HOXA9 and its Role in Acute Myeloid

LeukemiaBrent Hoffman

HOXA9 is one of the HOX transcription factors regulating Anterior to Posterior patterning in early development

HOXA9 regulates bone marrow stem cell proliferation and cells differentiate as

HOXA9 expression decreases

HOXA9 -/- bone marrow cells showed inhibited ability to repopulate in vitro after

hematopoietic stress

Acute Myeloid Leukemia is a cancer of the bone marrow affecting white blood cell proliferation and differentiation

In AML, a translocation joinsHOXA9 to NUP98

Fusion of the NUP98 gene to HOXA9 induces AML in mice cells

Current treatment for AML is divided into two phases: remission induction and post-remission therapy

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