quando associar platina ao tratamento do crpc (não … · 2019-04-18 · (neuroendocrine-like) dna...
TRANSCRIPT
![Page 1: Quando associar platina ao tratamento do CRPC (não … · 2019-04-18 · (Neuroendocrine-like) DNA damage. Aggarwal et al. JCO 2018 • Up to 1/5 of mCRPC presents treatment-emergent](https://reader035.vdocument.in/reader035/viewer/2022070905/5f743c686216800b757e724e/html5/thumbnails/1.jpg)
Quando associar platina ao tratamento do CRPC
(não neuroendócrino)
Denis F. Jardim, MD, PhDOncologista Titular Hospital Sírio Libanês-SP
![Page 2: Quando associar platina ao tratamento do CRPC (não … · 2019-04-18 · (Neuroendocrine-like) DNA damage. Aggarwal et al. JCO 2018 • Up to 1/5 of mCRPC presents treatment-emergent](https://reader035.vdocument.in/reader035/viewer/2022070905/5f743c686216800b757e724e/html5/thumbnails/2.jpg)
Satraplatin
![Page 3: Quando associar platina ao tratamento do CRPC (não … · 2019-04-18 · (Neuroendocrine-like) DNA damage. Aggarwal et al. JCO 2018 • Up to 1/5 of mCRPC presents treatment-emergent](https://reader035.vdocument.in/reader035/viewer/2022070905/5f743c686216800b757e724e/html5/thumbnails/3.jpg)
Quigley DA et al Cell 2018
![Page 4: Quando associar platina ao tratamento do CRPC (não … · 2019-04-18 · (Neuroendocrine-like) DNA damage. Aggarwal et al. JCO 2018 • Up to 1/5 of mCRPC presents treatment-emergent](https://reader035.vdocument.in/reader035/viewer/2022070905/5f743c686216800b757e724e/html5/thumbnails/4.jpg)
TAXANES
AR abnormalities are not a negative predictive factor!
Quigley DA et al Cell 2018Conteduca V et al. Eur Urol 2019
![Page 5: Quando associar platina ao tratamento do CRPC (não … · 2019-04-18 · (Neuroendocrine-like) DNA damage. Aggarwal et al. JCO 2018 • Up to 1/5 of mCRPC presents treatment-emergent](https://reader035.vdocument.in/reader035/viewer/2022070905/5f743c686216800b757e724e/html5/thumbnails/5.jpg)
Quigley DA et al Cell 2018Conteduca V et al. Eur Urol 2019
TAXANES
AR abnormalities are not a negative predictive factor!
Immuno Platinum
+ RB1 (Neuroendocrine-like)
DNA damage
![Page 6: Quando associar platina ao tratamento do CRPC (não … · 2019-04-18 · (Neuroendocrine-like) DNA damage. Aggarwal et al. JCO 2018 • Up to 1/5 of mCRPC presents treatment-emergent](https://reader035.vdocument.in/reader035/viewer/2022070905/5f743c686216800b757e724e/html5/thumbnails/6.jpg)
Aggarwal et al. JCO 2018
• Up to 1/5 of mCRPC presents treatment-emergent SCNC • Shortened survival • Mutually exclusive with DNA repair alterations
![Page 7: Quando associar platina ao tratamento do CRPC (não … · 2019-04-18 · (Neuroendocrine-like) DNA damage. Aggarwal et al. JCO 2018 • Up to 1/5 of mCRPC presents treatment-emergent](https://reader035.vdocument.in/reader035/viewer/2022070905/5f743c686216800b757e724e/html5/thumbnails/7.jpg)
DNA repair defects: therapeutic implications
16/18 (88%) responses olaparibe
Mateo J et al. NEJM 2015Pomerantz et al. Cancer 2017
6/8 (75%) responses carboplatinGermline BRCA2
![Page 8: Quando associar platina ao tratamento do CRPC (não … · 2019-04-18 · (Neuroendocrine-like) DNA damage. Aggarwal et al. JCO 2018 • Up to 1/5 of mCRPC presents treatment-emergent](https://reader035.vdocument.in/reader035/viewer/2022070905/5f743c686216800b757e724e/html5/thumbnails/8.jpg)
Elevated Gleason combined with low PSA are associated with a Neuroendocrine signatureMahal BA et al. Eur Urol 2018
Aparicio A et al. CCR 2013
![Page 9: Quando associar platina ao tratamento do CRPC (não … · 2019-04-18 · (Neuroendocrine-like) DNA damage. Aggarwal et al. JCO 2018 • Up to 1/5 of mCRPC presents treatment-emergent](https://reader035.vdocument.in/reader035/viewer/2022070905/5f743c686216800b757e724e/html5/thumbnails/9.jpg)
Phase IImCRPCAgressive VariantN=135
Cabazitaxel
Cabazitaxel+
Carboplatin
Corn PG et al. ASCO 2015
![Page 11: Quando associar platina ao tratamento do CRPC (não … · 2019-04-18 · (Neuroendocrine-like) DNA damage. Aggarwal et al. JCO 2018 • Up to 1/5 of mCRPC presents treatment-emergent](https://reader035.vdocument.in/reader035/viewer/2022070905/5f743c686216800b757e724e/html5/thumbnails/11.jpg)