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Metabolism Metabolism An Introduction

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Page 1: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

MetabolismMetabolismAn Introduction

Page 2: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

EnergyEnergy

Every reaction that occurs in a living organism requires the use of Energy◦Energy = ability to do work

Metabolism: capture and use of energy through catabolic and anabolic reactions ◦ Catabolic reaction = breaking apart molecules into

simpler compounds Eg. Protein amino acids

◦ Anabolic reaction = building complex molecules out of smaller compounds

Eg. Glucose + glucose maltose

Page 3: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

Energy cont’dEnergy cont’d

Cells need a constant supply of energy in order to live

The nature of energy is important when considering metabolism

In metabolism, ATP molecules are the cell’s source of energy ATP = energy currency

Page 4: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

What does Energy look What does Energy look like?like?

Energy used to do work takes on many forms ◦ Electrical, kinetic, thermal, light,

sound

The types of energy fall into 2 categories:1.Kinetic energy- energy in

MOVING objects thermal (heat), mechanical,

electrical

2.Potential energy- STORED energy gravitational, chemical

Ex. Roller coaster car Top: potential

energy As drops: kinetic

energy

Page 5: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

Laws of thermodynamics Laws of thermodynamics (I)(I)

1st law:◦Total energy in a system always

remains constant ◦Energy is converted from on form to

another

• Metabolism- in the context of biochemical reactions in living cells, energy is constantly changing form and thermal energy is generally lost from the organism

Page 6: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

An interactive exampleAn interactive example

http://www.wiley.com/legacy/college/boyer/0470003790/animations/catalysis_energy/catalysis_energy.htm

Page 7: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

Free energy diagram

#1

Energy changes are what drive all chemical reactions

Free energy ( G) is the potential energy in a chemical reaction energy available to do work

#1- the reactants have a higher level of free energy than the products

Glucose

Carbon dioxide + water

Page 8: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

Free energy diagram

#2- a temporary state where both reactant bonds are breaking and product bonds are forming *intermediary step

The activation energy (Eact)is the jumpstart needed for reactions to proceed Needed to strain/break bonds

#2

Ex. Racket ball turning inside out

Glucose

Carbon dioxide + water

Page 9: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

http://www.wiley.com/legacy/college/boyer/0470003790/animations/catalysis_energy/catalysis_energy.htm

Page 10: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

Free energy diagram

#3- Decline in overall free energy as the free energy decreases in the reactants as they become products.

#3

Glucose

Carbon dioxide + water

Page 11: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

Free energy diagram

#4- Products have formed, the reaction is complete, the overall free energy has decline

#4

G is negative

Glucose

Carbon dioxide + water

An exothermic reaction

Page 12: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

In a living organism/cell, G < 0 in a reaction is harnessed to do useful work, leaving less free energy available & more entropy

What is entropy?

Page 13: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

What are some words you would use to describe the change in this room?

Page 14: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

Laws of thermodynamics Laws of thermodynamics (II)(II)2nd law:

◦The universe is constantly increasing in disorder As energy changes forms, it becomes more

disordered

◦Entropy is a measure of disorder Increased entropy = increase in disorder

When thinking of chemical reactions, we must consider both energy AND entropy◦Text pg 61

Page 15: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

Spontaneous vs Non-Spontaneous vs Non-Spontaneous ReactionsSpontaneous Reactions

◦Chemical reactions occur spontaneously when both energy & entropy are favoured

◦Chemical reactions may not occur spontaneously if energy is favoured but entropy is not

◦In summary- cells favour spontaneous reactions

Page 16: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

• Less entropy• More free energy

• More entropy• Less free energy

ATP ↔ ADP + Pi

Page 17: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

HomeworkPg 68 #1, 2, 3, 5, 6

Page 18: Metabolism An Introduction. Energy Every reaction that occurs in a living organism requires the use of Energy ◦ Energy = ability to do work Metabolism:

http://users.humboldt.edu/rpaselk/ChemSupp/Plots/RxnProg.gif

ResourcesResources

http://www.accessexcellence.org/RC/VL/GG/ecb/ecb_images/03_32_ATP_and_ADP_cycle.jpg