practical 2nd revision pharmacology

8/3/2019 Practical 2nd Revision pharmacology

1/18


2/18

Computer simulationexperiments of effect of

different autonomic drugs onarterial blood pressure & heart

rate of rats

2


3/18

This tracing represents the effect of NA on BP & HR of a dog,

before & after unknown (X). look carefully at the curve & answer

the following questions:

1. Drug (X) most probably would be 2. Explain its own effect on BP & HR.

3. Complete:NA raises the BP by acting on

4. How does drug (X) affect the pressor effect of NA?..

Noradrenaline (X) Noradrenaline


4/18

Epinephrine would cause a decrease in

mean arterial blood pressure if it isadministered after pre-treatment with :

a. A beta 1 antagonist .

b. An alpha 1 antagonist .

c. A beta 2 antagonist .d. A non-selective beta antagonist.

e. Both alpha 1 and beta 1 antagonist


5/18

The receptors mediating Acetylcholine

reversal are:

1. Muscarinic M2 and M3 receptors.

2. Muscarinic M1 and M3 receptors.3. Nicotinic NM receptors.

4. Nicotinic NN receptors.


6/18

Draw a curve to differentiate between the effect of NA &

adrenaline on BP & HR of an anesthetized dog.


7/18


8/18

Questions

1. Why Salicylates did not inhibit mouse

hot plate Method response?

2. What is the mechanism of analgesicactivity of morphine?


9/18

Questions

Hotplate method is used for screening of morphine, while

acetic acid induced writhes is used for screening of NSAIDs.

Prostaglandins and bradykinin are mediators of inflammation. Acetyl saliycilic acid is an example of NSAIDs.

Fill in the space:

..

.


10/18

Questions

The hot plate method is suitable for:

1. evaluation of all types of analgesics2. evaluation of non-narcotic analgesics3. evaluation of narcotic analgesics4. screening ofnon-steroidal anti-

inflammatory drugs


11/18

Questions

Fill in the space:

SedationNo. of micelicking/jumping

before after

Drug

absent55Na

salicylate

present15Morphine


12/18

Questions

Match:

a. Licking of the paw.b. a chemical method.c. mediators of inflammationd. an e.g. of narcotic analgesice. writhesf. a thermal methodg. an e.g. of non

narcotic analgesic

Morphine is ( ) Aspirin is ( ) Acetic acid induces ( ) Hot plate is ( )

Prosaglandins are ( ) Assessment of NSAIDs

is by ( )


13/18

DRUGS ACTING ON EYE


14/18

Determine the nature of the drug applied to

the rabbit's eye based on the following data.

DilatedSize of pupil:

AbsentLight reflex:

Intraocular pressure HighOther observation:

NormalConjunctival blood vessels:

1.The drug is most probably ----------------------

2. Name two different mydriatics used clinically and mention twoimportant therapeutic uses?


15/18

A drug of abuse that causesactive mydriasis is:

a) Morphine.b) Cocaine.

c) Dipivefrine.d) Phenylephrine


16/18

A drug of choice for treatment ofopen angle glaucoma in a patientsuffering from bronchial asthmais:a) PG analogue (latanoprost)

b) Mannitolc) Timolold) Pilocarpine


17/18

A topically applied drug to the eye,would induce mydriasis &cyclopelgia is:

a- Phenylephrine.b- Brimonidine

c- Cocaine.d- Tropicamide.


18/18

Mark (F )or (T):

1. Accomodation for near vision is lost bytopical pilocarpine eye drops.2. Cyclopentolate is a longer-acting mydriatic

drug than tropicamide.

3. Mannitol can be used to treat open angleglaucoma if timolol is contraindicated.

4. Stimulation ofE2-adrenoreceptors in the

ciliary body reduces aqueous humourproduction.

5. Corticosteroids should be avoided in caseof glaucoma.

practical 2nd revision pharmacology

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