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HVTN SUB-SAHARAN AFRICA REGIONAL MEETING 2017

TABLE OF CONTENTS

General Information . . . . . . . . . . . . . . . . . . . . . . . . . . 1

Special Sessions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2

Monday, 27 February. . . . . . . . . . . . . . . . . . . . . . . . . 3

Tuesday, 28 February. . . . . . . . . . . . . . . . . . . . . . . . . 3

Program-at-a-Glance . . . . . . . . . . . . . . . . . . . . . . . . 4

Wednesday, 1 March . . . . . . . . . . . . . . . . . . . . . . . . . . 6

Conference Room Locations. . . . . . . . . . . . . . . . . 10

HVTN SUB-SAHARAN AFRICA REGIONAL MEETING 2017 1

GENERAL INFORMATION

MEETING VENUE

Hyatt Regency Hotel-Johannesburg191 Oxford RoadRosebank, 2196, RSA

MEETING REGISTRATION DESK

The registration desk will be located in the Ballroom Foyer on Monday.

Monday, 27 February 4:00 pm – 7:00 pm

The registration desk will be located in the Ayanda Lobby on the 2nd floor on Tuesday and Wednesday.

Tuesday, 28 February 7:00 am – 5:00 pm Wednesday, 1 March 7:00 am – 3:30 pm

NAME BADGES

All registered meeting attendees will be issued a meeting name badge when they check in. Name badges are required for all meeting attendees. Please be sure to wear your name badge at all times when attending conference-related functions. If you do not have a name badge, or you have lost yours, please return to the registration desk, and another badge will be issued.

SPEAKER CHECK-IN

All presenting speakers must check in at the registration desk at least 30 minutes prior to their plenary session to hand in their presentation slides, unless they have already done so. The AV technician will be available in Ayanda 1 & 2:

Tuesday, 28 February 7:00 am – 1:00 pmWednesday, 1 March 7:00 am – 1:00 pm

HVTN OPENING RECEPTION WITH THE ROCKETEERS

Monday, 27 February 6:00 pm – 9:00 pm Ballroom

Please join your colleagues in the Ballroom for an opening night reception and celebration. We look forward to seeing you there!

SGC DINNER

Tuesday, 28 February 7:00 pm – 9:00 pmResidence

Invited guests only

PROGRAM-AT-A-GLANCE

For an overview of the meeting program, please refer to the Program-at-a-Glance on pages 6-7. The sessions are color-coded to indicate plenary sessions, open sessions, closed sessions, interpretation, and catering.

MEALS

Breakfast located in oneNINEone Restaurant. Teas & Lunch located in Ayanda Foyer.

MONDAY, 27 FEBRUARY

HVTN Opening Reception 6:00 pm – 9:00 pm

TUESDAY, 28 FEBRUARY

Breakfast 6:30 am – 8:00 amMorning Tea 10:30 am – 11:00 amLunch 12:00 pm – 1:00 pmAfternoon Tea 3:00 pm – 3:30 pm SGC Dinner (invite only) 7:00 pm – 9:00 pm

WEDNESDAY, 1 MARCH

Breakfast 6:30 am – 8:00 amMorning Tea 10:00 am – 10:30 amLunch 12:00 pm – 1:00 pmAfternoon Tea 3:00 pm – 3:30 pm

PLENARY PRESENTATIONS

Ayanda 1 & 2


Plenary 1: 8:00 am – 10:30 amPlenary 2: 11:00 am – 12:00 pm

WEDNESDAY, 1 MARCH

Plenary 3: 8:00 am – 10:00 amPlenary 4: 10:30 am – 12:00 pm

Please note, a majority of the plenary presentation slides will be available on the Members website following the conclusion of the meeting at:

https://members.hvtn.org/hvtn-conference/SitePages/February-2017-Conference.aspx

Use Twitter hashtag #hivvax to live tweet during the meeting#HIVVAX

CONFIDENTIALITY: Just a reminder — information shared in plenaries and other sessions is confidential.

Phone: +27.11.280.1234 Check-in: 2:00 pmCheck-out: 12:00 pm


SPECIAL SESSIONS

GET HIP. APPLY FOR THE HVTN INITIATIVES PROGRAM!

GENERAL INFORMATION

MEETING EVALUATIONS

At the conclusion of the meeting, registered participants will be asked to complete a brief online evaluation. The link will be sent to the email address you provided at registration. Your feedback is appreciated as it better prepares our Event Staff for future meetings.

INTERNET ACCESS

Wireless internet service is available for all meeting attendees. All guests of the hotel will be given a WiFi code at check-in. All others, please see the HVTN registration desk for the code.

KEY

MEALS * INTERPRETATION PROVIDED

MEET THE MENTORS: RESEARCH AND CAREER DEVELOPMENT FOR EARLY STAGE AND JUNIOR HVTN RESEARCHERSThe Atrium

Monday, 27 February 5:00 pm – 6:00 pm

Early Stage and Junior Researchers: join the party before the reception! This structured event will allow Early Stage and Junior investigators to connect with experienced HVTN investigators and leaders to explore opportunities for scientific mentorship, career guidance and/or coaching. Drinks and snacks will be served. Join us to make valuable connections before the reception!

INTRODUCTION TO IMMUNOLOGY & VACCINOLOGY FOR RESEARCHERSIlanga 1 & 2

Tuesday, 28 February 7:00 am – 8:00 am

This session will provide a foundation to help investigators and other clinicians better understand the scientific concepts presented in Plenary Session lectures. The session will be repeated for Community Members from 3:00 pm to 4:30 pm.

UNRAVELING THE MYSTERIES OF SITE INSPECTIONS: THE REGULATORY ENVIRONMENT & EXPECTATIONSNina 1 & 2

Tuesday, 28 February 5:30 pm – 7:00 pm

Panel session addressing preparedness for a site audit. Topics include who the players are, their responsibilities, and roles and expectations, including Dos and Don’ts before and during an audit.

HVTN FOR FIRST TIMERSIlanga 1 & 2

Wednesday, 1 March 7:00 am – 8:00 am

Is this your first time attending a major meeting hosted by the HIV Vaccine Trials Network? We welcome you to this session designed to note how your important work fits with the rest of the network in the global search for an HIV vaccine.

The HVTN Initiatives Program (HIP) is designed to support novel investigator-driven research proposals within the scope of the HVTN research agenda using HVTN-procured specimens, clinical, laboratory, and/or behavioral data, as well as pilot proposals. This mechanism will fund studies led by HVTN-affiliated investigators that are exploratory in nature, ground-breaking, or extend previous HIV vaccine discoveries toward new directions. HVTN intends to fund up to four proposals up to $75,000 for one year.

Letters of Intent are due 5 April 2017, and proposals are due 31 May 2017.

For more information, visit https://members.hvtn.org/HIP

INTERPRETATION SERVICES

Congress Reutal South Africa will provide simultaneous Portuguese interpretation for all plenary sessions, as well as many sessions in Ilanga 1 & 2 and Nina 1 & 2 meeting rooms. Interpretation headsets can be picked up from the Congress Reutals table in the Ayanda Lobby.

MEALS

Complimentary meals are provided during the meeting. Breakfast will be located in the oneNINEone Restaurant, with teas & lunch being located in the Ayanda Foyer.



TUESDAY, 28 FEBRUARYMONDAY, 27 FEBRUARY

7:00 am - 5:00 pm OPEN REGISTRATION Ayanda Lobby

6:30 – 8:00 am BREAKFAST BUFFET oneNINEone Restaurant

7:00 – 8:00 am SPECIAL SESSION

Ilanga 1 & 2 Introduction to Immunology & Vaccinology open for Researchers* Session chair: Gail Broder

7:00 – 8:00 am BREAKOUT SESSIONS

Maita HVTN 116 Operations MeetingBoardroom Session Chair: Philipp Mann closed

Mila HVTN 915 Writing Team – Part 1Boardroom Session chair: Fatima Laher closed

4:00 - 7:00 pm OPEN REGISTRATION Near the Ballroom on the 1st floor

5:00 - 6:00 pm SPECIAL SESSION

The Atrium Meet the Mentors: Research & Career Development for Junior HVTN Researchers

6:00 – 9:00 pm HVTN Opening Reception Ballroom

8:00 - 10:30 am PLENARY SESSION 1* Ayanda 1 & 2 AMP Session Chair: Larry Corey, MD Fred Hutch/HVTN 8:00 – 8:30 Neutralizing Antibodies 101: How will results from AMP help inform HIV Vaccine Design? Lynn Morris, PhD, RN, FAAN, FGSA National Institute of Communicable Diseases

8:30 – 8:45 Antibody Mediated Prevention in Sub-Saharan Women: HVTN 703/HPTN 081 Updates Nyaradzo Mgodi, MBChB, MMed University of Zimbabwe-University of California San Francisco Collaborative Research Program

8:45 – 9:00 Antibody Mediated Prevention in MSM & TG: HVTN 704/HPTN 085 Updates Shelly Karuna, MD Fred Hutch/HVTN

9:00 – 9:20 First Infusion Reactions: Experience of eThekwini CRS Kathy Mngadi, MBChB Centre for the AIDS Programme of Research in South Africa

9:20 – 9:40 Next Generation mAbs Penny Moore, PhD AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg

9:40 – 10:00 The CAP256-VRC26.25.LS mAb HIV Prevention Research Plan Salim Karim, MD, PhD, DSc Centre for the AIDS Programme of Research in South Africa

10:00 – 10:30 Questions & Answers

10:00 - 10:30 am MORNING TEA Ayanda Lobby

continued on page 6


HVTN SUB-SAHARAN AFRICA REGIONAL MEETING, 28 FEB - 1 MARCH, 2017

PLENARY OPEN SESSION CLOSED SESSION CATERING OFF AGENDA


PROGRAM AT-A-GLANCE

* INTERPRETATION


HVTN CONFERENCE AGENDA TUESDAY, 28 FEBRUARY

WEDNESDAY, 1 MARCH

8:00 – 10:00 am PLENARY SESSION 3* Ayanda 1 & 2 HVTN 702 Session Chair: Glenda Gray, MBBCH, FCPAED, Perinatal HIV Research Unit/Medical Research Council

8:00 – 8:15 Epidemic in Kwa Zulu Natal Gita Ramjee, PhD, FRCPE Medical Research Council

8:15 – 8:30 Update on Where We Are Glenda Gray, MBBCH, FCPAED Perinatal HIV Research Unit/Medical Research Council

7:00 am - 5:00 pm OPEN REGISTRATION Ayanda Lobby

6:30 – 8:00 am BREAKFAST BUFFET oneNINEone Restaurant

7:00 – 8:00 am SPECIAL SESSION

Ilanga 1 & 2 HVTN for First Timers* open Session chair: S. Wakefield

7:00 – 8:00 am BREAKOUT SESSION

Mila HVTN 915 Writing Team – Part 2Boardroom Session chair: Fatima Laher closed

Noon - 1:00 pm LUNCH BUFFET Ayanda Foyer

1:00 - 3:00 pm BREAKOUT SESSION

Ilanga 1 & 2 AMP All-Site Staff Meeting*closed Session chairs: Carissa Karg, Shelly Karuna, and Phil Andrew

3:00 – 5:00 pm BREAKOUT SESSION

Nina 1 & 2 AMP Clinical Breakout Session*closed Session chair: Simba Takuva

5:00 – 7:00 pm SPECIAL SESSION

Nina 1 & 2 Unraveling the Mysteries of Site Inspections: open The Regulatory Environment & Inspections* Session chair: Manizhe Payton

7:00 – 9:00 pm Scientific Governance Invited Guests Only Committee Dinner Residence


Ilanga 1 & 2 CAB Breakout Session*closed Session chair: Emilder Chihota

3:00 – 4:30 pm SPECIAL SESSION

Ilanga 1 & 2 Introduction to Immunology & Vaccinology open for Community Members* Session chair: Gail Broder

11:00 am - Noon PLENARY SESSION 2* Ayanda 1 & 2 Vaccinology & Immunology: Early Scientific Investigator’s Plenary Session Chair: Jim Kublin, MD, MPH Fred Hutch/HVTN 11:00 – 11:20 Immunology 101 Nadine Rouphael, MD Emory University

11:20 – 11:40 Passive vs Active Immunization Against HIV Stephen Walsh, MD Partners Health Care

11:40 – Noon Vaccinology 101: History of Vaccine Science Hyman Scott, MD University of California San Francisco Medical Center

Questions & Answers

3:00 – 3:30 pm AFTERNOON TEA Ayanda Foyer


WEDNESDAY, 1 MARCH

10:30 – Noon PLENARY SESSION 4* Ayanda 1 & 2 Mucosal Sampling Plenary Session Chair: Julie McElrath, MD, MPH, Fred Hutch/HVTN Lab Center

10:30 – 10:40 Mucosal Immunity, Methodology & Findings Nigel Garrett, MBBS, MRCP, MSc Centre for the AIDS Programme of Research in South Africa

10:40 – 11:00 Considering Mucosal Sampling in Adolescents as Part of HIV Vaccine Trials Jo-Ann Passmore, PhD University of Cape Town

11:00 – 11:20 Mucosal Sampling: Site Experience Linda-Gail Bekker, MBChB, DCH, FCP, MD, PhD Desmond Tutu HIV Centre

11:20 – 11:40 Cross-protocol Analysis of Mucosal Antibodies Georgia Tomaras, PhD Duke University

11:40 – Noon Questions & Answers

Noon - 1:00 pm LUNCH BUFFET Ayanda Foyer

Noon - 2:00 pm BREAKOUT SESSION

Nina 1 & 2 HVTN 702 All-Site Staff Meetingclosed Session chair: Nicole Grunenberg


Ballroom 3 Meeting of the SSA Social Behavioral open Working Group Session chair: Janan Dietrich


Nina 1 & 2 P5 Mucosal Training closed Session chair: Philipp Mann


Ballroom 3 South African Sites: Creating Educational closed Videos for South Africa Session chair: Michele Andrasik


Ilanga 1 & 2 HVTN 702 All Staff Video Consultation closed Breakout Session Session chair: Michele Andrasik

2:00 – 3:30 pm BREAKOUT SESSIONS

Ilanga 1 & 2 CER Breakout Session*closed Session chair: Nandi Luthuli

Nina 1 & 2 HPX2008/HVTN 705 Investigator’s Meetingclosed Session chair: Philipp Mann

8:30 – 8:45 Site Perspective Fatima Laher, MD, MBCh Perinatal HIV Research Unit- Vaccine Research & Mookho Malahleha, MBChB Setshaba Research Centre

8:45 – 9:00 HVTN 100 Durability Data Linda-Gail Bekker, MBChB, DCH, FCP, MD, PhD Desmond Tutu HIV Centre

9:00 – 9:15 PrEP & HVTN 702 Kathy Mngadi, MBChB Centre for the AIDS Programme of Research in South Africa

9:15 – 10:00 Questions & Answers

3:00 – 3:30 pm AFTERNOON TEA Ayanda Foyer

10:00 - 10:30 am MORNING TEA Ayanda Foyer


NOTES

10

The HVTN Sub-Saharan Africa Regional Meeting will convene throughout the Ballroom Floor and Conference Floor of the Hyatt Regency Johannesburg. If you need additional assistance, an attendant at the Registration Desk will be happy to assist you.

Ballroom Floor

Conference Floor

HYATT REGENCY JOHANNESBURG

Ballroom Floor

BALLROOM 2 BALLROOM 3BALLROOM 1

BALLROOM LOBBY

REGISTRATION DESK

(MONDAY AFTERNOON)

MAITA

MILA

ILANGA I

ILANGA II

NINA I

NINA II

EXHIBITION AREA

AYANDA I

AYANDA II

Conference Floor

REGISTRATION DESK

(TUESDAY & WEDNESDAY)

#hivvax - hvtn.org...hvtn opening reception 6:00 pm – 9:00 pm tuesday, 28 february breakfast 6:30...

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