phillip g. popovich, ph.d. - heart lung i ohio state ... g. popovich, ph.d. department of molecular...

PHILLIP G. POPOVICH, Ph.D.

DEPARTMENT OF MOLECULAR VIROLOGY, IMMUNOLOGY & MEDICAL GENETICS The Ohio State University College of Medicine & Public Health 2066 Graves Hall • 333 West 10th Avenue • Columbus, Ohio 43210

(614) 688-8576 • FAX# 292-9805 • E-mail: [email protected] PROFESSIONAL EXPERIENCE

2006-: Director • OSU Center for Brain and Spinal Cord Repair (CBSCR)

2006-: Ray W. Poppleton Research Chair

2004-: Associate Professor (with tenure) • Dept. Molecular Virology, Immunology & Medical Genetics • The Ohio State University • Columbus, Ohio

2004-: Associate Professor (with tenure) • Dept. Neuroscience • The Ohio State University • Columbus, Ohio

2003-: Director • Spinal Trauma and Repair Laboratories • The Ohio State University College of Medicine and The Neurobiology of Disease Institute

1999-2004: Assistant Professor • Dept. Molecular Virology, Immunology & Medical Genetics • The Ohio State University • Columbus, Ohio

2003-2004: Assistant Professor • Department of Neuroscience • The Ohio State University • Columbus, Ohio (joint appointment)

1997-1999: Research Scientist/Adjunct Assistant Professor • Dept. Medical Microbiology & Immunology • The Ohio State University • Columbus, Ohio

1995-1997: Sandoz Research Scholar • Dept. Medical Microbiology & Immunology • The Ohio State University • Columbus, Ohio

1990-1995: Graduate Research Assistant • Department of Physiology • The Ohio State University, Columbus, Ohio

EDUCATION AND PROFESSIONAL TRAINING

1995: Ph.D. (Physiology) • Ohio State University, Columbus, Ohio

1992: M.S. (Physiology) • Ohio State University, Columbus, Ohio

1990: B.S. (Biology) • Penn State University, University Park, Pennsylvania RESEARCH INTERESTS

Neuroimmunology/neuropathology of spinal cord injury • neural regeneration/plasticity • multiple sclerosis/experimental autoimmune encephalomyelitis (EAE) • neuropathic pain

AWARDS/HONORS

1997: Michael E. Goldberger Award for Research in Neural Regeneration and Functional Recovery • Awarded by the National Neurotrauma Society

1995-97: Special Medical Research Fellowship • The Sandoz Corporation and The Ohio State University

Phillip G. Popovich, Ph.D. 2

1993-95: NINDS Neural Development, Plasticity, and Regeneration Training Grant

2000: Invited Speaker NIH Workshop – “Role of the Immune System in Spinal Cord Injuries”

2000: Invited Speaker NINDS Workshop – “Safety of Electrical Stimulation in the CNS”

2003: Excellence in Teaching Award: OSU College of Medicine & Public Health and Department of Molecular Virology, Immunology & Medical Genetics

2004-: Member, Clinical Neuroplasticity and Neurotransmitters (CNNT) Study Section, NIH-NINDS

2006-7: Vice President, National Neurotrauma Society

2006: Ray W. Poppleton Research Chair

SERVICE Local

• The Ohio State Initiative for the Development of Minority Training in the Neurosciences (1996-1997)

• Coordinator, Department of Molecular Virology, Immunology & Medical Genetics Seminar Series (Fall, Winter, Spring 2001), Ohio State

• Administrative Committee for IBGP Neuroscience track, Ohio State (2001-present)

• Release Time Committee – Department of Molecular Virology, Immunology & Medical Genetics, Ohio State

• Organizing Committee: Hunt-Curtis Symposium on Translational Neuroscience (Columbus, Ohio, September, 2002)

• Roessler Research Scholarship Committee – OSU College of Medicine & Public Health (COMPH; 2002-2005)

• OSU Intranet (OneSource) Committee – OSU COMPH, 2003-2004

• IBGP Admissions Committee – OSU, 2004-present

• Coordinator for IBGP Faculty Appointments, 2004-2006

• Graduate Studies Committee - Neuroscience Graduate Studies Program, 2004-present

• Steering Committee – Campus Microscopy and Imaging Facility, 2004 – present

• Seminar Committee – MVIMG, 2005.

• Rules Committee/Patterns of Administration Revision – MVIMG, 2005-2006.

• MVIMG Advisory Committee – MVIMG, 2005-present.

• Immunology Search Committee – MVIMG, 2005-present.

• Planning for Neurosciences in Biomedical Research Tower – OSUCOM, 2006

• Revised Strategic Plan for People Task Force – OSUCOM, 2006

• Search Committee for Chair, Department of Neuroscience – OSUCOM, 2006-07

• Search Committee, Chair, Division of Physical Therapy – OSUCOM, 2006-07


• Spine/Spine Trauma Taskforce – Neuroscience Signature Program – co-Chair – OSUCOM, 2006

• Clinical Translational Research Advisory Group – OSUCOM, 2007

Professional Memberships and National Service:

• Society for Neuroscience

• National Neurotrauma Society

• American Association of Anatomists (AAA)

• Faculty Judge, Student Abstract Competition, National/International Neurotrauma Societies (1997, 1998, 1999, 2002, 2003)

• Councilor, National Neurotrauma Society (2004-2006)

• American Society for Neurochemistry (2004-)

• Program Committee for NNS 2005, National Neurotrauma Society

• Program Committee for ASN 2006, American Society for Neurochemistry.

• Vice President, National Neurotrauma Society (2007) TEACHING:

1992: Physiology • Teaching assistant for Ohio State University School of Dentistry

1993: Neurophysiology • Teaching assistant for OSU Medical Independent Study Program

1993: Physiology • Instructor

1996: Co-authored Systems Neuroscience Module of The Princeton Review Manual

1997: Neuroimmunology • Co-coordinator/Instructor • Ohio State University Neuroscience Program (Neuroscience 797)

1997: Immunology Tutorials: Ohio State University Medical School (MED II, Med 663)

1998: Neuroimmunology • Co-coordinator/Instructor Medical Microbiology & Immunology (MMI 801)

1998: Immunology Tutorials: Ohio State University Medical School (MED II, Med 663)

2000: Neuroimmunology • Instructor • Medical Microbiology & Immunology (MMI 801)

2000: Cellular & Molecular Biology of Wound Healing (DENT 803) • Healing in the Nervous System (1.5 hours)

2000: Medical and Dental Immunology (MEDII) • Antigen Recognition, Cell Interactions, Immune Regulation (4 hours)

2000: Reeve-Irvine Center: Spinal Cord Injury Techniques Course, University of California – Irvine • Neuroinflammation in Spinal Cord Injury (2 hours)

2001: Molecular Virology, Immunology & Medical Genetics 750 (MVIMG750) • Principles of Neuroimmunology (created, coordinated and taught course; approx. 14 lecture hours/offered every other year).



2001: Molecular Virology, Immunology & Medical Genetics 701 (MVIMG 701): Cell migration/Inflammation; Wound Healing (2 lecture hours)


2002: Neuroimmunology • Coordinator/Instructor • Neuroscience Graduate Studies Program (NGSP 797) (15 lecture hours)

2002: Integrated Biomedical Sciences Grad Studies Program (IBGP) - Host Defense Module • T-/B-Lymphocyte Interactions, Neuroimmunology (2 hours)




2002: Cellular & Molecular Biology of Wound Healing (DENT 803) • Healing in the Nervous System (1.5 hours)

2003: Spinal Cord Anatomy/Function (NeuroGSP 725) • Department of Neuroscience •




2003: Integrated Pathway Medical (Med I) Curriculum • Antigen Recognition, Cell Interactions, Immune Regulation (2 hours)

2003: Integrated Biomedical Sciences Grad Studies Program (IBGP) 851: Advanced seminars in integrative biomedical science. (1 lecture hour/4 facilitation sessions).


2004: Integrated Pathway Medical (Med I) Curriculum • Antigen Recognition, Cell Interactions, Immune Regulation, B-cell Development (3 hours)




2005: Integrated Pathway Medical (Med I) Curriculum • Antigen Recognition, Cell Interactions,


Immune Regulation, B-cell Development (3 hours)






2003-06: OSU Spinal Cord Injury Research Training Techniques Course – 3 weeks annually


Student and Post-Doctoral Mentoring: 1. 1997: Dedra Hawkins: Research mentor in cooperation with OSU Summer Research

Opportunities Program for Minority Students: Spinal cord injury neuropathology

2. 1997-99: Jenny Yu: Honors Thesis Mentor: Isolation of Macrophages from the Injured Spinal Cord

3. 1999: DeMarco Speight (co-mentor with D.M. Basso): OSU Summer Research Opportunities Program for Minority Students: Spinal cord injury neuroimmunology

4. 2000-01: Julie Sroga: Undergraduate Honors Thesis Mentor: Species differences in spinal cord inflammation following contusion trauma

5. 2000-02: Mr. Craig Serpe – Loyola University, Loyola, IL: External member of PhD Dissertation committee.

6. 2000-04: Ms. T. Bucky Jones: PhD Thesis advisor; Neuroscience Graduate Studies Program

7. 2000-03: Ms. Susanna Coers – Loyola University, Loyola, IL: External member of PhD Dissertation committee.

8. 2000-1: Ms. Traci Wilgus, Molecular Virology, Immunology & Med Genetics: PhD Dissertation Committee

9. 2001: Ms. Gretchen Neigh McCandless, Neuroscience Graduate Studies Program: Committee member for PhD candidacy exam

10. 2001-04: Ms. Melanie McClain, Molecular Virology, Immunology & Med Genetics: PhD Dissertation Committee

11. 2001-6: Ms. Nicole D’Amico, Molecular Virology, Immunology & Med Genetics: PhD Dissertation Committee

12. 2001-02: Ms. Caitlin Hill: Neuroscience Graduate Studies Program, PhD Dissertation Committee

13. 2002-3: Asfand Ashiek: Undergraduate Honors Thesis Mentor: ‘Neuroprotective consequences of autoreactive lymphocyte vaccination’

14. 2001-2: Dr. Kim Campbell (Ph.D.), Research Scientist, MVIMG


15. 2002-6: Ms. Kristina Kigerl: PhD Thesis Advisor; Integrated Biomedical Sciences Graduate Program

16. 2002-6: Thomas Carsillo: Molecular Virology, Immunology & Med Genetics: PhD Dissertation Committee

17. 2002-04: Nate Huber: Integrated Biomedical Sciences Graduate Program: PhD Dissertation Committee

18. 2002-: Ms. Tracy Papenfuss: Veterinary Biosciences Graduate Program: PhD Dissertation Committee

19. 2002-: Ms. Erin McDaniel: PhD Thesis Advisor, OSU Integrated Medical Scientist Program (MD/PhD)

20. 2002-03: Ms. Cindy DeBoy: Loyola University, Loyola, IL: External member of PhD Dissertation committee.

21. 2003-: Mr. Kurt Lucin: PhD Thesis Advisor (co-advisor with Dr. Virginia Sanders), OSU Integrated Biomedical Sciences Graduate Program

22. 2003-6: Dr. Daniel Ankeny (Ph.D.), Post-doctoral Researcher, MVIMG

23. 2004-5: Ms. Kristen Reinhart: PhD Thesis Advisor; Integrated Biomedical Sciences Graduate Program (withdrew from program)

24. 2004: Mr. Ian Begley: summer undergraduate research advisor

25. 2004: Mr. John McCarter (OSU MD student): Summer research advisor

26. 2004-: Dr. Satoshi Nakamura (M.D.): post-doctoral fellow, MVIMG

27. 2005-6: Dr. La’Tonia Stiner (Ph.D.), post-doctoral fellow, MVIMG

28. 2005-6: Brandon Miller: Neuroscience Graduate Studies Program (MD/PhD): PhD Dissertation Committee

29. 2005-: Richa Tripathi: Neuroscience Graduate Studies Program: PhD Dissertation Committee

30. 2005: David Sterling: University of British Columbia: External Reviewer of PhD Dissertation (Wolfram Tetzlaff, mentor)

31. 2005: Amanda Matovich: First Year Advisor (IBGP)

32. 2005: Kate Pantzer (OSU Med I student): summer research advisor

33. 2005-: Megan Detloff: NGSP, PhD Dissertation committee

34. 2005-: NaTosha Gatson (MD/PhD), PhD Dissertation committee

35. 2006-: Dustin Donnelly (MD/PhD), PhD Thesis Advisor, OSU Integrated Medical Scientist Program (MD/PhD)

36. 2007-: Jessica Alexander : NGSP, PhD Thesis advisor

37. 2006-: Joe Carl: Integrated Biomedical Sciences Graduate Program: PhD Dissertation committee

38. 2006: Randall Butler: Roessler Medical Student Scholarship Mentor

39. 2006: David Schoenberg: Neuroscience Graduate Studies Program ; PhD Dissertation committee

40. 2006-: Lindsay Wallace: PhD Thesis advisor: Molecular, Cellular & Developmental Biology (MCDB) Program.


Invited Lectures and Seminars:

1. The Cellular Immune Response to Experimental Spinal Cord Injury • FASEB Summer Research Conference on CNS Injury • Copper Mountain, CO, 1996.

2. Immunological Mechanisms of Spinal Cord Injury • 8th Annual Spring Brain Conference, Sedona, AZ, 1997.

3. T-Lymphocytes and Spinal Cord Injury • University of California at San Francisco, San Francisco, CA, 1997.

4. The Cellular Immune Response to Experimental Spinal Cord Injury • The Immune Response Corporation • Carlsbad, CA, 1997.

5. Macrophage Depletion and Spinal Cord Injury • The National Neurotrauma Society • New Orleans, LA, 1997

6. The Neuroimmunology of Spinal Cord Trauma • University of Pennsylvania, CNS Injury Seminar • Philadelphia, Pennsylvania, 1998

7. The Neuroimmunology of Spinal Cord Trauma • University of Kentucky, Department of Physiology • Lexington, Kentucky, 1998

8. The Neuroimmunology of Spinal Cord Trauma • The Pennsylvania State University, Department of Biobehavioral Health, University Park, PA, 1999

9. GUEST LECTURE • Neuroimmunology of Central Nervous System Disease • Department of Biobehavioral Health (BBH470 - Functional and Integrative Neuroscience), Penn State Univ., 1999.

10. The Neuroimmunology of Spinal Cord Trauma • The Ohio State University, Molecular Life Sciences Initiative, Columbus, OH, 1999.

11. The Neuroimmunology of Spinal Cord Trauma • University of California, Irvine, Department of Anatomy and Neurobiology, Irvine, CA, 1999.

12. The Neuroimmunology of Spinal Cord Trauma • The Miami Project to Cure Paralysis, Miami, FL, 1999.

13. Neuroinflammation: The Catch-22 of Spinal Cord Injury • The McLaughlin Research Institute, Great Falls, MT, 1999.

14. Inflammation, Autoimmunity and Spinal Cord Injury • 7th Annual Shock Forum, Vienna, Austria, 1999

15. Targeted Immune Therapies: Strategies to Promote Repair of the Injured Spinal Cord • The 8th International Symposium on Neural Regeneration, Pacific Grove, CA, 1999.

16. Macrophage Heterogeneity after Spinal Cord Injury • NIH Workshop – “Role of the Immune System in Spinal Cord Injury, Bethesda, MD, 2000.

17. Manipulating the Neuroimmune Axis after Spinal Cord Injury: Experimental and Clinical Considerations • Mini-symposium on Animal Models of Spinal Cord Injury • FASEB • San Diego, CA, 2000.

18. Targeted Immune Therapies: Strategies to Promote Repair of the Injured Spinal Cord • Department of Cell Biology, Neurobiology & Anatomy, Loyola University Medical Center, Maywood, Ill, 2000.


19. Neuroimmunology and Spinal Cord Injury • Spinal Cord Injury Summer Course Lecture Series • Reeve-Irvine Center, University of California, Irvine • Irvine, CA, 2000.

20. Targeted Immune Therapies: Strategies to Promote Repair of the Injured Spinal Cord • Neuroscience Graduate Studies Program, The Ohio State University • Columbus, OH, 2000.

21. Cellular Responses to CNS Injury • 31st Neural Prosthesis Workshop • National Institutes of Health, Bethesda, MD, 2000.

22. Inflammation in the Traumatized Spinal Cord: A Potential Target for Regenerative and Neuroprotective Therapy • Mini-symposium • Experimental Biology • Orlando, FL, 2001.

23. Manipulating the Neuroimmune Axis: A Novel Approach to Repairing the Injured Spinal Cord • The John P. Robarts Research Institute • The Neurodegeneration Research Group • London, Ontario, 2001.

24. Inflammation and Spinal Cord Injury: Revealing Mechanisms of Neural Repair & Neuroprotection in the New Millennium• The Ohio State University • Department of Physiology & Cell Biology • Columbus, OH, 2001.

25. Inflammation in the traumatized spinal cord: a potential target for regenerative and neuroprotective therapy • FASEB Minisymposium on Neuroimmune Interactions • Orlando, FL, 2001.

26. Secondary Injury and Neuroinflammation after Spinal Cord Injury • 67th Ohio Physical Therapy Association Meeting • Columbus, OH, 2002.

27. Vaccines and Clinical Trials in Spinal Cord Injury • 67th Ohio Physical Therapy Association Meeting • Columbus, OH, 2002.

28. Inflammation in the traumatized spinal cord: a potential target for regenerative and neuroprotective therapy • Department of Biological Sciences • Rutgers University • Newark, NJ, 2002.

29. Inflammation in the traumatized spinal cord: a potential target for regenerative and neuroprotective therapy • Keck Center for Collaborative Neuroscience • Rutgers University • New Brunswick, NJ, 2002.

30. Inflammation in the traumatized spinal cord: a potential target for regenerative and neuroprotective therapy • Psychobiology and Behavioral Neuroscience Seminar Series • The Ohio State University • Columbus, OH, 2002.

31. Manipulating the Immune System to Repair the Injured Spinal Cord • IBGP Lecture Series • The Ohio State University • Columbus, OH, 2002.

32. Manipulating the Immune System to Repair the Injured Spinal Cord • Collaboration on Repair Discoveries (CORD) and NeuroTherapeutics Inc. • Vancouver, British Columbia, 2002

33. Revealing microglia and macrophage function after traumatic spinal cord injury • ASN Colloquium on Differential Function of Microglia and Macrophages in CNS Inflammation • 33rd Annual Meeting of American Society for Neurochemistry • Palm Beach, FL, 2002

34. Manipulating the Immune System to Repair the Injured Spinal Cord • Case Western Reserve University Immunology Seminar Series • Department of Pathology • Cleveland, OH, 2002.


35. Neuroinflammatory Mechanisms of Secondary Injury and Repair after Spinal Cord Injury • Dept. Physiology and The Spinal Cord and Brain Injury Research Center • University of Kentucky • Lexington, KY, 2002.

36. Neuroinflammatory Mechanisms of Secondary Injury and Repair after Spinal Cord Injury • Centocor, Inc. • Malvern, PA, 2002.

37. Behavioral and Endocrine Modulation in Spinal Cord Injury • Meeting of the NIH Mind/Body Centers • Pittsburgh, PA, 2002.

38. Exploiting macrophage heterogeneity to repair the pathologic CNS: can we do it? • Hunt-Curtis Symposium on Translational Neuroscience • Columbus, OH, 2002.


40. Manipulating the Immune System to Repair the Injured Spinal Cord • ACORDA Therapeutics • Hawthorne, NY, 2002.

41. Inflammatory Responses to CNS Injury • The First Joint Symposium of the National and International Neurotrauma Societies • Tampa, FL, 2002.

42. Manipulating the Immune System to Repair the Injured Spinal Cord • Department of Anatomy & Neurobiology • University of Arkansas Medical Center • Little Rock, AR, 2003.

43. Neuroinflammation in rat and mouse spinal cord injury • Spring Brain Conference • Sedona, AZ, 2003

44. T-Lymphocytes and Spinal Cord Injury: Pathological and Physiological Implications • American Society for Neurochemistry • Colloquium on Microglia and T-cells in CNS • Newport Beach, CA, 2003

45. Macrophage/Microglial-Mediated Injury and Repair in Traumatically Injured Spinal Cord • Biogen, Inc • Cambridge, MA, 2003

46. Secondary Injury and Spinal Cord Trauma: Role of the Immune System • Frontiers in Spinal Cord Regeneration Symposium • Kentucky Spinal Cord and Head Injury Research Trust Meeting • Louisville, KY, 2003.

47. Secondary Injury and Spinal Cord Trauma: Role of the Immune System • Department of Neuropharmacology, The Scripps Research Institute • San Diego, CA, 2003

48. Secondary Injury and Spinal Cord Trauma: Role of the Immune System • Department of Neurobiology & Anatomy, Drexel Univeristy • Philadelphia, PA, 2003.

49. Secondary Injury and Spinal Cord Trauma: Role of the Immune System • Department of Molecular Virology, Immunology & Medical Genetics • Ohio State University, Columbus, OH, 2003.

50. Secondary Injury and Spinal Cord Trauma: Role of the Immune System • Medical Grand Rounds, The Ohio State University • Columbus, Ohio 2004.

51. Immune-mediated CNS injury and repair after traumatic spinal cord injury • Department of Neuroscience, Case Western Reserve University • Cleveland, Ohio 2004.


52. “Obtaining and Maintaining a Career in Academia” • Graduate Student Association for Veterinary Biosciences – 2004 Veterinary Biosciences Career Day • The Ohio State University, Columbus, OH

53. Immune-mediated CNS injury and repair after traumatic spinal cord injury • FASEB

Summer Research Conference on Neuroimmunology • Tucson, AZ, 2004.

54. Immune-mediated CNS injury and repair after traumatic spinal cord injury • American Paralplegia Society • Las Vegas, NV, 2004.

55. Inflammatory-mediated injury and repair in the traumatically injured spinal cord • 38th Winter Conference on Brain Research • Breckenridge, CO, 2005.


57. Regulating Innate and Adaptive Immunity Following Spinal Cord Injury • 8th Annual Spinal Research Trust Meeting • Kensington Forum • London, UK, 2005

58. Regulating Innate and Adaptive Immunity Following Spinal Cord Injury • Stark Neuroscience Institute • Indiana University School of Medicine • Indianapolis, IN, 2005

59. Regulating Innate and Adaptive Immunity Following Spinal Cord Injury • Pennington Biomedical Research Insitute • Louisiana State University • Baton Rouge, LA, 2005

60. Debate: Increasing Inflammation is Beneficial for Neural Repair and Outcome • The 11th International Symposium on Neural Regeneration • Pacific Grove, CA, 2005

61. Regulating Innate and Adaptive Immunity Following Spinal Cord Injury • The Miami Project to Cure Paralysis • Miami, FL, 2006

62. Innate Immune Responses in the Injured Spinal Cord • The John P. Robarts Research Institute • The Neurodegeneration Research Group • London, Ontario, 2006.

63. Neuroinflammatory mechanisms in spinal cord injury • FASEB Summer Research Conference on Neuroimmunology • Tucson, AZ, 2006.


65. Central and peripheral consequences of activating the immune system after spinal cord injury • Charité Universitätsmedizin Berlin • Berlin, Germany, 2006.

66. Neuroimmunology and Spinal Cord Injury • Geron Corporation • Menlo Park, CA • 2006.

67. Central and peripheral consequences of activating the immune system after spinal cord injury • 40th Annual Winter Conference on Brain Research • Snowmass, CO • 2007.

68. Central and peripheral consequences of activating the immune system after spinal cord injury • Kentucky Spinal Cord Injury Research Center • Louisville, KY • 2007.

Peer Review Activities:

Journal Review

Editorial Board:


• Journal of Neurodegeneration and Regeneration

Ad hoc review:

• Neuron • Journal of Comparative Neurology • Experimental Neurology • Journal of Neuroscience • Journal of Neurochemistry • Brain • Trends in Neuroscience • Trends in Pharmacological Sciences • Trends in Molecular Medicine • Physiology & Behavior • Journal of Histochemistry and Cytochemistry • Journal of Spinal Cord Medicine • Journal of Neuroimmunology • Journal of Neuroscience Research • Journal of Neuroscience Methods • Journal of Neurotrauma • Experimental Biology & Medicine • Expert Opinion on Investigational Drugs • Behavioral Neuroscience • The FASEB Journal • Glia • European Journal of Neuroscience • Journal of Neuropathology & Experimental Neurology

Grant Review

• NIH: Clinical Neuroplasticity and Neurotransmitters Study Section (CNNT): formerly Brain Disorders & Clinical Neuroscience-2 (BDCN-2), Ad-Hoc (1999, 2000, 2002, 2003, 2004)

• Paralyzed Veterans of America – Spinal Cord Research Foundation Research Grants (1999-2000)

• Christopher Reeve Paralysis Foundation – Ad-Hoc Review (2002,2003) • Department of Veterans Affairs, VA Medical Research Service Merit Review (2001) • Canadian Institutes of Health Research – External Review (2001) • Texas A&M Life Sciences Task Force – External Review (2003) • The Ohio State University College of Medicine Seed Grants (1999-2001) • Israeli Science Foundation (2002) • The Roman-Reed Fund (state of California spinal cord injury grant applications) (2003-2006) • New Jersey Commission on Spinal Cord Research (2004, 2005) • Member, Clinical Neuroplasticity and Neurotransmitters (CNNT) Study Section, NIH-

NINDS (2004-2008) • International Spinal Research Trust (Spinal Cord Foundation, UK) (2004) • Multiple Sclerosis Society of Canada (2005) • Wings for Life Foundation (Zurich) 2006, 2007 • The Wellcome Trust (UK) 2006


• Craig H. Neilsen Foundation, US, 2006 • New Jersey Commission on Brain Injury Research (2006)

PUBLICATIONS

1. POPOVICH, P.G., Streit, W.J., Stokes, B.T. Differential expression of MHC class II antigen in the contused rat spinal cord. J. Neurotrauma, 10(1), 37-46, 1993.

2. POPOVICH, P.G., Reinhard, J.F., Jr., Flanagan, E.M., Stokes, B.T. Elevation of the neurotoxin quinolinic acid occurs following spinal cord trauma. Brain Res., 633, 348-352, 1994.

3. Colachis, S.C., POPOVICH, P.G., Stokes, B.T. Gallium nitrate and spinal cord injury: A pilot study of efficacy using an experimental model. Paraplegia, 32, 86-92, 1994.

4. Semple-Rowland, S.L., Mahatme, A., POPOVICH, P.G., Green, D.A., Hassler, G., Jr., Stokes, B.T., Streit, W.J. Analysis of TGF-β1 gene expression in contused rat spinal cord using quantitative RT-PCR. J.Neurotrauma, 12(6), 1003-1014, 1995.

5. POPOVICH, P.G., Horner, P.J., Mullin, B.B., Stokes, B.T. A quantitative spatial analysis of the blood-spinal cord barrier: I. Permeability after spinal contusion injury. Exp. Neurol., 142, 258-275, 1996.

6. POPOVICH, P.G., Stokes, B.T., Whitacre, C.C. The concept of autoimmunity following spinal cord injury: possible roles for T-Lymphocytes in the traumatized CNS. J. Neurosci. Res., 45, 349-363, 1996.

7. Horner, P.J., POPOVICH, P.G., Mullin, B.B., Stokes, B.T. A quantitative spatial analysis of the blood-spinal cord barrier: II. Permeability after intraspinal fetal transplantation. Exp. Neurol., 142, 226-243,1996.

8. POPOVICH, P.G., Wei, P., Stokes, B.T. The cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats. J. Comp. Neurol., 377(3), 443-464, 1997.

9. POPOVICH, P.G., Yu, J.Y., Whitacre, C.C. Spinal cord neuropathology in rat experimental autoimmune encephalomyelitis: modulation by oral administration of myelin basic protein. J. Neuropathol. Exp. Neurol., 56(12), 1323-1338, 1997.

10. POPOVICH, P.G., Whitacre, C.C, Stokes, B.T. Is spinal cord injury an autoimmune disorder? The Neuroscientist, 4(2), 71-76, 1998.

11. Streit, W.J., Semple-Rowland, S.L., Hurley, S.D., Miller, R. C., POPOVICH, P.G., Stokes, B.T. Cytokine mRNA transcription profiles in contused spinal cord and axotomized facial nucleus suggest a pro-regenerative role for inflammation and gliosis. Exp. Neurol., 152(1):74-87, 1998.

12. POPOVICH, P.G., Guan, Z., Wei, P., Yu, J.Y., Huitinga, I., van Rooijen, N., Stokes, B.T. Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. Exp. Neurol., 158(2):351-365, 1999.

13. McTigue, D.M., POPOVICH, P.G., Morgan, T.E., Stokes, B.T. Localization of TGF-β1 and receptor mRNA after experimental spinal cord injury, Exp. Neurol., 163:220-230, 2000.

14. Jakeman, LB, Guan, Z., Wei, P., Ponnappan, R., Dzwonczyk, R., POPOVICH, P.G., Stokes B.T. Traumatic spinal cord injury produced by controlled contusion in mouse, J. Neurotrauma, 17(4): 299-319, 2000.

15. POPOVICH, P.G., Stuckman, S., Gienapp, I.E., Whitacre, C.C. Alterations in leukocyte phenotype and function following experimental spinal cord injury, J. Neurotrauma 18(9): 957-966, 2001.


16. POPOVICH, P.G. and Hickey, W.F. Bone-marrow chimeric rats reveal the unique distribution of resident and recruited macrophages in the contused rat spinal cord, J. Neuropathol. Exp. Neurol., 60(7) 676-685, 2001.

17. Jones, T.B., Basso, D.M., Sodhi, A., Pan, J.Z., Hart, Hart, R.P., MacCallum, R.C., Lee, S., Whitacre, C.C., POPOVICH, P.G. Pathological central nervous system autoimmune disease is triggered by traumatic spinal cord injury: implications for autoimmune vaccine therapy, J. Neuroscience, 22: 2690-2700, 2002.

18. Hayes, K.C., Hull, T.C.L., Delaney, G.A., Potter, P.J., Sequeira, K.A.J., Campbell, K., POPOVICH, P.G. Elevated serum titers of proinflammatory cytokines and CNS autoantibodies in patients with chronic spinal cord injury, J. Neurotrauma, 19(6): 753-761, 2002.

19. POPOVICH, P.G., Guan, Z., McGaughy, V., Fisher, L., Hickey, W.F., Basso, D.M.. The neuropathological and behavioral consequences of intraspinal microglial/macrophage activation, J. Neuropathol Exp. Neurol., 61(7):623-633, 2002.

20. POPOVICH, P.G. and Jones, T.B. Manipulating neuroinflammatory reactions in the injured spinal cord: back to basics. Trends Pharmacol. Sci., 24(1):13-17, 2003.

21. P.G. POPOVICH, van Rooijen, N., Hickey, W.F., Preidis, G., McGaughy, V. Hematogenous macrophages express CD8 and distribute to regions of cavitating pathology after spinal cord injury. Exp. Neurol, 182, 275-287, 2003 (doi:10.1016/S0014-4886(03)00120-1).

22. Sroga, J.M., Jones, T.B., McGaughy, V., POPOVICH, P.G. Rats and mice exhibit distinct inflammatory responses after spinal cord injury, J. Comp. Neurol, 462(2):223-240, 2003.

23. Jones, T.B., Ankeny, D.P., Guan, Z., McGaughy, V., Fisher, L., Basso, D.M., POPOVICH, P.G. Passive or active immunization with myelin basic protein impairs neurological function and exacerbates neuropathology after spinal cord injury in rats. J. Neurosci., 24(15) 3752-3761, 2004.

24. Jones, T.B., McDaniel, E.E., POPOVICH, P.G. Inflammatory-mediated injury and repair in the traumatically injured spinal cord. Current Pharmaceutical Design, 11(10) 1223-1236, 2005.

25. Jones, T.B., Hart, R.P., POPOVICH, P.G. Molecular control of physiological and pathological T-cell recruitment to the injured mouse spinal cord. J. Neurosci., 25(28) 6576-6583, 2005.

26. Kigerl, K.A., McGaughy, V.M., POPOVICH, P.G. A comparative analysis of lesion development and inflammation in four strains of mice following spinal contusion injury, J. Comp. Neurol., 494(4) 578-594, 2006.

27. Pasterkamp, R.J., Dai, H. Terman, J.R., Wahlin, K., Kim, B., Bregman, B.S., POPOVICH, P.G., Kolodkin, A.L. MICAL flavoprotein monooxygenases: expression in the developing and adult rat nervous system and following spinal cord injuries, Mol. Cell. Neurosci, 31(1),52-69, 2006.

28. Kigerl, K and POPOVICH, P, Drug evaluation: ProCord – a potential cell-based therapy for spinal cord injury, IDrugs, 9(5): 354-360, 2006.

29. Basso, D.M., Fisher, L.C., Anderson, A.J., Jakeman, L.B. McTigue, D.M., POPOVICH, P.G. The Basso Mouse Scale for Locomotion (BMS) Detects Differences in Recovery After Spinal Cord Injury in Five Common Mouse Strains. J. Neurotrauma, 23(5) 635-659, 2006.

30. Crutcher, K.A., Gendelmen, H.E., Kipnis, J, Perez-Polo, J.R., Perry, V.H., POPOVICH, P.G., Weaver, L.C. Debate: Is increasing neuroinflammation beneficial for neural repair. J. Neuroimmune Pharm. 1(3) 195-211, 2006.

31. Ankeny, D.P., Lucin, K.L., Hart, R.P., Sanders, V.M., POPOVICH, P.G. Spinal cord injury triggers pathological autoantibody synthesis: evidence for systemic and intraspinal B cell activation and differentiation", J. Neurochemistry, 99(4)1073-87, 2006.


32. Kigerl, K.A., Rivest, S. Hart, R.P., Satoskar, A.R., POPOVICH, P.G. Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury, J. Neurochemistry, in press.

33. Gray, M. POPOVICH, P.G., van Rooijen, N., Gupta, R. Macrophage depletion alters the blood nerve barrier without affecting Schwann cell function after neural injury, J. Neurosci Res., in press.

34. Ankeny, D.P. and POPOVICH, P.G. CNS and non-CNS antigen vaccines exacerbate neuropathology caused by nerve injury, European J. Neuroscience, in press.

35. Neigh, G.N., Glasper, E.R., Bowers, S.L., POPOVICH, P.G., DeVries, A.C. Stress increases anxiety-like behavior and microglial activation following cardiac arrest/cardiopulmonary resuscitation, in review.

36. Lucin, K.M., Sanders, V.M., Jones, T.B., Malarkey, W.B., POPOVICH, P.G. Impaired systemic immunity after spinal cord injury is level-dependent and results from sympathetic nervous system dysregulation, in review.

37. McDaniel, E.E., Lai, W. and POPOVICH, P.G. In vitro modeling of monocyte-derived macrophage functions for traumatic spinal cord injury, in review.

38. Detloff, M.R., Fisher, L.C., McGaughy, V., McDaniel, E.E., POPOVICH, P.G., Basso, D.M. Neuropathic pain induced by spinal trauma or nerve ligation activates microglia independent of changes in the p2X4 ATP receptor, in review.

39. Holmes, F.E., Arnott, N., Vanderplank, P., Kerr, N.C.H., Longbrake, E., POPOVICH, P.G., Imai, T., Combadiere, C. Murphy, P.M. and Wynick, D. Fractalkine attenuates neuropathic pain-like behavior via activation of CX3CR1, in review.

40. Alexander, J.K., DeVries, A.C. and POPOVICH, P.G., Stress exacerbates neuropathic pain, in review.

41. Kostyk, S.K., POPOVICH, P.G., Stokes, B.T., Wei, P. and Jakeman, L.B. Robust axonal growth is coupled with a blunted macrophage response after spinal cord injury in the MRL/MpJ mouse., in review.

42. Lai, W. and POPOVICH, P.G. Combining quantitative PCR with laser capture microdissection to detect macrophage function in the injured spinal cord., in preparation.

43. Donnelly, D.J., Ankeny, D.P. and POPOVICH, P.G. Comparison of techniques for quantifying CNS macrophage infiltration in experimental models of CNS pathology., in preparation.

BOOK CHAPTERS

1. POPOVICH, P.G., Jakeman, L.B. and McTigue, D.M. Neural repair: regeneration and functional recovery: glial responses to injury. The Encyclopedia of Neuroscience, in press.

2. Jones, T.B., Lucin, K. and POPOVICH, P.G. The immune system of the brain. Neuroimmune Biology, Vol. 4, The Hypothalamic-Pituitary-Adrenal Axis. (Ed. H.O. Besedovsky, G. Chrousos & A. del Rey). Elsevier, Amsterdam, in press.

3. Kostyk S.K., POPOVICH, P.G., Stokes B.T. Mechanisms and natural history of spinal cord injury. In: Spinal Cord Medicine: Principles and Practice. (Ed: V. Lin) Demos Medical Publishing, NY, Sept, 2002.

4. POPOVICH, P.G. Role of microglia and macrophages in the injured spinal cord: troublemakers or scapegoats?, Microglia in the Regenerating and Degenerating Central Nervous System (Ed. Wolfgang,


J. Streit), p. 152-165, 2002.

5. POPOVICH, P.G. Inflammation and repair of the injured spinal cord: Lessons from peripheral wound healing and evolution. Inflammatory Events in Neurodegeneration (Eds. S.C. Bondy & A. Campbell), p. 276-290, 2001.

6. POPOVICH, P.G. Immunological regulation of neuronal degeneration and regeneration in the injured spinal cord, Prog. Brain Res, Neural Plasticity and Regeneration, vol 128 (ed. F.J. Seil), p. 43-58, 2000.

7. McTigue, D.M., POPOVICH, P.G., Jakeman and Stokes, B.T. Strategies for spinal cord injury repair. Prog. Brain Res, Neural Plasticity and Regeneration, vol 128 (ed. F.J. Seil), p. 3-8, 2000.

8. Horner, P.J., POPOVICH, P.G., Reier, P.J. and Stokes, B.T.. Fetal spinal transplant vascularity: Metabolic and Immunologic Mechanisms. Neural Transplantation, CNS Neuronal Injury, and regeneration. Recent advances. (eds. J. Marwah, H. Teitelbaum, and K. Prasad), p. 119-140, 1994.

ABSTRACTS

1. Gray, M., POPOVICH, P., van Rooijen, N and Gupta, R. Macrophage depletion alters the blood nerve barrier without affecting Schwann cell function after neural injury. 36th Annual Society for Neuroscience Meeting, Atlanta, GA, 2006.

2. McDaniel, E.E. and POPOVICH, P.G. Fractalkine (CX3CL1)/fractalkine receptor (CX3CR1) interactions influence motor and sensory recovery after spinal cord injury. 11th International Symposium on Neural Regeneration, Pacific Grove, CA, 2005.

3. Kigerl, K.A., Rivest, S., Hart, R.P., Satoskar,A.R., POPOVICH, P. G. Innate Immune Responses Mediated by Toll-Like Receptor (TLR) 2 and TLR4 Signaling are Important for Anatomical and Functional Recovery after Spinal Cord Injury. 11th International Symposium on Neural Regeneration, Pacific Grove, CA, 2005.

4. Alexander, J.K., Devries, A.C., POPOVICH, P.G. Restraint stress immediately prior to SNI enhances neuropathic pain. 8th International Conference on Mechanisms and Treatment of Neuropathic Pain, San Francisco, CA, 2005.

5. Ankeny D.P., POPOVICH, P. G. Vaccination with myelin-antigens exacerbates loss of axotomized facial motor neurons in mice. FASEB Summer Res. Conference on Neuroimmunology, Tucson, AZ, 2004.

6. Ankeny, D.P., Lucin, K.M., Sanders, V.M., POPOVICH, P. G. Spinal cord injury triggers B-cell activation and antibody synthesis. Keystone Symposium: B cell development, function and disease, Steamboat Springs, CO, 2005.

7. Ankeny, D.P., POPOVICH, P. G. Myelin-reactive T cells are pathogenic effector cells in the injured nervous system, 35th Annual Society for Neuroscience Meeting, Washington, D.C., 2005.

8. Ankeny, D.P., Jones, T.B., POPOVICH, P. G. Myelin-reactive T cells are pathogenic effector cells in the injured nervous system, (Presentation), Mini-symposium on Neuroinflammatory mechanisms in CNS injury, 35th Annual Society for Neuroscience Meeting, Washington, D.C., 2005

9. Lucin, K.M. Sanders, V.M. Jones, T.B. Malarkey, W.B. POPOVICH, P. G. Alterations in sympathetic nervous system and hypothalamic-pituitary-adrenal axis function after experimental spinal cord injury. National Neurotrauma Society, Washington, DC, 2005.

10. Lucin, K.M. Sanders, V.M. Jones, T.B. Malarkey, W.B. POPOVICH, P. G. Alterations in sympathetic nervous system and hypothalamic-pituitary-adrenal axis function after experimental spinal cord injury. Society for Neuroscience, Washington, DC, 2005.


11. Lucin, K.M. Sanders, V.M. Jones, T.B. Malarkey, W.B. POPOVICH, P. G. Alterations in sympathetic nervous system and hypothalamic-pituitary-adrenal axis function after experimental spinal cord injury. Psychoneuroimmunology Research Society, Denver, CO, 2005.

12. Kigerl, K.A., Rivest, S., Hart, R.P., Satoskar,A.R., POPOVICH, P. G. Innate Immune Responses Mediated by Toll-Like Receptor (TLR) 2 and TLR4 Signaling are Important for Anatomical and Functional Recovery after Spinal Cord Injury. Society for Neuroscience, Washington D.C. 2005.

13. Kigerl, K.A., Rivest, S., Hart, R.P., Satoskar,A.R., POPOVICH, P. G. Innate Immune Responses Mediated by Toll-Like Receptor (TLR) 2 and TLR4 Signaling are Important for Anatomical and Functional Recovery after Spinal Cord Injury. National Neurotrauma Symposium, Washington D.C. 2005.

14. McDaniel, E.E. and POPOVICH, P.G. Fractalkine (CX3CL1)/fractalkine receptor (CX3CR1) interactions influence motor and sensory recovery after spinal cord injury. National Neurotrauma Symposium, Washington D.C. 2005.

15. Lucin, K.M., Sanders, V.M., Jones, T.B., Malarkey, W.B., POPOVICH, P. G. Alterations in sympathetic nervous system and hypothalamic-pituitary-adrenal axis function after experimental spinal cord injury. American Society for Neurochemistry, Madison, WI, 2005.

16. K.A. Kigerl, S. Rivest, POPOVICH, P. G. Regulation of innate immunity after spinal cord injury in mice: involvement of toll-like (TLR) receptors. American Society for Neurochemistry, Madison, WI, 2005.

17. POPOVICH, P. G., Jones, T.B., Hart, R.P. T-cell recruitment to the injured mouse spinal cord: Molecular control of physiological and pathological function. Society for Neuroscience, San Diego, CA, 2004.

18. Ankeny, D.P., Lucin, K. M. Sanders, V.M. and POPOVICH, P. G. Spinal cord injury triggers B-cell activation and antibody synthesis. Society for Neuroscience, San Diego, CA, 2004.

19. Kigerl, K.A. Rivest, S., POPOVICH, P. G. Regulation of innate immunity after spinal cord injury in mice: involvement of toll-like (TLR) receptors. Society for Neuroscience, San Diego, CA, 2004.

20. Detloff, M.R., Fisher, L.C., Kloos, A.D., Miller; E., McGaughy, V. M., POPOVICH, P. G., Basso, D.M.. Neuropathic pain after spinal cord injury and its relationship to glia and ATP receptor upregulation. Society for Neuroscience, San Diego, CA, 2004.

21. Jones, T.B., Basso, D.M., Fisher, L., and POPOVICH, P.G. Expansion of myelin-reactive T-cells via passive or active immunization impairs motor function and exacerbates neurodegeneration in a model of rat spinal cord injury. Society for Neuroscience, New Orleans, LA, 2003.

22. Kigerl, K.A. McGaughy, V.M. and POPOVICH, P.G. A Comparative Analysis of Lesion Development and Inflammation in Spinal Cord Injured Mice. Society for Neuroscience, New Orleans, LA, 2003.

23. POPOVICH, P.G., van Rooijen, N., Hickey, W.F., Preidis, G. and McGaughy, V.M. Hematogenous Macrophages Express CD8 and Distribute to Regions of Lesion Cavitation after Spinal Cord Injury. 1st Joint Meeting of the National and International Neurotrauma Societies, Tampa, FL, 2002.

24. POPOVICH, P.G., Hickey, W.F., McGaughy, V.M. and Guan, Z. Revealing microglia and macrophage heterogeneity after traumatic spinal cord injury. 33rd Annual American Society for Neurochemistry Meeting, Palm Beach, FL, 2002.

25. POPOVICH, P.G., Jones, T.B., McGaughy, V.M., Wang, X.M. T-lymphocyte infiltration of the traumatically injured spinal cord: pathological and physiological implications. 34th Annual Meeting for the American Society for Neurochemistry, Newport Beach, CA, 2003.


26. Jones, T.B., Basso, D.M., Fisher, L., and POPOVICH, P.G. Expansion of myelin-reactive T-cells via passive or active immunization impairs motor function and exacerbates neurodegeneration in a model of rat spinal cord injury. Society for Neuroscience, New Orleans, LA, 2003.

27. Kigerl, K.A. McGaugy, V.M. and POPOVICH, P.G. A Comparative Analysis of Lesion Development and Inflammation in Spinal Cord Injured Mice. Society for Neuroscience, New Orleans, LA, 2003.

28. Jones, TB, Sodhi, A., Pan, J.Z., Hart, R.P. and POPOVICH, P.G. Destructive CNS autoimmune reactions triggered by spinal cord injury are associated with the production of inflammatory chemokines and enhanced recruitment of CD4+ T-lymphocytes. 1st Joint Meeting of the National and International Neurotrauma Societies, Tampa, FL, 2002.

29. Hassenzahl, D.L., Fisher, L.C., POPOVICH, P.G. and D.M. Basso. Inherent locomotor differences in mouse strains impact recovery after spinal cord injury. 1st Joint Meeting of the National and International Neurotrauma Societies, Tampa, FL, 2002.

30. Lewis, E.A., Fisher, L.C., McGaughy, V.M., Hassenzahl, D.L., POPOVICH, P.G. and D.M. Basso. Ventral funiculus lesions of the spinal cord produce lasting sensory but not motor deficits. 1st Joint Meeting of the National and International Neurotrauma Societies, Tampa, FL, 2002.

31. POPOVICH, P.G., van Rooijen, N., Hickey, W.F., Preidis, G. and McGaughy, V.M. Hematogenous Macrophages Express CD8 and Distribute to Regions of Lesion Cavitation after Spinal Cord Injury. 1st Joint Meeting of the National and International Neurotrauma Societies, Tampa, FL, 2002.

32. POPOVICH, P.G., Hickey, W.F., McGaughy, V.M. and Guan, Z. Revealing microglia and macrophage heterogeneity after traumatic spinal cord injury. 33rd Annual American Society for Neurochemistry Meeting, Palm Beach, FL, 2002.

33. Sroga, J.M., Jones, T.B., McGaughy, V. and POPOVICH, P.G. Rats and mice exhibit unique inflammatory reactions following spinal cord injury. Eighteenth Annual National Neurotrauma Society, San Diego, CA, 2001.

34. T. B. Jones, I.E. Gienapp, C. C. Whitacre, B.T. Stokes, W.B. Malarkey and POPOVICH, P.G. Spinal cord injury is a physiological stressor capable of altering peripheral lymphocyte function: implications for vaccination. Eighteenth Annual National Neurotrauma Society, San Diego, CA, 2001.

35. T.B. Jones, D. M. Basso, C.C. Whitacre and P. G. POPOVICH. Impaired Functional Recovery Following Spinal Contusion Injury in Myelin Basic Protein T-Cell Receptor Transgenic Mice. XXIII Center for Research in Neurological Sciences Symposium, Montreal, Canada, 2001.

36. T.B. Jones, D. M. Basso, C.C. Whitacre and P. G. POPOVICH. Impaired Functional Recovery Following Spinal Contusion Injury in Myelin Basic Protein T-Cell Receptor Transgenic Mice. Society for Neuroscience, San Diego, CA, 2001.

37. POPOVICH, P.G., Jones, T.B., Campbell, K.A., Whitacre, C.C., McGaughy, V.M. Inflammation in the traumatized spinal cord: a potential target for regenerative and neuroprotective therapy. Experimental Biology, Orlando, FL, 2001.

38. Yu, J.Y., POPOVICH, P.G. White matter sparing in the injured spinal cord: the presence of myelin ghosts and regional variations in neurofilament phosphorylation. Seventeenth Annual Neurotrauma Society Meeting, New Orleans, LA, November, 2000.

39. POPOVICH, P.G., Guan, Z. Non-traumatic intraspinal macrophage activation causes axonal damage, demyelination and cavitation without behavioral deficits. Seventeenth Annual Neurotrauma Society Meeting, New Orleans, LA, November, 2000.


40. POPOVICH, P.G. Manipulating the neuroimmune axis after spinal cord injury: experimental and clinical considerations. Experimental Biology, San Diego, CA, April, 2000.

41. POPOVICH, P.G., McTigue, D.M., Basso, D.M., Stokes, B.T., Whitacre, C.C. Targeted immune therapies: Strategies to promote repair of the injured spinal cord. 8th International Symposium on Neural Regeneration, Pacific Grove, CA, December, 1999.

42. POPOVICH, P.G., Whitacre, C.C., Stokes, B.T. Inflammation, Autoimmunity and Spinal Cord Injury, Shock, 12, 4, 1999.

43. Jakeman, L.B., POPOVICH, P.G., Wei, P., Guan, Z., Ponnappan, R., Stokes, B.T. Development of a controlled spinal cord contusion injury model in the mouse. Sixteenth Annual Neurotrauma Society Meeting, Los Angeles, CA, 1998.

44. POPOVICH, P.G., Hawkins, D., Huitinga, I., van Rooijen, N. Stokes, B.T. Circulating macrophages as pathological effector cells after spinal cord injury. 5th International Congress on Neuroimmunology, Montreal, Canada, August, 1998.

45. POPOVICH, P.G., Huitinga, I., van Rooijen, N., Stokes, B.T. Selective depletion of peripheral macrophages attenuates myelin loss and improves hindlimb function in spinal injured rats. 7th International Symposium on Neural Regeneration, Pacific Grove, CA, December, 1997.

46. POPOVICH, P.G., Huitinga, I., van Rooijen, N., Stokes, B.T. Selective depletion of peripheral macrophages attenuates myelin loss and improves hindlimb function in spinal injured rats. J. Neurotrauma, 14(10), 790, 1997.

47. POPOVICH, P.G., Yu, J.Y., Gienapp, I.E., Whitacre, C.C. Oral tolerance in experimental autoimmune encephalomyelitis (EAE): Effects on microglial activation. American Association of Immunologists/AAI/CIS Joint Meeting, San Francisco, CA, February, 1997.

48. POPOVICH, P.G., Stokes, B.T. Quantitative and qualitative analysis of intraparenchymal inflammation in a rat spinal contusion injury model. 6th International Symposium on Neural Regeneration, Pacific Grove, CA, December, 1995.

49. Basso, D.M., POPOVICH, P.G., Stokes, B.T., Beattie, M.S., Bresnahan, J.C. Serial spinal cord and red nucleus lesions cause a progressive decline in recovered locomotor function in rats. 13th Annual Neurotrauma Symposium, San Diego, CA, 1995.

50. Stokes, B.T., Horner, P.J., POPOVICH, P.G., Saska, T.A. Specific alterations in metabolic aspects of transplant-evoked spinal repair. Spring Brain Conference, Sedona, AZ, 1995.

51. POPOVICH, P.G., Horner, P.J., Mullin, B.B., and Stokes, B.T. Blood-spinal cord barrier permeability: spatial quantitation and insight to novel mechanisms of barrier dysfunction. 3rd International Neurotrauma Symposium, Toronto, Canada, 1995.

52. Saska, T.A., Horner, P.J., POPOVICH, P.G., Mullin, B.B., and Stokes, B.T. Longitudinal analysis of angiogenesis, glucose transporter expression and blood-brain barrier permeability in fetal spinal transplants. 3rd International Neurotrauma Symposium, Toronto, Canada, 1995.

53. POPOVICH, P.G., Horner, P.J., Mullin, B.B., Wei, P., and Stokes, B.T. A quantitative spatial analysis of blood-brain barrier permeability after spinal contusion injury. Society for Neuroscience, Miami, FL, 1994.

54. Horner, P.J., POPOVICH, P.G., Mullin, B.B., Wei, P., and Stokes, B.T. A quantitative spatial analysis of blood-brain barrier permeability in fetal transplants following spinal contusion injury. Society for Neuroscience, Miami, FL, 1994.

55. POPOVICH, P.G., Stokes, B.T., and Whitacre, C.C. Sensitization of the host immune system to central nervous system antigens following experimental spinal cord injury: a model for traumatically


induced autoimmune disease. Experimental Biology, Anaheim, CA, 1994.

56. POPOVICH, P.G., Stokes, B.T., and Whitacre, C.C. Sensitization of the host immune system to CNS antigens following spinal cord injury: a model of trauma-induced autoimmunity. 5th International Symposium on Neural Regeneration. Pacific Grove, CA, December, 1993.

57. POPOVICH, P.G., Streit, W.J., Reinhard, J.F., Jr., Whitacre, C.C., and Stokes, B.T. Immunological reactivity following spinal cord injury: potential mechanisms of secondary degeneration. 11th Annual Neurotrauma Symposium, Washington, D.C., November, 1993.

58. POPOVICH, P.G., Streit, W.J., and Stokes, B.T. Longitudinal analysis of immune activity following spinal cord injury in the rat. Gordon Research Conference on Neuroimmunology, New London, NH, June, 1993.

59. POPOVICH, P.G., Reinhard, J.F., Jr., Flanagan, E.M., and Stokes, B.T. Elevated macrophage density and increased levels of quinolinic acid following contusion injury to the rat spinal cord. Society for Neuroscience, Washington, D.C., November, 1993.

60. POPOVICH, P.G., Streit, W.J., Reier, P.J., and Stokes, B.T. Immunological competence of contused rat spinal cord. J. Neurotrauma, 9(4), p. 397, 1992.

61. Stokes, B.T., Horner, P.J., POPOVICH, P.G., Akino, M., Thompson, F.J., and Reier, P.J. Functional evaluation of spinal transplants: convincing the skeptical. 2nd International Neurotrauma Symposium. Glasgow, Scotland, July, 1993.

LICENSED TECHNOLOGY/PATENTS • United States patent 5,932,563- Methods for Treating Spinal Cord Injury. Liposome encapsulated

dichloromethylene bisphosphonate (clodronate) as a means of depleting macrophages in central nervous system trauma. Co-inventors: Dr. Bradford T. Stokes, Dr. Nico van Rooijen, Dr. Inge Huitinga

CURRENT FUNDING 1. “Macrophage Heterogeneity after Spinal Cord Injury” Principal Investigator – P.G. Popovich (04/05/1999 - 03/31/2009) Agency: NINDS Type: R01 (2 R01 NS037846-06) 2. “T-cell functions in the injured spinal cord”

Principal Invetigator: P.G. Popovich (09/30/03-07/31/08) Co-Investigators: R. Hart

Agency: NIH-NINDS Type: R01 (NS047175)

3. “Macrophage TLR4 and Demyelination” –Pre-Doc NRSA Principal Invetigator: Kristina Kigerl (09/04-08/07) Mentor: Phillip Popovich

Agency: NIH-NINDS

4. “Sparing and exercise training promote recovery in spinal cord injury” Principal Investigator: D.M. Basso (04/01/02-03/31/07) Co-I: Phillip Popovich Agency: NINDS


Type: RO1 (NS43798) 5. “Facilities for research in spinal cord injury”

Principal Invetigator: J.C. Bresnahan (04/01/03-03/31/08) Co-Investigators: P.G. Popovich, D.M. McTigue, M.S. Beattie, M. Basso, L.B. Jakeman, S.K. Kostyk, J. Buford

Agency: NIH-NINDS Type: BAA-RFP

6. Integrative Immunobiology Training Program Principal Investigator: Virginia Sanders, Ph.D. (07/01/2003 – 06/30/2008) Preceptors: P.G. Popovich, Ron Glaser, Janice-Kiecolt Glaser, John Sheridan, Carol Whitacre, David Padgett, Ning Quan, Firdaus Dhabber, William Malarkey, Bruce Zwilling Agency: NIH-NIAID

7. Antibody treatment after Spinal Cord Injury in Mice Principal Investigator – P.G. Popovich Agency: Centocor, Inc. PAST FUNDING 1. Research Training Program in Psychoneuroimmunology

Agency: National Institutes of Health NIH T32 MH18831-11 (08/01/98-6/30/03) Principal Investigator: Caroline C. Whitacre, Ph.D.

2. Intracellular pathways regulating monocyte survival Principal Investigator: Clay Marsh, M.D. (7/01/2000 - 6/30/2003) Co-Investigator: P.G. Popovich, 5% Agency: National Heart, Lung & Blood Institute

3. Immune function and secondary complications in patients with spinal cord injury Principal Investigator: Keith C. Hayes, PhD Co-Investigators: Popovich, P.G. (WOC), G. Reid; M. Fehlings; G. Dekaban; N. Duggal; A. Krassioukov; P. Potter; K. Smith. Agency: Ontario Neurotrauma Foundation

4. Shared Instrument Grant - Scanning Laser Confocal Microscope Principal Investigator: Richard Burry

Co-Investigators: P.G. Popovich, Beattie, M.S., Hackshaw, K.V., King, J.S., Kniss, D.A., Lin, C.-L.G., Robinson, J.M., Obrietan, K.H., Rafael, J.A., Sack, F.D., Verma, D.S.

Agency: NIH-NCCR 5. Stress, Aging and Wound Healing Principal Investigator: R. Glaser Agency: NIH/NIA Type: PO1 (AG16321) Project Title - Immunohistopathology Core Facility Principal Investigator - P.G. Popovich 6. Center for Stress and Wound Healing” Principal Investigator: R. Glaser (09/30/1999 - 08/31/2004)

Agency: NIH Type: RFA- P50 (AG17811)


Project Title – “Behavioral and Neuroendocrine Modulation in a Spinal Cord Injury Model” Co-Principal Investigators: C.C. Whitacre, P.G. Popovich, W. B. Malarkey 7. Center for Stress and Wound Healing” Principal Investigator: R. Glaser (09/30/1999 - 08/31/2004)

Agency: NIH Type: RFA- P50 (AG17811)

Project Title – “Immunohistochemical Core Facility” Principal Investigator - P.G. Popovich PENDING FUNDING: “Role of Lumbar Microglia in Behavioral Impairments after SCI” PI:: D.M. Basso (04/06-05/11) Co-I: Phillip Popovich Agency: NINDS Type: RO1 (NS43798)

phillip g. popovich, ph.d. - heart lung i ohio state ... g. popovich, ph.d. department of molecular...

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