PB-1005298 Rev F

Baseline 3 months after 3 treatments

Universal IPL with OPT TM - Vascular Lesions

Courtesy of Matteo Tretti Clementoni, MD

Vascular filter, 18 J/cm2 , 3 & 4 ms double pulse, with 20 ms delay

PB-1005298 Rev F

Baseline 3 months after 3 treatments

Universal IPL with OPT TM - Vascular Lesions

Courtesy of Matteo Tretti Clementoni, MD

Vascular filter, 18 J/cm2 , 3 & 4 ms double pulse, with 20 ms delay

PB-1005298 Rev F

Baseline 3 months after 3 treatments

Courtesy of Matteo Tretti Clementoni, MD

Vascular filter, 18 J/cm2 , 3 & 4 ms double pulse, with 20 ms delay

Universal IPL with OPT TM - Vascular Lesions

PB-1005298 Rev F

Baseline 3 months after 3 treatments

Universal IPL with AOPTTM - Vascular Lesions

Courtesy of Matteo Tretti Clementoni, MD

Vascular filter and Advanced OPT, double pulse, 8 and 12 J/cm2, 4 & 5 ms, with 20 ms delay

PB-1005298 Rev F

Baseline 3 months after 3 treatments

Universal IPL with AOPTTM - Vascular Lesions

Courtesy of Matteo Tretti Clementoni, MD

Vascular filter and Advanced OPT, double pulse, 10 and 11 J/cm2, 6 & 6 ms, with 20 ms delay

PB-1005298 Rev F

Baseline 3 months after 3 treatments

Universal IPL with AOPTTM - Vascular Lesions

Courtesy of Matteo Tretti Clementoni, MD

Vascular filter and Advanced OPT, double pulse, 6 and 12 J/cm2, 3 & 5 ms, with 20 ms delay

PB-1005298 Rev F

Baseline 3 months after 3 treatments

Universal IPL with AOPTTM - Vascular Lesions

Courtesy of Matteo Tretti Clementoni, MD

Vascular filter and Advanced OPT, double pulse, 6 and 12 J/cm2, 3 & 5 ms, with 20 ms delay

PB-1005298 Rev F

Baseline 3 months after 3 treatments

Universal IPL with AOPTTM - Vascular Lesions

Courtesy of Matteo Tretti Clementoni, MD

Vascular filter and Advanced OPT, double pulse, 6 and 12 J/cm2, 3 & 5 ms, with 20 ms delay

PB-1005298 Rev F

Baseline 3 months after 3 treatments

Universal IPL with AOPTTM - Vascular Lesions

Courtesy of Matteo Tretti Clementoni, MD

Vascular filter, 18 J/cm2 , 3 & 4 ms double pulse, with 20 ms delay

PB-1005298 Rev F

Baseline 1 month after last treatment

Universal IPL with OPTTM - Vascular Lesions

Courtesy of Hiroki Kanda, MD

590 nm filter, 20 J/cm2, 3 ms triple pulse, with 20 ms delay

PB-1005298 Rev F

6 months after last treatmentBaseline

Courtesy of Melanie D. Palm, MD

560 nm filter, 17-18 J/cm2, 4 ms double pulse, with 15 ms delay

Universal IPL with OPTTM - Vascular Lesions

PB-1005298 Rev F

Baseline After 5 treatments

Universal IPL with OPTTM + Multi-SpotTM Nd:YAG - PWS

Courtesy of Dr. Matteo Tretti Clementoni, MD

Nd:YAG 100 J/cm2, 12ms, 6mm tip – where blood flow is slow / skin is thick | Nd:YAG 80 J/cm2, 10ms, 6mm tip – where blood flow is quick / skin is thin | IPL with crossing technique, 590nm filter, 18J/cm2, 4-4 ms pulses with 15ms delay; and 560nm, 18J/cm2, 3-3 ms pulses with 20ms delay

PB-1005298 Rev F

Baseline

Universal IPL with OPTTM - PWS

Courtesy of Gilly Munavalli, MD

After treatment

PB-1005298 Rev F

After 4 treatmentsBaseline

Universal IPL with OPTTM - PWS

560 nm filter, 21 J/cm2, 6 ms single pulse

Courtesy of Li Yuanhong, MD

PB-1005298 Rev F

1 month after 1 treatmentBaseline

Universal IPL with OPTTM - Lentigines

590nm filter, 12J/cm2, 4ms pulse, small rectangular light guide, 38 total pulses

Courtesy of J. Matthew Knight, MD

PB-1005298 Rev F

3 weeks after 2 treatments,with 15 months between treatments

Baseline

Universal IPL with OPTTM - Lentigines

Tx1: 590nm filter, 12J/cm2, 4ms pulse, individual lentigos treated with small light guide (23 pulses)Tx2: 560nm filter, 13J/cm2, 4ms pulse, treated globally with large light guide (42 pulses)

Courtesy of J. Matthew Knight, MD

PB-1005298 Rev F

Baseline After 2 treatments

Universal IPL with OPTTM - Lentigines

Courtesy of Mariela Nazar, MD

PB-1005298 Rev F

After 3 treatmentsBaseline

Universal IPL with OPTTM - Lentigines

560 nm filter, 13 J/cm2, 4 ms single pulse

Courtesy of Li Yuanhong, MD

PB-1005298 Rev F

After 1 treatmentBaseline

Universal IPL with OPTTM - Lentigines

560 nm filter, 14 J/cm2, 3 ms double pulse, with 20 ms delay

Courtesy of Li Yuanhong, MD

PB-1005298 Rev F

8 weeks after 3 treatmentsBaseline

Universal IPL with OPTTM - Skin Rejuvenation

Courtesy of B. Kent Remington, MD

PB-1005298 Rev F

Baseline 3.5 months after last treatment

Universal IPL with OPTTM - Skin Rejuvenation

Courtesy of Hiroki Kanda, MD

560 nm filter, 28 J/cm2, 3 ms double pulse, with 20 ms delay

PB-1005298 Rev F

Baseline 2 months after last treatment

Universal IPL with OPTTM - Skin Rejuvenation

Courtesy of Hiroki Kanda, MD

640 nm filter, 28 J/cm2, 3 ms double pulse, with 5 ms delay

PB-1005298 Rev F

Baseline 1 month after last treatment

Universal IPL with OPTTM - Skin Rejuvenation

Courtesy of Hiroki Kanda, MD

560 nm filter, 12-18 J/cm2, 3 ms double pulse, with 20 ms delay590 nm filter, 16-22 J/cm2, 3 ms triple pulse, with 30 ms delay

PB-1005298 Rev F

Baseline 1 year after 8 treatments

Universal IPL with OPTTM - Skin Rejuvenation

Courtesy of Hiroki Kanda, MD

560 nm filter, 12-18 J/cm2, 3 ms double pulse, with 20 ms delay590 nm filter, 16-22 J/cm2, 3 ms triple pulse, with 30 ms delay

PB-1005298 Rev F

Baseline 1 month after 8 treatments

Courtesy of Hiroki Kanda, MD

560 nm filter, 12-16 J/cm2, 3 ms double pulse, with 20 ms delay590 nm filter, 16-20 J/cm2, 3 ms triple pulse, with 30 ms delay

Universal IPL with OPTTM - Skin Rejuvenation

PB-1005298 Rev F

Baseline 4 month after 7 treatments

Universal IPL with OPTTM - Skin Rejuvenation

Courtesy of Hiroki Kanda, MD

560 nm filter, 12-16 J/cm2, 3 ms double pulse, with 20 ms delay590 nm filter, 16-20 J/cm2, 3 ms triple pulse, with 30 ms delay

PB-1005298 Rev F

After 2 treatmentsBaseline

640 nm filter, 18 J/cm2, 3 ms triple pulse, with 30 ms delay

Courtesy of Li Yuanhong, MD

Universal IPL with OPTTM - Skin Rejuvenation

PB-1005298 Rev F

3 months after 2 treatmentsBaseline

Courtesy of Melanie D. Palm, MD

560 nm filter, 16-17 J/cm2, 3.5 ms double pulse, with 20 ms delay

Universal IPL with OPTTM - Skin Rejuvenation

PB-1005298 Rev F

3 months after 2 treatmentsBaseline

Courtesy of Melanie D. Palm, MD

560 nm filter, 16-17 J/cm2, 3.5 ms double pulse, with 20 ms delay

Universal IPL with OPTTM - Skin Rejuvenation

PB-1005298 Rev F

1 month after 3 treatments with 5-6 weeks between treatments

Baseline

Universal IPL with OPTTM - Skin Rejuvenation

Tx1: 560nm filter, 16J/cm2, 3.5-3.5ms pulses with 15ms delay, large light guideTx2: 515nm filter, 15J/cm2, 4ms pulse duration large light guideTx3: 560nm filter, 17J/cm2, 3.5-3.5ms pulses with 15ms delay, large light guide

Courtesy of J. Matthew Knight, MD

PB-1005298 Rev F

After treatmentBaseline

Universal IPL with OPTTM - Rosacea

Courtesy of Gilly Munavalli, MD

PB-1005298 Rev F

Baseline

Universal IPL with OPTTM - Rosacea

Courtesy of Gilly Munavalli, MD

After treatment

PB-1005298 Rev F

Baseline

Universal IPL with OPTTM - Rosacea

Courtesy of Mary Lupo, MD

After treatment

PB-1005298 Rev F

Baseline

Universal IPL with OPTTM - Rosacea

Courtesy of Mary Lupo, MD

After treatment

PB-1005298 Rev F

Baseline After 2 treatments

Universal IPL with OPTTM - Rosacea

Courtesy of Mariela Nazar, MD

PB-1005298 Rev F

Baseline After 2 treatments

Universal IPL with OPTTM - Rosacea

Courtesy of Mariela Nazar, MD

PB-1005298 Rev F

Baseline 3.5 months after last treatment

Universal IPL with OPTTM - Rosacea

Courtesy of Hiroki Kanda, MD

590 nm filter, 16-22 J/cm2, 3 ms triple pulse, with 30 ms delay

PB-1005298 Rev F

Baseline 3 weeks after 6 treatments

Universal IPL with OPTTM - Rosacea

Courtesy of Hiroki Kanda, MD

590 nm filter, 16-22 J/cm2, 3 ms triple pulse, with 30 ms delay

PB-1005298 Rev F

Baseline 5 weeks after 5 treatments

Universal IPL with OPTTM - Rosacea

Courtesy of Hiroki Kanda, MD

590 nm filter, 16-22 J/cm2, 3 ms triple pulse, with 30 ms delay

PB-1005298 Rev F

Baseline 1 month after 2 treatments

Universal IPL with OPTTM - Erythema of Rosacea

Courtesy of Hiroki Kanda, MD

590 nm filter, 16-22 J/cm2, 3 ms triple pulse, with 30 ms delay

PB-1005298 Rev F

Baseline 1.5 months after last treatment

Universal IPL with OPTTM - Erythema of Rosacea

Courtesy of Hiroki Kanda, MD

590 nm filter, 16-22 J/cm2, 3 ms triple pulse, with 30 ms delay

PB-1005298 Rev F

Baseline 2 months after 10 treatments

Universal IPL with OPTTM - Erythema of Rosacea

Courtesy of Hiroki Kanda, MD

590 nm filter, 16-22 J/cm2, 3 ms triple pulse, with 30 ms delay