AnoverviewofMRIinbiomedicalresearch

Whatisbiomedicalresearch?

“Biomedical research is the broad area of science that involves the investigation of the biological process and the causes of disease through careful implementation, observation, laboratory work, analysis and testing”

Andgooglescholarsays….

Agenda

• OverviewofMRIsystem• Understandingofbiologicalprocess•  Developmentalbiology

• Understandingthecauseofpathology

•  Angiogenesisincancer

• WorkflowofanMRIprojectinbiomedicalresearch

Gradientcoils

Subject

Radiofrequency

coil

Magnet

OverviewofaMRIsystem

Imagecourtesy:MRIscannercutaway:Colinmcnulty.com

y

x

z

Larmor Equation

MagneJsm:EffectoftheB0,G.randB1fields

OverviewofaMRIsystem

Imagecourtesy:MRIscannercutaway:Colinmcnulty.com

Contrastagents&nanotubes

Developmentalbiology

Drugdelivery

Clinicaltrials

Strokeimaging

DiagnosJcs&prognosJcs

Angiography

DWI

Perfusion

Behaviour

Cancerimaging SWI

Biomaterials

DynamicsPK

TBI

DCE-MRI

Neuropathology

PrevenJvehealthcare

MIRC 7

hYp://embryo.soad.umich.edu/.

Developmentalbiology–growthofthefetus

SmithaR.S.,et.al.,ISMRM2014Imagescourtesy:Dr.SonaPungavkar,NanavaJMumbai

Pathologymanagement

C(t)=f(ΔR1(t))

T1–weightedimagesforbaseline

T1shorteningcontrastagent

[10]YankeelovTE,et.alMRI;23(4).2005*ModelimplementedbyDr.VikramKodibagkarinMATLAB

[10]

Tissueperfusion,microvasculardensityandextravascular-extracellularvolume--tumorstaging,monitortreatmentresponse

Imagingcancer–dynamiccontrastenhancedMRI

Startsatframe6(post-contrast)

CS

CS_Gauss

CS_Glines

CS_Thresh

DCEinacJon

T2w Overlay

T1wpre-contrast

T1wpost-contrast

0 10 20 30 40 50 600.150

0.175

0.200

0.225

0.250

RO

I Int

ensi

ty

Frame #

Original Keyhole Keylines Keythresh Gauss Glines Gthresh

Muscle

0 10 20 30 40 50 60

0.175

0.200

0.225

0.250

RO

I Int

ensi

ty

Frame #

Original Keyhole Keylines Keythresh Gauss Glines Gthresh

Poorlyperfusedregion

0 10 20 30 40 50 600.15

0.20

0.25

0.30

0.35

0.40

RO

I Int

ensi

ty

Frame #

Original Keyhole Keylines Keythresh Gauss Glines Gthresh

Wellperfusedregion

Imagingcancer–regionwiseanalysis

WorkflowofanMRproject

Biomedicalengg.quesJon

Hardware–RFcoils

Pulsesequencedesign–RFpulses,

trajectories

ReconstrucJon–undersampleddata

QuanJtaJon–MRparameterizaJon

MulJ-stagevalidaJon

PARTII

PARTIII