Related to liver inflammation disease

Hepaviridae family, hepevirius genus.

Transmitted through fecal-oral route.

Pregnancy,a most risk factor for HEV

HISTORYFirstly documented in

1955 in Delhi.MS Khuroo in 1980Dr.BayalanMajor Outbreaks

India 1955 Burma 1976 Kashmir 1978 China 1986 Maxico 1989

Signs and symptoms Incubation period It has 2 phases

Prodromal phase Arthralgia Mylegia Fever Anorexia Nausea/vomiting Dehydration

Icteric phase Jaundice Dark urine Light color stools Diarrhea Malaise Pruritus

Prevalence

GENOTY

PES O

F HEV

Genotype 1: has 5 subtypes

Genotype 2 : has 2 subtypes

Genotype 3 : has 10 subtypes

Genotype 4 : has 7 subtypes

GENOME OF HEV

Life cycle of hev

TRANSMISSION OF HEV

•Waterborne transmission• Zoonotic and foodborne

transmission• Vertical transmission• Person-to-person

transmission

DAIGNOSISELISART PCRImmunoflourescentImmune

electronmicroscopy

Treatment

Acute chronic

Treatment ??? Self limitingRibavirin(antiviral drug Interferon Serum immunoglobulin

Infections

PREVENTIONMaintaining

clean waterProper sanitationMaintaining

hygienic practicesAvoid eating

uncooked food

Vaccination

No commercialliazation Recombinant vaccine

Subunit hev vaccine

China,the only producer.