le programme de la toulouse onco week

7/25/2019 Le programme de la Toulouse Onco Week

1/6

PROGRAM

Wednesday, February 3rd2016

TOULOUSE ONCO WEEK 2016 ............................................................................................................................................10

08:30 12:30 One-To-One Meetings

08:30 09:00Open Lecture : Daniel Roug (Deputy Mayor)and Jean-Jacques Fourni (Director of the CRCT)

SESSION 1: GENECTIC INSTABILITY AND CELL CYCLEChairs : J.S. Hoffmann & A. Besson - CRCT, Toulouse, France

09:00 09:45 Lecture 1

Targeting DNA repair in cancer treatment

Helleday Thomas

09:45 10:15 Short talk 1Whole exome sequencing in osteosarcoma revealsimportant heterogeneity of genetic alterationsGomez-Bouchet Anne

Short talk 2

A first DNA damage-based mouse model formyelodysplastic syndromes (MDS): Homologousrecombination deficient MCM8/9 knock out micedevelop MDS with final bone marrow fibrosis and failureLutzmann Malik

10:15 10:45 Coffee break / Poster session

10:45 11:30 Lecture 2Targeting Mitosis and Mitotic Exit in CancerMalumbres Marcos

11:30 12:15 Short talk 3

A novel cytoprotective function for the DNA repairprotein Ku in regulating p53 mRNA translation andfunctionMillevoi Stefania

Short talk 4Implication of the DNA damage tolerance in theresistance of cancer cells to the therapyMaiorano Domenico

Short talk 5

Chk1 stability requires DNA polymerase Kappa in

response to replication stressPillaire Marie-Jeanne

12:15 12:45 Clinical TalkTargeting oncogene-induced replication stressfor cancer therapyFernandez-Capetillo Oscar

12:45 14:45Company/technology Presentations (8x5mn): Acobiom, Celenys,Genoskin, Invest in Toulouse, Mimabs, Oncodesign, Pierre Fabre, Seppic

Lunch

Poster session


2/6

PROGRAM

Wednesday, February 3rd

2016

............................................................................................................................................................................. Program 11


SESSION 2: GENE EXPRESSION AND EPIGENETICSChairs: P. Cordelier & J. Torrisani, CRCT, France

14:45 15:30 Lecture 1The role of 5-hydroxymethylcytosine in the aberrantDNA methylation in cancerFernandez Fraga Mario

15:30 16:15 Short talk 1

The histone demethylase JMJD2A/KDM4A linksribosomal RNA transcription to nutrients and growthfactors availabilityTrouche Didier

Short talk 2Targeting mRNA translation in pancreatic cancerMller David

Short talk 3

The ROS/SUMO axis is involved in chemosensitiveacute myeloid leukemia (AML) cells responseto chemotherapeutics and constitutes a potential targetto overcome chemoresistancePiechaczyk Marc


16:45 17:30 Lecture 2Epigenetics and Epigenomics in CancerFuks Francois

17:30 18:00 Short talk 4Chromatin-based memory of Cell Identity: Novelinsights from single-cell 'omics'Cuvier Olivier

Short talk 5Reversal of microRNA-150 silencing disadvantagescrizotinib-resistant NPM-ALK-positive cell growthHoareau-Aveilla Coralie

18:00 18:30 Clinical TalkGenetic and epigenetic insights in chronicmyelomonocytic leukemiaSolary Eric

19:30 22:30 Gala Dinner (on registration only)


3/6

PROGRAM

Thursday, February 4th

, 2016

08:30 - 12:30 One-To-One Meetings

SESSION 3: METABOLISMChairs: M. Poirot & T. Levade, CRCT, France

8:30 9:15 Lecture 1

Sex Steroid - Induced Apoptosis in Steroid DeprivedBreast Cancer: a General Principal for Breast,Prostate and Ovarian Cancer Treatment StrategiesCraig Jordan Virgil

9:15 10:00 Short talk 1

Identification of a cholesterol onco-metabolite,promoter of tumor in breast cancers, and of the enzymeinvolved in its biosynthesisSilvente-Poirot Sandrine

Short talk 2Disruption of cholesterol metabolism regulates thegrowth of EGFR/KRAs-dependent tumors via LXRAstsaturov Igor

Short talk 3Transcriptional repression of glycolysis by RIP140inhibits cell proliferationTeyssier Catherine


10:30-11:15 Lecture 2Targeting PI 3-kinase for cancer therapyCantley Lewis

11:15 11:45 Short talk 4

Lessons learned from first-in-man gene therapy clinicaltrial for pancreatic cancer : targeting tumor metabolismto tackle chemoresistanceCordelier Pierre

Short talk 5Metabolic flexibility in acute myeloid leukemia with IDHmutationStuani Lucille

11:45 12:15 Clinical Talk

Targeting isocitrate dehydrogenase (IDH)1 and IDH2mutations : clinical results in advanced hematologicmalignanciesDe Botton Stphane

12:15 13:00

Symposiumsponsorizedby BectonDickinson

Histone acetyltransferase inhibitor CPTH6 preferentiallytargets lung cancer stem-like cells Daniela TrisciuoglioAccelerate cancer research using the BD AccuriTMflowcytometry solution Meuwissen Pieter Jan

13:00 14:15Company/technology Presentations (4x5mn): Hyprevention, Innopsys,Isotop4life, Nenuphar

Lunch

Poster session



4/6

PROGRAM

Thursday, February 4th

, 2016


SESSION 4: TUMOR BIOLOGY AND STEM CELLSChairs: J. Guillermet & S. Pyronnet, CRCT, France

14:15 15:00 Lecture 1Targeting K-Ras driven lung and pancreatic tumorsBarbacid Mariano

15:00 15:45 Short talk 1

MAP3K8/TPL-2/COT is a potential predictive marker forMEK inhibitor treatment in high-grade serous ovariancarcinomasMieulet Virginie

Short talk 2Control of invasion by PKC theta in triple negativebreast cancerChadelle Lucie

Short talk 3

Isoform-specific PI3K-induced signalling differs alongpancreatic cancerogenesis but controls the inductionof other signalling pathwaysGuillermet-Guibert Julie


16:15 17:00 Lecture 2Oncogenic Ras and inflammation form a pathologicalpartnership that transforms normal cells into cancerLogsdon Craig

17:00 17:30 Short talk 4

Mammary morphogenesis and breast carcinoma pro-gression: a local integration of epithelial-mesenchymaltransition pathways controls cell plasticity, proliferationand stemness/differentiationSavagner Pierre

Short talk 5Circulating tumor cell ex-vivo culture from patient withcolorectal cancer display cancer stem cell hallmarks

Pannequin Julie

17:30 18:00 Clinical TalkTumor-associated macrophages as therapeutictarget in oncologyRttinger Dominik

18:00 20:00 Public Open Debates

............................................................................................................................................................................. Program 13


5/6

PROGRAM

Friday, February 5th

, 2016

SESSION 5: IMMUNITYChairs: J.J. Fourni & P. Brousset, CRCT, France

08:30 9:15 Lecture 1Innate Immunity : from flies to humansHoffmann Jules

09:15 10:00 Short talk 1Immunosurveillance and therapy of multiple myelomais CD226-dependentMartinet Ludovic

Short talk 2In vivo imaging and tracking reveal a differentialmigration mechanism between tumor-associated-and non tumoral macrophagesLe Cabec Vronique

Short talk 3TNF-R1, an immune checkpoint in melanoma?Bertrand Florie


10:30 11:15 Lecture 2Towards the manipulation of Innate Lymphoid Cellsin CancerVivier Eric

11:15 11:45 Short talk 4

Immunomodulatory activity screening and preclinicalassessment of several new synthetic cyclicdinucleotides for use in cancer therapyTiraby Grard

Short talk 5Role of autophagy in FLT3-ITD positive Acute MyeloidLeukemiaHeydt Quentin

11:45 12:15 Clinical TalkRestoring immune control of cancer: progressesand challenges of cancer immunotherapyVan den Eynde Benoit

12:15 13:00

Symposiumsponsorizedby Bristol-MyersSquibb

Immuno - oncology: from the biology to the clinicJean-Pierre Delord and Jean-Jacques Fourni

13:00 14:15Company/technology Presentations (3x5mn): Intelligent Pharma,Urosphere, Vectalys

Lunch

Poster session



6/6

PROGRAM

Friday, February 5th

, 2016

SESSION 6: HEALTH TECHNOLOGIESSponsorized by Toulouse Cancer Health FoundationChairs: E. Moyal & H. Avet-Loiseau, CRCT, France

14:15 15:00 Lecture 1Tissue Phenomics Characterizing the Immuno-TumorEcosystem by a New MethodBinnig Gerd

15:00 15:45 Short talk 1New technology to exploit existing medical imagingarchives for secondary use in research

Seymour Karine

Short talk 2Combined analysis of DNA methylation and cell cyclein cancer cellsRiond Joelle

Short talk 3Next generation sequencing for colorectal cancermolecular diagnosticAzzam Falak


16:15 17:00 Lecture 2Interrogating the architecture of cancer genomes

Campbell Peter

17:00 17:30 Short talk 4

Focal HIFU treatment of localized prostate cancerdiagnosed and controlled with MRI-ultrasound fusiontargeted biopsies: functional outcomes and short-termoncological controlPotiron Eric

Short talk 5Modeling spontaneous metastasis following surgery:an in vivo-in silico approachBenzekry Sebastien

17:30 18:00 Clinical TalkBreaking of Space and Time resolution Limitsin Biomedical Ultrasound

Tanter Mickael

Sunday February 7th, 2016

11:00 15:00Charityevent

Pink N Go5km foot race starting in the Grand Rond and continuingin the Jardin des Plantes and the Jardin Royal

17:00 19:30

Charity

event

Concert

Toulousecon

Tour, Special Showat the mythical Halle aux Grains (on booking only)

............................................................................................................................................................................. Program 15

le programme de la toulouse onco week

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