seminar spring 2012

8/2/2019 Seminar Spring 2012

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Supramolecular Copolymer

Micelles Based on the

Complementary Multiple Hydrogen

Bonds of Nucleobases for Drug

Delievery

Wang D. et al

Presented bySunita Sharma

1/30/2012


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Background

Main Cancer Treatments

SurgeryInvasive and onlyeffective in stage I and IIcancer treatment.

Radiation therapyCan possibly damagenormal tissue and organsnear the tumor

ChemotherapyDrugs only present in thebody for a limited timeperiod

Block Copolymer Micelles

Improve solubility andbioavailability of hydrophobicdrugs in water.

Size allows prolong drugcirculation time afteradministration

Programmable delivery systemwhich the release of drugs can becontrolled via pH of environment.

Main paper objective based uponthe finding that rapid drug releasewill reduce drug resistance incells.


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Supramolecular Polymers

Supramolecular polymer is a polymer whose monomerrepeat units are held together by non-covalent bonds,like co-ordination, pi-pi interaction and hydrogenbonding.

In this article, two polymers have been used toassemble is supramolecular polymer PCL-A andPEG-U


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Purpose and method

Synthesis of PCL-A and U-PEG

Synthesis of PCL-A:U-PEG micelles

Insure pH-Triggered DOX Release

Cell Internalization and DOX Release


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Synthesis and

Characterization of PCL-A


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Synthesis and

Characterization of U-PEG


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Synthesis of PCL-A:U-PEG

micellesTable 2. Properti es of the PCL-A:U-PEG Micelles

sample CMCa(mg/ mL) diameterb ( nm) PDIb

PCL25-A:U-PEG114 6.5 102 142 0.097

PCL40-A:U-PEG114 3.9 102 156 0.093

PCL49-A:U-PEG114 1.8 102 172 0.139


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Insure pH-Triggered DOX

Release


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Cell Internalization and

DOX Release


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Conclusion

Successful development of stimuli responsivemicelles, self assembled from PCL-A:U-PEG

These micelles strongly respond to mild acidic

pH and release the drug inside the shell, leadingto increased drug efficacy

Stimuli responsive micelles are promising

candidates for improvements in drug deliverysystems.


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Questions?


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Supplemental Info

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Akali Catalyst

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ReferenceWang, D.; Su, Y.; Jin, C.; Zhu, B.; Pang, Y.; Zhu, P.; Liu, J.; Tu, C.;

Yan, D.; Zhu, X. Biomacromolecules2011

, 12, 1370-1379.

Toncheva, V.; Schacht, E.; Ng, S. y.; Barr, J.; Heller, J. J. DrugTargeting2003, 11, 345-353.

seminar spring 2012

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