The 9th eeting of h Consortium orGlobalization of Chinese Medicine 2010

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Discussion Sessionon

Quality Control (Methodology)

August 23,2010, 16:20 -18:50

The h 1e ting of the Co sortium foGlobalization of Chinese Medicine 2010

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August 23,2010,12:30 - 13:00• 17 Posters, very high level• Topics overlapping with other sessions

especially Herbal Resources I und II (Cultivation and Quality Control, andIdentification and Manufacturing)

• Posters presented various modern technologies like- HPLC-MS/MS

- MALO I like techniques- NMR- IR

• Topics:- Authentication- Pharmacokinetic studies- Relationship to activity- Multi component analysis

The 9th Meeting f he Consortium orGlobalization of Chinese Medicine 2010

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Discussion Session on Quality Control (Methodology)August 23,2010, 16:20 -18:50

Chairman:• Prof. Rudolf Bauer, University of Graz, Austria

Co-chairmen:• Prof. Kelvin Chan, University of Sydney and University of Western

Sydney, Australia• Prof. Ian Sutherland, Brunei University, UK

Panelists:• Prof. Chau Foo-Tirn, Hong Kong Polytechnic University, China• Prof. Luo Guo-An, Tsinqhua University, Beijing, China• Dr. Ng Kwan-Ming, The University of Hong Kong, China

The 9 h Meeting of the Consortium forGlobalization of Chinese Medicine 2010

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Discussion Session on Quality Control (Methodology)August 23, 2010, 16:20 -18:50

he gt ing f 0 ortium f rGlobalization of Chinese Medicine 2010

Discussion Session on Quality Control (Methodology)16:20 Rudolf Bauer Introductory Remarks16:30 Kelvin Chan Statement on progress in monographic standards relating

minimum QC requirements16:40 Discussion, remarks from the audience16:50 Ian Sutherland The Strategy of using Counter-current Chromatography17:00 Chau Foo-Tim The Strategy of "Quantitative Pattern-Activity Relationship"17:10 Luo Guo-An The Strategy of .Chemornlcs"17:20 Liu Shwu The Strategy of .Phytomlcs"17:30 Discussion18:00 Yao Zhi-hong

Short Presentation of Poster 380 .Gold-NanoparticlesAssisted Laser Desorption/lonization Imaging Massspectrometric Analysis of American Ginseng and Cordyceps"

18:05 Discussion18:15 Kwan-Ming Ng

Short Presentation of Poster 374 "Investigation on HPLCFingerprint of TCM Prescription .Xlaoyanlidan Tablet on Market"

18:20 Discussion18:30 Peter Hylands Short Presentation of Poster 385 "Multivariate Data Analysis

Using HPLC, NMR and IR Methods on the Quality Control ofDanshen Products"

18:35 Discussion18:45 Rudolf Bauer18:50 Closing

Summary and Closing Remarks

"Emperor" (jun): responsible formain effect

"Minister" (chen): supports maineffect or coverssecond indication

"Assistant" (zuo): supports maineffects or antago-nizes side effects

"Envoy" (shi): channels actionsThe therapeutic activity of Chinese herbal medicine

is based multiple herbs and constituents

Multiplecompounds

)Single •

compound

Multiple targetsSingle target

CODOI91C1

Chinese Angelica RootAngelicae sinensis radix

Chinese Angelica is the dried root of Angelica sinensis (Oliv.) Diels (Fam.Umbelliferae). The drug is collected in late autumn, removed from rootlet andsoil, slightly dried and tied up in small bundles, placed on a shelf and smokedried.

Content: not less than 0.05 per cent of trans-ferulic acid (C1OH1004• Mr 194.184),calculated with reference to the dried drug.

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..~Claims and properties:• antioxidant• neutralizes free radicals• protects from UV light.• decreases blood glucose levels• blocks nitrosamine formation• protects against cancer, bone

degeneration, menopausal symptoms• reduces cholesterol and triglycerides '.00

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tuppner, H., Bauer, R., Phytochemical Analysis 2,283-290 (1998)

',nru~l',\rtiU rGlobalization of Chines Medicine 2010

Discussion Session on Quality Control (Methodology)16:20 Rudolf Bauer Introductory Remarks16:30 Kelvin Chan Statement on progress in monographic standards relating

minimum QC requirementsDiscussion, remarks from the audienceIan Sutherland The Strategy of using Counter-current chromatographyChau Foo-Tim The Strategy of "Quantitative Pattern-Activity Relationship"Luo Guo-An The Strategy of .Chemomics"Liu Shwu The Strategy of .Phytornics"DiscussionYao Zhi-hong

16:4016:5017:0017:1017:2017:3018:00 Short Presentation of Poster 374 .Investigation on HPLC

Fingerprint ofTCM Prescription .Xiaoyanlidan Tablet on Market"18:0518:15

DiscussionKwan-Ming Ng Short Presentation of Poster 380 .Gold-Nanoparticles

Assisted Laser Desorptionllonization Imaging Massspectrometric Analysis of American Ginseng and Cordyceps"

DiscussionPeter Hylands

18:2018:30 Short Presentation of Poster 385 .Multivariate Data Analysis

Using HPLC, NMR and IR Methods on the Quality Control ofDanshen Products'

DiscussionRudolf BauerClosing

18:3518:4518:50

Summary and Closing Remarks