india: pancreatitis working groups and activities 10 3b... · 2019. 8. 9. · india: pancreatitis...
TRANSCRIPT
India: Pancreatitis Working
Groups and Activities
Rupjyoti TalukdarDirector, Pancreas Clinic
Clinical Pancreatologist & Clinician Scientist
Head, Pancreas Research Group and Division of
Microbiome research (Wellcome-DBT Labs.)
Asian Healthcare Foundation/Asian Healthcare Foundation
Hyderabad.
…..the next 7 mins
Research sample
What we see
Our vision
How we do
Our team
PancreasFest 2019; 26th July, 2019
…….our research sample
Northeast India
10.5%
Bangladesh
4.1%
Nepal
1.1%
Eastern India
37.2%
Southern India
33.5%
Northern India
2.6%
Western India
2.1%
Central India
8.9%
PancreasFest 2019; 26th July, 2019
…..what we see
Total patient turnover in the Pancreas Clinic in
last one year (268 working days):
5404 pancreatic diseases
>95% pancreatitis
~ 50% each of acute and chronic pancreatitis
~ 35-40% new patients
AP
(n= 426)
CP
(n=177)
RAP
(n= 378)
9.6%
36%
N=804
Manuscript under preparation
PancreasFest 2019; 26th July, 2019
…… our vision
PancreasFest 2019; 26th July, 2019
Genetic risk factors (Claudin, PRSSS1-PRSS2)
Disease Onset
(Acinar injury)
SIRS Necrosis MODS (15-20%)
Infected necrosis MODS/POF
WON with complicatn. High output fistula
Pseudoaneurysms
1st week after onset 2nd week onwards 4th week onwards
STERILE
1st wave of
mortality
SEPSIS
2nd wave of
mortality
Disease Onset
(Acinar injury)
SIRS Necrosis MODS (15-20%)
Infected necrosis MODS/POF
WON with complicatn. High output fistula
Pseudoaneurysms
1st week after onset 2nd week onwards 4th week onwards
STERILE
1st wave of
mortality
SEPSIS
2nd wave of
mortality
Jakkampudi et al.
Sci Rep 2017 Intestinal
inflammation
Gut barrier
Dysbiosis
HLA-DR; IL-10
KMOSharma et al.
Dig Dis Sci 2017
Jakkampudi et al.
DDW 2019
Avanthi et al.
JGH 2015
Talukdar et al.
(under review)
Lakhtakia et al.
GIE 2017
PancreasFest 2019; 26th July, 2019
…… our vision
Complex pain
patternsExocrine &
endocrine
dysfunction
Psychological
dysfunction
Bach2
repression
Th cell
infiltration
Talukdar et al.
Pancreas 2016
Mitnala et al.
UEGJ 2018
Jandhyala et al.
Sci Rep 2017
Sarkar et al.
DDW 2018
Sarkar et al.
DDW 2019
Galande et al.
DDW 2019
Talukdar et al.
DDW 2018
Presubmission
Tandan et al.
2019 in revision
Tandan et al.
GIE 2013
Agarwal et al.
GIE 2014
DYSBIOSIS
PancreasFest 2019; 26th July, 2019
…… how we doPancreas
clinicAP CP
Clinical
assessment/
data
Blood sampling
Research
sample
Diagnostic
sample
Stool
sampling
DAY 1
DAY 2
Clinical assessment/ data
Nutrition/Anthropometry
Depression
QOL
DNA and RNA isolation
Sequencing
PCR
Biochemical assays
ELISA
Metabolomics/GC-MS/MS
I n f o r m e d c o n s e n t
Imaging
DAY 2/3
onwardsRx initiation/Referrals/Diet consult/Counselling/Follow-up plan
Metagenomic DNA isolation &
sequencing (ion proton)
Metabolomics/GC-MS/MS
Diagnostic
Research (MRS)
PancreasFest 2019; 26th July, 2019
Genetics labsRavi Kanth VV (Lead)
Steffie Avanthi (PhD scholar)
Govardhan Bale (PhD Scholar)
Vishesh Chandra (Research Fellow)
Islet labsSasikala Mitnala (Lead)
Pavan Kumar (Scientist)
Ratnakar Reddy (Post doc)
Sheetal Galande (PhD scholar)
Wellcome DBT Labs
ClinicalSubhaleena Sarkar (Research Fellow)
Misbah Unnisa (Research Fellow)
Chandrakanth (GI Fellow)
Avadh Patel (GI Fellow)
Revanth K (Consultant Radiologist)
Rajesh Goud (Research Co-ordinator)
Research labsPriyanka Sarkar (Post Doc)
Aparna Jakkampudi (PhD scholar)
Subhaleena Sarkar (Research Fellow)
Mojibur Rahman (Collaborator)
Mridusmita Dehingya (Collaborator)
…… our team
…… our team
Advanced endoscopy teamManu Tandan
Sundeep Lakhtakia
Rajesh Gupta
Mohan Ramchandani
Rakesh Kalapala
Jagangeer Basha
Zaheer Nabi
Research team other than pancreasMithun Sharma
Anand Kulkarni
Pramod Kumar
Bala Kumar Reddy
Ranjeet Tokala
Sashidhar Rao
Krishna Reddy
Renuka G
Ambika
Research advisors
D. Nageshwar Reddy
GV Rao
PN Rao
Harigopal B
PancreasFest 2019; 26th July, 2019
Surgical teamGV Rao
R Pradeep
