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SUNDAY, MAY 8, 2016 | PARADE.COM LORI ALF, multiple myeloma survivor ONE MOM’S FIGHT AGAINST THAT SAVED HER —AND THE CANCER MIRACLE CURE THE THAT MOUSE © PARADE Publications 2016. All rights reserved.

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  • PAGE: 01 CODE: 11A1 BOOK: 12 ISSUE: 05-08-16

    S U N DAY, M AY 8 , 2 0 1 6 | PA RA D E .CO M

    LORI ALF, multiple myeloma

    survivor

    ONE MOMSFIGHT AGAINST

    THAT SAVED HER

    AND THECANCER

    MIRACLE CURE

    THE THATMOUSE

    0508_Cover.indd 1 4/20/16 3:11 PM04202016152214

    PARADE Publications 2016. All rights reserved.

  • PAGE: 2 CODE: 21A1 BOOK: 12 ISSUE: 05-08-2016

    2 | MAY 8, 2016

    WALTER S

    COTTS

    With 2014s The Grand Budapest Hotel and now A Bigger Splash, Ralph Fiennes seems to have discovered his

    funny side. How did that happen? Thomas H., Beaufort, S.C.

    A: Fiennes is best known, indeed, for his darker characters in Schindlers List, The English Patientand the Harry Potter franchise, but hes always up for a good comedy role when one comes around. In A Bigger Splash (in theaters May 4), he plays Harry, a record producer who interrupts the holiday of an old fl ame (Tilda Swinton). I dont think I had ever been asked to play a guy who gets naked and dances and sings bad karaoke before, says Fiennes, 53.

    Email your questions for Walter Scott to [email protected]

    Detour is an album of cover songs. What cover versions of your songs have you enjoyed? I heard Patti LaBelle sing Time After Time. That had to be one of the most extraordinary experiences. I also heard a really fun version of She Bop that I thought was awesome.

    So how does the girl have fun these days? I really have been working quite a bit. Im a mom, a wife, a daughter and a sister, so its hard to juggle everything all at once, but Im trying. Not a lot of fun!

    WALTER SCOTT ASKS ... CYNDI LAUPER

    Fiennes and Tilda Swinton co-star in the new movie A Bigger Splash.

    What were Laupers musical infl uences? Go to Parade.com/cyndi to fi nd out.

    The Girls Just Want to Have Fun singer, 62, takes a musical Detour with the release of her new country classics album. No surprise, this 80s lady puts her unique spin on country tunes from the 40s, 50s and 60s.Are you a recent country convert? No, I always listened to country. There were some country artists that were more than country. They were big icons in the rock n roll community, like Patsy Cline. She was a rockabilly gal.

    How did you decide which songs to in-clude on Detour? There are a lot of great ones, because country musics very soulful. Misty Blue is a perfect example of a country song crossing over to soul, because Dorothy Moore had a hit with it on the soul charts 10 years after Wilma Burgess [did on the country charts].

    Are you nervous about starting your tour May 9 at Nashvilles Ryman Auditorium, where every great coun-try artist has performed? Its a little nerve-racking. I want to be great, but sometimes youve got to just let go and be happy to be there.

    Is Patti LuPone headed back to Broadway? She is such a talented singer and I would like to catch her on my next trip to New York. Gerald L., Milwaukee, Wis.

    A: The Tony Awardwinning actress for Gypsy and Evita, who was last seen in the off-Broadway production Shows for Days in 2015, has been touring with a series of classic show-tunes concerts called Dont Monkey With Broadway. But if you cant swing a ticket, check out Showtimes Penny Dreadfulon Sunday nights. She joined the cast this season in the role of Dr. Seward, a thera-pist who treats Vanessa (Eva Green) with an unconven-tional new approach.

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    Mmmmm... BACONKevin Bacon, 57, stars in a new horror fi lm, The Darkness, about a family that brings back a supernatural souvenir from their vacation at the Grand Canyon. It opens, appropriately enough, on Friday, May 13. But fi rst, here are fi ve facts about the Philadelphia-born actor/musician. 1. He and brother Michael perform as the musical duo the Bacon Brothers.

    2. His father, a famous Philadelphia city planner, was featured on the cover of Time magazine in 1964.

    3. In 2010, J&D Foods commissioned a

    larger-than-life-size bust of Bacon made out of bacon. Auctioned off for charity, it was named Bacon Kevin Bacon.

    4. The game Six Degrees of Kevin Bacon came about because the actor has appeared in so many fi lms, with so many co-stars, he can be linked to almost any other actor in six steps or less.

    5. Bacon and wife Kyra Sedgwick discovered they are ninth cousins when they appeared on PBS ancestry search series Finding Your Roots.

    0508_Personality.indd 2 4/20/16 3:16 PM04202016152245 Approved with warnings

    PARADE Publications 2016. All rights reserved.

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    PARADE Publications 2016. All rights reserved.

  • ASSIGNING EDITOR ___________ | MANAGING EDITOR __________ | COPY EDITOR __________ | PHOTO EDITOR __________ | EDIT. DIRECTOR __________ | EIC __________

    PAGE: 4 CODE: 89A1 BOOK: 12 ISSUE: 05-08-16

    FLASHBACK

    Edited by Alison Abbey / L I K E U S AT FACEBOOK .COM/PARADEMAG

    Parade

    4 | MAY 8, 2016

    Its hard to forget Sean Penn (Spicoli) sporting Vans checkerboard slip-ons in the 1982 classic Fast Times at Ridgemont High, but the shoemaker actually launched 16 years earlier in a corner shop in Anaheim, Calif. This year Vans is celebrating 50 years with a special collection (including the checkerboards) and a book about the iconic canvas shoe. Vans: O the Wall, 50th Anniversary Edition (Abrams) brings to life Vans culture and couture. $30, Barnes & Noble stores and online; Checkered Past shoe line, prices vary, at select retailers

    Relive your favorite mix-tape days with the I Love the 90s Tour. The show will play 35 dance-able dates with a roster of recognizable R&B, rap and hip-hop acts, including Salt-N-Pepa, Vanilla Ice, Coolio, Color Me Badd and Tone Loc, to name a nostalgic few. Visit ilovethe90stour.com for dates and ticket information. 50 YEARS OF THE

    FINAL FRONTIERIts the golden anniversary of Star Trek, and fans are celebrat-ing all year long with Trek Talks, conventions and more. (Parade celebrated the fi rst Star Trek fi lm with a trip to the movie set in 1978.) Visit Parade.com/startrek or startrek.com for more info.

    A HALLMARK MOMENT

    Americans have been offi -cially celebrating Mom since 1908, but it wasnt until 1920, when Hallmark began selling Mothers Day cards, that the holiday became a card-carrying occasion. Today there are also cards for stepmoms, same-sex moms and pet moms. Visit Parade.com/momcards for a gallery of Hallmark cards over the years.

    1978

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    ANILLA

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    E LIFE

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    0508_Picks.indd 4 4/20/16 3:19 PM04202016152300 Approved with warnings

    PARADE Publications 2016. All rights reserved.

  • 2016 BGE 17-00129-001-M29

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    PARADE Publications 2016. All rights reserved.

  • ASSIGNING EDITOR ___________ | MANAGING EDITOR __________ | COPY EDITOR __________ | PHOTO EDITOR __________ | EDIT. DIRECTOR __________ | EIC __________

    PAGE: 6 CODE: 31A1 BOOK: 12 ISSUE: 05-08-16

    ASSIGNING EDITOR ___________ | MANAGING EDITOR __________ | COPY EDITOR __________ | PHOTO EDITOR __________ | EDIT. DIRECTOR __________ | EIC __________

    6 | MAY 8, 2016

    C arl H. June, M.D., whospends his days in a sterile research laboratory, had never met the woman who crossed the room and hugged him at a conference in New York City last fall. But she had a good reason. Just one year earlier June had saved her from a blood cancer that might have killed her within weeks.

    Lori Alf, now 50, was the fi rst volunteer for a clinical trial using immunotherapywhich boosts the bodys natural defensesto fi ght a blood cancer called multiple myeloma. e highly experimental trial was run by June at the Uni-versity of Pennsylvania. To him, Alf had been only a code ending in 01, for the fi rst anonymous patient. But with her hug, Alf personifi ed the millions of cancer patients June

    and his colleagues hope to save by transforming a patients own im-mune system into a cancer killer.

    During his presentation later that day at the Multiple Myeloma Research Foundations Leadership Circle Summit, June choked up as he showed Alf s before and after slides. In the former, round liquid myeloma tumors clog 95 percent of her bone marrow, crowding out all but a whisper of healthy cellsbarely enough to survive. e second slide is completely clear. Alf s cancerous blood tumors had vanished within a month or two after her treatment.

    How? Researchers withdrew some of her immune systems white blood cells, transformed them in the lab into hunters retrained to track down and kill her cancer

    cells, then let them loose in her body.And it worked: Alf is cancer-free.

    ats nothing short of a medical miracle.

    Findings by June and his researchersas well as new studiessuggest that immuno-therapy could fi ght more than two dozen types of cancer. Before too long, for example, blood cancer patients could walk into outpatient clinics and get one-time, 10-minute intravenous drips of their own commercially repro-grammed immune cells and become cancer-free within weeks.

    As for Alf: I was supposed to die. But here I am, she says. I feel as if I was placed into one of the lifeboats from the Titanicand I cant help looking back and wishing that everyone on that ship could join me.

    A Mean CancerBefore Alf got very lucky in the clini-cal trial, she was profoundly unlucky. Back in 2009, the smart, speed-talking mother of three, who runs an Olympic-class ice rink in West Palm Beach, Fla., thought she had a worsening case of

    With only weeks to live, Lori Alf volunteered for a therapy that hadnt even been tested on mice. Her cancer vanishedand medical science took

    a leap closer to a cure.

    B Y F R A N K L A L L IC O V E R A N D O P E N I N G P H OTO G R A P H Y B Y A L I S S A D R A G U N

    MOUSETHE THAT

    (Above) Alf with husband Chris and children (from left) Christer, Chapin and Caterina; (right) Alf with her clinical trial doctors, Edward Stadtmauer (left) and Alfred Garfall

    0508_Feature.indd 6 4/20/16 3:14 PM04202016152214

    PARADE Publications 2016. All rights reserved.

  • ASSIGNING EDITOR ___________ | MANAGING EDITOR __________ | COPY EDITOR __________ | PHOTO EDITOR __________ | EDIT. DIRECTOR __________ | EIC __________ ASSIGNING EDITOR ___________ | MANAGING EDITOR __________ | COPY EDITOR __________ | PHOTO EDITOR __________ | EDIT. DIRECTOR __________ | EIC __________

    PAGE: 7 CODE: 31A2 BOOK: 12 ISSUE: 05-08-16

    MAY 8, 2016 | 7 from page 8

    and his colleagues hope to save by transforming a patients own im-mune system into a cancer killer.

    During his presentation later that day at the Multiple Myeloma Research Foundations Leadership Circle Summit, June choked up as he showed Alf s before and after slides. In the former, round liquid myeloma tumors clog 95 percent of her bone marrow, crowding out all but a whisper of healthy cellsbarely enough to survive. e second slide is completely clear. Alf s cancerous blood tumors had vanished within a month or two after her treatment.

    How? Researchers withdrew some of her immune systems white blood cells, transformed them in the lab into hunters retrained to track down and kill her cancer

    cells, then let them loose in her body. And it worked: Alf is cancer-free.

    ats nothing short of a medical miracle.

    Findings by June and his researchersas well as new studiessuggest that immuno-therapy could fi ght more than two dozen types of cancer. Before too long, for example, blood cancer patients could walk into outpatient clinics and get one-time, 10-minute intravenous drips of their own commercially repro-grammed immune cells and become cancer-free within weeks.

    As for Alf: I was supposed to die. But here I am, she says. I feel as if I was placed into one of the lifeboats from the Titanicand I cant help looking back and wishing that everyone on that ship could join me.

    A Mean CancerBefore Alf got very lucky in the clini-cal trial, she was profoundly unlucky. Back in 2009, the smart, speed-talking mother of three, who runs an Olympic-class ice rink in West Palm Beach, Fla., thought she had a worsening case of

    bronchitis. Her family doctor delivered the bad news: Alf had multiple my-eloma, a treatable but incurable blood cancer that aff ects fewer than 90,000

    Americansand rarely someone so young. She was 43.

    I walked out to my car, she says, slumped down onto the hood and stayed there paralyzed, crying.

    But within a week, she and her husband, Chris, took control of what became a

    seven-year ordeal to keep her particu-larly aggressive cancer in check. While many myeloma patients fi nd therapies that allow them to enjoy the semblance of normal health for years, Alf lurched from one disappointing treatment to another, including a debilitating stem cell transplant using her own blood. Few therapies helped her for more than months at a time. I had a really mean cancer, she says.

    Her lead myeloma specialist, the renowned Kenneth C. Anderson, M.D., of Bostons Dana-Farber Cancer Institute, agrees: Lori had one of the worst myelomas I have ever seen.

    By 2014, Alf was down to 80 pounds, with a grim prognosis.

    In desperation, she and her doctors were considering her second stem cell transplant, this time with cells from her

    L ori Alfs remarkable recovery is the Holly-wood version of what happens in a clinical trial. The reality can be far different. Heres why: A clinical trial is not about the individual patientits purpose is to test a new drug, treat-ment, procedure or medical device on human volunteers. What happens to the individual, good or bad, is incidental to the researchers discov-eries about the entire group and the broader implications of the collective data.

    And clinical trials can be risky. According to Center Watch, a research-information fi rm, about 1 in 30 participants in drug trials suffers a serious side effect and 1 in 10,000 dies.

    Still, the benefi ts can be considerable, even barring a miracle cure. Youll likely get the attention of experts who have spent their entire careers focused on your disease, and their insights about your case may be invaluable.

    Beyond that, in trials put on by the National Institutes of Health (NIH), an arm of the U.S. Department of Health and Human Services, chances are youll get the cutting-edge medi-cines or therapies largely free of cost. You may even be compensated for your time and inconvenience, particularly if you are a healthy volunteer sought for early-stage research.

    HOW TO FIND A TRIALTo look for a trial for a specifi c illness, begin by consulting with your doctor; many disease specialists are familiar with trials in their fi elds. Then, like Alf, you can turn to the internet. Start with the comprehensive list of current trials at nih.gov. Check clinicaltrials.gov, centerwatch.com and emergingmed.com for trials and their locations. You also can fi nd trials through nonprofi t research foundations, or call and ask for the medical research department at large hospitals or universities.

    If you fi nd a trial that appears promising, circle back to your doctor or specialist for help applying. Be prepared to meet with the trial team in person to determine whether youre a good fi t.

    With only weeks to live, Lori Alf volunteered for a therapy that hadnt even been tested on mice. Her cancer vanishedand medical science took

    a leap closer to a cure.

    BY FRANK LALL ICOVER AND OPENING PHOTOGRAPHY BY AL ISSA DRAGUN

    Visit Parade.com/clinicaltrials for the fi ve questions you should ask before signing up

    for a clinical trial.

    TRUTHTHE ABOUTCLINICAL TRIALS

    (Above) Alf with husband Chris and children (from left) Christer, Chapin and Caterina; (right) Alf with her clinical trial doctors, Edward Stadtmauer (left) and Alfred Garfall

    0508_Feature.indd 7 4/21/16 10:22 AM04212016102425

    PARADE Publications 2016. All rights reserved.

  • PAGE: 8 CODE: 31A3 BOOK: 12 ISSUE: 05-08-16

    8 | MAY 8, 2016

    PEN

    N M

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    from page 7

    sister, who is not a perfect ge-netic match. The doctors told her that the complications triggered if the transplanted cells attacked her body rather than helped her, known as graft-versus-host disease, could end her life.

    One Last ChanceThere was one other option. Scouring the internet, Alf and her husband discovered some-thing so new even her own doctors hadnt heard about it. University of Pennsylvania re-searchers were organizing clinical trials to reprogram the immune systems of seriously ill myeloma patients like her. Instead of using chemotherapy drugs to attack the cancer, immunotherapy as-saults cancer cells from within with a patients own re-engi-neered immune system.

    Alf had long believed im-munotherapywhich avoids graft-versus-host complica-tions by using the patients own cellsheld the key to curing her cancer. She was determined to get into the trial funded by drug manufacturer Novartis. She told her then-16-year-old daughter Caterina, a competitive figure skater, If they reject me, you go into that doctors office and cry your eyes out. Make a scene until they change their minds.

    But Alf was exactly the type of patient the researchers wantedseriously ill with the abnormality they were targeting, yet hopefully strong enough to survive the rigors of the trial itself.

    The stakes were high: The immunotherapy hadnt even been tested on animals. University researchers were moving fast to treat the seriously ill myeloma volunteers under expedited

    breakthrough status from the U.S. Food and Drug Admin-istration and did not stop to experiment, even on mice.

    Alf was the mouse model.In a process similar to kidney

    dialysis, she was hooked up to a machine that collected a type of white blood cells called T cells. Then the lab made my T cells very angry, she explains. Actually, the lab transformed the T cells with a protein called chimeric antigen receptor (CAR) into what they hoped would be an army of hunters that would recognize her enemy myeloma cells and kill them.

    Twelve days later, the doctors dripped the red, garlicky-smelling CAR T cells into her veins. The next day, she felt sicker than ever. But that was about what the doctors had hoped: In their ear-lier trials with leukemia patients, when the immune systems army overwhelmed the enemy, the warfare commonly triggered high fevers, nausea, muscle pain and sometimes serious neuro-logical symptoms.

    Our goal is to cure cancer, says Carl H. June, M.D., who hopes to apply the lessons from Alfs trial to find treatments for other types of cancer.

    0508_Feature.indd 8 4/20/16 3:14 PM04202016152214

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    SWEEPSTAKES FACTS:Giveaway No. 6900; End Date: 2/28/17;Est. Odds of Winning: 1 in 2,600,000,000. You Have Not YetWon. All Entries Have the Same Chance of Winning. We dontknow who the winner is. Enter For Free. You dont have to buyanything to enter. Enter As Often As You Like.You may submitadditional entries by writing to the address provided. Each entryrequest must be mailed separately. Buying Wont Help YouWin. Your chances of winning are the same as someone whobuys something.

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    PARADE Publications 2016. All rights reserved.

  • PAGE: 9 CODE: 31A4 BOOK: 12 ISSUE: 05-08-16

    MAY 8, 2016 | 9

    PEN

    N M

    EDIC

    INE

    sister, who is not a perfect ge-netic match. The doctors told her that the complications triggered if the transplanted cells attacked her body rather than helped her, known as graft-versus-host disease, could end her life.

    One Last ChanceThere was one other option. Scouring the internet, Alf and her husband discovered some-thing so new even her own doctors hadnt heard about it. University of Pennsylvania re-searchers were organizing clinical trials to reprogram the immune systems of seriously ill myeloma patients like her. Instead of using chemotherapy drugs to attack the cancer, immunotherapy as-saults cancer cells from within with a patients own re-engi-neered immune system.

    Alf had long believed im-munotherapywhich avoids graft-versus-host complica-tions by using the patients own cellsheld the key to curing her cancer. She was determined to get into the trial funded by drug manufacturer Novartis. She told her then-16-year-old daughter Caterina, a competitive figure skater, If they reject me, you go into that doctors office and cry your eyes out. Make a scene until they change their minds.

    But Alf was exactly the type of patient the researchers wantedseriously ill with the abnormality they were targeting, yet hopefully strong enough to survive the rigors of the trial itself.

    The stakes were high: The immunotherapy hadnt even been tested on animals. University researchers were moving fast to treat the seriously ill myeloma volunteers under expedited

    breakthrough status from the U.S. Food and Drug Admin-istration and did not stop to experiment, even on mice.

    Alf was the mouse model.In a process similar to kidney

    dialysis, she was hooked up to a machine that collected a type of white blood cells called T cells. Then the lab made my T cells very angry, she explains. Actually, the lab transformed the T cells with a protein called chimeric antigen receptor (CAR) into what they hoped would be an army of hunters that would recognize her enemy myeloma cells and kill them.

    Twelve days later, the doctors dripped the red, garlicky-smelling CAR T cells into her veins. The next day, she felt sicker than ever. But that was about what the doctors had hoped: In their ear-lier trials with leukemia patients, when the immune systems army overwhelmed the enemy, the warfare commonly triggered high fevers, nausea, muscle pain and sometimes serious neuro-logical symptoms.

    Our goal is to cure cancer, says Carl H. June, M.D., who hopes to apply the lessons from Alfs trial to find treatments for other types of cancer.

    0508_Feature.indd 9 4/20/16 3:14 PM04202016152245 Approved with warnings

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  • PAGE: 10 CODE: 31A5 BOOK: 12 ISSUE: 05-08-16

    10 | MAY 8, 2016

    Fortunately, Alf was spared the worst of that and was well enough to be discharged a week later to a nearby hotel. Still, she continued to feel jittery, itchy, twitchy and miserably nauseous.

    But her blood tumors de-creasedthen disappeared. Im sure we killed my mother cancer cells, she says of the stem cells where cancer originates. More than one of her oncologists agree. Nothing else explains her remarkable recovery.

    I cry from happiness every time I see her, says Alf s Florida oncologist Robert J. Green, M.D. When she went to Pennsylvania, I didnt think Id see her alive again. Lori is proof that these new immuno-therapies do magical things.

    Cancer-FreeNearly two years later, Alf s blood is totally normal, and shes finding joy in the smallest moments of life, like the smell of my dog, Versace, she says.

    Husband Chris marvels at the resilience of the woman he fell in love with 27 years ago. And their three teenagers cherish a bedtime ritual they started in childhood, Caterina says: We all go in and kiss her goodnight.

    Whenever possible, Alf shares her story at conferences and events in hopes of raising more research money for the treat-ment that saved her life.

    The mighty mouse roars on.

    The Health Care Detective Frank Lalli is producing a book for Simon & Schuster this fall on how to get affordable health care.

    Go to Parade.com/lori for Alfs three rules for fighting cancer.

    0508_Feature.indd 10 4/20/16 3:16 PM04202016152214

    I

    CUT COUPO

    N ALO

    NG DOTTED

    LINE

    ONE OF OUR HUNDREDS OF THOUSANDS OF ITEMS.Valid in store only. Copies not accepted. Limit one coupon; Savings Certi cate, special offer or discount per item; cannot be combined with a price match. Coupon valid for one use only; electronic copies of physical coupons are treated as one coupon. Any return of purchase will reduce your savings proportionately. The costs of shipping; taxes or gift cards are not counted toward any minimum purchase required, and coupon cannot be applied to such items. Not valid for wholesale purchases; Company reserves the right to limit quantities. Valid only in the U.S. Offer excludes the following: A Pea in the Pod, Alessi, Arthur Court, Baby Brezza, Baby Jogger, Babyletto, Babymel, BABYZEN, BABA, Bloom, Breville, Brookstone, Bugaboo, Bumbleride, clek, Coravin, CYBEX, DaVinci, DKNY, Dyson, Ergobaby, Fitbit, Foundations, franklin & ben, HALO Bassinest, Inglesina, kate spade, Kenneth Cole Reaction Home, KitchenAid PROLINE, Kosta Boda, Le Creuset, Lladr, Maxi-Cosi, Miele, Million Dollar Baby Classic, Monique Lhuillier, Motherhood Maternity, Mountain Buggy, Nambe, Nautica, Nespresso, Nursery Works, Oeuf, Orbit Baby, Orrefors, Peg Prego, Petunia Pickle Bottom, Phil & Teds, Quinny, Riedel, Romero Britto, Roomba 800 & 900 Series Vacuums, Shun, Southern Tide, Star Wars BB8 by Sphero, Stokke, storksak, Svan, Swarovski, Swash, Swiss Diamond, Thule, Under Armour, UPPAbaby, Vera Bradley, Vera Wang, Victorinox Luggage, Vitamix, Waterford, Wusthof, diapers, wipes, formula, baby food, or portrait studio services. Alcoholic beverages excluded where required by law. Additional online items excluded. See www.bedbathandbeyond.com/exclusions05151

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  • PAGE: 11 CODE: 75A1 BOOK: 12 ISSUE: 05-08-16

    MAY 8, 2016 | 11

    Ask MarilynBy Marilyn vos Savant

    Say you pick up a person who is ill but awake. While in your arms, the person loses consciousness and suddenly be-comes "dead weight." Why is the person now so much heavier?

    John C., Louisburg, N.C.

    The person is not actually heavier; he is just more difficult to heft because he's no longer using his muscles to hold himself together or to hold on to his helper to avoid being dropped. So his weight becomes loose and floppy with his head, arms and legs hang-ing down. Protestors who "go limp" do this on purpose to make themselves harder to carry off. Consider lifting a 30-pound box of tightly packed books. Heavy, yes, but let's say you can manage. Now consider lifting a laundry bag with the same books. That's much, much harder.

    Numbrix

    Complete 1 to 81 so the numbers follow a horizontal or vertical pathno diagonals.

    45

    15

    47

    21

    59

    75

    61

    65

    69

    79

    77

    43

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    3

    1

    13Visit Parade.com/numbrix for more Marilyn vos Savant Numbrix puzzles

    and todays solution.

    Send questions to marilyn@ parade.com

    0508_AskMarilyn.indd 11 4/20/16 3:10 PM04202016152214

    Waterproof designworks in the shower

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    25% off ends 5/28/16.*Good Housekeeping Research Institute - Aug. 2014. $200 savings calculation was determined by averaging PERS market leaders monthly fees (not all PERS have the same features). Requires a one-time setup fee of $35 and valid credit or debit card for monthly service. The Splash is rated IPX7, and can be submerged in up to 3ft of water for up to 30 mins. Fall Detection is an optional feature. Fall Detection may not always accurately detect a fall. GreatCall is not a healthcare provider. Seek the advice of your physician if you have questions about medical treatment. 5Star or 9-1-1 calls can only be made when cellular service is available. 5Star Service will be able to track an approximate location when your device is turned on, but we cannot guarantee an exact location. Monthly service fee does not include government taxes or assessment surcharges, and is subject to change. GreatCall and 5Star are registered trademarks of GreatCall, Inc. Copyright 2016 GreatCall, Inc.

    AND FIRST MONTH FREE, EXCLUSIVELY AT:

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    3-1/2" SUPER BRIGHT

    NINE LED ALUMINUM

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    20"

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    NINE LED ALUMINUM

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