LECTURE 1:COURSE OUTLINE4/5 JANUARY 2016

Smith & Kohalmi

where am I?

& who are you?

BIOLOGY 2581B GENETICS

Hi

Welcome

to class

=)

course coordinator & instructor

Dr. Susanne Kohalmi

Team 2581BDr. David Smith

instructor

subject line: person you want to talk to (Prof. Smith or Kohalmi or TA) and/or topic

Biological & Geological Sciences, room 3028

Western Science Centre, room 319

Fri 3:00-5:00Thu 2:30-4:30office hours

course email: bio2581@uwo.ca

Questions

?General questions/concerns/exams

Contact Dr. Susanne Kohalmi

Questions about lectureContact Professor responsible for lecture

Questions about your tutorialYour TA or lead TA

Remember, the course email is bio2581@uwo.ca

course information

2581B OWL site contains all of the course information.

https://owl.uwo.ca/portal

Use UWO email ID & password to access site.

lecture schedule powerpoints tutorial info admin info

Mon Tue Wed Thu9:30 1:30 9:30 1:30

stick to your section

Tentative Schedule BIOLOGY 2581B LECTURE & TUTORIAL SCHEDULE (2016)

Date Topic (text reference & accompanying papers) Lecturer Tutorials (4)

Jan 4-5 Lec1. Course outline Smith & Kohalmi

No tutorials UNIT1 (SMITH) – FROM BIG TO SMALL (Lec2-6)

Jan 6-7 Lec2. The tree of life: what is a genome, where are they found, & where did they come from? Smith

Jan 11-12 Lec3. You are what you eat: endosymbiosis shapes genomes. Smith

No tutorials Jan 13-14 Lec4. Organelles & their genomes. Smith Jan 18-19 Lec5. Genomic architectural diversity: size. Smith

Tutorial #1: Meiosis & genetic mapping Jan 20-21 Lec6. Genomic architectural diversity: chromosomes &

chromatin. Smith

UNIT2 (KOHALMI) – CHANGES TO DNA SEQUENCES (Lec7-13)

Jan 25-26 Lec7. Understanding mutation. Kohalmi Tutorial #1: Meiosis & genetic mapping Jan 27-28 Lec8. Allele classification. Kohalmi

Feb 1-2 Lec9. Selected genetic technologies. Kohalmi Tutorial #2: Mutations Feb 3-4 Lec10. Mapping and genome sequencing. Kohalmi

Feb 8-9 Lec11. Generating mutants. Kohalmi Tutorial #2: Mutations Feb 10-11 Lec12. Detection of mutation and genetic variation. Kohalmi

Feb 15-19 READING WEEK No tutorials Feb 22-23 Lec13. Chromosomal rearrangements. Kohalmi

Drop in for questions UNIT3 – FROM SMALL TO BIG (Lec14-17)

Feb 24-25 Lec14. Genes & gene expression (part 1). Smith

Feb 25 REVIEW SESSION 4:30-6:30 Room NCB-101 Smith & Kohalmi

Feb 27 MIDTERM (Lec2-12) 9:00-12:00 (Locations TBA) Feb 29-Mar 1 Lec15. Genes & gene expression (part 2). Smith Tutorial #3: Genetic

techniques Mar 2-3 Lec16. Genetic modifications: methylation, RNA-editing. Smith Mar 7-8 Lec17. Mechanisms of genome evolution. Smith

Tutorial #3: Genetic techniques UNIT4 – GAME CHANGERS (Lec18-19)

Mar 9-10 Lec18. Bioinformatics & big genomic breakthroughs. Smith Mar 14-15 Lec19. Synthetic genomics & sci-fi genetics. Smith

Tutorial #4: Bioinformatics UNIT5 – SELECTED TOPICS IN APPLIED GENETICS (Lec20-

24)

Mar 16-17 Lec20. Guest lecture: Synthetic biology part 2. Guest lecturer Mar 21-22 Lec21. TEs and copy number variation. Kohalmi Tutorial #4:

Bioinformatics Mar 23-24 Lec22. The ins and outs of transgenics. Kohalmi Mar 28-29 Lec23. Developmental genetics. Kohalmi Drop in for

questions Mar 30-31 Lec24. SFTs. Kohalmi

Apr 4-5 Review Session. Smith & Kohalmi

Apr 6-15 Extended office hours & TA hours Smith & Kohalmi

TBA FINAL EXAM (Lec13-23)

This is a tentative timetable — topics & schedule might deviate from what is listed above.

Tutorials

4Bi-weekly, 2hrs longBegin week of Jan 18 / Jan 25

1) Meiosis & genetic mapping

2) Mutations

3) Genetic Techniques

4) Bioinformatics

TutorialsOutline of tutorial posted on OWL one week prior to starting.

Contains readings, assignments, and sample problems to be completed prior to the tutorial.

New material (not from lecture or textbook).

Do you have to go? You betcha! It’s 10% of the final grade.

You must go to your assigned tutorial to receive the grade. (If not, you need special permission from the Dean’s office).

Tutorials schedule

Be there or be square

Monday' Tuesday' Wednesday' Thursday' Friday'' 9:30–11:30'am' ' ' 9:30–11:30'am'

' Section'006'UCC'59' ' ' Section'016'

KB'K208'

'Section'017'PAB'36'

'

'

'Section'025'UCC'59'

'

' ' Section'035'KB'K208'

Section'036'PAB'36'

11:30–1:30'pm' 11:30–1:30'pm' 11:30–1:30'pm' 11:30–1:30'pm' 11:30–1:30'pm!'

Section'003'PAB'36'

'

Section'007'PAB'36'

Section'011'PAB'36'

Section'013'PAB'150'

Section'018'PAB'150'

'Section'022'PAB'36'

'

Section'026'PAB'36'

Section'030'PAB'36'

Section'032'PAB'150'

Section'037'PAB'150'

1:30–3:30'pm' ! ! 1:30–3:30'pm! 1:30–3:30'pm!

Section'004'UCC'54A' ' '

'Section'014'

TC'204''

Section'019'KB'K208'

'Section'020'PAB'36'

'

Section'023'UCC'54A'

'' ' Section'033'

TC'204'

'Section'038'KB'K208'

'

'Section'039'PAB'36'

3:30–5:30'pm' 3:30–5:30'pm' 3:30–5:30'pm' 3:30–5:30'pm' 3:30–5:30'pm!

Section'005'PAB'150'

Section'008'UCC'54B'

'Section'009'

MC'17''

Section'010'PAB'150'

Section'012'KB'K103'

Section'015'PAB'117'

Section'021'BGS'1056'

Section'024'PAB'150'

Section'027'UCC'54B'

Section'028'MC'17'

'Section'029'PAB'150'

'

Section'031'KB'K103'

Section'034'PAB'117'

Section'040'BGS'1056'

!BGS!%!Biological!&!Geological!Sciences!Bldg.! ! KB!%!Kresge!Building! ! ! MC!%!Middlesex!College!! ! ! !PAB!%!Physics!&!Astronomy!Bldg.!! ! ! TC!%!Talbot!College! ! ! UCC%!University!Community!Centre! ! !! !!Yellow!Fill:!Tutorials!Begin!Week!of!January!18th!Brown!Fill:!!Tutorials!Begin!Week!of!January!25th!! ! ! ! ! ! ! !

Grading

45%midterm

exam45%

final exam

10%tutorials

multiple choice

Tutorials 1–3: multiple choice quiz

Tutorial 4: assignment

This course uses cheating detection software for analyzing multiple choice exams

YOU MUST PASS AT LEAST ONE OF THE EXAMS TO PASS

THE COURSE!

Questions about exams & tutorial outcomes

There will be deadlines and procedures to follow to look at exams and tutorial outcomes.

We will provide opportunity for you to see exams and tutorial outcomes (if necessary).

Stay posted.

Important dates

First tutorial: week of Jan 18 or Jan 25 (depending on which week you start)

Midterm Exam – Sat Feb 27, 9am–12pm. (Locations TBA)

Final Exam – Date/Time/Locations TBA

Electronic devices during exam

NOT ALLOWED: If calculations are required, they will be simple and can be done using paper and pencil.

NOT ALLOWED: any electronic devices, such as cell phones & iPods. Cheating will be assumed if present.

Missed exam or tutorial

Only those with permission from Dean’s office (Academic Counsellor) will be able to write a remake of a missed exam or will be assigned to a new tutorial section.

Carefully review and follow Western’s Medical Accommodation policy (Medical Notes) available on OWL

Course foundation

Builds on material from 1st year Biology & Biochemistry 2280A

You must have received >60% in 1st-year Biology and a passing grade in Biochemistry 2280A to remain in this course.

switch

LecturesDr. KohalmiDr. Smith

Lec 2–6 Lec 7–12

Lec 14–19

EXAMS WILL BE BASED ON MATERIAL COVERED IN LECTURE, ASSIGNED READING MATERIAL & TUTORIALS

Lec 13, 21–24Lec 20 (guest lecture)

Tutorials

Tut 1 & 2

Tut 3 & 4

MIDTERM EXAM

FINAL EXAM

Doing well in 2581B

come to class

pay attention

Doing well in 2581Bkeep up

with material

get help soonerrather

than later

Office hours Textbook Lectures Profs TA’s Web

Assistance

posted lectures

come to class

YOU: read & study

what’s this course

all about?

genes genomes &

DNA, dude!

and their role in shaping the diversity,

complexity & evolution of life

in a modern frameworkGENETICS

in a modern frameworkGENETICS

500,000

VAST

Biol 2581B

Hartwell LH, et al. (2014) Genetics: From Genes to Genomes, 1st Canadian Edition,  McGraw-Hill, Ryerson, Toronto, ON.  (ISBN-13:978-0-07-094669-9)

Great resource but not the sole authoritative voice on genetics.

Doesn’t contain all of the info relevant to the course.

Feel free to use other resources.

in a modern frameworkGENETICS

TED TALK

Craig Venter