pecoraro research group - university of...
TRANSCRIPT
Dendrimers (BLB)
Pecoraro Research GroupVincent L. Pecoraro: [email protected]
Webpage: https://sites.lsa.umich.edu/pecoraro-lab
Synthetic Method (BS / BLB)
MC (large MC image)
Toxic Metal Binding Sites
Molecular MagnetismLanthanide Luminescence
Hydroxamic
acid
derivatives
Metal salts M = Ring Metal
M = Center Metal
Dendrimers
16Cys
19Leu
12Leu
N terminus
C terminus
GRAND-CSL16CL30Ha site
X-ray crystallography
NMR structural determination
Molecular Recognition/Catalysis
Ru or Rh style catalyst
Rational design to improve NiR activity
Gated NiR Catalysis
Carbonic
Anhydrase(PDB 3PBJ)
Spectroscopy
2 4 6 8 10 12
-3
-1
1
3
k/Å-1
k3 ´ E
XAFS
0 1 2 3 4 5 60.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
R/Å
FT m
agnit
ude
A B
C
8960 8990 9020 90500
1
2
3
E/eV
Norm
alize
d In
tens
ity
Superoxide Dismutase
Asymmetric
3SCC
PECTIDES(large pymol) Enzyme Design
ab
(c)de
fg
a’
• Inductively Coupled-Plasma Optical Emission• Electronic Absorption• X-Ray Absorption• Heavy metal NMR• Circular Dichroism•Magnetic CD• Fluorescence• Stopped Flow• 111mCd PAC• Fun trips to Stanford• Mass spectrometry• EPR• Electrochemistry
Outside the Lab