Eats ‘clean, lean,

vegetable based diet’ and her blood sugar is consistently unstable but

her deep depression outweighs her concern about her blood sugar.

These 4 patients have in common ONLY blood

sugar and insulin dysregulation. Yet, all 4 of

these patients have the SAME diagnosis:

DIABETES

???????

CREATIVITY

“When people talk listen

completely.”

Ernest Hemingway

How Diabetes Drives

Atherosclerosishttps://www.sciencedaily.com/releases/2008/03/080313124430.htm

Artery of a Diabetic

THE ROLE

OF

SUGAR

GENES FOR DIABETES

Friendly Committee Genes

vs.Tyrant Genes

LOCK & KEY

DIABETES

DIABETES 2

• https://www.hindawi.com/journals/ecam/2014/492193/

•29.1 million + 80.1m undiagnosed

•1.4m new cases dx annually

•1 in 10 adults 20 years or older has

diabetes

https://www.hindawi.com/journals/ecam/2014/492193/

“Whenever I eat sugar I

get a sore throat.”

Patient

SUGAR

• Highly acidic.

• As humans we can’t turn sugar into vitamin C.

• Glucose and ascorbic acid compete with each other.

• Diet high in sugar will result in heat, dampness and

ultimately infection and lower vitamin C.

GLYCATION

• GLYCATION triggered by rapidly digesting carbs & sugar

• Blood Sugar Spikes Quickly = Formation of AGEs

• SUGAR + FAT or PROTEIN = Formation of AGEs

GLUCOPHAGE

METFORMIN

$5.00

METFORMIN

Dimethylbiguanide

Most widely prescribed, least expensive,

drug prescribed for diabetes 2.()

METFORMIN

• Galega officinalis (goat’s rue; French lilac)

• Nicholas Culpepper, 17th century herbalist, wrote about it’s effect

on symptoms now associated with Type 2 Diabetes.

• Shown in 1800’s to be rich in GUANIDINE

• 1930’s demonstrated guanidine effective in reducing blood sugar

• Guanidine too strong with harsh side effects for consistent use.

• 1957 - Dr. Jean Stern, French pharmacologist, diabetologist,

discovers Glucophage (Metformin).

GALEGA OFFICINALIS

METFORMIN

Geroprotective Agent?•Reduces all cause mortality &

diseases of aging independent of its

effect on diabetes control:

•a systemic review

•& meta-analysis.

• https://www.ncbi.nlm.nih.gov/pubmed/28802803

http://www.nature.com/nm/journal/v19/n10/fig_tab/nm.3373_F1.html

METFORMIN

THE SHADOW

• Metformin Lowers B12 - <B12 = > neuropathy

• 40% of Diabetics who have had diabetes for 10 or more

years - suffer with Neuropathy

• Neuropathy associated with B1 and B12 deficiency

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199287/

METFORMIN

•30-40% reduction in cancer incidence among

diabetics who use metformin in comparison with other

drugs.

•Patients using metformin showed more robust

lymphocytes

• http://www.pnas.org/content/112/6/1809.full


http://www.pnas.org/content/112/6/1809.full

Metformin

Not Only About The Earth

Is it Impacting Wood/Earth Relationship?

• Shown in 8 studies to lower elevated Liver Enzymes ALT

(Alanine transaminase) & AST Aspartate transaminase


CASE HISTORY

WILLIAM

LIFESTYLE

THE CRACKER TESTLOW (taste doesn’t change - 30 seconds)

MEDIUM - (taste changes 15-30 sec)

HIGH - taste changes (1-14 sec)Dr. Moalem

Low Vitamin D3

• Low Vitamin D3 = macrophages stress

and increased blood pressure.

• Low D3 = higher risk for insulin

resistance and metabolic syndrome

• Note: a D3 dose of 2,000 IU daily

shown to reduce symptoms in patients

at risk for diabetes


Higher Vitamin D Levels Associated

With Lower Pancreatic Cancer Risk

•“In two U.S. cohorts, higher intakes

of vitamin D were associated with

lower risks for pancreatic cancer. Our

results point to a potential role for

vitamin D in the pathogenesis and

prevention of pancreatic cancer.”


Consumption of Fructose & High Fructose Corn Syrup Increase Postprandial

Triglycerides, LDL, Cholesterol & Apolipoprotein-B in Young Men & Women

• Sugar >s CVD

• Triglycerides, LDL, VLDL


MAGNESIUM Lowers Glucose

in DiabeticsMg. Levels Inversely Associated w/ CHD,

Hypertension & Type 2 Diabeteshttps://www.ncbi.nlm.nih.gov/pubmed/28927411

The Yin & Yang of Egg Freshness

AVOIDANCE OF

GLUTEN?

CARBS?

SATURATED FATS?

TRANSFATS?

IRON?

COPPER?

Huang Lian Die Du Tang

“Coptis Decoction To Relieve Toxicity”

Relieves Heat 3 Jiaos

• “Berberine regulates insulin resistance”

• Berberine lowers blood sugar

• Regulates intestinal microbiota

• New treatment target for type 2.




https://www.ncbi.nlm.nih.gov/pubmed/28862668


DR. METCHNIKOFF

Microbiome

How Our Bellies

Rule Our Brains

Bone & Microbiome



GUT MICROBIOME & THE

BRAIN

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259177/

Brain Structure & Response to Emotional

Stimuli Relates to

Gut Microbial Environment

• Gut microbiota have been associated with mood and

behavior. (metal feeding water?)

• https://insights.ovid.com/crossref?an=00006842-900000000-98803

https://insights.ovid.com/crossref?an=00006842-900000000-98803

CANCER & THE MICROBIOME


WEIGHT & MICROBIOME

http://mbio.asm.org/content/5/3/e01011-14.full

http://mbio.asm.org/content/5/3/e01011-14.full

SACCHAROMYCES BOULARDII

Reduces Body Weight & Fat Mass in

Type 2 Diabetic Mice

LACTOBACILLUS GASSERI

Reduces Weight in

Overweight Adults


Lactobacillus casei - digestion, immune fx & soothes the bowels.

Lactococcus lactis - associated with leaky gut restoration

Lactobacillus gasseri - digestion, blood sugar, supports normal body weight

Lactobacillus acidophilus - digestion, especially lactose digestion & immune fx.

Lactobacillus bulgaricus - creation of natural gut antibiotics. Releases acids that neutralize

bowel toxins.

Lactobacillus paracasei - fatigue; teeth; may diminish environmental sensitivities

Lactobacillus brevis - soothes oral & colon tissue

Streptococcus thermopiles - enhances healthy tissue in small intestine.

Lactobacillus plantarum - supports calcium metabolism; hormone production; immune fx;

helps in production of L. lysine.

Bifidobacterium breve - essential for colon health; post antibiotics; variety of digestive

complaints associated with low levels

Bifidobacterium longum - balances acid levels; post antibiotics

Bifidobacterium lactis - neutralizes gliadin (wheat protein that can damage the intestinal

lining & result in leaky gut

Bifidobacterium bifidum - improves digestion & immune fx.; skin benefits

Bifidobacterium infantis - supports digestion; prevents harmful organisms from sticking to

bowel; constipation

Pediococcus acidilactici - prevents undigested food from rotting in gut; keeps harmful

organisms from inflaming bowel

Bacillus laterosporus - fights toxic organisms including candida

BODY PARTS

What We Can See

Structural Changes

About 80% of US population will

experience back pain

The Effects of Deep Abdominal Strengthening Exercises On

Respiratory Function &

Lumbar Stability

PAIN = <LUMBAR INSTABILITY

ABDOMINAL MUSCLE STRENGTH = >VITAL CAPACITYhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805012/

Reduction in Pain Medication Prescriptions &

Self Reported Outcomes Associated with

Acupuncture in a Military Patient Population

• “the number of opiod prescriptions

decreased and patients reported

improved symptom control, ability to

function and sense of well-being after

receiving courses of acupuncture.”



Is FAT around

The abdomen

A predictor of

Cancer Risk?

https://www.sciencedaily.com/releases/2017/05/170524085530.htm

Signals from the Adipose Microenvironment and

the Cancer Link - A Systemic Review

“Moreover visceral white adipose tissue plays a more central role, as it is

more bioenergetically active and more closely associated with a more

procancer secretome.”

https://www.ncbi.nlm.nih.gov/pubmed/28864539https://www.ncbi.nlm.nih.gov/pubmed/28959684https://www.ncbi.nlm.nih.gov/pubmed/28954980

FAT CANCER?



ARE YOUR PATIENTS

SITTING

TOO MUCH?

THE KIDNEY

Source of All Yin & Yang

• Lu Zhi, “Human body is only Jing, Qi & Shen. These are

the 3 treasures. In order to attain true health & happiness,

we must value the 3 treasures. 3 treasures must not be

wasted. They must be nourished & protected as one’s life.” https://www.ncbi.nlm.nih.gov/pubmed/28386511

80.2 million Americans

over the age of 6 are

inactive

EXERCISE

WHY?

• After 2 weeks of sitting only 6 hours a day LDLs>

• Fat burning enzymes decrease = weight gain.

Physical Activity, Sedentary Behavior, and Long Term

Changes In Aortic StiffnessHigher levels of physical activity associated with a significantly slower rate of

Age Related progression of Aortic Stiffness

Aug. 2017


Gravity

• Skylab - 1970’s

• Aging in space similar to being bedridden

• Note for Patients: Try to sit for 3 hours or less each day.

VASPERhttp://vasper.com

• COMPRESSION

• COOLING

• CIRCULATION

• Androgens >

• Inflammatory markers <

• Blood sugar <

http://vasper.com

EXERCISE PREVAILS

GRAND SLAM OF HEALTH

SITTING

DEEP VEIN

THROMBOSIS• Long periods of sitting - desk, car, long flight, couch =

• Increase risk of DVT (blood clot that forms mainly in a

deep vein in the leg, which may lead to a pulmonary

embolism - often fatal)

• If one sits for more than 6 hours a day there is a 48%

increased risk of mortality from blood clots that originate

in the veins.

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291423

• http://www.acc.org/latest-in-cardiology/ten-points-to-remember/2017/03/02/15/24/diagnosis-and-management-of-acute-deep-vein-thrombosis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291423

Replacing sedentary time w

physical activity & sleeping

•“Although replacing sedentary behavior with

walking and moderate-to-vigorous physical

activity are associated with the lowest mortality

risk, replacements with equal amounts of

standing and sleeping (in low sleepers only)

are also linked to substantial mortality risk

reductions.” Dr. Stamakis• https://www.ncbi.nlm.nih.gov/pubmed/26419654

Can TV Kill?

• 40% increased risk of pulmonary

embolism for every 2 hours of TV

watched each day beyond a threshold

of 2.5 hours.

• 5 hours or more of TV = 2.5 times

greater risk than under 2.5 hrs.

• http://circ.ahajournals.org/content/134/4/355

http://circ.ahajournals.org/content/134/4/355

Too Much Sitting: The Population

Health Science of Sedentary Behavior

• Have patients take a ‘movement break’ every 30 minutes.

• Standing desks

• Note: no matter how much exercise one gets, sitting

excessively for long periods of time is a risk factor for an

earlier death


ACTIVITY

• Physical Benefits

• Mental Benefits

• Effects of Exercise on Cognitive Function & Brain

Plasticity



Effect of Tai Chi Chuan on degeneration of lumbar vertebrae & lumbar

discs in middle aged and aged people: a cross sectional study based on

magnetic resonance images

January, 2017https://www.ncbi.nlm.nih.gov/pubmed/28984177

• The most severely affected lumbar vertebrae & discs were

L5/L4. Conclusion: Regular performance of a simplified

Tai Chi 24 form could possibly retard the degeneration

of lumbar vertebrae & lumbar discs in middle aged

and aged people..

FACIAL CHANGES

Facial Reading

• Lillian Bridges

• https://www.amazon.com/Lillian-Bridges/e/B001ITYPG2

https://www.amazon.com/Lillian-Bridges/e/B001ITYPG2

Skin Changes


LOSS OF YIN

WHAT Happens Outside Happens Inside

Aging-related changes in the diversity of women’s

skin micro biomes associated with oral bacteria

September 2017

• Propionibacterium - gram positive, anaerobic bacteria.

Member of the genus Propionibacterium widely used in the

production of B12, as well as in probiotics. Decreases with

aging.

• Health of the bacteria in our mouths is associated with our

skin.


KAMILLOSANAfter 2 weeks mild superiority to

.5% CORTISONE CREAM


Heart & Kidney

Triple Heater

Pericardium

Large Intestine & Stomach

Lung & Spleen

Check Lunula

Color of Lunula

• Ivory - normal. strong & healthy

• Dark Pink - onset of heat; diabetes; hyperthyroidism

• Gray - low energy; anemia; fatigue

• Purple - stagnation; poor blood circulation of heart &

brain; lower oxygen; dizziness; headache

• Black - severe illness

NAILS

Liver Blood Flourishing

•Brittle & split easily - fatty acid, protein,

Vitamin A, Iron or Calcium deficiency.

• White flecks or lines Zinc or Vitamin B6

deficiency.

•Broaden and curve downwards at the tip may

be a symptom of lung damage.

•Excessively dry nails often B12 deficiency

NAILS(continued)

Split easily consider hydrochloric acid deficiency in the

stomach (weak earth)

•Grow slowly or dry may be indicative of a Vitamin A

or Iron deficiency

•Discoloration of the nails may be due to prolonged

illnesses or stress, smoking or allergies

•Pale color may occur due to Iron or protein deficiencies as seen in anemia, kidney or liver disorders

EAR WAX

Body Odor

Alcohol Tolerance

• Wet yellow

• Dry white

DOES EXTERIOR

STRUCTURE

RELATE TO THE

INTERNAL?

Elevated Triglycerides

Correlated with Fracture

•2000 premenopausal women with high triglycerides have

increased risk of fractures.

•An > of 50mg/dl in blood triglycerides found in annual exam was

associated with a 31% increased risk of fractures within the next

2-5 years.

•CALL TO ACTION:

• Women must lower elevated triglycerides.

•WOOD/EARTH relationship

• https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2016-1366

SITTING MORE THAN

10 HOURS EACH DAY

• Heart disease >s 64%

• Lifespan <s 7 years

96

BLOOD

=

communication

97

Messages

Blood delivers

messages

throughout

the body

Improper Nutrition

Compromised Digestion

Neuroendocrine Imbalances

Infections

Heavy metal & chemical

toxicity

Energetic Imbalances

Trauma & Structural problems

Genetics

Environmental Insult

Associated With

•Dementia

•Alzheimer’s

•Parkinson’s

Which Blood Test is

THE GREATEST

BLOOD WORK BARGAIN?

C REACTIVE PROTEIN

(CRP)

CRP is produced in the liver. It is

considered an ‘acute’ phase biomarker

and increases with inflammation.

Measuring HEAT

C REACTIVE PROTEIN >

Prevalence of Metabolic Syndrome,

Hypertension & Diabetes 2


C REACTIVE PROTEIN

High CRP correlated with depressive symptoms in patients

with schizophrenia.



<Magnesium = > CRP

http://www.jle.com/download/mrh-278789-magnesium_and_its_relationship_to_c_reactive_protein_among_hemodialysis_patients--Wb-xd38AAQEAAB@GVqQAAAAF-a.pdf

<Selenium = >CRP

https://link.springer.com/article/10.1007/s12011-007-8018-2

<Zinc = >CRP

>Endothelial Cell Senescence

Zinc + Sage Oil

< Inflammation <CRP <Sugar


< Zinc

> CRP



> Iron

< Zinc

Alzheimer’s >s

Dementia >s


Andrea

Case History

STEALTH

PATHOGENS

“Defects in the regulatory circuits of the host

that control bacterial homeostasis, through

environmental changes (infection, diet or

lifestyle), may disturb the symbiotic

relationship and promote disease”

HIJACKED

1 in 6 cancers worldwide

associated with infection

Chronic Illness

Infection

HIV vs. EBV

• Chronic Viral Infections

• HIV

• Virus that destroys the cell

• EBV

• Virus that makes itself at home

Cytomegalovirus (CMV)

AGE ACCELERATOR

•60-90% of us harbor this infection

•Known to shorten life span

•Adversely affect cognitive thinking

•Damage endothelial lining of our arteries

•Speed Immune Senescense

Aging =

decreased ability

to fight infection

IMMUNE SENESCENCE

Aging of Immune System

http://www.anti-agingfirewalls.com/2014/09/08/prospectus-for-reversing-age-related-immune-senescence/

Serious infections, Cancers &

Inflammatory Disease Leading

Causes of Premature Death

Immunosenescence of Aging

•“Aging is a complex process that negatively impacts the

development of the immune system and its ability to function.

The mechanisms that underlie these age-related defects are

broad and range from defects in the haematopoietic bone

marrow to defects in peripheral lymphocyte migration,

maturation and function. The thymus is a central lymphoid

organ responsible for production of naïve T cells, which play a

vital role in mediating both cellular and humoral immunity.”




Aging & Autoimmune

Disorders

• With aging immune competence fades

• Thymic T cell & B cell greatly reduced


AGING = < IMMUNE FX

•More Vulnerable To Infection, Chronic Dx & Malignancy

•Bu Zhong impact - IMPROVES IMMUNOLOGICAL

RESPONSE

•120 days of 7.5gm daily

•Natural Killer Cell Activity against K562 target cells

significantly enhanced

•Significant increase in serum IFN-gamma level (interferon)


TCM

PATHOGENIC SLAYER

• Shang Han Lun - Six Divisions (3rd century)

• Wen Bing - Four Levels (18th century)

Yin Qiao Jie Du Pian vs.

Gan Mao Ling

ANTI VIRAL

Gan Mao Ling

HEAT CLEARING

• Gang Mei Gen (Radix Ilex Asprella)

• San Cha Ku (Radix Evodia Lepta)

• Ban Lan Gen (Radix Isatis)

• Jin Yin Hua (Flos Lonicera)

ANDROGRAPHIS FORMULA

CHUAN XIN LIN

• ACHYRANTHES - Huai Niu Xi

• ANDROGRAPHIS - Chuan Xin Lin

• COPTIS - Huang Lian

• LICORICE - Gan Cao

• PLATYCODON GRANDIFLORUS - Jie Geng

• RHIZOMA CORYDALIS - Yanhusuo

Bu Zhong Impact on

Lung Inflammation•These results suggests the possibility that BZ may enhance

inhibition of pulmonary-alveolar macrophage inflammation

response to TLR-ligands stimulus in conditions of high blood

glucose.

•Note: We know asthma is a complex disease of the lungs, which

is characterized by airway inflammation and airway

hyperresponsiveness (AHR). Alveolar macrophages (AMs), one

of the prominent immune system cells found in the airways, have

been implicated in the development and progression of asthma.

• EARTH FEEDING METAL

• http://erj.ersjournals.com/content/38/Suppl_55/p3865

Higher IL-6 Levels Associated With a

2 Fold Increased Risk of Death

Centenerians have

unusually LOW levels of

Interleukin 6

Pu-Erh Tea - Yunnan Province

Hei Cha

• Inhibits Interleukin 6

• Increases Natural Killer Cells

• Increases Naive T Cells

QUERCETIN

• Plant flavonoid shown to protect against the damaging

influence of pesticides.

• Improves liver & kidney fx

• Inhibits oxidative stress

QUERCETINRheumatoid Arthritis

500MG. Daily 8 Weeks

<Early morning stiffness

<Morning pain

Inflammatory Biomarkers Reduced


Dihydroquercetin

1)Flavonoid that allows Vitamin C greater

longevity & efficacy

2) Inhibits lipid peroxidation

3) Lowers LDL

4) Reduces oxidative stress

5) Aids in inhibition of chronic bacterial & viral

infections

Cistanche

Rou Cong Rong

• Supports increased lifespan in

animals

• Optimizes the ratio of CD4 to CD8

cells = younger immune system.

Protective Effects of Ancient Common

Kidney Tonic

Cistanche - Rou Cong Rong

Epimedium - Yin Yang Huo

Polygonatum - Yu Zhu

Significantly protects against neurological damage

Parkinson’s Researchhttps://www.ncbi.nlm.nih.gov/pubmed/28386511

THE EARTH

THE BREAST

BREAST Arterial Calcification Is A Strong

Indicator of

Coronary Arterial Calcification•76% of the 371 women scanned,

those with breast arterial calcification

score of 0 also had a coronary artery

calcification score of 0.

•As the breast arterial calcification

score increased there was a similar

increase in the coronary artery

calcification score.

AGING & THE EARTH

HEARTBURN60% of US Adults will experience

Gastroesophageal Reflux Disease

(GERD) within a 12 month period

20-30% - weekly symptoms

GERD speeds the

Aging of Blood Vesselshttp://circres.ahajournals.org/content/early/2016/04/19/CIRCRESAHA.116.308807

http://circres.ahajournals.org/content/early/2016/04/19/CIRCRESAHA.116.308807

PPIS

• PPIs inhibit proton pumps

• Specifically the

• proton/potassium pump of the

• parietal cells of the stomach.

PPIs

HERE LIES THE RUB

Shutting down the EARTH

• PPIs are not only found in the stomach.

• They are in almost every cell in the body with the

exception of the RED BLOOD CELLS.

• With the shutting down of PPIs energy systems - ATP

cycle is compromised and the TRANSPORTATION of

nutrition and energy substances must rely on other

systems such as anaerobic secondary systems which

don't function very efficiently.

PPIs meant to be prescribed for 8-

12 weeks but are often used for

years

Proton Pump Inhibitors

Speed the Aging of Blood

Vessels

Proton Pump Inhibitors> Dementia

>Cognitive Impairment w short term PPIs

(Nexium, Prevacid, Prilosec)

http://jamanetw ork.com/journals/jamaneurology/fullarticle/2487379?version=meter%20at%200&module=meter-

Links&pgtype=Blogs&contentId=&mediaId=%%EF%BF%BDID%%&referrer=https://w w w.google.com/&priority=true&action=click&contentCollection=meter-links-click

Patients 75 & older who use PPIs

Have a 44% greater risk of dementia

Including Alzheimer’s

60% of people using

PPIs don’t require them


Among Top 10 Prescribed Classes of Drugs

• PPIs second only in sales to Statins

• Used to treat

• Indigestion

• Acid Reflux

• Peptic Ulcers

ABOUT 20 million

Americans Suffer With

GERD


Popular Heartburn Drugs Linked to >ed

Early Death Risk

• Prevacid; Prilosec; Nexium Etc.

• Linked to a variety of health problems:

• Kidney Damage

• Bone Fractures

• Dementia

• WHY?

• Resulting cascade from Diminishment of the Earth?

• Yan Xie, Benjamin Bowe, Tingting Li, Hong Xian, Yan Yan, Ziyad Al-Aly. Risk of death among users of Proton Pump Inhibitors: a longitudinal observational cohort study of United States veterans. BMJ

Open, 2017; 7 (6): e015735 DOI: 10.1136/bmjopen-2016-015735

http://dx.doi.org/10.1136/bmjopen-2016-015735

Alternatives to PPIs

• 1. Resolve Stomach Heat & Harmonize Wd/Earth

• TCM Calcium Carbonate - Hai Jiao Xiao https://www.redpinechineseherbs.com/blogs/chinese-herb-blog/6340188-hai-piao-xiao-good-for-stomach-acid

• 2. Calcium Carbonate, Magnesium Carbonate,

Deglycyrrhizinated Licorice Extract - neutralize stomach

acid without shutting down production of stomach fx.

• 3. Melatonin -protects epithelial tissue of GI Tract



FARE YOU

DIETARY

STRATEGIES

Dietary Oxidative Stress

Contributes to Age Related

Degenerative Dx

• CANCER

• DIABETES TYPE 2

• MACULAR DEGENERATION

• ALZHEIMER’S

• PARKINSONS

BASIC DIETARY

STRATEGIES• DELETE HEAT CREATING FOODS (INFLAMMATORY)

• Sugar

• Overcooked, burnt meats

• Elimination of processed foods, food additives

• Elimination of plastic & toxic metals: arsenic, aluminum,

etc.

CASE HISTORY

ELISABETH

“Foods are not drugs but over a

lifetime of repetitive consumption

they can alter the trajectory and

development of disease.”

Super Food

Or

Super Habits

The RESET Button

RESEARCHED FOODS• POMEGRANATE

• CILANTRO

• PARSLEY

• GARLIC

• GINGER

• CELERY

• WILD BLUEBERRIES

• RASPBERRIES

• ASPARAGUS

• SPINACH

• BROCCOLI

Higher Dietary Potassium Linked

to Lower Risk of Death, Stroke

• “High potassium intake is associated with a lower risk of

all stroke and ischemic stroke, as well as all-cause

mortality in older women, particularly those who are not

hypertensive.”


SUPPLEMENTS and

Western BOTANICALS• CURCUMIN

• RED CLOVER

• ELDERBERRY

• NETTLE LEAF

• LICORICE ROOT

• CAT’S CLAW (alkaloid removed)

• LEMON BALM

• ZINC

• SELENIUM

• L-LYSINE

• ESTER C (BUFFERED C)

• OMEGA 3’S , DHA, EPA & ESSENTIAL FATTY ACIDS

• METHYLCOBALAMIN

• METHYLFOLATE - 5-MTHF - (5-METHYLTETRAHYDROFOLATE)

• VITAMIN B1 (Benfotiamine)

DANG SHEN

CODONOPSIS

•TONIFY MIDDLE BURNER

•Regulated Liver Enzymes & Alkaline

Phosphatase better than placebo

•Improved biomarkers associated

with senescence • https://www.ncbi.nlm.nih.gov/pubmed/28671103

DIETARY

STRATEGIES•KETOGENIC DIET

•LOW CARBOHYDRATE/MEDITERRANEAN DIET

•GLUTEN FREE DIET

•MAPS DIET

•VEGAN DIET

•VEGETERIAN DIET

•CALORIE RESTRICTION DIET

•BLOOD TYPE DIET

•ATKINS DIET

•RAW FOOD DIET

•WEIGHT WATCHER’S DIET

•SOUTH BEACH DIET

•HIGH PROTEIN DIET

CALORIE RESTRICTION

BENEFITS NON-OBESE

Giving The Center A Rest•218 subjects (30% men & 70% women) BMI 22-28

•2/3 of subjects 25% calorie restriction for 2 years

•1/3 no restriction for 2 years

•Calorie Restriction Group lost 16.7 pounds

•Improved Sleep after 1 year

•Decreased tension/stress

•Improved Mood

•Increased Energy

•Improved Sex Drive

• http://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2517920

DIETARYFISH EATING VEGETARIANS

Lowest Risk of Colorectal Cancer

•77,659 Pescaterians

•Vegetarians who also ate fish - men

and women had 27% lower risk of

contracting colorectal cancer.


Fish Eating Vegetarians Have

Lowest Risk of Colorectal Cancer

•Compared to non-vegetarians

43% reduced risk of colorectal

cancer with vegetarian diet &

fish once or more a month

• http://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2174939

NUTRIENT

TIMING

FAT SOLUBLE

VITAMINS• Fat soluble supplements such as Omega 3’s, Vitamin E,

Vitamin A, Vitamin D, CoQ10, Vitamin K, Lycopene

• Absorbed differently than water soluble vitamins

• Best taken w meal providing the most dietary fat - heaviest

meal of the day

• Note: Heaviest meal usually contains more dietary

mutagens - fried, overcooked etc. - so fat soluble

vitamins ideally taken with DNA protective supplements

such as chlorophyl, blueberry, pomegranate

Offending Substances

YIN & YANG

SODIUM

• Average American consumes 10 times minimum

requirement for SODIUM AND 2x as much sodium than

potassium

• Consuming 5x more potassium than sodium is

recommended for individuals with hypertension

PROCESSED MEATS

Group 1 Carcinogen

•Eating only 50 grams

(2oz) daily of processed

meats increases risk of

colorectal cancer by 18%

Artificial Sweeteners•Because artificial sweeteners are SWEET,

they encourage sugar craving. Repeated

exposure creates flavor preference. The more

of one flavor we eat - the more we desire it.

•In order for us to reverse obesity epidemic -

do we have to retrain the universal

tastebuds?


ALCOHOL

• “Although excessive drinking has negative health

consequences, these results suggest that regular,

moderate drinking may play a role in cognitively healthy

longevity.”

• https://www.ncbi.nlm.nih.gov/pubmed/28671111 (June 28, 2017)


CARDIOVASCULAR

DISEASE

(CVD)

Contributors to CVD• Hypertension

• Hyperlipidemia

• Hypergylcemia (Dysglycemia)

• Stress

• Hypersympathetic Nervous System

• Elevated Cortisol (PM)

• Lifestyle

• Diet

• Exercise

HYPERTENSION

Marker for Vascular Dysfunction• Often first biomarker to be detected

• Normal 120/80 mmHg but risk for CVD has been noted

beginning at 110/70 mmHg.

• Each > of 20/10 doubles cardiovascular risk

• **Before age 50 diastolic (pressure in your arteries

between beats) BP is best predictor of risk

• **After age 50 systolic (maximum pressure your heart

exerts while beating) BP is best predictor of risk

TCM Increased BP

PHASE 1

• Excess Syndromes - Hyperfunctioning

• Liver Yang Excess >

• Qi Stagnation

• Blood Stasis

• Accumulation of Phlegm & Dampness

TCM Increased BP

PHASE 2

• Deficiency

• Qi Deficiency W/ Blood Stagnation

• Yin Deficiency sets in

• Phlegm accumulates & causing

obstruction

TCM Increased BP

PHASE 3

• Deficiencies & Stagnations more pronounced

• Liver & Kidney Qi & Yin Deficiencies

TCM Strategies To

Lower BP

• Resolve Dampness & Phlegm

• Activate Blood & Resolve Stagnation

• Rid Wind & Harmonize Liver

• Nourish Yin

24 Hr. BP Monitoring

• Early Detection

• Most Important Issue

CASE HISTORY

RICHARD

Resistant Hypertension

Hx: 3 cardiologists over 7 years

Rx: Diuretic

&

3 Hypertensive Medications

BP Medications

TIMING

• Most meds should be given at night (Exception Diuretics)

• Taking meds at night - 25-50% < in CV risk due to

stroke & MI.

• WHY? (Reinforcing Yin Function?)

• Down regulates ̂ BP morning reactions

Jiang Ya Pian

MELATONIN LOWERS

BLOOD PRESSURE In Male Patients

9 MG. controlled release melatonin daily 6 weeks

7.3 - 13.3mmHg lowers systolic

http://hyper.ahajournals.org/content/43/2/192

DAN SHENhttps://www.ncbi.nlm.nih.gov/pubmed/19943333

http://www.worldscientific.com/doi/abs/10.1142/s0192415x86000053


http://www.worldscientific.com/doi/abs/10.1142/s0192415x86000053

MAGNESIUM

• 4th most abundant mineral in body

• 300 enzymes need magnesium to fx properly

• Regulates Blood Sugar

• Protects Blood Vessels

• Regulates Heart Function

• Brain’s Neurological Activity

Magnesium

Over Age 70

• 80% of men & 70% of women FAIL to get the minimum

requirement of 350 mg. for men & 265mg. for women

Drugs Interfering With

Magnesium Absorption

•Proton Pump Inhibitors

Higher Risk of Death

With Magnesium Deficiency

• Low Mg. accelerates aging at the cellular level

• Harder for good cells to replicate and provide in healing

Magnesium

• The risk of death is significantly higher in people 65 and

older who have lower Mg. blood levels.

• 55% of hospitalized patients who had <levels of Mg. died

• VS.

• 35% of hospitalized patients who had normal levels of Mg.

died

MAGNESIUM

• 50 mg. > of daily MG. intake decreased calcification of the

heart’s main arteries by 22% AND

• 12% reduction in calcification of the aorta

• Highest MG. intake = 58% less likely to have calcification

of the coronary arteries AND

• 34% less likely to have any calcification of the abdominal

aorta

MAGNESIUM

• BLOOD SUGAR

• BONES

• DENTAL

• MIGRAINES



Magnesium Helps to

Reduce Wiry Pulse

LIPIDS

Is measurement of

Total Cholesterol Obsolete?

CHOLESTEROL - ESSENTIAL FOR LIFE

NO CHOLESTEROL = NO LIFE

•We eat it

•We make it

•We store it

•We excrete it

ENDOGENOUS

SYNTHESIZED CHOLESTEROL

• Dominant source of cholesterol is in our body

• Most of the cholesterol in our body was made by our body

• Dietary cholesterol has relatively little impact on the

cholesterol levels in our body

Cholesterol Transport In Plasma

• Cholesterol travels from

• the liver (wood) and

• small intestine (fire)

• towards the periphery

• and back to the liver and

• small intestine.

CONVENTIONAL BIOMARKERS

Cholesterol Normals

Analyte Optimal Desirable Threshold for Intervention

Total ≤ 150 ≤ 200 ≥ 200

HDL (female) ≥ 50 ≤ 50

HDL (male) ≥ 40 ≤ 40

TG ≤ 100 ≤ 100 ≥ 100

TG/HDL ≤ 3 ≤ 4 ≥ 4

LDL ≤ 100 ≤ 130 ≥ 160

Units are mg/dl

Wood Earth

Relationship

?

STATIN

EZETIMIBE

Lowers blood cholesterol interfacing and

preventing absorption in the

Small Intestine

Hyperlipidemia

Blood Stasis

Xuefuzhuyu Decoction

•LDL Reduction



WHY IS THE EARTH SO

IMPORTANT TO COMBAT AGING?

•TRANSFORMATION &

TRANSPORTATION OF

NUTRITION

•THE RESOLUTION OF JUNK

Transformation

&

Transportation

•EXTRACELLULAR JUNK

•INTRACELLULAR JUNK

PASTY LOOKING

RATS

•Pasty loose stools, decrease in endurance, lackluster, loose

stool, loose & disorderly behavior, <ed weight of liver & spleen.

•The restorative effect of BZYQT in rats w spleen deficiency

confirmed. Four identified biomarkers correlated w sp. qi xu.

These biomarkers are all identified as playing a role in energy,

protein assimilation & glycolytic metabolisms.

•Treatment with BZYQT restored compromised biomarkers.


EXTRACELLULAR JUNK

EJ

• Accumulations of sticky, malformed proteins that no longer

serve their function, but instead impair cell or tissue

function by their presence.

• Most EJ is known as AMYLOID

• Beta Amyloid - most well known EJ - identified with the

brain plaques of Alzheimer’s & all of us aging - slowing

our mental function

WARFARIN

BLOOD THINNER

Inhibits the Vitamin K dependent synthesis of clotting

factors

TURNING TO STONE

Warfarin

Increased Peripheral Calcification

With RX: WARFARIN

• Warfarin blocks Vitamin K.

• After 30 days: Warfarin 50% increased prevalence of

arterial calcification

• Warfarin use associated with increased breast calcification



OTHER AMYLOIDS

• CARDIOVASCULAR DISEASE

• Senile Cardiac Amyloidosis (closely associated w heart

failure)

• TYPE 2 DIABETES

• Islet Amyloids (EJ accumulating on the pancreas)

Lifestyle Markers Predict Cognitive Function

9/17

“Modifiable biomarkers that impact cognitive performance favorably include greater aerobic

fitness & strength, lower blood sugar levels, lower body fat, avoidance of tobacco and alcohol

intake.”


HIGH FAT DIET

Heat

INTRACELLULAR JUNK

IJ

Heat & Stagnation

• BIOCHEMICAL MISHAPS during normal metabolism

• Our cell constituents are all ultimately damaged and compromised

• We have exceptional mechanisms for clearing debris & reusing

what is useable.

• LYSOSOMES

• Cellular debris eaters

• With age the functionality of the lysosome is not always

perfect - leading to an accumulation of debris and/or the cell

implodes from excess debris burden.

LYSOSOMES

STAGNATION MONITORING

•The debris that has not been destroyed and disposed

of or recycled accumulates in the wrong places

(STAGNATION).

•Stagnation is the lesser problem. More importantly:

•Cells that are meant to last a lifetime (eyes, heart,

lungs, brain)

•Compromised - garbage disposal - junk accumulates

- impairs inherent cell function - and ultimately tissue

function -and then organ function = AGING

STRATEGY FOR IMPROVING

GARBAGE IN & GARBAGE

OUT

•Strengthening Water

•Strengthening Earth

•Smoothing Wood/Earth

Case History

Melissa

Non Alcoholic Fatty Liver Disease (NAFLD)

• Most common cause of abnormal liver function among US

adults

• 32% of general population in India

• Ultrasound - radiation free; cost effective

Chronically Elevated

Cortisol = Inflammation =

Aging

Strategies

For Balancing Cortisol

Botanical

Magnolia Xin Yi Hua

Phellodendron Huang Baihttps://www.ncbi.nlm.nih.gov/pubmed/23924268


ALZHEIMER’S & NUTRIENTSVitamins A, C, E, D3, B1, B6, B9, B12,

Magnesium, Choline, Inositol, Anthocyanins,

Isoflavones

VITAMIIN D3

Vitamin D has multiple roles, including the regulation of bone and calcium homeostasis.

Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D, is associated

with an increased risk of age-related chronic diseases, including Alzheimer’s disease,

Parkinson’s disease, cognitive impairment, and cancer.

http://w w w.cell.com/cell-reports/fulltext/S2211-1247(16)31362-6

D3Engages Longevity Genes To > Lifespan

Prevents Accumulation of Toxic Proteins

Associated with Chronic DX (e.g.Alzheimer’s)

VITAMIN B12• Peripheral Nerves

• Spinal Cord

• Impaired Mental Function: memory; slower thinking; confusion

• Inhibition of methionine synthase, key enzyme responsible for the

conversion of homocysteine to methionine. High Homocysteine correlated with damaged blood vessel lining (endothelial tissue) and

more susceptible to clotting.

• Compromised methylation (one molecule passes a methyl group, which is a carbon atom linked to three hydrogens, to another molecule, it’s a

basic biochemical process)- takes place a billion times a second in our bodies.

• https://www.researchgate.net/profile/C_L_Chao/publication/51360581_Effect_of_short-term_vitamin_folic_acid_vitamins_B6_and_B12_administration_on_endothelial_dysfunction_induced_by_post-

Methionine_load_hyperhomocysteinemia/links/54d9b6b00cf2970e4e7c886c/Effect-of-short-term-vitamin-folic-acid-vitamins-B6-and-B12-administration-on-endothelial-dysfunction-

induced-by-post-Methionine-load-hyperhomocysteinemia.pdf

METHYLFOLATE

Vitamins C & E Lower Risk of

Developing Cognitive Decline

23% Lower

http://journals.sagepub.com/doi/full/10.1177/1060028016673072

Vitamin C May Encourage Compromised

Blood Stem Cells To Die

• Vitamin C speaks to compromised stem cells in the bone

marrow to mature and die normally.

• https://www.sciencedaily.com/releases/2017/08/170817141722.htm

https://www.sciencedaily.com/releases/2017/08/170817141722.htm

Reduced Risk of ALZHEIMER’S With Use

of

ANTIOXIDANT VITAMIN SUPPLEMENTS

•Antioxidants (Vit. E&C)

protect the brain against

oxidative damage preventing

Alzheimer’s cascade

ALZHEIMER’S

PREVENTATIVE STRATEGIES

• METAL CHELATORS

• ANTIOXIDANTS

• ANTIHYPERTENSIVES

• VITAMINS: E, B12, B6, FOLATE

• NEUROTRANSMITTER SUPPORT

• HERBS (Ginkgo biloba)

• COLD WATER FISH (reduces beta-amyloid plaques)

• DHA***

ALZHEIMER’S & SATURATED FAT DIET

• High intake of processed saturated fat - doubles the risk of

Alzheimer’s disease.

• Moderate intake of trans fat > risk by 2-3 times


OBESITY

&

ALZHEIMER’S DISEASE

• After age 40 - obesity associated with a reduction in gray matter

(neurons) in the brain.

• High insulin levels associated with higher incidence of Alzheimer’s

Dx.

• Insulin deficiency or Insulin resistance can increase aggregation of

the amyloid beta or tau proteins associated with Alzheimer’s Dx.

• Dr. Suzanne Craft - use of moderate doses of insulin to improve

cognition in early onset Alzheimer’s Dx.



SEX

•Frequent Sexual Activity

Improves Mental Cognition

in Older Adults

• http://neurosciencenews.com/aging-brain-sex-6960/

Higher DHEA Levels Associated with

Lower Risk of Diabetes 210 yr. study - top 1/3 serum DHEA =

27% lower risk of diabetes

Testosterone

Improves Insulin Sensitivity

in Diabetic Men

• PARTICIPANTS WITH LOW TESTOSTERONE RECEIVED A

WEEKLY TESTOSTERONE INJECTION OR PLACEBO FOR 24

WEEKS.

• Body weight, body fat, inflammatory markers, insulin sensitivity

assessed before & after.

• Loss of 6 pounds & > in muscle mass.

• Decreased C Reactive Protein (CRP)

• DRAMATIC increase in insulin sensitivity

• 32% increase in the uptake of glucose by tissues in response to

insulin

Hormonal

Replacement Therapy

• Optimize gut & liver/GB physiology prior and during HRT

• Improve adrenal & insulin physiology prior & during HRT

• Benefits & Risks of HRT

• Delivery systems for HRT: topical; ingestible; pellets

healthy scaffolding - traditional chinese medicine

Documents