rulai.cshl.edurulai.cshl.edu/tissuespecclass/motifpairs.pdf · accession factor logo accession...

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Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec Novel-1 None A G T G GA G AG GA G C G T C M00445 Xvent-1 A C G T C G A T C G A G T C G A T G A TC T C T T G G C T T G C G T C FG 0.384 0.454 0.778 Novel-3 None G C G T C TA G T G GT A G C G Novel-4 None T A G A G A G GA G AA G G GA G FG 0.385 0.474 0.756 Novel-5 None C G GAA G G G C G T C T G G M01000 AIRE C G A C G TTA TTT A AG T T GGT TAT C G A TTG G C G T C G T G T A FG 0.390 0.416 0.804 Novel-7 None G T CT C CC T CC G T G C T C M00238 BarbieBox C T A A G T T A C C G T A AAAGG C C A T T G T A G C G T A A T G A G FG 0.392 0.560 0.656 Novel-9 None AT C A C T A G A AC T AG C T A G A Novel-10 None T A G C T A TT G T G A T C G AG A BG 0.394 0.476 0.736 Table 1: Five motif pairs with lowest classification error in Human AdiposeTissue. Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec Novel-1 Sp1 A G GA G G C G T C C G A G G C G M00468 AP-2rep T A C C T A A C G C T C T A G A C T G C A T G FG 0.353 0.736 0.558 Novel-3 None A G A G C G CG C A T G G G C C T M00528 PPAR G T A C G T A T G C A C T C T G A GGA C T G A T C AT A A GT G T G C T A FG 0.364 0.584 0.688 Novel-5 Sp-1 G G G CT G G T A G G M01014 SOX A T C G T CA T TTGA T G T C T A A G C T A C G C G T A FG 0.365 0.732 0.538 Novel-7 None T A G A C A AATT A T A T A G A Novel-8 None T A T A TAT A T A C G AG A G A BG 0.378 0.342 0.902 Novel-9 None ATA T A T G T A T C A C A T A T M00078 Evi-1 T A GAC T AAGAC T T A AGAT A A BG 0.380 0.442 0.798 Table 2: Five motif pairs with lowest classification error in Mouse AdiposeTissue.

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Page 1: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None A

GTGGA

GAGGAG

CG

TC M00445 Xvent-1

ACG

TCG

ATCG

AGTC

GAT

GATC

TCTT

GGCT

TGC

GTC FG 0.384 0.454 0.778

Novel-3 None GCG

TCTA

GTGGT

AGCG Novel-4 None

TAG

AG

AGGA

GAAGGGA

G FG 0.385 0.474 0.756Novel-5 None

CGGAA

GGGCG

TC

TGG M01000 AIRE

CG

ACGTTC

TATA

TGTA

CTA

CGT

ACTGG

GAT

CT

GA

CGT

CGA

CTTC

TG

ACGC

GT

CGTG

TA FG 0.390 0.416 0.804

Novel-7 None GTCT

CCCTCCG

TGC

TC M00238 BarbieBox

GCTA

CAGT

GTAC

CGTAAAAGA

TGC

GCAT

ACTG

CTAG

CGTA

ATG

CTAG FG 0.392 0.560 0.656

Novel-9 None ATCA

CTA

GAAC

TAGC

TAG

A Novel-10 None TA

GC

TATT

GTGA

TCGAG

A BG 0.394 0.476 0.736

Table 1: Five motif pairs with lowest classification error in Human AdiposeTissue.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 Sp1 A

GGAGGC

GTC

CGA

GGCG M00468 AP-2rep

TAC

CTA

ACG

CT

CTAG

ACTG

CATG FG 0.353 0.736 0.558

Novel-3 None AG

AGC

GCGC

ATGGGCC

T M00528 PPARCGTA

CGTA

ATGC

GACT

CTGAGA

GACTG

GATC

GA

CGTA

CGTA

AGT

GCGT

TGC

GTA FG 0.364 0.584 0.688

Novel-5 Sp-1 GGGCTGGT

AGG M01014 SOX

ATC

GTCA

TTTGAT

GT

CTA

AGCT

ACG

CGTA FG 0.365 0.732 0.538

Novel-7 None TA

GA

CAAATT

ATA

TA

GA Novel-8 None T

ATATAT

ATA

CGAG

AGA BG 0.378 0.342 0.902

Novel-9 None ATAT

AT

GTA

TCA

CAT

AT M00078 Evi-1GTAGAG

CT

TAAGAC

TTAAGAC

GT

CTA

CTA BG 0.380 0.442 0.798

Table 2: Five motif pairs with lowest classification error in Mouse AdiposeTissue.

Page 2: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 KROX GA

GGCTGGC

GAGA

CG M00469 AP-2α GCCAGTC

ATCG

TCAG

TCAG

TCAG

ATCG FG 0.379 0.536 0.706

Novel-3 NoneCGA

TAAA

TGA

CTTTG

AT

GT M00421 MEIS1BHOXA9 TGACG

ATCG

ACGT

AT

AT

CGAT

GA

GCT

TAG

CAG BG 0.382 0.570 0.666

Novel-5 None TTCT

CAT

AT

TAG

ATTA

CAG Novel-6 None

ATT

CAGA

TGA

TAGAC

TCT BG 0.385 0.444 0.786

Novel-7 Sp-1 GAGA

GGTGT

CTGGGG M00974 SMAD

GACT

CTGA

ACTG

ATGC

TCAGC

GACG

CTA

ATCG FG 0.385 0.518 0.712

Novel-9 None CGC

GCGGGAG

ACT

CG Novel-10 NoneCGGAA

GGGCG

TC

TGG FG 0.386 0.632 0.596

Table 3: Five motif pairs with lowest classification error in Human AdrenalGland.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 Sp1 GT

CCT

GCCTAGA

GCAA

C M00088 Ik-3AGT

TGAC

GTC

CAT

AGGGAAC

TTGA

ATC

ATC FG 0.336 0.652 0.676

Novel-3 None GTCG

AGCA

GC

ACC

ACGG Novel-4 KROX GGGCGGGT

AC FG 0.338 0.794 0.530

Novel-5 None GC

CAGT

AGGA

GCGAGA

G Novel-6 None GCGCCAGGGC FG 0.338 0.800 0.524

Novel-7 None TAAT

ATAA

TTATGA

TTA M00162 Oct-1

AGC

GTA

CGAT

CTA

CTATG

TGTA

AGCATT

AG

CT

CGAT BG 0.371 0.444 0.814

Novel-9 None CAT

AGAATATA M00145 Brn-2

ACTG

AGCT

AGTC

TA

ATA

CGT

ATGC

TAG

ATAAAT

TCAG

GTCA

TAG

GATC BG 0.371 0.462 0.796

Table 4: Five motif pairs with lowest classification error in Mouse AdrenalGland.

Page 3: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None GGCGA

CG

TGGGG

CCG Novel-2 None C

GCG

CG

CAGGAGGAC

G FG 0.378 0.440 0.804Novel-3 None

TAC

AAGCTT

GTCTC

GCG M00063 IRF-2

CGAT

AAACGC

TGAAAGC

GTC BG 0.380 0.412 0.828

Novel-5 None GCG

CGGA

CGCTAGC

G Novel-6 KROX CTGCCCG

CCTGCA

GC FG 0.381 0.500 0.738

Novel-7 NoneGCG

ATAAC

GCTG

CTCTG Novel-8 None GGT

CTTGC

GACGG

TAG BG 0.382 0.466 0.770

Novel-9 None TGCA

CGC

TAG

AGA

CGTG M00104 CDP-CR1

CGTA

CA

GACT

GTC

CTAG

CTA

CGT

AGTC

ATCG

ATGC BG 0.383 0.424 0.810

Table 5: Five motif pairs with lowest classification error in Human Amygdala.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None A

GGAGAG

TGGT

CG

TA

TG Novel-2 None A

TGC

AC

ATCCTCCT

CTC FG 0.391 0.586 0.632

Novel-3 None AG

TG

TGAA

TCGTAAAC

G M00025 Elk-1AGTC

ATGC

TGCA

CTGA

TGAC

TGACGGAT

ATCAG

AGCT

GTAC

GTAC BG 0.392 0.488 0.728

Novel-5 None AGGC

AAGA

GGGCAGC

A M00073 δEF1GCAT

GATC

AGCT

GTC

TAC

G

CTCATG

CTGA

TCGA FG 0.392 0.490 0.726

Novel-7 Sp-1 TGGGGGA

TTGGT

CG

TG Novel-8 None GC

GTAGGC

AGCG

TCGG FG 0.394 0.416 0.796

Novel-9 None TATCCA

TAGAGG

TAT

AC M00239 v-ErbA

ACG

GCTA

ACGT

GT

CAG

GAGGTCAA

TC

ATCG

AGC

AGTC

GTCA BG 0.394 0.428 0.784

Table 6: Five motif pairs with lowest classification error in Mouse Amygdala.

Page 4: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None AGC

AACAA

GAG

TGC

TTC M00193 NF-1

GACT

GATC

ACTTGG

G

AC

GCTA

TCGA

TACG

GTCA

CTGA

ACTG

GATC

AGTC

GCTA

CTGA

CTGA FG 0.380 0.466 0.774

Novel-3 None CTCA

CAC

GAGG

CTAC

TC Novel-4 None C

GAT

ATGGC

GCCTAGG FG 0.384 0.460 0.772

Novel-5 Sp1 GAGCGGGGA

GC

GC

TCG M00394 Msx-1

GATC

AGTC

ATCG

ACGT

CGTA

CTA

CGAT

CGT

ACTG BG 0.386 0.574 0.654

Novel-7 NoneAGC

GAC

CTGGCGCA

GG Novel-8 CdxA AGTAAT

AATTAT BG 0.387 0.592 0.634

Novel-9 None AG

AGG

CACAGGA

CTTG M00764 HNF-4

AGT

CG

TGA

GTAC

ACC

TACT

AT

AGC

GTA

TGC

TC

GATC FG 0.388 0.408 0.816

Table 7: Five motif pairs with lowest classification error in Human BoneMarrow.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None G

CCGCGG

CCGCG

CTGG

C M00916 CREBTACG

CATG

CGAT

ACGT

TGAC

CAGTG

CCA

ACTG

AGTC

CATG

ATCG BG 0.367 0.654 0.612

Novel-3 None TC

ACA

TCG

GC

ACTCT

CC Novel-4 NRF-2 GCCGGC

AACG

ATC

CG

AC BG 0.374 0.526 0.726

Novel-5 None CTCT

AGCTA

GA

CATT

CC Novel-6 Sp-1 ACGGC

GGCGCG BG 0.376 0.640 0.608

Novel-7 Sp1ACC

GGGCT

CGCCT

GTCC M00277 Lmo2

ATGC

ATCG

TAGCCAA

TG

ACGTGG

TC

GCAT

ATCG BG 0.378 0.498 0.746

Novel-9 NoneGAG

ATCCCTA

TGT

CGCA Novel-10 Nrf-1 GCGG

CTAC

CTGCT

CG

TC BG 0.379 0.550 0.692

Table 8: Five motif pairs with lowest classification error in Mouse BoneMarrow.

Page 5: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None G

AATTC

TTTC

TCTC

TGC M00321 MuscleInit

CAGT

ATGC

TAGC

TAGC

ATCG

TGAC

AGTC

TCAG

GTACCAA

GTC

AGTC

AGC

TAC

TACG

ATCG

TGAC

ACG

AGTC

GATC FG 0.390 0.462 0.758

Novel-3 None AAGACT

AGGA

GTGTC

T Novel-4 Sp-1 GTC

TC

ACCGCCT

CTC FG 0.397 0.390 0.816

Novel-5 PITX2GT

CGTAG

ATTC

ATC

AC

GA M00017 ATF

GTAC

ACGT

TACGTGACG

GCAT

GTAC

CGTA

TACG

AGTC

AGTC FG 0.397 0.462 0.744

Novel-7 Lyf-1 TTTAGGT

GCAGA

GAGC M00032 c-Ets-1

CGTA

AC

TACGGAC

TA

CAG

ACT

TCGA FG 0.400 0.492 0.708

Novel-9 None AT

GAAC

ATGA

TAAATG

ATA

TA M00431 E2F-1

AGCT

CGT

ATG

CCG

GC

CG

TGC FG 0.401 0.428 0.770

Table 9: Five motif pairs with lowest classification error in Human CD4TCells.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None A

GGACCC

AAGCA

CTA

AG M00650 MTF-1

ACGT

CGTTGCG

ACTCACC

TAG

CTG

AGC

GTAC

TGC FG 0.368 0.520 0.744

Novel-3 None AG

TAGA

GGC

TCAT

GGCC Novel-4 None C

TAG

CAC

GTGTCC

TAGGA

GA FG 0.372 0.412 0.844Novel-5 Hmx3 GCACC

TGTGG Novel-6 None G

CAGGCCTAGA

GTG

GCC

TCA FG 0.374 0.526 0.726

Novel-7 NoneCAA

GAT

TG

GCA

TGGAGA M00025 Elk-1

AGTC

ATGC

TGCA

CTGA

TGAC

TGACGGAT

ATCAG

AGCT

GTAC

GTAC FG 0.376 0.448 0.800

Novel-9 None CGAC

GGACAA

GTGAGC

G M00447 ARGA

AGA

TGA

GC

CGTA

CGT

ACTG

CAT

ATGTA

TCAT FG 0.376 0.558 0.690

Table 10: Five motif pairs with lowest classification error in Mouse CD4TCells.

Page 6: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecM00691 ATF-1 CG

CT

AGTC

CGT

CGAA

CGAT

AC

TA M00743 c-Ets-1

GC

GCAGGAT

AGTC FG 0.384 0.500 0.732

Novel-3 None ATGGT

GAAC

AGAG

ACAT

G Novel-4 None TC

ACTG

TGTCC

TCTC

CT BG 0.387 0.398 0.828

Novel-5 None AGGGG

ATGA

GAG

AGAG Novel-6 AP-4 AGCTG

CTGTG BG 0.390 0.496 0.724

Novel-7 None GGGTAGC

ATG

TGGAA

G M00626 RFX1 AC

AG

AT

CT

GA

AC

GCT

CTA

TG

AGG

CGTA

CAA

C BG 0.392 0.506 0.710Novel-9 None TT

CTCTA

CATCA

CCATC M00264 Staf

GTCA

GACT

CGT

CAT

ATCCCG

AACGT

GAC

CTGA

GT

CTGCT

AC

CGAT

GACT

ACTG

AC

CTAG

CGA BG 0.395 0.450 0.760

Table 11: Five motif pairs with lowest classification error in Human CD8TCells.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None G

AAGGA

CAGGA

AG

CAGC M00761 p53decamer

TCGA

AGG

AT

AGC

CGTA

CGTA

AGG

ACT

ATGC

AGTC FG 0.388 0.576 0.648

Novel-3 None TA

CGT

GCTTGGA

CTC

CT Novel-4 None AA

GGTGC

TCTA

TCATCA

TAG FG 0.390 0.546 0.674

Novel-5 NoneTCA

GC

TAA

GCGCAGA

GG M00317 PolyAGTAC

CATG

GTAC

TCGTGA

GT

CTG

CTG

AT

AGTC

ACT

TGAC

GTAG

CT

AGTC FG 0.393 0.502 0.712

Novel-7 None GA

TGT

GCGAGAA

GAG

TC Novel-8 None

CAGT

AAGA

CTAGA

GAGA FG 0.398 0.432 0.772

Novel-9 None ACA

CAGG

AAAG M01009 HES1CTGA

TCGA

ACG

TCG

ACG

TGTCGTGT

CG

ATGC

AGCT

GTAC

CTAG FG 0.401 0.520 0.678

Table 12: Five motif pairs with lowest classification error in Mouse CD8TCells.

Page 7: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 Sp-1 GGC

GCGT

CTGGGGA

G Novel-2 NoneTGGA

GGACGCC

AGAG FG 0.360 0.504 0.776

Novel-3 NoneCTAAAAC

TATA

TCTA

GTC

T M00526 GCNFTGAC

ACGT

TAGC

CTGA

GTA

A

GCGTTCAC

ATG

A

CGT

A

CGT

TC

CGTAG

TAC

AGTC BG 0.363 0.568 0.706

Novel-5 None ACA

GAT

ATAC

TGTAAG

ACA M00225 STAT3

ACGT

ACTG

ACTG

ATGC

GA

CATTTCCC

GGT

GAATGA

A

GCT

TACG

CTGA

CGAT

GACT BG 0.366 0.640 0.628

Novel-7 None CT

TAAAG

AACT

CA

GCA

TA M00128 GATA-1

CTGA

ACGT

TGAC

CGTAGATAC

TGA

TCAG

CTAG

TCAG

ATCG BG 0.370 0.588 0.672

Novel-9 None TTGTT

GAG

TAG

TAA

GGC M00742 HFH-4GCTA

AT

ATG

GACT

AG

A

TTTAG

CT

AT

AT

GTA BG 0.374 0.632 0.620

Table 13: Five motif pairs with lowest classification error in Human Cerebellum.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None GA

GAG

CGGA

CTCAGC

GG Novel-2 None GCTAGGT

AGGC

GACA

GG FG 0.371 0.462 0.796Novel-3 None C

GAG

AGGT

GACGC

GCGG Novel-4 None GGT

ACGAGC

GGAGC

GCG FG 0.379 0.526 0.716

Novel-5 None AC

GCA

CGACT

CCCAT

GCCT

C Novel-6 None CGCAGCTGCC FG 0.379 0.636 0.606

Novel-7 CAC-bind GGCGC

GATGGGT

CG

TCG Novel-8 Sp1 C

GCAGGGA

GGAC

AGGA

GAG FG 0.380 0.530 0.710

Novel-9 None TGCA

CAAC

AAGAAT

GTA Novel-10 None AA

GTTAC

CA

TAA

GTGT

A BG 0.381 0.442 0.796

Table 14: Five motif pairs with lowest classification error in Mouse Cerebellum.

Page 8: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None GC

ACG

CGG

CTGGAA

GG Novel-2 Nrf-1 CGCATGGCG BG 0.326 0.714 0.634

Novel-3 Sp-1 CGAGGGCGG M00651 NF-muE1

GCC

GGCCATTC

GT BG 0.336 0.728 0.600

Novel-5 Sp-1 ATA

GTCGG

AGAGCGT

GG M00189 AP-2GAC

ATG

TCCT

CACG

AGC

TGAC

ACTG

ACG

GAC

ATCG BG 0.346 0.588 0.720

M00539 ArntTAGC

TGCA

CTGA

GTCA

CATG

TCAG

AGTCACGTGT

CA

AGTC

GATC

ACGT

GACT

ACGT

ATCG M00803 E2F

CG

CGCGG

CACTG BG 0.347 0.832 0.474

Novel-9 None CGAGGCGT

CG M00025 Elk-1AGTC

ATGC

TGCA

CTGA

TGAC

TGACGGAT

ATCAG

AGCT

GTAC

GTAC BG 0.348 0.698 0.606

Table 15: Five motif pairs with lowest classification error in Human DorsalRootGanglia.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None C

GTCGGC

GTGT

CTGGC

G M00057 COMP1ACGT

ACG

ACGT

ACGT

AT

AGT

CG

TA

AT

AT

AG

CGA

GC

CTGA

TGA

TGC

TGA

CGAA

CG

CA

CAG

CAG

CGT

ATCG FG 0.365 0.802 0.468

Novel-3 None GCTCGG

CAGGG

CGC

CG M00927 AP-4

CAG

GTAC

GC

CTA

CG

AGCTGA

TC FG 0.368 0.612 0.652

Novel-5 None CG

CGGAC

GCGC

GAC

AGG Novel-6 None C

GGC

TC

CGGGCT

GCG

CGGC FG 0.369 0.684 0.578

Novel-7 None CG

ACGCC

GGCTGCG

C M00233 MEF-2GTCA

TAGC

AGCT

ATG

GAT

GTT

GA

G

CC

TC

TAT

AAAAC

TAA

GTGCA

CTA

G

TCA

GTAC

GACT FG 0.371 0.648 0.610

Novel-9 Sp-1 TAGGGA

CATG

CG

CGGT

C M00532 RP58ACTG

TCGA

CA

GACAG

TG

CTGCTG

GCA FG 0.374 0.432 0.820

Table 16: Five motif pairs with lowest classification error in Mouse DorsalRootGanglia.

Page 9: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None AG

AACTA

CTGT

AGAAC

A Novel-2 None TA

GTAAT

AAGTATG

TTA

GA BG 0.351 0.636 0.662

Novel-3 None ATA

CA

GTTTTC

A M00241 Nkx2-5GCA

TTAATAT

ACG BG 0.351 0.662 0.636

Novel-5 None AC

GCCCTG

CGCCA

CAC Novel-6 None

TGCCT

ACG

TCCA

TGGG FG 0.354 0.670 0.622Novel-7 None C

TTTTTCACT

GCC

TGACT Novel-8 None TTTC

TACC

ACGAT

GTC

TAT BG 0.355 0.548 0.742

Novel-9 None TGGG

AGTG

GCA

TCGAG Novel-10 None CA

TGGGTG

AGCCT

CGC FG 0.355 0.682 0.608

Table 17: Five motif pairs with lowest classification error in Human Heart.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 Sp-1 A

GACG

TA

TGGGC

AGGAG Novel-2 None GA

GAC

CGA

GTGGCG

TCG BG 0.389 0.454 0.768

Novel-3 None CA

CG

TGGAGT

GCGG

AAG Novel-4 None GGA

CTGC

GCG

AC

AGGT

C BG 0.390 0.444 0.776Novel-5 KROX G

TGCCT

CGT

TCCCA

CTC M00124 Pbx1b

TGAC

GCTA

GTAC

C

GA

C

TCCAATC

G

T

CA

C

GTA

CGTA

GCAT

GCAT BG 0.402 0.492 0.704

Novel-7 None CAAA

GGCCCA

TCGT

CCATC

G M00075 GATA-1ATGC

TACG

GACTG

C

TA

A

C

G

TCTAG

ATCG

ACTG

ACTG BG 0.404 0.496 0.696

Novel-9 NoneTAT

AGAG

CA

GAGC

GGAA M00985 Stra13

ATGC

AGCT

TACG

CGTCAT

CGTGTCAT

GC

AGTC

CGTA FG 0.405 0.412 0.778

Table 18: Five motif pairs with lowest classification error in Mouse Heart.

Page 10: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None GC

GTAGA

GAG

AGGCT

G M00243 Egr-1CGTA

CAGT

AG

T

CA

GCGTA

GGGTACGG

T FG 0.394 0.536 0.676Novel-3 KROX GC

GTACGC

GGGGAC

CG M00941 MEF-2

TAG

TCGT

CCT

CTATATA

TATA

TGA

CTAG FG 0.401 0.524 0.674

Novel-5 Sp-1 TC

GCCCCA

TGCG

CACC Novel-6 None GT

GGAAGGC

GTGA

GCG FG 0.402 0.432 0.764

Novel-7 NoneCAAAG

TTA

GCT

TA

TAAC

A Novel-8 None CA

CAAGC

AT

TGCTC

GCG BG 0.403 0.464 0.730

Novel-9 KROX GGAGGGCT

GCG

TGC

G M00331 LV-TATAGTAC

GA

TCAG

TA

TCGA

CA

ACG

CTA

TA

AGC

GT

TAGC

AT

GA

GACCC

AG

ACAG

AAG

GTCA FG 0.403 0.486 0.708

Table 19: Five motif pairs with lowest classification error in Human Hypothalamus.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None GT

CGGC

AGCG

AG

AGGA

C M01013 IPF1GACT

ATCG

CATG

ACG

ACT

TACATC

TTAC

TAG

GCTA

ATCG

GACT

ATGC FG 0.374 0.516 0.736

Novel-3 None TG

CGC

GGCG

TCA

TGTCG Novel-4 None GGA

CTAGA

CTA

TGCC FG 0.380 0.492 0.748

Novel-5 None CGA

GGTAGA

GCAGC

GCG M00744 POU1F1

GTATGG

CTA

TATG

TAT

AGTA

CAT FG 0.382 0.548 0.688

Novel-7 None GGTAGT

GGAG

TG

TAG

CG Novel-8 None CT

ATGAGC

ATCAAA

GAG FG 0.384 0.482 0.750

Novel-9 None AC

AG

AC

ACC

GCTAGCG

C M00423 FOXJ2CGA

ACTA

CTAC

TAACT

GA

CGT

CT

GT

AGT

ACGT FG 0.385 0.546 0.684

Table 20: Five motif pairs with lowest classification error in Mouse Hypothalamus.

Page 11: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None A

GGGCAGAG

TG

TAG

CG Novel-2 None T

GGAGCCCAG FG 0.370 0.462 0.798

Novel-3 None GCCA

CTGGGCA

TGTCG Novel-4 None T

GGGCTGCTG FG 0.381 0.476 0.762

Novel-5 None TAGA

GCGCCT

AAGC

GAC Novel-6 None C

GTAGGG

CCAGGCG

AC FG 0.381 0.564 0.674

Novel-7 None AGTTTTG

AT

TA

CGA

TA

CTA M00326 Pax-1 CCGTTA

CCGGCTCTAGATAT BG 0.383 0.624 0.610

Novel-9 None GCA

CGCCTGG Novel-10 None CCA

CGAGG

CCCT

CGC

G FG 0.384 0.588 0.644

Table 21: Five motif pairs with lowest classification error in Human Kidney.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None AC

GGAG

AGA

TACC

AATA Novel-2 PPAR AA

GGGGA

CAAC

AG

TGAG FG 0.389 0.396 0.826

Novel-3 None CG

GC

TCTG

CCT

GCTGA

G M00684 XPF-1GTCG

AT

TGG

ATAG

CGAC

AGC FG 0.389 0.460 0.762

Novel-5 None ATCTG

TGTCAG M00469 AP-2α GCCA

GTC

ATCG

TCAG

TCAG

TCAG

ATCG FG 0.392 0.690 0.526

Novel-7 None AGAC

GGC

GTCT

ACGAA

G M00206 HNF-1GTAGG

CT

CT

GA

GTA

ATC

GT

TCA

GATTG

CTA

GTAA

CATC

CTA

GCA FG 0.393 0.438 0.776

Novel-9 None CT

AGC

CA

TCT

CTCTGTA Novel-10 None T

CTC

TC

TCTA

GCTCCC

T FG 0.393 0.554 0.660

Table 22: Five motif pairs with lowest classification error in Mouse Kidney.

Page 12: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None CT

AGAG

ACG

ACA

TGAGG Novel-2 None C

TCA

GCT

AGAG

GC

ACTC

GAG FG 0.346 0.570 0.738Novel-3 None

AGGCA

TGGAG

CG

AT

TG Novel-4 None CCA

TGACG

ACCT

CCTA FG 0.355 0.566 0.724

Novel-5 NoneTGC

ACT

ACGCCA

TGGG Novel-6 None CATCT

AGAGGA

CCTC FG 0.358 0.482 0.802

Novel-7 None GCGGCTCGG

CCGG

C M00103 CloxCGAT

GCTA

CAGTATT

CGATG

ACT

C

GTA

CAGT

GACT

CAGT

CGAT BG 0.358 0.630 0.654

Novel-9 NoneCAT

GA

CTTTC

AT

TAAT

ACA Novel-10 None T

CGCCGG

CACT

GCGCG BG 0.359 0.570 0.712

Table 23: Five motif pairs with lowest classification error in Human Liver.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None GC

GCG

TCC

GCG

AGC

GCG Novel-2 GABP CAGCC

TTCCG BG 0.325 0.654 0.696Novel-3 None C

GTCGC

GCG

CGCT

GGCG M00332 Whn

CGTA

TCGA

AGTC

TACGACGCA

GCT

CGAT

ACGT BG 0.329 0.682 0.660

Novel-5 None AG

TGC

GCG

TCC

GGCGGC Novel-6 None GT

CCGGA

CTGC

GACC

GG BG 0.332 0.572 0.764Novel-7 None C

GTGCGC

GCGC

GACGG

C Novel-8 None CGCG

AGGCG

CCGCA

TCG BG 0.332 0.598 0.738

Novel-9 None AGTGT

AGAGCT

CTCTT

G Novel-10 None AAGGC

ATCAAC

GAGGCA FG 0.379 0.530 0.712

Table 24: Five motif pairs with lowest classification error in Mouse Liver.

Page 13: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 HNF1

GTAAT

ACTA

CT

GATTT

AATA Novel-2 None

GA

GA

CAT

ATGTA

TTA

GAT

A BG 0.307 0.588 0.798Novel-3 None AT

ATA

GTC

ACTA

ATTT

ACAT Novel-4 None AC

AGTATA

TTGATG

ACA

CTA BG 0.307 0.610 0.776

Novel-5 MEF-2 AT

CGATTTAG

TA

CTA

CAAT

A M00102 CDPCGAT

GCTA

CAGTATA

TCGATG

ACT

C

T

GA

CAGT

G

ACT

CGAT

GCAT BG 0.308 0.640 0.744

Novel-7 None TCCG

CTA

CGCCA

TGCG Novel-8 None CT

ACGCCCA

CAGG

CAC FG 0.331 0.618 0.720

Novel-9 None ATGGAGTG

TGG

CGA

CG Novel-10 Sp-1 G

CCTCT

GCCCTACGG

C FG 0.339 0.532 0.790

Table 25: Five motif pairs with lowest classification error in Human Lung.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 Sp-1

TCG

AGGT

GACGC

GGGAC Novel-2 None C

GGC

TC

CG

AGGC

GTAGG FG 0.334 0.706 0.626

Novel-3 Sp-1 GCG

TAG

AG

TGC

GCTGGG Novel-4 CAC-bind

CTGGGC

GATGGGA

GTCG FG 0.347 0.600 0.706

Novel-5 Sp-1 CGA

GAGGGC

AGGA

CTGG Novel-6 None GC

AGAGGC

GAC

CAG

AGG FG 0.347 0.602 0.704

Novel-7 None ACA

TAG

AACAT

ATCAT

A Novel-8 IRF ATACATGAATA BG 0.364 0.458 0.814

Novel-9 None TA

GT

GAAG

ATAATG

ATA Novel-10 None T

ACAGAT

GAATGG

TACT BG 0.365 0.472 0.798

Table 26: Five motif pairs with lowest classification error in Mouse Lung.

Page 14: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None G

TTGA

GCT

CT

GTCTTG

T Novel-2 None TTG

TGCCTGA

TG

AG

CG

CT FG 0.383 0.612 0.622

Novel-3 None TC

TC

TCTG

CTCA

CTGAG Novel-4 None AGC

GTAAG

CTA

CG

TAA

G FG 0.393 0.426 0.788Novel-5 None GGG

CGC

TCG

AGGGCG M00214 SEF-1

CGA

GA

TGC

CACC

GCG

CAC

GT

GA

GCTCTGC

TGGTATC BG 0.402 0.436 0.760

Novel-7 IRF AACGA

TAGT

AGAAC

ACT Novel-8 None AGC

GCAAA

GTC

TG

CGG

C FG 0.403 0.372 0.822Novel-9 None TG

CCGGC

GC

TCGG

CGC M00670 TCF-1

AGG

TGCA

GGTGTT BG 0.405 0.412 0.778

Table 27: Five motif pairs with lowest classification error in Human LymphNode.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None GCT

GCTAC

CGGG

CCG

GC M00095 CDP

ATC

TC

TA

CATAT

ACT

GTCA

GGTA

CGAT BG 0.363 0.474 0.800

Novel-3 NoneTGG

CAC

TGC

GCGCAG

CG M00734 CIZ C

GAAAAATCGA

AGCT

GTAC BG 0.364 0.570 0.702

Novel-5 NoneACG

CG

ACGC

GTGGCGC

G Novel-6 None GGAGCT

GCGG BG 0.365 0.506 0.764Novel-7 None

TGCGG

CGC

TCCT

CCGG

C Novel-8 None CGCGGC

TCCC

GCGC BG 0.368 0.530 0.734

Novel-9 CAC-bind GAGG

ATGGA

CTAGA

GCG M00035 v-Maf

CGTA

CGAT

GCTA

G

ACT

T

AG

T

AC

ACT

A

CTG

GAT

CACGT

TGAC

C

GTA

A

TG

TAGC

TCGA

GATC

TGCA

TGCA FG 0.371 0.468 0.790

Table 28: Five motif pairs with lowest classification error in Mouse LymphNode.

Page 15: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecM00025 Elk-1

AGTC

ATGC

TGCA

CTGA

TGAC

TGACGGAT

ATCAG

AGCT

GTAC

GTAC M00695 ETF

TGA

GC

TGGA

CCGG BG 0.387 0.596 0.630

Novel-3 NoneATC

TCT

ATG

TACGTAC

AG Novel-4 Nrf-1 CGCAT

GGCG BG 0.392 0.364 0.852Novel-5 None AG

AGA

CAAT

CACGA

GTA

GT Novel-6 None G

AATG

ATAATG

ATGA

ATC

GAT FG 0.394 0.572 0.640

M00444 VDRAGA

GTGG

TTACG

CGTA

CAG

ACTG

CTAG

TAG

AGT

GCGAT

TCG

CGTA Novel-8 None T

GGGCGG

CTGAGGA

CG FG 0.396 0.434 0.774

Novel-9 None TAGT

GGAGAA

GAG

TGTA Novel-10 None C

AAAGGC

AAGA

TA

CTG

TA FG 0.398 0.450 0.754

Table 29: Five motif pairs with lowest classification error in Human OlfactoryBulb.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 CAC-bind

ATC

TG

AGGGG

CTGGCG Novel-2 None A

CCATC

TCAT

AGC

GCATTGC FG 0.366 0.600 0.668

Novel-3 None CGC

GCG

AGGC

GGACGC Novel-4 None CA

CAGGG

CTGCC

ATGG

C FG 0.379 0.458 0.784M00773 MYB

CTGA

ATCG

CAGT

ACTG

ATCG

AGTC

TGCAGTG

TTCAG Novel-6 None C

TAAATCT

CCA BG 0.385 0.652 0.578Novel-7 None

CT

ATTT

ACATA

TC

ACCA Novel-8 None T

AATA

TTCTGA BG 0.389 0.438 0.784Novel-9 None AG

ACA

TCC

AAGA

GACA

T Novel-10 None GT

GTTG

TGTGC

GTTTG

T BG 0.391 0.520 0.698

Table 30: Five motif pairs with lowest classification error in Mouse OlfactoryBulb.

Page 16: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None T

CTGTCT

CTGAG

CA

GTCA Novel-2 None

CAT

CTTC

TTCA

GAT

AT

GTA FG 0.364 0.482 0.790

M00976 AHRHIFACGT

AG

A

CGTGGTAC

ATCG

TACG Novel-4 Sp1

CAG

AGGC

GCGAGGA

GC BG 0.364 0.544 0.728Novel-5 None G

TCACA

CGCCGTC

GCG Novel-6 None

AGG

CGCAC

TGGCC

GTC BG 0.368 0.564 0.700

Novel-7 None AC

TGG

CCACCCGG

CAG Novel-8 None

AG

AGAC

GGCCGGG

ACG BG 0.371 0.524 0.734

Novel-9 None TG

CG

CAGG

CCACCCA

G Novel-10 None GCGCC

GCG

CGGT

CGG BG 0.376 0.512 0.736

Table 31: Five motif pairs with lowest classification error in Human Ovary.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecM00716 ZF5

TAG

TACG

CAG

TAGC

CTAG

AGTC

ACTGA

G Novel-2 Sp-1TAGGGT

CGGAG

CG

ACG

CG FG 0.295 0.740 0.670

M00079 Evi-1CGTA

TGAC

TAAGACT

CAG

A M00802 Pit-1GCTA

TCA

AT

CGTCC

TA

AT

CTGA

CTA

GAT

CGT

CGA

CAT

GCTA

GATC

GTCA

GATC

CTA BG 0.334 0.644 0.688

M00619 Alx-4 CCTGAGAATAATC Novel-6 MEF-2 AAAATACA

CTA

CT

GCTA BG 0.338 0.612 0.712

M00138 Oct-1CAGT

GACT

CGTA

ACGT

CTAG

CGTA

CGAT

GCAT

T

GCA

CGT

C

ATG

GATC

CTA

GTA

C

GA

CGAT

GCAT

GCTA

CGTA

CGTA

GTCA

ATCG

CGTA Novel-8 None A

TATC

ATTGTC

TTCTC

A BG 0.344 0.542 0.770M00616 AFP1 AA

TATAAT

CATG

AGCAT

C Novel-10 None ATA

TTAT

AT

GT

GAAAA BG 0.345 0.498 0.812

Table 32: Five motif pairs with lowest classification error in Mouse Ovary.

Page 17: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecM00489 Nkx6-2

CTAG

CAT

TGA

GTATAAA

TAGT

CGTA

ACGT

ACGT M00976 AHRHIF

ACGT

AG

A

CGTGGTAC

ATCG

TACG BG 0.394 0.628 0.584

M00701 SMAD-3ACT

AGG

TCCTGA

CTCA

CT Novel-4 None C

GACG

TAGT

GTGCAA

GG FG 0.397 0.434 0.772Novel-5 None

AGC

ACT

ACGCCCAGT

G Novel-6 None CAGCT

ATGCCA

CCAG

C FG 0.399 0.522 0.680Novel-7 None GT

GCG

ACT

AGGCGAC

G Novel-8 None AGCGCAC

GAG FG 0.400 0.452 0.748M00698 HEB A

GCCTAGCTG Novel-10 None AT

GAG

AG

CGAGGA

GTCA FG 0.401 0.462 0.736

Table 33: Five motif pairs with lowest classification error in Human Pancreas.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecM00803 E2F

CG

CGCGG

CACTG Novel-2 GABP A

GCCTTCCGC

G BG 0.310 0.684 0.696M00144 BSAP

CAG

GA

TAC

ACG

GAT

AG

GTA

ACGT

GAT

GCT

GTC

CT

ACTG

GA

GAGCGG

TAG

TACA

CG

GA

CT

CGTA

ACG

TAC Novel-4 None

TACGGGCCGCG BG 0.317 0.752 0.614

Novel-5 None TCT

GTTT

CACTG

CATG

T Novel-6 None ATG

GA

CAAT

AC

TACAT

G FG 0.368 0.530 0.734M00342 Oct-1

G

ACTATG

A

CGAAG

ACAGT

TGAC Novel-8 None T

ATGGAT

AGAT

AGA

TGA FG 0.372 0.448 0.808

M00209 NF-YGCAT

GTCTGATTGGC

TACT

GAA

CG

ACT Novel-10 None T

AGCAGAGT

CA

CA

TAA

G FG 0.376 0.532 0.716

Table 34: Five motif pairs with lowest classification error in Mouse Pancreas.

Page 18: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None G

TCTC

TCAGA

CGTAGAC

G Novel-2 None GACT

CACT

CGCTCA

TTC BG 0.394 0.478 0.734

M00155 ARP-1CT

CG

CAA

GGTC

TCT

CACTTGG

AGAC

AC

TC

GTC

AT Novel-4 None AAT

ACAG

TTGC

GTA

CGA BG 0.395 0.412 0.798

M00313 GEN-INIATGC

ATGC

AGCT

TC

CAC

AGT

GAT

AGCT Novel-6 None GC

GCGAGT

CGAGCGC

G FG 0.397 0.432 0.774M00634 GCM

TAC

GTCA

ACGT

TAGCCA

CATGCAG

TAGT Novel-8 None A

TGGC

GCACC

TTCCAA

G BG 0.398 0.442 0.762Novel-9 None A

GTGGAGC

TAGT

CTGG Novel-10 None GA

CCAG

CGC

GAG

AGGT

CGG FG 0.400 0.370 0.830

Table 35: Five motif pairs with lowest classification error in Human Pituitary.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecM00448 Zic1

ACGT

TCAG

ACTG

ACTG

ACGT

ATCG

ACG

AGCT

TGAC Novel-2 None T

GGGTCG

AT

AGA

TGAGG FG 0.385 0.606 0.624

Novel-3 None CACATA

TCTA

TAC

CAT

A Novel-4 None GAAC

AGATT

AGT

CA

CAA BG 0.392 0.462 0.754

M00761 p53decamerTCGA

AGG

AT

AGC

CGTA

CGTA

AGG

ACT

ATGC

AGTC Novel-6 Sp-1

AG

TGA

GGAC

CGGC

GAGC FG 0.393 0.468 0.746

M00419 MEIS1GATC

GCTA

TCAG

AGTG

GTACAA

TCG

CTAG

CAGT

ATGC Novel-8 Sp-1 C

GTGGGGT

CGATG

TGA

G FG 0.394 0.500 0.712M00312 Bel-1

GTA

GAT

GCA

TAC

C

ATGCTT

GAGTC

TAG

GTC

CGAT

ATG

GAC

CAG

ATCG

CTG

ACTG

GTCAT

CGAT

GCAT

GTC

AGC

GCA

GCA Novel-10 Sp-1 C

AGGCAG

AGGT

CGTGA

G FG 0.398 0.428 0.776

Table 36: Five motif pairs with lowest classification error in Mouse Pituitary.

Page 19: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 Sp-1

TGGGGA

GCAGGC

AG

AG Novel-2 None CTCCT

CGC

GC

AGCCG

C FG 0.358 0.542 0.742M00040 CRE-BP1 TG

TACAGTT

CA

CA Novel-4 None AC

AGCAT

GATTTTG

ATA

TA BG 0.361 0.600 0.678

Novel-5 MAZR AG

TGGG

CGAGA

GGGAC Novel-6 None CCG

AGGGAG FG 0.363 0.632 0.642Novel-7 Sp-1 GA

GGTGA

GTCGA

GGCG Novel-8 None GGAA

CG

ACCT

CCGA

GCG FG 0.363 0.652 0.622

M00465 POU6F1CAG

TAC

TA

AT

CTA

CGAA

TTATAG

T Novel-10 None TTAT

AGT

CTAT

GAAG

ACA BG 0.364 0.526 0.746

Table 37: Five motif pairs with lowest classification error in Human Placenta.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecM00616 AFP1 AA

TATAAT

CATG

AGCAT

C Novel-2 None GGTC

TACA

CATG

TGA

CC BG 0.387 0.386 0.840Novel-3 NF-muE1 ATGGCC

GGAC Novel-4 Nrf-1 CGCC

AGCTGCGT

CCGA BG 0.387 0.428 0.798

M00102 CDPCGAT

GCTA

CAGTATA

TCGATG

ACT

C

T

GA

CAGT

G

ACT

CGAT

GCAT Novel-6 None AA

GGCTC

TCGA

AGCCC

T BG 0.392 0.540 0.676Novel-7 None C

TCTCG

AT

ATC

GTCA

TG Novel-8 NoneCTG

CTCCA

TAGTG

CCTCTA

G FG 0.393 0.394 0.820M00626 RFX1 A

CAG

ATCT

GA

AC

GCT

CTAT

GAGG

CGTA

CAA

C Novel-10 None CG

GA

AGGA

CTCAGC

GCG BG 0.393 0.454 0.760

Table 38: Five motif pairs with lowest classification error in Mouse Placenta.

Page 20: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecM00444 VDR

AGA

GTGG

TTACG

CGTA

CAG

ACTG

CTAG

TAG

AGT

GCGAT

TCG

CGTA Novel-2 None GT

CGCCA

CTGGCC

TCG FG 0.372 0.550 0.706

Novel-3 NoneAGC

ACA

GGCGCG

TGGG Novel-4 None CCATGGGGCCTC

GGC FG 0.375 0.514 0.736

Novel-5 None TA

CA

GA

TCAAG

TGAA

TTCT Novel-6 None G

AACAG

ACGA

TGAT

ACAGT BG 0.377 0.440 0.806

Novel-7 None CTGCC

ACCTCCG

CA

AG Novel-8 None ATGGT

CGCA

CACA

GCCCAC FG 0.380 0.508 0.732

Novel-9 None AGCAT

GAAAG

TA

CTA

TCTA Novel-10 None AAAG

TCAATTG

T BG 0.381 0.566 0.672

Table 39: Five motif pairs with lowest classification error in Human Prostate.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecM00099 S8

CGAT

GCAT

CAGT

CGTA

TGAC

GACT

A

TC

CGAATTAC

TGA

AGTC

ATGC

CGAT Novel-2 Sp1

TCG

AGGGCT

GGGACG

TC FG 0.384 0.490 0.742

M01000 AIRECG

ACGTTC

TATA

TGTA

CTA

CGT

ACTGG

GAT

CT

GA

CGT

CGA

CTTC

TG

ACGC

GT

CGTG

TA Novel-4 None

CA

CAATG

AACAT

ACAT

A BG 0.385 0.454 0.776M00476 FOXO4

GTCA

ACGT

CTGTTGTTC

AT

TA

TCT

ACG

GCAT

ACGT Novel-6 None C

GAC

TGC

GCAGGT

CGGG FG 0.385 0.570 0.660M00793 YY1

ATG

AGC

TC

CGA

CGT

AGTC

CAGT

ACGT

ACTG Novel-8 Sp1 C

GAGC

GACG

TGGGCA

GG FG 0.387 0.620 0.606Novel-9 MEF-2 C

TGCTTTTC

AGAAG

AGA Novel-10 None

CGGT

CTGGGCT

GAGC

G FG 0.393 0.626 0.588

Table 40: Five motif pairs with lowest classification error in Mouse Prostate.

Page 21: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecM00939 E2F

GACT

AGT

AGCT

A

CG

CGCGG

CACTG Novel-2 KROX

AGCCGCCC

TGC

TC

AG

AC BG 0.320 0.740 0.620

Novel-3 Sp-1AGA

GGGCGGTGA

GAC Novel-4 None G

TCACGCCC

TGC

GC

GC BG 0.322 0.712 0.644

M00978 LEF1TCF1TGAC

GC

ACTTTA

GTA

AT

ACG

GACT

AGCT Novel-6 None AT

AATTC

GAAC

AACGA

CTA FG 0.324 0.546 0.806

Novel-7 None AGTA

AT

CGA

CT

ATTTG

TCA Novel-8 Oct-1 TTA

TCTCAT

ATA FG 0.327 0.546 0.800

Novel-9 Sp1 GGCGCGGGT

CTCG

CG Novel-10 None GC

GAGT

CGT

AG

GC

GAGG BG 0.327 0.750 0.596

Table 41: Five motif pairs with lowest classification error in Human SalivaryGland.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None GG

AATC

TCA

TAG

AAGGC Novel-2 None GGAA

GGCCG

CG BG 0.362 0.626 0.650

Novel-3 None GAG

CAGC

GGC

CGAGAA

G Novel-4 None GGCGTAGGCG BG 0.363 0.674 0.600

M00104 CDP-CR1CGTA

CA

GACT

GTC

CTAG

CTA

CGT

AGTC

ATCG

ATGC Novel-6 Nrf-1 GCGG

CCA

TGC

AGCC

GTC BG 0.369 0.706 0.556

M00803 E2FCG

CGCGG

CACTG Novel-8 NRF-2 A

GTCCGGG

AAG BG 0.374 0.728 0.524M00109 C/EBPβ

CTGA

CATG

TCGA

AT

AGT

TAG

CAGTGT

AC

CAAC

AGT

TACG

ACGT Novel-10 None TG

ATGAAG

AAGT

GA

TAA FG 0.384 0.414 0.818

Table 42: Five motif pairs with lowest classification error in Mouse SalivaryGland.

Page 22: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None G

CTA

GC

ATTCCGG

CGC Novel-2 Nrf-1

AGCGCT

GCA

GTGCGT

C BG 0.334 0.656 0.676M00227 v-Myb

AGCT

TAGC

CTAAC

CTGGA

TC M00939 E2F

GACT

AGT

AGCT

A

CG

CGCGG

CACTG BG 0.337 0.700 0.626

M00221 SREBP-1CGT

GATCACCCCAC Novel-6 GABP CG

ACTTCCTGC

GAGTC BG 0.348 0.492 0.812

M00238 BarbieBoxGCTA

CAGT

GTAC

CGTAAAAGA

TGC

GCAT

ACTG

CTAG

CGTA

ATG

CTAG Novel-8 Sp-1 GA

CGGGGCG BG 0.348 0.722 0.582Novel-9 Sp-1 A

GAG

ATC

TCCCGCCT

C Novel-10 None GCGGAC

ACGCCGG

C BG 0.348 0.742 0.562

Table 43: Five motif pairs with lowest classification error in Human SkeletalMuscle.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecM00773 MYB

CTGA

ATCG

CAGT

ACTG

ATCG

AGTC

TGCAGTG

TTCAG Novel-2 ISRE G

AGAAAT

GAAT

CGAAG

A BG 0.385 0.678 0.552Novel-3 None G

ATACA

TTCAG

AACA

TA Novel-4 None AAG

AGAT

GGAAAT

ATGA BG 0.392 0.448 0.768

Novel-5 None ACT

CTCT

AGAG

GA

CGAG Novel-6 None

GCTCT

CCCAT

GCCA

C FG 0.393 0.456 0.758Novel-7 None T

ACTAGG

TTA

GT

TCTA

G Novel-8 NoneTAG

TAGGGAGA

GAGGT

A FG 0.397 0.444 0.762Novel-9 None A

CCGTCTGTG

CTC

TC

TC Novel-10 None C

GTGGGC

GAGACG

TGC

G FG 0.399 0.434 0.768

Table 44: Five motif pairs with lowest classification error in Mouse SkeletalMuscle.

Page 23: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecM00481 AR

CTAG

T

GCGAT

CTAC

CTGA

ACTG

ACTG

CTAG

ACTG

AGTC

AGT

AC

AGCT Novel-2 None ATT

GGTCCCT

CAGC

GC FG 0.364 0.504 0.768Novel-3 None

GTTG

TGTAAC

AGA

GTA

CTA Novel-4 OCT-x T

AGCAAAATT

G BG 0.368 0.444 0.820Novel-5 None A

TTCT

CAT

GTAT

AACA

CTA Novel-6 HP1 ATAA

TTCT

GCTTAC

ACAT

A BG 0.371 0.500 0.758Novel-7 None AG

CCTTG

TCAT

TA

TATATA Novel-8 None TTA

TGAT

ATA

GAT

AAT

GT BG 0.372 0.510 0.746

M00332 WhnCGTA

TCGA

AGTC

TACGACGCA

GCT

CGAT

ACGT Novel-10 None C

GCT

TGAG

AGTCT

CCAG FG 0.373 0.534 0.720

Table 45: Five motif pairs with lowest classification error in Human Testis.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecM00795 Octamer

CAGT

CATG

GCTA

CAT

GCAT

CGAT

CTAG

TAC

TA

A

C

GTCGTA Novel-2 None A

TGACA

GCA

ATCAT

CTA FG 0.376 0.482 0.766

M00532 RP58ACTG

TCGA

CA

GACAG

TG

CTGCTG

GCA Novel-4 None GT

GC

GCGCT

GCGCG

CCG BG 0.381 0.470 0.768

M00141 Lyf-1CGT

CT

ACT

AG

AG

CGG

ATAGG

A Novel-6 None ATAC

ACGTCAT

CAGA

TA FG 0.382 0.458 0.778

Novel-7 NoneAG

TCG

GCCGCCG

TCGG

C Novel-8 NoneCAGGC

GGTACGGC

AGCG BG 0.386 0.424 0.804

Table 46: Five motif pairs with lowest classification error in Mouse Testis.

Page 24: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None T

AGTA

GA

GA

CAG

ATTA

TAA Novel-2 None T

AGAAT

GA

TG

GAAT

ACGAT BG 0.355 0.532 0.758

M00045 E4BP4GTAC

CAG

ATG

TACT

AGTAAG

TC

CTAG Novel-4 None C

AATTA

TCTC

TTA

CAAT

A BG 0.355 0.590 0.700Novel-5 None TG

ATTG

TCTC

AATA

CTA

TA Novel-6 None G

AGTA

GAT

AATGTTC

AGAT BG 0.364 0.474 0.798

Novel-7 None GAGA

GGCTT

GCAGGG

C Novel-8 None TGGA

GGCGC

AC

CG

CGG FG 0.364 0.482 0.790

Novel-9 None ATAT

ACATTA

TGTA

GAGT

A Novel-10 None TA

GTAAT

GCGAAT

AATTG

T BG 0.368 0.498 0.766

Table 47: Five motif pairs with lowest classification error in Human Thymus.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecM00918 E2F

AGCT

AGT

AGCTC

GCGCGG

CATCG Novel-2 None AAG

ATC

TCA

TAAAC

AGC FG 0.350 0.608 0.692

Novel-3 Sp-1CGGGT

CGTG

TG

TAGCG

C Novel-4 GABP CGACTTCCC

G FG 0.374 0.518 0.734M00476 FOXO4

GTCA

ACGT

CTGTTGTTC

AT

TA

TCT

ACG

GCAT

ACGT Novel-6 None A

TCGCA

GCTAT

GCGG

CG FG 0.379 0.446 0.796Novel-7 None C

AAAACCA

CA

GA

TGA

TA Novel-8 Sp-1 C

AAG

TAGGGGCGT

GAG FG 0.381 0.462 0.776

Novel-9 None CTCTC

TCTTG

ACG

TA

AG Novel-10 None

AGC

CTCA

TTCTC

GGCAG BG 0.392 0.332 0.884

Table 48: Five motif pairs with lowest classification error in Mouse Thymus.

Page 25: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None C

GTCTGG

AAG

CGCC

AG Novel-2 None CCG

GTGA

CCGCCA

GCTCC

G FG 0.379 0.454 0.788M01017 PBX1

TGCA

AGTC

TGCA

ACT

AC

TCA

CTGA

GCAT

GTC

CTGA

CGAT

CTAG Novel-4 Sp1 GC

GCAGC

GAGGCC

GG FG 0.379 0.570 0.672M00652 Nrf-1 CA

GCTGATGCGCG

A Novel-6 Sp-1 TGGG

CCAGT

GAGC

AGC FG 0.390 0.516 0.704M00331 LV-TATA

GTAC

GA

TCAG

TA

TCGA

CA

ACG

CTA

TA

AGC

GT

TAGC

AT

GA

GACCC

AG

ACAG

AAG

GTCA Novel-8 None GCCGCT

GGG FG 0.390 0.534 0.686M00105 CDP-CR3

AGC

GCA

AGCG

AC

TCGA

GA

ACGT

TCGA

GACT

TCAG

CTATT

CGG Novel-10 Sp-1

ATGGGGCT

GGTGGA

C FG 0.391 0.508 0.710

Table 49: Five motif pairs with lowest classification error in Human Thyroid.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 AP-2 C

AAGATGAAC

TGAT

ACA Novel-2 None CGCCCGA

TGCC BG 0.331 0.780 0.558

M00657 PTF1β GAG

AGG

AAACA

GTC

GTC

GATCC

AAGC

G Novel-4 None GCGC

GCTCC

GCCGG

CGC BG 0.333 0.716 0.618

Novel-5 None TA

GTA

GT

GAAAAG

TATA Novel-6 Nrf-1 GCGCA

CCGTGC BG 0.333 0.726 0.608

Novel-7 Sp-1 GAAC

ATGGA

CA

CAT

AAG Novel-8 None GGCCGCGT

ACG BG 0.334 0.696 0.636

Novel-9 GABP AGCTG

TCCGCG Novel-10 None G

CCGC

GCGG

CCGC

GC

CG BG 0.340 0.564 0.756

Table 50: Five motif pairs with lowest classification error in Mouse Thyroid.

Page 26: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None TTA

GC

CTTG

TGT

CAAC

AG Novel-2 None CAGC

AGCTG FG 0.391 0.402 0.816M00241 Nkx2-5

GCA

TTAATAT

ACG Novel-4 None

ACTTT

CCATCTT

CTGCC FG 0.393 0.450 0.764

M00801 CREBAGTC

C

T

A

GCTC

C

T

AACGT Novel-6 None

CGG

AAG

CGCC

TAGAGG BG 0.397 0.402 0.804

Novel-7 None ACTT

CTTGGAC

A Novel-8 NoneGTCT

CCTC

TTCCTT

CTC FG 0.398 0.466 0.738

M00626 RFX1 AC

AG

AT

CT

GA

AC

GCT

CTA

TG

AGG

CGTA

CAA

C Novel-10 ISRE TAC

ATC

TCTTT

CTCCC

T FG 0.399 0.484 0.718

Table 51: Five motif pairs with lowest classification error in Human Trachea.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None C

AAACAT

CATA

TCAAC

A Novel-2 None GT

GCT

CTCCA

TGCCCCATG

C FG 0.387 0.410 0.816Novel-3 HFH-4 AG

ATACAAC

ACCA

GCAA Novel-4 Sp-1 GA

GGTG

TGA

CTGGA

GCG FG 0.387 0.534 0.692

Novel-5 NoneCTT

GCT

CTG

TGCTTA

TG Novel-6 None AGGCTAGGA

GC FG 0.388 0.514 0.710M00665 Sp3 AT

CG

TAC

AC

CGT

AGT

CG

TGGA

CG

CGA

AG

CGG Novel-8 None

GCA

GC

GCT

AGGCTCGT

G FG 0.393 0.514 0.700Novel-9 None A

GAGC

GATC

AC

CAGGGC Novel-10 None

CAAC

ACAC

ACAC

AAACACC

A FG 0.396 0.624 0.584

Table 52: Five motif pairs with lowest classification error in Mouse Trachea.

Page 27: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecM00918 E2F

AGCT

AGT

AGCTC

GCGCGG

CATCG Novel-2 None

CT

ACG

CTAG

AGTCCCC

A BG 0.326 0.668 0.680Novel-3 None

CTAGGCC

TGCG

CTAGT Novel-4 Nrf-1 CGCC

ACGTGCGCC

AG BG 0.329 0.708 0.634

M00651 NF-muE1GCC

GGCCATTC

GT Novel-6 None CGG

CGCCCCGG

CAGC BG 0.337 0.718 0.608

Novel-7 None GGCGCCGCG Novel-8 GABP CCGGAAGT

C BG 0.339 0.736 0.586Novel-9 None AT

CAAT

GCG

TAG

AAGA

TA Novel-10 HNF-3β ATA

TAT

GAT

CT

CTC

TAT

CA FG 0.341 0.536 0.782

Table 53: Five motif pairs with lowest classification error in Human TrigeminalGanglion.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 None AAAG

AGTAT

ACGA

CGTA Novel-2 None AA

TTAT

GAT

GCTTTG

CT BG 0.396 0.466 0.742Novel-3 None C

AACG

TAGGGC

AAGGA

G Novel-4 None AGACTATGACA FG 0.398 0.476 0.728

M00999 AIREGCAT

CAT

CGTA

CAGT

CAGT

GCTA

GTCA

GACT

CGATGGC

ATGCATC

GTA

CGAT

CGTA

CGAT

GCATGGC

GAT

AGCT

CGTA

GCTA

GCTA

CGAT Novel-6 None AGCT

AAGGC

GCTA

AG

AG FG 0.400 0.386 0.814

M00809 FOXCTG

GTA

GCAT

GTA

GTAGT

GTG

ACT

CT

GAT

GTA Novel-8 CACCC-bind T

ATGA

GGTGGT

AAG

CGG FG 0.400 0.426 0.774

M00405 MEF-2AGC

AGT

TCG

CAGT

ACTTAT

AATA

TA

CAT

CGA

GAC

AGTC

ATC Novel-10 None

CGAAGT

GCGAAAA

GGGA FG 0.402 0.434 0.762

Table 54: Five motif pairs with lowest classification error in Mouse TrigeminalGanglion.

Page 28: rulai.cshl.edurulai.cshl.edu/TissueSpecClass/motifPairs.pdf · Accession Factor Logo Accession Factor Logo Enrich Error Sens Spec M00939 E2F G A C T A G T A G C T A C G C GCG GC A

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecM00237 AhR-Arnt

CTAG

CTAG

ATCG

ACTG

TGA

GTT

CGCGTGTCA

ATGC

GTA

CTGA

TCG

TGCC Novel-2 None AG

AACATC

TTAC FG 0.385 0.612 0.618

M00721 CACCC-bindTCG

ACAGT

GTC

GAC

AGTC

ACGT

ATGGGG

TGAGT

AG

CG Novel-4 None GT

AGTGCA

TGGA

CGC

G BG 0.386 0.522 0.706M00978 LEF1TCF1

TGAC

GC

ACTTTA

GTA

AT

ACG

GACT

AGCT Novel-6 None T

AATGTTC

AAGA FG 0.388 0.504 0.720

M00277 Lmo2ATGC

ATCG

TAGCCAA

TG

ACGTGG

TC

GCAT

ATCG Novel-8 None GC

GTAC

TTGA

GCAC

GAG BG 0.389 0.498 0.724

Novel-9 Lyf-1 GA

TCC

TTCTGGA

GTAT

G Novel-10 None GCTGC

GCTCA BG 0.391 0.548 0.670

Table 55: Five motif pairs with lowest classification error in Human Uterus.

Accession Factor Logo Accession Factor Logo Enrich Error Sens SpecNovel-1 Sp-1

AGGGT

CGCGA

GGACG

CG Novel-2 None GGG

CGTGGA

CC FG 0.348 0.748 0.556Novel-3 None GGA

CCAGCGT

G Novel-4 None GCGCG

TGGAAG FG 0.349 0.678 0.624

Novel-5 CACCC-bindGCCT

AGC

AGCCCCT

AGC Novel-6 Sp-1 GGCGGGT

CAGC FG 0.350 0.672 0.628

Novel-7 Sp-1 TC

ACA

CTGCCCT

AC

TGC Novel-8 None A

GAGGC

GCTAGA

GTA

CG FG 0.353 0.656 0.638

M00665 Sp3 ATCG

TAC

AC

CGT

AGT

CG

TGGA

CG

CGA

AG

CGG Novel-10 Sp-1 GC

GAG

CG

TGT

CTGGA

GG FG 0.355 0.614 0.676

Table 56: Five motif pairs with lowest classification error in Mouse Uterus.