Editorial Boarde002080 doi: 10.1161/JAHA.116.002080

Editorials Caffeine Consumption and Cardiovascular Risks: Little Cause for Concern Peter W. F. Wilson and Heather L. Bloom e003089 doi: 10.1161/JAHA.115.003089

Biomarkers and the Fontan Circulation Kurt R. Schumacher and David J. Goldberg e002926 doi: 10.1161/JAHA.115.002926

Original Research Arrhythmia and Electrophysiology

Ambulatory Monitoring and Arrhythmic Outcomes in Pediatric and Adolescent Patients With Duchenne Muscular Dystrophy Chet R. Villa, Richard J. Czosek, Humera Ahmed, Philip R. Khoury, Jeffrey B. Anderson, Timothy K. Knilans, John L. Jefferies, Brenda Wong, and David S. Spar e002620 doi: 10.1161/JAHA.115.002620

Preserved Autonomic Cardiovascular Regulation With Cardiac Pacemaker Inhibition: A Crossover Trial Using High-Fidelity Cardiovascular Phenotyping Karsten Heusser, Jens Tank, Julia Brinkmann, Christoph Schroeder, Marcus May, Anika Großhennig, Daniela Wenzel, André Diedrich, Fred C. G. J. Sweep, Heidrun Mehling, Friedrich C. Luft, and Jens Jordan e002674 doi: 10.1161/JAHA.115.002674

Consumption of Caffeinated Products and Cardiac Ectopy Shalini Dixit, Phyllis K. Stein, Thomas A. Dewland, Jonathan W. Dukes, Eric Vittinghoff, Susan R. Heckbert, and Gregory M. Marcus e002503 doi: 10.1161/JAHA.115.002503

Novel Bloodless Potassium Determination Using a Signal-Processed Single-Lead ECG Zachi I. Attia, Christopher V. DeSimone, John J. Dillon, Yehu Sapir, Virend K. Somers, Jennifer L. Dugan, Charles J. Bruce, Michael J. Ackerman, Samuel J. Asirvatham, Bryan L. Striemer, Jan Bukartyk, Christopher G. Scott, Kevin E. Bennet, Dorothy J. Ladewig, Emily J. Gilles, Dan Sadot, Amir B. Geva, and Paul A. Friedman e002746 doi: 10.1161/JAHA.115.002746

An Integrated Management Approach to Atrial Fibrillation Lindsey Carter, Martin Gardner, Kirk Magee, Ann Fearon, Inna Morgulis, Steve Doucette, John L. Sapp, Chris Gray, Amir Abdelwahab, and Ratika Parkash e002950 doi: 10.1161/JAHA.115.002950

Cardiovascular Surgery Histopathological Correlates of Global and Segmental Left Ventricular Systolic Dysfunction in Experimental Chronic Chagas Cardiomyopathy Luciano Fonseca Lemos de Oliveira, Minna Moreira Dias Romano, Eduardo Elias Vieira de Carvalho, Jorge Mejia Cabeza, Hélio Cesar Salgado, Rubens Fazan Jú nior, Renata Sesti Costa, João Santana da Silva, Maria de Lourdes Higuchi, Benedito Carlos Maciel, Edécio Cunha-Neto, José Antônio Marin-Neto, and Marcus Vinícius Simões e002786 doi: 10.1161/JAHA.115.002786

JAHA: Journal of the American Heart AssociationVolume 5, Issue 1

January 2016

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Congenital Heart Disease Rac1 Signaling Is Required for Anterior Second Heart Field Cellular Organization and Cardiac Outflow Tract Development Carmen Leung, Yin Liu, Xiangru Lu, Mella Kim, Thomas A. Drysdale, and Qingping Feng e002508 doi: 10.1161/JAHA.115.002508

Digoxin Use Is Associated With Reduced Interstage Mortality in Patients With No History of Arrhythmia After Stage I Palliation for Single Ventricle Heart Disease David W. Brown, Colleen Mangeot, Jeffrey B. Anderson, Laura E. Peterson, Eileen C. King, Stacey L. Lihn, Steven R. Neish, Craig Fleishman, Christina Phelps, Samuel Hanke, Robert H. Beekman III, Carole M. Lannon on behalf of the National Pediatric Cardiology Quality Improvement Collaborative e002376 doi: 10.1161/JAHA.115.002376

Galectin-3 Is Elevated and Associated With Adverse Outcomes in Patients With Single-Ventricle Fontan Circulation Alexander R. Opotowsky, Fernando Baraona, Justin Owumi, Brittani Loukas, Michael N. Singh, Anne Marie Valente, Fred Wu, Susan Cheng, Gruschen Veldtman, Eric B. Rimm, and Michael J. Landzberg e002706 doi: 10.1161/JAHA.115.002706

Association of Digoxin With Interstage Mortality: Results From the Pediatric Heart Network Single Ventricle Reconstruction Trial Public Use Dataset Matthew E. Oster, Michael Kelleman, Courtney McCracken, Richard G. Ohye, and William T. Mahle e002566 doi: 10.1161/JAHA.115.002566

Nationwide Hospitalization Trends in Adult Congenital Heart Disease Across 2003–2012 Shikhar Agarwal, Karan Sud, and Venu Menon e002330 doi: 10.1161/JAHA.115.002330

Coronary Heart Disease Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris Yunpeng Ding, Gard F. T. Svingen, Eva R. Pedersen, Jesse F. Gregory, Per M. Ueland, Grethe S. Tell, and Ottar K. Nygård e002621 doi: 10.1161/JAHA.115.002621

Heart Failure Complicating Acute Myocardial Infarction; Burden and Timing of Occurrence: A Nation-wide Analysis Including 86 771 Patients From the Cardiovascular Disease in Norway (CVDNOR) Project Gerhard Sulo, Jannicke Igland, Stein Emil Vollset, Ottar Nygård, Marta Ebbing, Enxhela Sulo, Grace M. Egeland, and Grethe S. Tell e002667 doi: 10.1161/JAHA.115.002667

Epidemiology Circulating Galectin-3 Is Associated With Cardiometabolic Disease in the Community Matthew Nayor, Na Wang, Martin G. Larson, Ramachandran S. Vasan, Daniel Levy, and Jennifer E. Ho e002347 doi: 10.1161/JAHA.115.002347

Changes in Body Weight From Young Adulthood to Middle Age and Its Association With Blood Pressure and Hypertension: A Cross-Sectional Study in Hong Kong Chinese Women Yao Jie Xie, Suzanne C. Ho, Xuefen Su, and Zhao-Min Liu e002361 doi: 10.1161/JAHA.115.002361

Lifestyle Changes in Young Adulthood and Middle Age and Risk of Cardiovascular Disease and All-Cause Mortality: The Doetinchem Cohort Study Gerben Hulsegge, Moniek Looman, Henriëtte A. Smit, Martha L. Daviglus, Yvonne T. van der Schouw, and W.M. Monique Verschuren e002432 doi: 10.1161/JAHA.115.002432

Blood Pressure Reactivity to Psychological Stress in Young Adults and Cognition in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) Study Yuichiro Yano, Hongyan Ning, Jared P. Reis, Cora E. Lewis, Lenore J. Launer, R. Nick Bryan, Kristine Yaffe, Stephen Sidney, Emiliano Albanese, Philip Greenland, Donald Lloyd-Jones, and Kiang Liu e002718 doi: 10.1161/JAHA.115.002718

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Impact of Nonoptimal Intakes of Saturated, Polyunsaturated, and Trans Fat on Global Burdens of Coronary Heart Disease Qianyi Wang, Ashkan Afshin, Mohammad Yawar Yakoob, Gitanjali M. Singh, Colin D. Rehm, Shahab Khatibzadeh, Renata Micha, Peilin Shi, Dariush Mozaffarian on behalf of the Global Burden of Diseases Nutrition and Chronic Diseases Expert Group (NutriCoDE) e002891 doi: 10.1161/JAHA.115.002891

Serum Magnesium and the Risk of Death From Coronary Heart Disease and Sudden Cardiac Death Brenda C. T. Kieboom, Maartje N. Niemeijer, Maarten J. G. Leening, Marten E. van den Berg, Oscar H. Franco, Jaap W. Deckers, Albert Hofman, Robert Zietse, Bruno H. Stricker, and Ewout J. Hoorn e002707 doi: 10.1161/JAHA.115.002707

Dietary α-Linolenic Acid, Marine ω-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study Aleix Sala-Vila, Marta Guasch-Ferré, Frank B. Hu, Ana Sánchez-Tainta, Mònica Bulló, Mercè Serra-Mir, Carmen López-Sabater, Jose V. Sorlí, Fernando Arós, Miquel Fiol, Miguel A. Muñoz, Luis Serra-Majem, J. Alfredo Martínez, Dolores Corella, Montserrat Fitó, Jordi Salas-Salvadó, Miguel A. Martínez-González, Ramón Estruch, Emilio Ros for the PREDIMED Investigators e002543 doi: 10.1161/JAHA.115.002543

Health Services and Outcomes Research Implementation of Pit Crew Approach and Cardiopulmonary Resuscitation Metrics for Out-of-Hospital Cardiac Arrest Improves Patient Survival and Neurological Outcome Christy L. Hopkins, Chris Burk, Shane Moser, Jack Meersman, Clair Baldwin, and Scott T. Youngquist e002892 doi: 10.1161/JAHA.115.002892

How Reliable are Patient-Reported Rehospitalizations? Implications for the Design of Future Practical Clinical Studies Arun Krishnamoorthy, Eric D. Peterson, J. David Knight, Kevin J. Anstrom, Mark B. Effron, Marjorie E. Zettler, Linda Davidson-Ray, Brian A. Baker, Patrick L. McCollam, Daniel B. Mark, and Tracy Y. Wang e002695 doi: 10.1161/JAHA.115.002695

Effectiveness and Safety of Aldosterone Antagonist Therapy Use Among Older Patients With Reduced Ejection Fraction After Acute Myocardial Infarction Tracy Y. Wang, Amit N. Vora, S. Andrew Peng, Gregg C. Fonarow, Sandeep Das, James A. de Lemos, and Eric D. Peterson e002612 doi: 10.1161/JAHA.115.002612

Heart Failure Prognostic Benefits of Carvedilol, Bisoprolol, and Metoprolol Controlled Release/Extended Release in Hemodialysis Patients with Heart Failure: A 10-Year Cohort Chao-Hsiun Tang, Chia-Chen Wang, Tso-Hsiao Chen, Chuang-Ye Hong, and Yuh-Mou Sue e002584 doi: 10.1161/JAHA.115.002584

Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease Aaron L. Sverdlov, Aly Elezaby, Fuzhong Qin, Jessica B. Behring, Ivan Luptak, Timothy D. Calamaras, Deborah A. Siwik, Edward J. Miller, Marc Liesa, Orian S. Shirihai, David R. Pimentel, Richard A. Cohen, Markus M. Bachschmid, and Wilson S. Colucci e002555 doi: 10.1161/JAHA.115.002555

Full Expression of Cardiomyopathy Is Partly Dependent on B-Cells: A Pathway That Involves Cytokine Activation, Immunoglobulin Deposition, and Activation of Apoptosis Andrea M. Cordero-Reyes, Keith A. Youker, Alejandro R. Trevino, Rene Celis, Dale J. Hamilton, Jose H. Flores-Arredondo, Carlos M. Orrego, Arvind Bhimaraj, Jerry D. Estep, and Guillermo Torre-Amione e002484 doi: 10.1161/JAHA.115.002484

Diagnostic Accuracy of Tissue Doppler Index E/e’ for Evaluating Left Ventricular Filling Pressure and Diastolic Dysfunction/Heart Failure With Preserved Ejection Fraction: A Systematic Review and Meta-Analysis Oleg F. Sharifov, Chun G. Schiros, Inmaculada Aban, Thomas S. Denney, Jr, and Himanshu Gupta e002530 doi: 10.1161/JAHA.115.002530

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HECT-Type Ubiquitin E3 Ligase ITCH Interacts With Thioredoxin-Interacting Protein and Ameliorates Reactive Oxygen Species–Induced Cardiotoxicity Yoichiro Otaki, Hiroki Takahashi, Tetsu Watanabe, Akira Funayama, Shunsuke Netsu, Yuki Honda, Taro Narumi, Shinpei Kadowaki, Hiromasa Hasegawa, Shintaro Honda, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Hideaki Kamata, Osamu Nakajima, and Isao Kubota e002485 doi: 10.1161/JAHA.115.002485

Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy Andrea Iorga, Jingyuan Li, Salil Sharma, Soban Umar, Jean C. Bopassa, Rangarajan D. Nadadur, Alexander Centala, Shuxun Ren, Tomoaki Saito, Ligia Toro, Yibin Wang, Enrico Stefani, and Mansoureh Eghbali e002482 doi: 10.1161/JAHA.115.002482

Imaging Age-Related Changes of Normal Cerebral and Cardiac Blood Flow in Children and Adults Aged 7 Months to 61 Years Can Wu, Amir R. Honarmand, Susanne Schnell, Ryan Kuhn, Samantha E. Schoeneman, Sameer A. Ansari, James Carr, Michael Markl, and Ali Shaibani e002657 doi: 10.1161/JAHA.115.002657

Cardiac Time Intervals Measured by Tissue Doppler Imaging M-mode: Association With Hypertension, Left Ventricular Geometry, and Future Ischemic Cardiovascular Diseases Tor Biering-Sørensen, Rasmus Mogelvang, Peter Schnohr, and Jan Skov Jensen e002687 doi: 10.1161/JAHA.115.002687

Interventional Cardiology Comprehensive Assessment of Coronary Plaque Progression With Advanced Intravascular Imaging, Physiological Measures, and Wall Shear Stress: A Pilot Double-Blinded Randomized Controlled Clinical Trial of Nebivolol Versus Atenolol in Nonobstructive Coronary Artery Disease Olivia Y. Hung, David Molony, Michel T. Corban, Emad Rasoul-Arzrumly, Charles Maynard, Parham Eshtehardi, Saurabh Dhawan, Lucas H. Timmins, Marina Piccinelli, Sung Gyun Ahn, Bill D. Gogas, Michael C. McDaniel, Arshed A. Quyyumi, Don P. Giddens, and Habib Samady e002764 doi: 10.1161/JAHA.115.002764

Radial Artery Occlusion After Transradial Interventions: A Systematic Review and Meta-Analysis Muhammad Rashid, Chun Shing Kwok, Samir Pancholy, Sanjay Chugh, Sasko A. Kedev, Ivo Bernat, Karim Ratib, Adrian Large, Doug Fraser, James Nolan, and Mamas A. Mamas e002686 doi: 10.1161/JAHA.115.002686

Molecular Cardiology Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge Edward J. Miller, Timothy Calamaras, Aly Elezaby, Aaron Sverdlov, Fuzhong Qin, Ivan Luptak, Ke Wang, Xinxin Sun, Andrea Vijay, Dominique Croteau, Markus Bachschmid, Richard A. Cohen, Kenneth Walsh, and Wilson S. Colucci e002277 doi: 10.1161/JAHA.115.002277

Testosterone Antagonizes Doxorubicin-Induced Senescence of Cardiomyocytes Paola Altieri, Chiara Barisione, Edoardo Lazzarini, Anna Garuti, Gian Paolo Bezante, Marco Canepa, Paolo Spallarossa, Carlo Gabriele Tocchetti, Sveva Bollini, Claudio Brunelli, and Pietro Ameri e002383 doi: 10.1161/JAHA.115.002383

Preventive Cardiology Hydroxychloroquine Use Is Associated With Decreased Incident Cardiovascular Events in Rheumatoid Arthritis Patients Tarun S. Sharma, Mary Chester M. Wasko, Xiaoqin Tang, Deepak Vedamurthy, Xiaowei Yan, Jonida Cote, and Androniki Bili e002867 doi: 10.1161/JAHA.115.002867

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Effects of Diet Composition and Insulin Resistance Status on Plasma Lipid Levels in a Weight Loss Intervention in Women Tran Le, Shirley W. Flatt, Loki Natarajan, Bilge Pakiz, Elizabeth L. Quintana, Dennis D. Heath, Brinda K. Rana, and Cheryl L. Rock e002771 doi: 10.1161/JAHA.115.002771

Resuscitation Science Early Access to the Cardiac Catheterization Laboratory for Patients Resuscitated From Cardiac Arrest Due to a Shockable Rhythm: The Minnesota Resuscitation Consortium Twin Cities Unified Protocol Santiago Garcia, Todd Drexel, Wobo Bekwelem, Ganesh Raveendran, Emily Caldwell, Lucinda Hodgson, Qi Wang, Selcuk Adabag, Brian Mahoney, Ralph Frascone, Gregory Helmer, Charles Lick, Marc Conterato, Kenneth Baran, Bradley Bart, Fouad Bachour, Steven Roh, Carmelo Panetta, Randall Stark, Mark Haugland, Michael Mooney, Keith Wesley, and Demetris Yannopoulos e002670 doi: 10.1161/JAHA.115.002670

Stroke Interferon-β Modulates Inflammatory Response in Cerebral Ischemia Ping-Chang Kuo, Barbara A. Scofield, I-Chen Yu, Fen-Lei Chang, Doina Ganea, and Jui-Hung Yen e002610 doi: 10.1161/JAHA.115.002610

Stroke Severity Is a Crucial Predictor of Outcome: An International Prospective Validation Study Natalia S. Rost, Alex Bottle, Jin-Moo Lee, Marc Randall, Steven Middleton, Louise Shaw, Vincent Thijs, Gabriel J. E. Rinkel, Thomas M. Hemmen on behalf of the Global Comparators Stroke GOAL collaborators e002433 doi: 10.1161/JAHA.115.002433

Forced Expiratory Volume in the First Second and Aldosterone as Mediators of Smoking Effect on Stroke in African Americans: The Jackson Heart Study Wei Wang, Gui Shen, Eyal Shahar, Aurelian Bidulescu, W. Taylor Kimberly, Kevin N. Sheth, Brenda W. Campbell, Steven Horbal, Adolfo Correa, and Michael E. Griswold e002689 doi: 10.1161/JAHA.115.002689

Transplantation Comparison of Basiliximab and Anti-Thymocyte Globulin as Induction Therapy in Pediatric Heart Transplantation: A Survival Analysis David Ansari, Peter Höglund, Bodil Andersson, and Johan Nilsson e002790 doi: 10.1161/JAHA.115.002790

Pretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchymal Stem Cells Enhances Myocardial Repair Zhiwei Zhang, Junjie Yang, Weiya Yan, Yangxin Li, Zhenya Shen, and Takayuki Asahara e002856 doi: 10.1161/JAHA.115.002856

Valvular Heart Disease Synergistic Utility of Brain Natriuretic Peptide and Left Ventricular Strain in Patients With Significant Aortic Stenosis Andrew Goodman, Kenya Kusunose, Zoran B. Popovic, Roosha Parikh, Tyler Barr, Joseph F. Sabik, L. Leonardo Rodriguez, Lars G. Svensson, Brian P. Griffin, and Milind Y. Desai e002561 doi: 10.1161/JAHA.115.002561

Vascular Medicine Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction Qiumei Chen, Monika Varga, Xiaoyin Wang, Daniel J. Haddad, Songtao An, Lejla Medzikovic, Ronak Derakhshandeh, Dmitry S. Kostyushev, Yan Zhang, Brian T. Clifford, Emmy Luu, Olivia M. Danforth, Ruslan Rafikov, Wenhui Gong, Stephen M. Black, Sergey V. Suchkov, Jeffrey R. Fineman, Christian Heiss, Kirstin Aschbacher, Yerem Yeghiazarians, and Matthew L. Springer e002257 doi: 10.1161/JAHA.115.002257

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Simple Renal Cysts as Markers of Thoracic Aortic Disease Bulat A. Ziganshin, Panagiotis Theodoropoulos, Mohammad N. Salloum, Khaled J. Zaza, Maryann Tranquilli, Hamid R. Mojibian, Neera K. Dahl, Hai Fang, John A. Rizzo, and John A. Elefteriades e002248 doi: 10.1161/JAHA.115.002248

Intravenous Lipid Infusion Induces Endoplasmic Reticulum Stress in Endothelial Cells and Blood Mononuclear Cells of Healthy Adults Emmanouil Tampakakis, Corey E. Tabit, Monika Holbrook, Erika A. Linder, Brittany D. Berk, Alissa A. Frame, Rosa Bretón-Romero, Jessica L. Fetterman, Noyan Gokce, Joseph A. Vita, and Naomi M. Hamburg e002574 doi: 10.1161/JAHA.115.002574

Increased Peripheral Arterial Calcification in Patients Receiving Warfarin Kum Hyun Han and W. Charles O’Neill e002665 doi: 10.1161/JAHA.115.002665

Total Thrombus-Formation Analysis System (T-TAS) Can Predict Periprocedural Bleeding Events in Patients Undergoing Catheter Ablation for Atrial Fibrillation Miwa Ito, Koichi Kaikita, Daisuke Sueta, Masanobu Ishii, Yu Oimatsu, Yuichiro Arima, Satomi Iwashita, Aya Takahashi, Tadashi Hoshiyama, Hisanori Kanazawa, Kenji Sakamoto, Eiichiro Yamamoto, Kenichi Tsujita, Megumi Yamamuro, Sunao Kojima, Seiji Hokimoto, Hiroshige Yamabe, and Hisao Ogawa e002744 doi: 10.1161/JAHA.115.002744

Contemporary Reviews Overcoming Challenges With Statin Therapy J. David Spence and George K. Dresser e002497 doi: 10.1161/JAHA.115.002497

Clinical Phenotypes in Heart Failure With Preserved Ejection Fraction Rohan Samson, Abhishek Jaiswal, Pierre V. Ennezat, Mark Cassidy, and Thierry H. Le Jemtel e002477 doi: 10.1161/JAHA.115.002477

Corrections Development of Aortic Valve Disease in Familial Hypercholesterolemic Swine: Implications for Elucidating Disease Etiology e002007 doi: 10.1161/JAHA.115.002007

What are White Matter Hyperintensities Made of? : Relevance to Vascular Cognitive Impairment e002006 doi: 10.1161/JAHA.115.002006

Cardiac Autonomic Dysfunction: Particulate Air Pollution Effects Are Modulated by Epigenetic Immunoregulation of Toll-like Receptor 2 and Dietary Flavonoid Intake e002008 doi: 10.1161/JAHA.115.002008

Impact of Nonoptimal Intakes of Saturated, Polyunsaturated, and Trans Fat on Global Burdens of Coronary Heart Disease e002076 doi: 10.1161/JAHA.115.002076

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5 (1)

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