partnership for research and education in materials nsf/dmr 0934212

1
New Mexico Highlands University Morehouse College Georgia Institute of Technology Light-Matter Interactions: Theory and Applications (LMITA) PARTNERSHIP FOR RESEARCH AND EDUCATION IN MATERIALS NSF/DMR 0934212 The general goal of LMITA Thrust 1 to find efficient synthetic route to obtain E,E-3,5- bis(thienylidene)piperid-4-ones with donor substituents, that will be tested as materials for photodynamic therapy as photosensitizer. Photodynamic therapy (PDT) combines a drug (called a photosensitizer) with a specific type of light to kill cancer cells. Undergraduate student Rachel Lucero and graduate student Evgenia Leonova working on the synthetic project under supervision of Professors Timofeeva and Martinez. 740 760 780 800 820 840 860 0 200 400 600 800 1000 1200 1400 R=CH 3 ,R 1 =N M e 2 ,n=1 R=CH 3 ,R 1 =NEt 2 ,n=1 R=H,R 1 =N M e 2 ,n=1 TP A C ross S e ctio n (10 -50 cm 4 s/p h o to n) E xcitatio n W avelen g th (n m ) T w o D o u b le B onds Graph demonstrating significant two-photon activity of synthesized molecules with a long chain of conjugation.

Upload: platt

Post on 12-Jan-2016

30 views

Category:

Documents


0 download

DESCRIPTION

New Mexico Highlands University Morehouse College Georgia Institute of Technology Light-Matter Interactions: Theory and Applications (LMITA). Photodynamic therapy (PDT) combines a drug (called a photosensitizer) with a specific type of light to kill cancer cells. - PowerPoint PPT Presentation

TRANSCRIPT

Page 1: PARTNERSHIP FOR RESEARCH AND EDUCATION IN MATERIALS NSF/DMR 0934212

New Mexico Highlands UniversityMorehouse College

Georgia Institute of TechnologyLight-Matter Interactions: Theory and Applications (LMITA)

PARTNERSHIP FOR RESEARCH AND EDUCATION IN MATERIALS NSF/DMR 0934212

The general goal of LMITA Thrust 1 to find efficient synthetic route to obtain E,E-3,5-bis(thienylidene)piperid-4-ones with donor substituents, that will be tested as materials for photodynamic therapy as photosensitizer.

Photodynamic therapy (PDT) combines a drug (called a photosensitizer) with a specific type of light to kill cancer cells.

Undergraduate student Rachel Lucero and graduate student Evgenia Leonova working on the synthetic project under supervision of Professors Timofeeva and Martinez.

740 760 780 800 820 840 860

0

200

400

600

800

1000

1200

1400 R=CH

3, R

1=NMe

2, n=1

R=CH3, R

1=NEt

2, n=1

R=H, R1=NMe

2, n=1

TP

A C

ros

s S

ec

tio

n (

10

-50c

m4s

/ph

oto

n)

Excitation Wavelength (nm)

Two Double Bonds

Graph demonstrating significant two-photon activity of synthesized molecules with a long chain of conjugation.