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Page 1: static-content.springer.com10.1007... · Web viewSupplementary data S2. Aktaş, S., Zadeoğlulari, Z., Erçetin, P., and Olgun, N. (2010). The effect of differentiating and apoptotic

Supplementary data S2.

Aktaş, S., Zadeoğlulari, Z., Erçetin, P., and Olgun, N. (2010). The effect of differentiating and apoptotic agents on notch signalling pathway in hepatoblastoma. Hepatogastroenterology 57, 891–898.

Almeida, M.Q., Azevedo, M.F., Xekouki, P., Bimpaki, E.I., Horvath, A., Collins, M.T., Karaviti, L.P., Jeha, G.S., Bhattacharyya, N., Cheadle, C., et al. (2012). Activation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutations. J. Clin. Endocrinol. Metab. 97, E687-693.

Bacac, M., Migliavacca, E., Stehle, J.-C., McKee, T., Delorenzi, M., Coindre, J.-M., Guillou, L., and Stamenkovic, I. (2006). A gene expression signature that distinguishes desmoid tumours from nodular fasciitis. J. Pathol. 208, 543–553.

Bauer, M., Su, G., Casper, C., He, R., Rehrauer, W., and Friedl, A. (2010). Heterogeneity of gene expression in stromal fibroblasts of human breast carcinomas and normal breast. Oncogene 29, 1732–1740.

Bellei, B., Pitisci, A., Izzo, E., and Picardo, M. (2012). Inhibition of melanogenesis by the pyridinyl imidazole class of compounds: possible involvement of the Wnt/β-catenin signaling pathway. PLoS ONE 7, e33021.

Berschneider, B., and Königshoff, M. (2011). WNT1 inducible signaling pathway protein 1 (WISP1): a novel mediator linking development and disease. Int. J. Biochem. Cell Biol. 43, 306–309.

Berschneider, B., Ellwanger, D.C., Baarsma, H.A., Thiel, C., Shimbori, C., White, E.S., Kolb, M., Neth, P., and Königshoff, M. (2014). miR-92a regulates TGF-β1-induced WISP1 expression in pulmonary fibrosis. Int. J. Biochem. Cell Biol. 53, 432–441.

van Beuge, M.M., Ten Dam, E.-J.P.M., Werker, P.M.N., and Bank, R.A. (2015). Wnt pathway in Dupuytren disease: connecting profibrotic signals. Transl Res 166, 762–771.e3.

Bizama, C., Benavente, F., Salvatierra, E., Gutiérrez-Moraga, A., Espinoza, J.A., Fernández, E.A., Roa, I., Mazzolini, G., Sagredo, E.A., Gidekel, M., et al. (2014). The low-abundance transcriptome reveals novel biomarkers, specific intracellular pathways and targetable genes associated with advanced gastric cancer. Int. J. Cancer 134, 755–764.

Blom, A.B., Brockbank, S.M., van Lent, P.L., van Beuningen, H.M., Geurts, J., Takahashi, N., van der Kraan, P.M., van de Loo, F.A., Schreurs, B.W., Clements, K., et al. (2009). Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1. Arthritis Rheum. 60, 501–512.

van den Bosch, M.H., Blom, A.B., van Lent, P.L., van Beuningen, H.M., Blaney Davidson, E.N., van der Kraan, P.M., and van den Berg, W.B. (2014). Canonical Wnt signaling skews TGF-β signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8. Cell. Signal. 26, 951–958.

van den Bosch, M.H., Blom, A.B., Sloetjes, A.W., Koenders, M.I., van de Loo, F.A., van den Berg, W.B., van Lent, P.L., and van der Kraan, P.M. (2015a). Induction of Canonical Wnt Signaling by Synovial Overexpression of Selected Wnts Leads to Protease Activity and Early Osteoarthritis-Like

1

Page 2: static-content.springer.com10.1007... · Web viewSupplementary data S2. Aktaş, S., Zadeoğlulari, Z., Erçetin, P., and Olgun, N. (2010). The effect of differentiating and apoptotic

Cartilage Damage. Am. J. Pathol. 185, 1970–1980.

van den Bosch, M.H., Gleissl, T.A., Blom, A.B., van den Berg, W.B., van Lent, P.L., and van der Kraan, P.M. (2015b). Wnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritis. Rheumatology (Oxford).

Brigstock, D.R. (1999). The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family. Endocr. Rev. 20, 189–206.

Brigstock, D.R. (2003). The CCN family: a new stimulus package. J. Endocrinol. 178, 169–175.

Brzóska, K., Męczyńska-Wielgosz, S., Stępkowski, T.M., and Kruszewski, M. (2015). Adaptation of HepG2 cells to silver nanoparticles-induced stress is based on the pro-proliferative and anti-apoptotic changes in gene expression. Mutagenesis 30, 431–439.

Cano, M. del V., Karagiannis, E.D., Soliman, M., Bakir, B., Zhuang, W., Popel, A.S., and Gehlbach, P.L. (2009). A peptide derived from type 1 thrombospondin repeat-containing protein WISP-1 inhibits corneal and choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. 50, 3840–3845.

Case, N., Ma, M., Sen, B., Xie, Z., Gross, T.S., and Rubin, J. (2008). Beta-catenin levels influence rapid mechanical responses in osteoblasts. J. Biol. Chem. 283, 29196–29205.

Case, N., Xie, Z., Sen, B., Styner, M., Zou, M., O’Conor, C., Horowitz, M., and Rubin, J. (2010). Mechanical activation of β-catenin regulates phenotype in adult murine marrow-derived mesenchymal stem cells. J. Orthop. Res. 28, 1531–1538.

Cernea, M., Tang, W., Guan, H., and Yang, K. (2016). Wisp1 mediates Bmp3-stimulated mesenchymal stem cell proliferation. J. Mol. Endocrinol. 56, 39–46.

Cervello, M., Giannitrapani, L., Labbozzetta, M., Notarbartolo, M., D’Alessandro, N., Lampiasi, N., Azzolina, A., and Montalto, G. (2004). Expression of WISPs and of their novel alternative variants in human hepatocellular carcinoma cells. Ann. N. Y. Acad. Sci. 1028, 432–439.

Chakrabarti, S., Multani, S., Dabholkar, J., and Saranath, D. (2015). Whole genome expression profiling in chewing-tobacco-associated oral cancers: a pilot study. Med. Oncol. 32, 60.

Chen, J., Yin, J., Li, X., Wang, Y., Zheng, Y., Qian, C., Xiao, L., Zou, T., Wang, Z., Liu, J., et al. (2014). WISP1 polymorphisms contribute to platinum-based chemotherapy toxicity in lung cancer patients. Int J Mol Sci 15, 21011–21027.

Chen, J., Yin, J.-Y., Li, X.-P., Wang, Y., Zheng, Y., Qian, C.-Y., He, H., Fang, C., Wang, Z., Zhang, Y., et al. (2015). Association of Wnt-Inducible Signaling Pathway Protein 1 Genetic Polymorphisms With Lung Cancer Susceptibility and Platinum-Based Chemotherapy Response. Clin Lung Cancer 16, 298-304-2.

Chen, P.-P., Li, W.-J., Wang, Y., Zhao, S., Li, D.-Y., Feng, L.-Y., Shi, X.-L., Koeffler, H.P., Tong, X.-J., and Xie, D. (2007). Expression of Cyr61, CTGF, and WISP-1 correlates with clinical features of lung cancer. PLoS ONE 2, e534.

Chen, Z., Ding, X., Jin, S., Pitt, B., Zhang, L., Billiar, T., and Li, Q. (2016). WISP1-αvβ3 integrin

2

Page 3: static-content.springer.com10.1007... · Web viewSupplementary data S2. Aktaş, S., Zadeoğlulari, Z., Erçetin, P., and Olgun, N. (2010). The effect of differentiating and apoptotic

signaling positively regulates TLR-triggered inflammation response in sepsis induced lung injury. Sci Rep 6, 28841.

Cheng, Z., Lin, C., Hwang, T., and Teng, C. (2001). Broussochalcone A, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages. Biochem. Pharmacol. 61, 939–946.

Chiang, K.-C., Yeh, C.-N., Chung, L.-C., Feng, T.-H., Sun, C.-C., Chen, M.-F., Jan, Y.-Y., Yeh, T.-S., Chen, S.-C., and Juang, H.-H. (2015). WNT-1 inducible signaling pathway protein-1 enhances growth and tumorigenesis in human breast cancer. Sci Rep 5, 8686.

Chien, W., O’Kelly, J., Lu, D., Leiter, A., Sohn, J., Yin, D., Karlan, B., Vadgama, J., Lyons, K.M., and Koeffler, H.P. (2011). Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis. Int. J. Oncol. 38, 1741–1747.

Cho, Y.L., Bae, S., Koo, M.S., Kim, K.M., Chun, H.-J., Kim, C.K., Ro, D.Y., Kim, J.H., Lee, C.-H., Kim, Y.-W., et al. (2005). Array comparative genomic hybridization analysis of uterine leiomyosarcoma. Gynecol. Oncol. 99, 545–551.

Chuang, J.-Y., Chang, A.-C., Chiang, I.-P., Tsai, M.-H., and Tang, C.-H. (2013). Apoptosis signal-regulating kinase 1 is involved in WISP-1-promoted cell motility in human oral squamous cell carcinoma cells. PLoS ONE 8, e78022.

Chuang, J.-Y., Chen, P.-C., Tsao, C.-W., Chang, A.-C., Lein, M.-Y., Lin, C.-C., Wang, S.-W., Lin, C.-W., and Tang, C.-H. (2015). WISP-1 a novel angiogenic regulator of the CCN family promotes oral squamous cell carcinoma angiogenesis through VEGF-A expression. Oncotarget 6, 4239–4252.

Clausen, M.J.A.M., Melchers, L.J., Mastik, M.F., Slagter-Menkema, L., Groen, H.J.M., van der Laan, B.F.A.M., van Criekinge, W., de Meyer, T., Denil, S., Wisman, G.B.A., et al. (2016). Identification and validation of WISP1 as an epigenetic regulator of metastasis in oral squamous cell carcinoma. Genes Chromosomes Cancer 55, 45–59.

Colston, J.T., de la Rosa, S.D., Koehler, M., Gonzales, K., Mestril, R., Freeman, G.L., Bailey, S.R., and Chandrasekar, B. (2007). Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor. Am. J. Physiol. Heart Circ. Physiol. 293, H1839-1846.

Davies, S.R., Watkins, G., Mansel, R.E., and Jiang, W.G. (2007). Differential expression and prognostic implications of the CCN family members WISP-1, WISP-2, and WISP-3 in human breast cancer. Ann. Surg. Oncol. 14, 1909–1918.

Davies, S.R., Davies, M.L., Sanders, A., Parr, C., Torkington, J., and Jiang, W.G. (2010). Differential expression of the CCN family member WISP-1, WISP-2 and WISP-3 in human colorectal cancer and the prognostic implications. Int. J. Oncol. 36, 1129–1136.

Desnoyers, L., Arnott, D., and Pennica, D. (2001). WISP-1 binds to decorin and biglycan. J. Biol. Chem. 276, 47599–47607.

Ding, X., Wang, X., Zhao, X., Jin, S., Tong, Y., Ren, H., Chen, Z., and Li, Q. (2015). RGD peptides protects against acute lung injury in septic mice through Wisp1-integrin β6 pathway inhibition. Shock 43, 352–360.

3

Page 4: static-content.springer.com10.1007... · Web viewSupplementary data S2. Aktaş, S., Zadeoğlulari, Z., Erçetin, P., and Olgun, N. (2010). The effect of differentiating and apoptotic

Falconi, G., Fabiani, E., Fianchi, L., Criscuolo, M., Raffaelli, C.S., Bellesi, S., Hohaus, S., Voso, M.T., D’Alò, F., and Leone, G. (2016). Impairment of PI3K/AKT and WNT/β-catenin pathways in bone marrow mesenchymal stem cells isolated from patients with myelodysplastic syndromes. Exp. Hematol. 44, 75-83-4.

Fernández-Torres, J., Hernández-Díaz, C., Espinosa-Morales, R., Camacho-Galindo, J., Galindo-Sevilla, N. del C., López-Macay, Á., Zamudio-Cuevas, Y., Martínez-Flores, K., Santamaría-Olmedo, M.G., Pineda, C., et al. (2015). Polymorphic variation of hypoxia inducible factor-1 A (HIF1A) gene might contribute to the development of knee osteoarthritis: a pilot study. BMC Musculoskelet Disord 16, 218.

Fernando, C.A., Conrad, P.A., Bartels, C.F., Marques, T., To, M., Balow, S.A., Nakamura, Y., and Warman, M.L. (2010). Temporal and spatial expression of CCN genes in zebrafish. Dev. Dyn. 239, 1755–1767.

Fischer, H., Salahshor, S., Stenling, R., Björk, J., Lindmark, G., Iselius, L., Rubio, C., and Lindblom, A. (2001). COL11A1 in FAP polyps and in sporadic colorectal tumors. BMC Cancer 1, 17.

Frank, B., Hoffmeister, M., Klopp, N., Illig, T., Chang-Claude, J., and Brenner, H. (2010). Single nucleotide polymorphisms in Wnt signaling and cell death pathway genes and susceptibility to colorectal cancer. Carcinogenesis 31, 1381–1386.

French, D.M., Kaul, R.J., D’Souza, A.L., Crowley, C.W., Bao, M., Frantz, G.D., Filvaroff, E.H., and Desnoyers, L. (2004). WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair. Am. J. Pathol. 165, 855–867.

Geyer, M., Grässel, S., Straub, R.H., Schett, G., Dinser, R., Grifka, J., Gay, S., Neumann, E., and Müller-Ladner, U. (2009). Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology. Osteoarthr. Cartil. 17, 328–335.

Gurbuz, I., and Chiquet-Ehrismann, R. (2015). CCN4/WISP1 (WNT1 inducible signaling pathway protein 1): a focus on its role in cancer. Int. J. Biochem. Cell Biol. 62, 142–146.

Haddad, R., Romero, R., Gould, B.R., Tromp, G., Gotsch, F., Edwin, S.S., and Zingg, H.H. (2008). Angiogenesis gene expression in mouse uterus during the common pathway of parturition. Am. J. Obstet. Gynecol. 198, 539.e1-8.

Hale, L.V., Galvin, R.J.S., Risteli, J., Ma, Y.L., Harvey, A.K., Yang, X., Cain, R.L., Zeng, Q., Frolik, C.A., Sato, M., et al. (2007). PINP: a serum biomarker of bone formation in the rat. Bone 40, 1103–1109.

Hashimoto, Y., Shindo-Okada, N., Tani, M., Nagamachi, Y., Takeuchi, K., Shiroishi, T., Toma, H., and Yokota, J. (1998). Expression of the Elm1 gene, a novel gene of the CCN (connective tissue growth factor, Cyr61/Cef10, and neuroblastoma overexpressed gene) family, suppresses In vivo tumor growth and metastasis of K-1735 murine melanoma cells. J. Exp. Med. 187, 289–296.

Heise, R.L., Stober, V., Cheluvaraju, C., Hollingsworth, J.W., and Garantziotis, S. (2011). Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan

4

Page 5: static-content.springer.com10.1007... · Web viewSupplementary data S2. Aktaş, S., Zadeoğlulari, Z., Erçetin, P., and Olgun, N. (2010). The effect of differentiating and apoptotic

activation of innate immunity. J. Biol. Chem. 286, 17435–17444.

Hennemeier, I., Humpf, H.-U., Gekle, M., and Schwerdt, G. (2012). The food contaminant and nephrotoxin ochratoxin A enhances Wnt1 inducible signaling protein 1 and tumor necrosis factor-α expression in human primary proximal tubule cells. Mol Nutr Food Res 56, 1375–1384.

Heo, J., Ahn, E.-K., Jeong, H.-G., Kim, Y.-H., Leem, S.-H., Lee, S.-J., Park, E.-K., and Yang, M. (2013). Transcriptional characterization of Wnt pathway during sequential hepatic differentiation of human embryonic stem cells and adipose tissue-derived stem cells. Biochem. Biophys. Res. Commun. 434, 235–240.

Hou, C.-H., Chiang, Y.-C., Fong, Y.-C., and Tang, C.-H. (2011). WISP-1 increases MMP-2 expression and cell motility in human chondrosarcoma cells. Biochem. Pharmacol. 81, 1286–1295.

Hou, C.-H., Tang, C.-H., Hsu, C.-J., Hou, S.-M., and Liu, J.-F. (2013). CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts. Arthritis Res. Ther. 15, R19.

Hu, R., Tian, C., Meng, W., Zhang, J., Li, L., Zhang, P., Long, Q., and Tao, P. (2010). [The expression and clinical significance of Wnt-1 induced secreted protein-1 in breast carcinoma]. Sichuan Da Xue Xue Bao Yi Xue Ban 41, 231–234.

Hughes, J.M., Kuiper, E.J., Klaassen, I., Canning, P., Stitt, A.W., Van Bezu, J., Schalkwijk, C.G., Van Noorden, C.J.F., and Schlingemann, R.O. (2007). Advanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent retina. Diabetologia 50, 1089–1098.

Hurvitz, J.R., Suwairi, W.M., Van Hul, W., El-Shanti, H., Superti-Furga, A., Roudier, J., Holderbaum, D., Pauli, R.M., Herd, J.K., Van Hul, E.V., et al. (1999). Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia. Nat. Genet. 23, 94–98.

Inkson, C.A., Ono, M., Kuznetsov, S.A., Fisher, L.W., Robey, P.G., and Young, M.F. (2008). TGF-beta1 and WISP-1/CCN-4 can regulate each other’s activity to cooperatively control osteoblast function. J. Cell. Biochem. 104, 1865–1878.

Inkson, C.A., Ono, M., Bi, Y., Kuznetsov, S.A., Fisher, L.W., and Young, M.F. (2009). The potential functional interaction of biglycan and WISP-1 in controlling differentiation and proliferation of osteogenic cells. Cells Tissues Organs (Print) 189, 153–157.

Ji, J., Jia, S., Jia, Y., Ji, K., Hargest, R., and Jiang, W.G. (2015). WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-γ pathways. Br. J. Cancer 113, 921–933.

Jian, Y.-C., Wang, J.-J., Dong, S., Hu, J.-W., Hu, L.-J., Yang, G.-M., Zheng, Y.-X., and Xiong, W.-J. (2014). Wnt-induced secreted protein 1/CCN4 in liver fibrosis both in vitro and in vivo. Clin. Lab. 60, 29–35.

Jilka, R.L., O’Brien, C.A., Bartell, S.M., Weinstein, R.S., and Manolagas, S.C. (2010). Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms. J. Bone Miner. Res. 25, 2427–2437.

5

Page 6: static-content.springer.com10.1007... · Web viewSupplementary data S2. Aktaş, S., Zadeoğlulari, Z., Erçetin, P., and Olgun, N. (2010). The effect of differentiating and apoptotic

Jin, S., Chen, Z., Ding, X., Zhao, X., Jiang, X., Tong, Y., Billiar, T.R., and Li, Q. (2016). Mechanical Ventilation Augments Poly(I:C)Induced Lung Injury Via a Wisp1-Integrin Β3 Dependent Pathway in Mice. Mol Med. 2016 Jan 6.

Kalaydjieva, L., Gresham, D., Gooding, R., Heather, L., Baas, F., de Jonge, R., Blechschmidt, K., Angelicheva, D., Chandler, D., Worsley, P., et al. (2000). N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. Am. J. Hum. Genet. 67, 47–58.

Kapasa, M., Serafimidis, I., Gavalas, A., and Kossida, S. (2008). Identification of phylogenetically conserved enhancer elements implicated in pancreas development in the WISP1 and CTGF orthologs. Genomics 92, 301–308.

Katoh, M. (2007). Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change and genetic alteration in gastric cancer. Cancer Biol. Ther. 6, 832–839.

Katoh, M. (2008). WNT signaling in stem cell biology and regenerative medicine. Curr Drug Targets 9, 565–570.

Katoh, M., and Katoh, M. (2005). Comparative genomics on Norrie disease gene. Int. J. Mol. Med. 15, 885–889.

Katoh, M., and Katoh, M. (2007a). Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5’-promoter region of mammalian FZD7 orthologs. Int. J. Mol. Med. 19, 529–533.

Katoh, M., and Katoh, M. (2007b). Conserved POU/OCT- and GATA-binding sites in 5’-flanking promoter region of mammalian WNT8B orthologs. Int. J. Oncol. 30, 1273–1277.

Katoh, M., and Katoh, M. (2007c). STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer (Review). Int. J. Mol. Med. 19, 273–278.

Katoh, M., and Katoh, M. (2007d). WNT signaling pathway and stem cell signaling network. Clin. Cancer Res. 13, 4042–4045.

Katoh, Y., and Katoh, M. (2007e). Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. Int. J. Oncol. 30, 751–755.

Katula, K.S., Heinloth, A.N., and Paules, R.S. (2007). Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J. Nutr. Biochem. 18, 541–552.

Khor, T.O., Gul, Y.A., Ithnin, H., and Seow, H.F. (2006). A comparative study of the expression of Wnt-1, WISP-1, survivin and cyclin-D1 in colorectal carcinoma. Int J Colorectal Dis 21, 291–300.

Klee, S., Lehmann, M., Wagner, D.E., Baarsma, H.A., and Königshoff, M. (2016). WISP1 mediates IL-6-dependent proliferation in primary human lung fibroblasts. Sci Rep 6, 20547.

6

Page 7: static-content.springer.com10.1007... · Web viewSupplementary data S2. Aktaş, S., Zadeoğlulari, Z., Erçetin, P., and Olgun, N. (2010). The effect of differentiating and apoptotic

Klinke, D.J. (2014). Induction of Wnt-inducible signaling protein-1 correlates with invasive breast cancer oncogenesis and reduced type 1 cell-mediated cytotoxic immunity: a retrospective study. PLoS Comput. Biol. 10, e1003409.

Knoblich, K., Wang, H.-X., Sharma, C., Fletcher, A.L., Turley, S.J., and Hemler, M.E. (2014). Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits β-catenin degradation. Cell. Mol. Life Sci. 71, 1305–1314.

Knobloch, J., Lin, Y., Konradi, J., Jungck, D., Behr, J., Strauch, J., Stoelben, E., and Koch, A. (2013). Inflammatory responses of airway smooth muscle cells and effects of endothelin receptor antagonism. Am. J. Respir. Cell Mol. Biol. 49, 114–127.

Kohara, H., and Tabata, Y. (2011). Enhancement of ectopic osteoid formation following the dual release of bone morphogenetic protein 2 and Wnt1 inducible signaling pathway protein 1 from gelatin sponges. Biomaterials 32, 5726–5732.

Königshoff, M., Kramer, M., Balsara, N., Wilhelm, J., Amarie, O.V., Jahn, A., Rose, F., Fink, L., Seeger, W., Schaefer, L., et al. (2009). WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J. Clin. Invest. 119, 772–787.

Kulkarni, Y.M., Chambers, E., McGray, A.J.R., Ware, J.S., Bramson, J.L., and Klinke, D.J. (2012). A quantitative systems approach to identify paracrine mechanisms that locally suppress immune response to Interleukin-12 in the B16 melanoma model. Integr Biol (Camb) 4, 925–936.

Larsen, C.J. (1999). [The Wnt1 oncogene: from mice mammary tumors to human tumors (continuation)]. Bull Cancer 86, 252.

Lau, L.F. (2016). Cell surface receptors for CCN proteins. J Cell Commun Signal 10, 121–127.

Lemaire, R., Farina, G., Bayle, J., Dimarzio, M., Pendergrass, S.A., Milano, A., Perbal, B., Whitfield, M.L., and Lafyatis, R. (2010). Antagonistic effect of the matricellular signaling protein CCN3 on TGF-beta- and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan syndrome. J. Invest. Dermatol. 130, 1514–1523.

Li, H.-H., Li, Q., Liu, P., Liu, Y., Li, J., Wasserloos, K., Chao, W., You, M., Oury, T.D., Chhinder, S., et al. (2012). WNT1-inducible signaling pathway protein 1 contributes to ventilator-induced lung injury. Am. J. Respir. Cell Mol. Biol. 47, 528–535.

Li, N., Wang, Q., Chen, P., and Xie, D. (2008). [Study on expression of CTGF and WISP-1 genes in human lung cancers]. Wei Sheng Yan Jiu 37, 555–557.

Li, W.-F., Zhang, L., Li, H.-Y., Zheng, S.-S., and Zhao, L. (2014a). WISP-1 contributes to fractionated irradiation-induced radioresistance in esophageal carcinoma cell lines and mice. PLoS ONE 9, e94751.

Li, Z., Dang, J., Chang, K.-Y., and Rana, T.M. (2014b). MicroRNA-mediated regulation of extracellular matrix formation modulates somatic cell reprogramming. RNA 20, 1900–1915.

Lim, H.W., Lee, J.E., Shin, S.J., Lee, Y.E., Oh, S.H., Park, J.Y., Seong, J.K., and Park, J.-S. (2002).

7

Page 8: static-content.springer.com10.1007... · Web viewSupplementary data S2. Aktaş, S., Zadeoğlulari, Z., Erçetin, P., and Olgun, N. (2010). The effect of differentiating and apoptotic

Identification of differentially expressed mRNA during pancreas regeneration of rat by mRNA differential display. Biochem. Biophys. Res. Commun. 299, 806–812.

Lin, H., Liu, W., Fang, Z., Liang, X., Li, J., Bai, Y., Lin, L., You, H., Pei, Y., Wang, F., et al. (2015). Overexpression of DHX32 contributes to the growth and metastasis of colorectal cancer. Sci Rep 5, 9247.

Liu, H., Dong, W., Lin, Z., Lu, J., Wan, H., Zhou, Z., and Liu, Z. (2013a). CCN4 regulates vascular smooth muscle cell migration and proliferation. Mol. Cells 36, 112–118.

Liu, J.-F., Hou, S.-M., Tsai, C.-H., Huang, C.-Y., Hsu, C.-J., and Tang, C.-H. (2013b). CCN4 induces vascular cell adhesion molecule-1 expression in human synovial fibroblasts and promotes monocyte adhesion. Biochim. Biophys. Acta 1833, 966–975.

Liu, Z.-J., Li, Y., Tan, Y., Xiao, M., Zhang, J., Radtke, F., and Velazquez, O.C. (2012). Inhibition of fibroblast growth by Notch1 signaling is mediated by induction of Wnt11-dependent WISP-1. PLoS ONE 7, e38811.

Lough, D., Dai, H., Yang, M., Reichensperger, J., Cox, L., Harrison, C., and Neumeister, M.W. (2013). Stimulation of the follicular bulge LGR5+ and LGR6+ stem cells with the gut-derived human alpha defensin 5 results in decreased bacterial presence, enhanced wound healing, and hair growth from tissues devoid of adnexal structures. Plast. Reconstr. Surg. 132, 1159–1171.

Lu, S., Liu, H., Lu, L., Wan, H., Lin, Z., Qian, K., Yao, X., Chen, Q., Liu, W., Yan, J., et al. (2016). WISP1 overexpression promotes proliferation and migration of human vascular smooth muscle cells via AKT signaling pathway. Eur. J. Pharmacol. 788, 90–97.

Luisier, R., Lempiäinen, H., Scherbichler, N., Braeuning, A., Geissler, M., Dubost, V., Müller, A., Scheer, N., Chibout, S.-D., Hara, H., et al. (2014). Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors. Toxicol. Sci. 139, 501–511.

Macsai, C.E., Georgiou, K.R., Foster, B.K., Zannettino, A.C.W., and Xian, C.J. (2012). Microarray expression analysis of genes and pathways involved in growth plate cartilage injury responses and bony repair. Bone 50, 1081–1091.

Maeda, A., Ono, M., Holmbeck, K., Li, L., Kilts, T.M., Kram, V., Noonan, M.L., Yoshioka, Y., McNerny, E.M.B., Tantillo, M.A., et al. (2015). WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling. J. Biol. Chem. 290, 14004–14018.

Maiese, K. (2014). WISP1: Clinical insights for a proliferative and restorative member of the CCN family. Curr Neurovasc Res 11, 378–389.

Maiese, K. (2015a). FoxO Transcription Factors and Regenerative Pathways in Diabetes Mellitus. Curr Neurovasc Res 12, 404–413.

Maiese, K. (2015b). New Insights for Oxidative Stress and Diabetes Mellitus. Oxid Med Cell Longev 2015, 875961.

Maiese, K. (2015c). Novel applications of trophic factors, Wnt and WISP for neuronal repair and

8

Page 9: static-content.springer.com10.1007... · Web viewSupplementary data S2. Aktaş, S., Zadeoğlulari, Z., Erçetin, P., and Olgun, N. (2010). The effect of differentiating and apoptotic

regeneration in metabolic disease. Neural Regen Res 10, 518–528.

Maiese, K. (2015d). Programming apoptosis and autophagy with novel approaches for diabetes mellitus. Curr Neurovasc Res 12, 173–188.

Maiese, K. (2015e). Stem cell guidance through the mechanistic target of rapamycin. World J Stem Cells 7, 999–1009.

Maiese, K. (2016a). Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR. Neural Regen Res 11, 372–385.

Maiese, K. (2016b). Picking a bone with WISP1 (CCN4): new strategies against degenerative joint disease. J Transl Sci 1, 83–85.

Maiese, K. (2016c). Regeneration in the nervous system with erythropoietin. Front Biosci (Landmark Ed) 21, 561–596.

Maiese, K., Chong, Z.Z., Shang, Y.C., and Wang, S. (2012). Targeting disease through novel pathways of apoptosis and autophagy. Expert Opin. Ther. Targets 16, 1203–1214.

Marchand, A., Atassi, F., Gaaya, A., Leprince, P., Le Feuvre, C., Soubrier, F., Lompré, A.-M., and Nadaud, S. (2011). The Wnt/beta-catenin pathway is activated during advanced arterial aging in humans. Aging Cell 10, 220–232.

Margalit, O., Eisenbach, L., Amariglio, N., Kaminski, N., Harmelin, A., Pfeffer, R., Shohat, M., Rechavi, G., and Berger, R. (2003). Overexpression of a set of genes, including WISP-1, common to pulmonary metastases of both mouse D122 Lewis lung carcinoma and B16-F10.9 melanoma cell lines. Br. J. Cancer 89, 314–319.

Martin, E.D., and Marber, M.S. (2011). Will o’ the WISP1: a novel mediator of Ang-II induced cardiomyocyte hypertrophy. J. Mol. Cell. Cardiol. 50, 925–927.

Martinez-Ceballos, E., Chambon, P., and Gudas, L.J. (2005). Differences in gene expression between wild type and Hoxa1 knockout embryonic stem cells after retinoic acid treatment or leukemia inhibitory factor (LIF) removal. J. Biol. Chem. 280, 16484–16498.

Matsubara, D., Niki, T., Ishikawa, S., Goto, A., Ohara, E., Yokomizo, T., Heizmann, C.W., Aburatani, H., Moriyama, S., Moriyama, H., et al. (2005). Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes. Cancer Sci. 96, 844–857.

Mercer, K.E., Hennings, L., Sharma, N., Lai, K., Cleves, M.A., Wynne, R.A., Badger, T.M., and Ronis, M.J.J. (2014). Alcohol consumption promotes diethylnitrosamine-induced hepatocarcinogenesis in male mice through activation of the Wnt/β-catenin signaling pathway. Cancer Prev Res (Phila) 7, 675–685.

Mercer, K.E., Hennings, L., and Ronis, M.J.J. (2015). Alcohol consumption, Wnt/β-catenin signaling, and hepatocarcinogenesis. Adv. Exp. Med. Biol. 815, 185–195.

9

Page 10: static-content.springer.com10.1007... · Web viewSupplementary data S2. Aktaş, S., Zadeoğlulari, Z., Erçetin, P., and Olgun, N. (2010). The effect of differentiating and apoptotic

Mill, C., Monk, B.A., Williams, H., Simmonds, S.J., Jeremy, J.Y., Johnson, J.L., and George, S.J. (2014). Wnt5a-induced Wnt1-inducible secreted protein-1 suppresses vascular smooth muscle cell apoptosis induced by oxidative stress. Arterioscler. Thromb. Vasc. Biol. 34, 2449–2456.

Minchenko, D.O., Kharkova, A.P., Tsymbal, D.O., Karbovskyi, L.L., and Minchenko, O.H. (2015a). IRE1 inhibition affects the expression of insulin-like growth factor binding protein genes and modifies its sensitivity to glucose deprivation in U87 glioma cells. Endocr Regul 49, 185–197.

Minchenko, O.H., Kharkova, A.P., Minchenko, D.O., and Karbovskyi, L.L. (2015b). Effect Of Hypoxia on The Expression of Genes That Encode Some Igfbp And CCN Proteins In U87 Glioma Cells Depends on Ire1 Signaling. Ukr Biochem J 87, 52–63.

Misemer, B.S., Skubitz, A.P.N., Carlos Manivel, J., Schmechel, S.C., Cheng, E.Y., Henriksen, J.C., Koopmeiners, J.S., Corless, C.L., and Skubitz, K.M. (2014). Expression of FAP, ADAM12, WISP1, and SOX11 is heterogeneous in aggressive fibromatosis and spatially relates to the histologic features of tumor activity. Cancer Med 3, 81–90.

Murahovschi, V., Pivovarova, O., Ilkavets, I., Dmitrieva, R.M., Döcke, S., Keyhani-Nejad, F., Gögebakan, Ö., Osterhoff, M., Kemper, M., Hornemann, S., et al. (2015). WISP1 is a novel adipokine linked to inflammation in obesity. Diabetes 64, 856–866.

Nagai, Y., Watanabe, M., Ishikawa, S., Karashima, R., Kurashige, J., Iwagami, S., Iwatsuki, M., Baba, Y., Imamura, Y., Hayashi, N., et al. (2011). Clinical significance of Wnt-induced secreted protein-1 (WISP-1/CCN4) in esophageal squamous cell carcinoma. Anticancer Res. 31, 991–997.

Nioi, P., Taylor, S., Hu, R., Pacheco, E., He, Y.D., Hamadeh, H., Paszty, C., Pyrah, I., Ominsky, M.S., and Boyce, R.W. (2015). Transcriptional Profiling of Laser Capture Microdissected Subpopulations of the Osteoblast Lineage Provides Insight Into the Early Response to Sclerostin Antibody in Rats. J. Bone Miner. Res. 30, 1457–1467.

Ono, M., Inkson, C.A., Kilts, T.M., and Young, M.F. (2011). WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity. J. Bone Miner. Res. 26, 193–208.

Ono, M., Inkson, C.A., Sonn, R., Kilts, T.M., de Castro, L.F., Maeda, A., Fisher, L.W., Robey, P.G., Berendsen, A.D., Li, L., et al. (2013). WISP1/CCN4: a potential target for inhibiting prostate cancer growth and spread to bone. PLoS ONE 8, e71709.

Pasmant, E., Ortonne, N., Rittié, L., Laurendeau, I., Lévy, P., Lazar, V., Parfait, B., Leroy, K., Dessen, P., Valeyrie-Allanore, L., et al. (2010). Differential expression of CCN1/CYR61, CCN3/NOV, CCN4/WISP1, and CCN5/WISP2 in neurofibromatosis type 1 tumorigenesis. J. Neuropathol. Exp. Neurol. 69, 60–69.

Pennica, D., Swanson, T.A., Welsh, J.W., Roy, M.A., Lawrence, D.A., Lee, J., Brush, J., Taneyhill, L.A., Deuel, B., Lew, M., et al. (1998). WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc. Natl. Acad. Sci. U.S.A. 95, 14717–14722.

Perbal, B. (2009). Ten years later.. J Cell Commun Signal 3, 1–3.

Ponticos, M. (2013). Connective tissue growth factor (CCN2) in blood vessels. Vascul. Pharmacol.

10

Page 11: static-content.springer.com10.1007... · Web viewSupplementary data S2. Aktaş, S., Zadeoğlulari, Z., Erçetin, P., and Olgun, N. (2010). The effect of differentiating and apoptotic

58, 189–193.

Price, R.M., Tulsyan, N., Dermody, J.J., Schwalb, M., Soteropoulos, P., and Castronuovo, J.J. (2004). Gene expression after crush injury of human saphenous vein: using microarrays to define the transcriptional profile. J. Am. Coll. Surg. 199, 411–418.

Reddy, V.S., Valente, A.J., Delafontaine, P., and Chandrasekar, B. (2011). Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation. J. Cell. Physiol. 226, 3303–3315.

Ribeiro, I.P., Marques, F., Caramelo, F., Ferrão, J., Prazeres, H., Julião, M.J., Rifi, W., Savola, S., de Melo, J.B., Baptista, I.P., et al. (2014). Genetic imbalances detected by multiplex ligation-dependent probe amplification in a cohort of patients with oral squamous cell carcinoma-the first step towards clinical personalized medicine. Tumour Biol. 35, 4687–4695.

Rudovich, N., Pivovarova, O., Bernigau, W., Sparwasser, A., Tacke, C., Murahovshi, V., Mertes, G., Birkenfeld, A.L., Bergmann, A., Weickert, M.O., et al. (2016). Modulation of circulating vasoactive peptides and extracellular matrix proteins are two novel mechanisms in the cardioprotective action of acarbose. Minerva Endocrinol.

Sahin Ersoy, G., Altun Ensari, T., Subas, S., Giray, B., Simsek, E.E., and Cevik, O. (2016). WISP1 is a novel adipokine linked to metabolic parameters in gestational diabetes mellitus. J. Matern. Fetal. Neonatal. Med. 1–5.

Saidak, Z., Le Henaff, C., Azzi, S., Marty, C., and Marie, P.J. (2014). Low-dose PTH increases osteoblast activity via decreased Mef2c/Sost in senescent osteopenic mice. J. Endocrinol. 223, 25–33.

Sambroni, E., Rolland, A.D., Lareyre, J.-J., and Le Gac, F. (2013a). FSH and LH have common and distinct effects on gene expression in rainbow trout testis. J. Mol. Endocrinol. 50, 1–18.

Sambroni, E., Lareyre, J.-J., and Le Gac, F. (2013b). Fsh controls gene expression in fish both independently of and through steroid mediation. PLoS ONE 8, e76684.

Saxena, N., Banerjee, S., Sengupta, K., Zoubine, M.N., and Banerjee, S.K. (2001). Differential expression of WISP-1 and WISP-2 genes in normal and transformed human breast cell lines. Mol. Cell. Biochem. 228, 99–104.

Schlegelmilch, K., Keller, A., Zehe, V., Hondke, S., Schilling, T., Jakob, F., Klein-Hitpass, L., and Schütze, N. (2014). WISP 1 is an important survival factor in human mesenchymal stromal cells. Gene 551, 243–254.

Schneider, S., Kloimstein, P., Pammer, J., Brannath, W., Grasl, M.C., and Erovic, B.M. (2014). New diagnostic markers in salivary gland tumors. Eur Arch Otorhinolaryngol 271, 1999–2007.

Shang, Y.C., Chong, Z.Z., Wang, S., and Maiese, K. (2012). Wnt1 inducible signaling pathway protein 1 (WISP1) targets PRAS40 to govern β-amyloid apoptotic injury of microglia. Curr Neurovasc Res 9, 239–249.

Shang, Y.C., Chong, Z.Z., Wang, S., and Maiese, K. (2013). Tuberous sclerosis protein 2 (TSC2) modulates CCN4 cytoprotection during apoptotic amyloid toxicity in microglia. Curr Neurovasc Res

11

Page 12: static-content.springer.com10.1007... · Web viewSupplementary data S2. Aktaş, S., Zadeoğlulari, Z., Erçetin, P., and Olgun, N. (2010). The effect of differentiating and apoptotic

10, 29–38.

Shanmugam, P., Valente, A.J., Prabhu, S.D., Venkatesan, B., Yoshida, T., Delafontaine, P., and Chandrasekar, B. (2011). Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy. J. Mol. Cell. Cardiol. 50, 928–938.

Shao, H., Cai, L., Grichnik, J.M., Livingstone, A.S., Velazquez, O.C., and Liu, Z.-J. (2011). Activation of Notch1 signaling in stromal fibroblasts inhibits melanoma growth by upregulating WISP-1. Oncogene 30, 4316–4326.

Shimomura, T., Yoshida, Y., Sakabe, T., Ishii, K., Gonda, K., Murai, R., Takubo, K., Tsuchiya, H., Hoshikawa, Y., Kurimasa, A., et al. (2007). Hepatic differentiation of human bone marrow-derived UE7T-13 cells: Effects of cytokines and CCN family gene expression. Hepatol. Res. 37, 1068–1079.

Shitashige, M., Naishiro, Y., Idogawa, M., Honda, K., Ono, M., Hirohashi, S., and Yamada, T. (2007). Involvement of splicing factor-1 in beta-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing. Gastroenterology 132, 1039–1054.

Sklepkiewicz, P., Shiomi, T., Kaur, R., Sun, J., Kwon, S., Mercer, B., Bodine, P., Schermuly, R.T., George, I., Schulze, P.C., et al. (2015). Loss of secreted frizzled-related protein-1 leads to deterioration of cardiac function in mice and plays a role in human cardiomyopathy. Circ Heart Fail 8, 362–372.

Sleeman, M.A., Murison, J.G., Strachan, L., Kumble, K., Glenn, M.P., McGrath, A., Grierson, A., Havukkala, I., Tan, P.L., and Watson, J.D. (2000). Gene expression in rat dermal papilla cells: analysis of 2529 ESTs. Genomics 69, 214–224.

Soon, L.L., Yie, T.-A., Shvarts, A., Levine, A.J., Su, F., and Tchou-Wong, K.-M. (2003). Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation. J. Biol. Chem. 278, 11465–11470.

Su, B.-Y., and Cai, W.-Q. (2002). [Progress in the study of CCN family]. Di Yi Jun Yi Da Xue Xue Bao 22, 179–183.

Su, F., Overholtzer, M., Besser, D., and Levine, A.J. (2002). WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev. 16, 46–57.

Tai, H.-C., Chang, A.-C., Yu, H.-J., Huang, C.-Y., Tsai, Y.-C., Lai, Y.-W., Sun, H.-L., Tang, C.-H., and Wang, S.-W. (2014). Osteoblast-derived WNT-induced secreted protein 1 increases VCAM-1 expression and enhances prostate cancer metastasis by down-regulating miR-126. Oncotarget 5, 7589–7598.

Tanaka, S., Sugimachi, K., Saeki, H., Kinoshita, J., Ohga, T., Shimada, M., Maehara, Y., and Sugimachi, K. (2001). A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma. Oncogene 20, 5525–5532.

Tanaka, S., Sugimachi, K., Shimada, M., Maehara, Y., and Sugimachi, K. (2002). Variant WISPs as targets for gastrointestinal carcinomas. Gastroenterology 123, 392–393.

Tanaka, S., Sugimachi, K., Kameyama, T., Maehara, S.-I., Shirabe, K., Shimada, M., Wands, J.R.,

12

Page 13: static-content.springer.com10.1007... · Web viewSupplementary data S2. Aktaş, S., Zadeoğlulari, Z., Erçetin, P., and Olgun, N. (2010). The effect of differentiating and apoptotic

and Maehara, Y. (2003). Human WISP1v, a member of the CCN family, is associated with invasive cholangiocarcinoma. Hepatology 37, 1122–1129.

Tang, Q., Jiang, X., Li, H., Lin, Z., Zhou, X., Luo, X., Liu, L., and Chen, G. (2011). Expression and prognostic value of WISP-1 in patients with endometrial endometrioid adenocarcinoma. J. Obstet. Gynaecol. Res. 37, 606–612.

Tank, J., Lindner, D., Wang, X., Stroux, A., Gilke, L., Gast, M., Zietsch, C., Skurk, C., Scheibenbogen, C., Klingel, K., et al. (2014). Single-target RNA interference for the blockade of multiple interacting proinflammatory and profibrotic pathways in cardiac fibroblasts. J. Mol. Cell. Cardiol. 66, 141–156.

Tao, H., Yang, J.-J., Shi, K.-H., and Li, J. (2016). Wnt signaling pathway in cardiac fibrosis: New insights and directions. Metab. Clin. Exp. 65, 30–40.

Taylor, S., Ominsky, M.S., Hu, R., Pacheco, E., He, Y.D., Brown, D.L., Aguirre, J.I., Wronski, T.J., Buntich, S., Afshari, C.A., et al. (2016). Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats. Bone 84, 148–159.

Temiz, N.A., Moriarity, B.S., Wolf, N.K., Riordan, J.D., Dupuy, A.J., Largaespada, D.A., and Sarver, A.L. (2016). RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens. Genome Res. 26, 119–129.

Thorfve, A., Lindahl, C., Xia, W., Igawa, K., Lindahl, A., Thomsen, P., Palmquist, A., and Tengvall, P. (2014). Hydroxyapatite coating affects the Wnt signaling pathway during peri-implant healing in vivo. Acta Biomater 10, 1451–1462.

Tian, C., Zhou, Z.-G., Meng, W.-J., Sun, X.-F., Yu, Y.-Y., Li, L., Luo, H.-Z., Yang, L., Zhou, B., and Gu, J. (2007). Overexpression of connective tissue growth factor WISP-1 in Chinese primary rectal cancer patients. World J. Gastroenterol. 13, 3878–3882.

Tong, Y., Ding, X.-B., Chen, Z.-X., Jin, S.-Q., Zhao, X., Wang, X., Mei, S.-Y., Jiang, X., Wang, L., and Li, Q. (2016). WISP1 mediates hepatic warm ischemia reperfusion injury via TLR4 signaling in mice. Sci Rep 6, 20141.

Urano, T., Narusawa, K. ’ichiro, Shiraki, M., Usui, T., Sasaki, N., Hosoi, T., Ouchi, Y., Nakamura, T., and Inoue, S. (2007). Association of a single nucleotide polymorphism in the WISP1 gene with spinal osteoarthritis in postmenopausal Japanese women. J. Bone Miner. Metab. 25, 253–258.

Vargas, J.Y., Ahumada, J., Arrázola, M.S., Fuenzalida, M., and Inestrosa, N.C. (2015). WASP-1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by Aβ oligomers. Exp. Neurol. 264, 14–25.

Venkatachalam, K., Venkatesan, B., Valente, A.J., Melby, P.C., Nandish, S., Reusch, J.E.B., Clark, R.A., and Chandrasekar, B. (2009). WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte death. J. Biol. Chem. 284, 14414–14427.

Venkatesan, B., Prabhu, S.D., Venkatachalam, K., Mummidi, S., Valente, A.J., Clark, R.A.,

13

Page 14: static-content.springer.com10.1007... · Web viewSupplementary data S2. Aktaş, S., Zadeoğlulari, Z., Erçetin, P., and Olgun, N. (2010). The effect of differentiating and apoptotic

Delafontaine, P., and Chandrasekar, B. (2010). WNT1-inducible signaling pathway protein-1 activates diverse cell survival pathways and blocks doxorubicin-induced cardiomyocyte death. Cell. Signal. 22, 809–820.

Venkatesan, N., Kanwar, J., Deepa, P.R., Khetan, V., Crowley, T.M., Raguraman, R., Sugneswari, G., Rishi, P., Natarajan, V., Biswas, J., et al. (2016). Clinico-Pathological Association of Delineated miRNAs in Uveal Melanoma with Monosomy 3/Disomy 3 Chromosomal Aberrations. PLoS ONE 11, e0146128.

Wang, H., Xu, Q., Xiao, F., Jiang, Y., and Wu, Z. (2008). Involvement of the p38 mitogen-activated protein kinase alpha, beta, and gamma isoforms in myogenic differentiation. Mol. Biol. Cell 19, 1519–1528.

Wang, H., Zhang, R., Wen, S., McCafferty, D.-M., Beck, P.L., and MacNaughton, W.K. (2009). Nitric oxide increases Wnt-induced secreted protein-1 (WISP-1/CCN4) expression and function in colitis. J. Mol. Med. 87, 435–445.

Wang, J., Zhang, G.Y., and Li, X.H. (2006). Effect of indomethacin on Bfl-1, WISP-1 and proliferating cell nuclear antigen in colon cancer cell line HCT116 cells. Chin J Dig Dis 7, 219–224.

Wang, Q., Liu, H., Liu, T., Shu, S., Jiang, H., Cheng, S., Yuan, Y., Yang, W., and Wang, L. (2013a). BRCA2 dysfunction promotes malignant transformation of pancreatic intraepithelial neoplasia. Anticancer Agents Med Chem 13, 261–269.

Wang, S., Chong, Z.Z., Shang, Y.C., and Maiese, K. (2012a). WISP1 (CCN4) autoregulates its expression and nuclear trafficking of β-catenin during oxidant stress with limited effects upon neuronal autophagy. Curr Neurovasc Res 9, 91–101.

Wang, S., Chong, Z.Z., Shang, Y.C., and Maiese, K. (2012b). Wnt1 inducible signaling pathway protein 1 (WISP1) blocks neurodegeneration through phosphoinositide 3 kinase/Akt1 and apoptotic mitochondrial signaling involving Bad, Bax, Bim, and Bcl-xL. Curr Neurovasc Res 9, 20–31.

Wang, S., Chong, Z.Z., Shang, Y.C., and Maiese, K. (2013b). WISP1 neuroprotection requires FoxO3a post-translational modulation with autoregulatory control of SIRT1. Curr Neurovasc Res 10, 54–69.

Wang, S.-H., Xu, F., Dang, H.-X., and Yang, L. (2013c). Genetic variations in the Wnt signaling pathway affect lung function in asthma patients. Genet. Mol. Res. 12, 1829–1833.

White, I.A., Gordon, J., Balkan, W., and Hare, J.M. (2015). Sympathetic Reinnervation Is Required for Mammalian Cardiac Regeneration. Circ. Res. 117, 990–994.

Witte, F., Dokas, J., Neuendorf, F., Mundlos, S., and Stricker, S. (2009). Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation. Gene Expr. Patterns 9, 215–223.

Wu, C.-L., Tsai, H.-C., Chen, Z.-W., Wu, C.-M., Li, T.-M., Fong, Y.-C., and Tang, C.-H. (2013). Ras activation mediates WISP-1-induced increases in cell motility and matrix metalloproteinase expression in human osteosarcoma. Cell. Signal. 25, 2812–2822.

14

Page 15: static-content.springer.com10.1007... · Web viewSupplementary data S2. Aktaş, S., Zadeoğlulari, Z., Erçetin, P., and Olgun, N. (2010). The effect of differentiating and apoptotic

Xie, D., Nakachi, K., Wang, H., Elashoff, R., and Koeffler, H.P. (2001). Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. Cancer Res. 61, 8917–8923.

Xu, L., Corcoran, R.B., Welsh, J.W., Pennica, D., and Levine, A.J. (2000). WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene. Genes Dev. 14, 585–595.

Yamada, Y., Ando, F., and Shimokata, H. (2009). Association of polymorphisms of SORBS1, GCK and WISP1 with hypertension in community-dwelling Japanese individuals. Hypertens. Res. 32, 325–331.

Yan, J.-Y., Zhou, Q., Yu, H.-M., Hou, M.-L., and Lu, L.-H. (2015). [High glucose promotes vascular smooth muscle cell calcification by activating WNT signaling pathway]. Nan Fang Yi Ke Da Xue Xue Bao 35, 29–33.

Yanagita, T., Kubota, S., Kawaki, H., Kawata, K., Kondo, S., Takano-Yamamoto, T., Tanaka, S., and Takigawa, M. (2007). Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes. FEBS J. 274, 1655–1665.

Yang, C.-S., Lopez, C.G., and Rana, T.M. (2011). Discovery of nonsteroidal anti-inflammatory drug and anticancer drug enhancing reprogramming and induced pluripotent stem cell generation. Stem Cells 29, 1528–1536.

Yang, M., Zhao, X., Liu, Y., Tian, Y., Ran, X., and Jiang, Y. (2013). A role for WNT1-inducible signaling protein-1 in airway remodeling in a rat asthma model. Int. Immunopharmacol. 17, 350–357.

Yang, M., Du, Y., Xu, Z., and Jiang, Y. (2016). Functional Effects of WNT1-Inducible Signaling Pathway Protein-1 on Bronchial Smooth Muscle Cell Migration and Proliferation in OVA-Induced Airway Remodeling. Inflammation 39, 16–29.

Yang, Z.-H., Zheng, R., Gao, Y., Zhang, Q., and Zhang, H. (2014). Abnormal gene expression and gene fusion in lung adenocarcinoma with high-throughput RNA sequencing. Cancer Gene Ther. 21, 74–82.

Yeger, H., and Perbal, B. (2007). The CCN family of genes: a perspective on CCN biology and therapeutic potential. J Cell Commun Signal 1, 159–164.

You, Z., Saims, D., Chen, S., Zhang, Z., Guttridge, D.C., Guan, K.-L., MacDougald, O.A., Brown, A.M.C., Evan, G., Kitajewski, J., et al. (2002). Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J. Cell Biol. 157, 429–440.

Yu, C., Le, A.-T., Yeger, H., Perbal, B., and Alman, B.A. (2003). NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia. J. Pathol. 201, 609–615.

Yu, W., Song, T., Shi, L., Wang, X., Jiang, Z., Zhang, H., and Wu, S. (2014). [Targeted inhibition of WISP1 enhanced radiosensitivity in glioma cells]. Zhonghua Yi Xue Za Zhi 94, 1507–1511.

Zemans, R.L., McClendon, J., Aschner, Y., Briones, N., Young, S.K., Lau, L.F., Kahn, M., and Downey, G.P. (2013). Role of β-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury. Am. J. Physiol. Lung Cell Mol. Physiol. 304, L415-427.

15

Page 16: static-content.springer.com10.1007... · Web viewSupplementary data S2. Aktaş, S., Zadeoğlulari, Z., Erçetin, P., and Olgun, N. (2010). The effect of differentiating and apoptotic

Zhang, C., Zhu, Y., Feng, H., and Chen, X. (2015a). [Effect of irradiated human lung fibroblasts on activation of canonical Wnt/β-catenin signaling pathway in mesenchymal stem cells]. Zhejiang Da Xue Xue Bao Yi Xue Ban 44, 162–166.

Zhang, H., Li, W., Huang, P., Lin, L., Ye, H., Lin, D., Koeffler, H.P., Wang, J., and Yin, D. (2015b). Expression of CCN family members correlates with the clinical features of hepatocellular carcinoma. Oncol. Rep. 33, 1481–1492.

Zhang, H., Luo, H., Hu, Z., Peng, J., Jiang, Z., Song, T., Wu, B., Yue, J., Zhou, R., Xie, R., et al. (2015c). Targeting WISP1 to sensitize esophageal squamous cell carcinoma to irradiation. Oncotarget 6, 6218–6234.

Zhang, H., Luo, H., Jiang, Z., Yue, J., Hou, Q., Xie, R., and Wu, S. (2016). Fractionated irradiation-induced EMT-like phenotype conferred radioresistance in esophageal squamous cell carcinoma. J. Radiat. Res.

Zhang, X., Chen, X., Liu, J., Dong, X., Jin, Y., Tian, Y., Xue, Y., Chen, L., Chang, Y., Liu, Y., et al. (2015d). Knockdown of WISP1 inhibit proliferation and induce apoptosis in ALL Jurkat cells. Int J Clin Exp Pathol 8, 15489–15496.

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