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Wake-up spray from capsicum

MR. SOMJATE JAMPADANG

MISS SUDARAT CHOKKIJCHAI

A SPECIAL PROJECT SUBMITTED IN PARTIAL FULFILMENT

OF THE REQUIREMENT FOR

THE BACHELOR DEGREE OF SCIENCE IN PHARMACY

FACULTY OF PHARMACY

MAHIDOL UNIVERSITY

2004

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Wake-up spray from capsicum

Somjate Jampadang, Sudarat Chokkijchai

Project advisor: Vimol Srisukh*, Walla Tungrugsasut*, Nuntavan Bunyapraphatsara**,

Suwan Thirawaraphan***, Varaporn Junyaprasert****

*Department of Food Chemistry, Faculty of Pharmacy, Mahidol University

**Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University

***Department of Physiology, Faculty of Pharmacy, Mahidol University

****Department of Pharmacy, Faculty of Pharmacy, Mahidol University

Keyword: Oral spray, Capsicum frutescens L., Wake-up product

A wake-up oral spray from a capsicum fruit, Phrik Kheenuu Daeng (Capsicum

frutescens L.) (PKD), was developed in order to be used in place of stimulating

products which were detrimental to health. The formula consisted of the concentrated

form of 95% ethanol extract of PKD, at 5% v/v; other ingredients were PEG40

hydrogenated castor oil, citric acid, Acesulfame-K, sodium chloride, gelatin, sodium

benzoate, menthol, orange colorant and flavoring agent. The capsicum spray, a clear

orange solution, was evaluated among 30 male and female pharmacy student

volunteers. The result was analyzed using Analysis of Variance. The capsicum spray

caused significant increase (P<0.05) in systolic blood pressure, diastolic blood

pressure, heart rate and mean arterial pressure immediately after administration

compared to the normal state. When the capsicum spray was compared to the control

formula, only systolic blood pressure, heart rate, and mean arterial pressure were

significantly increased (P<0.05). In Home Use Test, the capsicum spray was distributed

among 50 people, divided into 2 groups. Group 1 consisted of people who read while

Group 2 were working people. It was found that among 50 volunteers, the average onset

of alertness was 0.93 minute and the average duration of alertness was 7.92 minutes.

The results showed that in Group 1, the average onset of alertness was 0.77 minute and

!

the average duration of alertness was 6.23 minutes while in Group 2, the average onset

of alertness was 1.1 minutes and the average duration of alertness was 9.6 minutes.