photoactuated*ionogel*microvalves*for water*quality ...photoactuated*ionogel*microvalves*for...
TRANSCRIPT
Photoactuated Ionogel Microvalves forWater Quality on-‐Chip Analysis
Monika CzugalaDr. F. Benito-‐Lopez, Prof. Dermot Diamond
Dublin City University, Ireland
Monday 17 September 12
Research Objectives• Integration of actuators developed in Task 3.7 into a microfluidic platform:
-biomimetic structures with detectors -fluidic manifolds-integral reagent addition and calibration standards -integral electronics-communications and power generation/storage
• Demonstration of fully functioning analytical platform.
• pH and turbidity - indicate that corrective action and investigation is required before it becomes a potential risk
- associated with outbreaks of Cryptosporidium (Carlow in 2006 and Galway City in 2007)
• nitrite - in public health terms is essential as prolonged exposure can lead to a potential health risk
Monday 17 September 12
Photo-responsive micro-valves• Photoswitchable materials - the use of non-contact, non invasive stimuli.
• Ionogels containing spiropyran moieties with photochromism properties.
• Protonated spiropyran ionogels exhibit a drastic swelling effect.
• Shrinking process of the ionogels happen upon white light irradiation.
PDMSPDMS
FLOW%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%FLOW
UV
VIS
glass)slideglass)slide)))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))))
Linear dimension change - 44%
Monday 17 September 12
Nitrite detection micro-fluidic device
Monday 17 September 12
Emitter
540 nm
Detector
660 nmWhite
LED for Valve
actuationMicrochip
Microcontroller board
Battery
Wireless RadioChip Cradle
(in house design)
Nitrite detection system
Monday 17 September 12
Nitrite detection system
)LJXUH�;��&$'�DVVHPEO\�PRGHO�VKRZLQJ�WKH�PLFURIOXLGLF�FUDGOH��PLFURIOXLGLF�FKLS�DORQJ�ZLWK�WKH�HPLWWHU��ZKLWH�JUHHQ��DQG�GHWHFWRU�/('�SODFHPHQWV��6LGH�DQG�IURQW�YLHZV�DUH�DOVR�SURYLGHG��WRS�OHIW��
0HDVXUHPHQW�SURFHGXUH3���6SHFWURSKRWRPHWHU�SURFHGXUH3���'HYLFH�SURFHGXUH
5HVXOWV�DQG�'LVFXVVLRQ5HIHUHQFH�,QVWUXPHQWDWLRQ�'DWD�$QDO\VLV3ODWIRUP�'HVLJQ�DQG�,PSOHPHQWDWLRQ5HVXOWV�IURP�WKH�'HYLFH&RPSDULVRQ�RI�6HQVLQJ�'HYLFH�WR�5HIHUHQFH�,QVWUXPHQW*HQHUDO�'LVFXVVLRQ�DQG�)XWXUH�:RUN
3���$GYDQWDJHV�RI�XVLQJ�D�OLJKW�YDOYH� ,W� KDV� EHHQ� GHPRQVWUDWHG� WKURXJK� WKLV� VWXG\� WKDW� WKH� XVH� RI� D� OLJKW�DFWXDWLRQ�YDOYH�FDQ�RSHUDWH�VXFFHVVIXOO\�ZLWKLQ�D�PLFURIOXLGLF�FKDQQHO��FDSDEOH�RI�FRQWUROOLQJ�WKH�IORZ�RI�UHDJHQW�DQG�VDPSOH�IRU�PL[LQJ�DQG�ODWHU�IRU�DQDO\VLV�YLD�D�3(''�WHFKQLTXH��$OWKRXJK�WKH�RYHUDOO�FRQWURO�RI�WKH�VHWXS�ZDV�SULPDULO\�PDQXDO��WKH�PHWKRGRORJ\� OHDUQHG� IURP�WKLV�VWXG\�FDQ�HDVLO\�EH�DSSOLHG� WR�DQ�DXWRPDWHG�V\VWHP�WR�SHUIRUP�DXWRPDWLF�PHDVXUHPHQWV� IRU� LQGXVWULDOLVHG�DSSOLFDWLRQV�RU� IRU�LQ�VLWX� ILHOG�PHDVXUHPHQWV�ZLWKLQ�WKH�HQYLURQPHQW�� �$�FULWLFDO�FKDOOHQJH�IDFHG�E\�VXFK� HQYLURQPHQWDO� V\VWHPV� LV� RSWLPLVDWLRQ� RI� LWV� GHSOR\PHQW� WLPH�� � 7ZR� NH\�DVSHFWV�DIIHFWV� WKLV� L�H�� UHJHQW�VXSSO\�DQG�SRZHU�FRQVXPSWLRQ�� �7KH�PLFURIOXLGLF�DSSURDFK�DGGUHVVHV�WKH�UHDJHQW�XVDJH�WKURXJK��WKH�XVH�RI�VPDOO�TXDQWLWLHV���$Q�DGYDQWDJH� RI� DGRSWLQJ� WKH� OLJKW� DFWXDWLRQ� YDOYH� LV� WKH� UHGXFWLRQ� RI� KLJK� SRZHU�
Chip Cradle (in house design)
Microchip
Battery
Wireless Radio
Microcontroller board
Monday 17 September 12
7
Monday 17 September 12
Method validation (off chip)
Concentration range of NO2: 0.0 - 1.2
Monday 17 September 12
Method validation (off chip)
Monday 17 September 12
Centrifugal Disc System
1
2
35
4
- Low cost single use microfluidic device.
- Multiple samples analysis in a single microfluidic device.
- Multiplexing capabilities (pH, turbidity, nitrite,...).
- Portable system: sample analysis at the point of care.
- Wireless communication system.
Monday 17 September 12
Training & Outreach
• Lab-on-a-Chip European Congress, 27-28 March 2012, Edinburgh, Scotland (POSTER)• 6th International Conference on Environmental Science and Technology 2012, which
will be held in June 25-29, Texas, USA (ORAL)• MicroTAS, The 16th International Conference on Miniaturized Systems for Chemistry and Life
Sciences, 31 Oct- 3 Nov 2012, Okinawa, Japan
Anticipated conferences
• MicroTAS, The 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 2-6 Oct 2011, Seattle, USA (ORAL)
• Marie Curie Researchers Symposium, SCIENCE – Passion, Mission, Responsibilities, Polish Presidency of the EU Council 25-27 Sept 2011, Warsaw, Poland (POSTER)
• SPIE-2011, Nanoscience + Engineering, 21 - 25 August, 2011, San Diego, California, USA, (INVITED TALK)
Conferences
Monday 17 September 12
Training & OutreachPublications
• Short course: Lab-on-a-chip technologies for applications in the life sciences, Transducers 2011 Conference,5-9 June 2011, Beijing, China.
• Short course: Microfluidics: Device Science and Technology; Transducers 2011 Conference, 5-9 June 2011, Beijing, China.
• Workshop: “Sensing: Changing the way we live our lives”, DCU, 21 Nov 2011, Dublin, Ireland• Cambridge Certificate in Advanced English English Course
Personal Developement
• The Key to Revolutionary Breakthroughs in Micro-fluidic Devices, Proceedings SPIE 8107, 81070C, 2011; doi:10.1117/12.895330 (REVIEW PAPER)
• Integrating Stimulus-Responsive Materials and Microfluidics – The Key to Next Generation Chemical Sensors, JIMMS (in preparation)
• Novel optical sensing system based on wireless paired emitter detector diode device for Lab-on-a-Disc water quality measurements, Lab Chip (in preparation)
Monday 17 September 12
Acknowledgments
11
• Cormac Fay & Damien Maher
• Adaptive Sensors Group, Dublin City University
• Marie Curie Initial Training Network funded by the EC FP7 People Program
• Science Foundation of Ireland under grant 07/CE/I1147
Dr. FernandoBenito-Lopez
Prof. Dermot Diamond
Monday 17 September 12