vet.osu.edu/biosciences

BIOS  

     

In the Department of Veterinary Bioscience, we discover the mechanisms of disease. We use this knowledge to educate others and to develop and utilize tools for disease diagnosis, treatment, and intervention to improve the health of animals and humans. In the process of educating others, several members of VBS were recently recognized for their teaching excellence!

Dr. Li Wu is shown receiving the Charles C. Capen Teaching Excellence Award for Graduate Education from Dean Lonnie King. This award honors faculty who excel in their roles as advisors and mentors for Master of Science and Doctor of Philosophy candidates, as participants in departmental graduate programs, or as resource persons for the graduate students of the College.

Dr. Mary Jo Burkhard is shown receiving the Class of 2018 Excellence in Teaching Award from Kristen Bartholomew (Class President). Excellence in Teaching awardees are selected by students in the professional veterinary medical education program based on their character, the caliber of their instruction and teaching ability, and their responsiveness to needs of the students.

Dr. Maggie Shoemaker (1st year PhD / anatomic pathology resident) is awarded the SCAVMA Outstanding Teacher Award for Resident/Graduate Teaching Associates by Lyle Simpson (SCAVMA President). This award recognizes teaching ability, knowledge in their area of expertise, responsiveness to the needs of students, and dedication to the College and the profession.

Our Educational Mission

 

 

It is not the strongest of the species that survive, nor the most intelligent, but the one most responsive to change. – Charles Darwin

 

Dr.  Salvador  (Sal)  Butera  was  recognized  as  a  Distinguished  Alumnus  of  the  College  of  Veterinary  Medicine  at  this  year’s  Oath  and  Hooding  Ceremony.    Sal  is  currently  Chief  Science  Officer  at  the  Center  for  HIV/AIDS  Vaccine  Immunology  and  Immunogen  Discovery  at  the  Scripps  Research  Institute.  His  career  path  has  been  inherently  impactful  –  he  has  utilized  an  extensive  background  of  laboratory  expertise,  senior-­‐level  management  experience,  and  knowledge  of  US  Government  health-­‐science  programs  to  advance  human  and  animal  disease  prevention  with  local  benefit  and  global  impact.    Dr.  Butera  completed  a  dual  degree  program  at  The  Ohio  State  University  receiving  his  DVM  and  MS  in  1985.  He  followed  this  with  a  PhD  at  Colorado  State  University  and  then  entered  a  22  year  career  at  CDC  where  he  rose  from  Staff  Research  Fellow  to  Virology  Section  Chief    to  the  Associate  Director  for  Laboratory  Science,  Office  of  the  Director,  National  Center  for  HIV/AIDS,  Viral  Hepatitis,  STD  and  TB  Prevention.      Sal  then  transitioned  to  The  Scripps  Research  Institute  in  La  Jolla  California,  where  he  now  serves  as  Director  of  Scientific  Support  for  the  Neutralizing  Antibody  Center,  which  is  part  of  the  International  AIDS  Vaccine  Initiative.  He  and  his  group  have  secured  funding  from  the  NIH  to  establish  the  Center  for  HIV/AIDS  Vaccine  Immunology  and  Immunogen  Discovery  -­‐  whose  goal  is  to  develop  an  HIV  preventative  vaccine.    Sal  has  an  extensive  record  of  peer-­‐reviewed  scholarship,  book  chapters,  and  invited  presentations,  as  well  as  editorial,  advisory,  and  review  panels.  However,  most  importantly,  by  embracing  leadership  roles  at  the  CDC  and  The  Scripps  Research  Institute,  Dr.  Butera  demonstrates  the  power  and  value  of  a  veterinary  medical  education  to  the  broader  biomedical  community.  

Distinguished alum Salvador Butera

 

 

 

Shannon  Binkley  Title:  Program  Assistant    Years  of  Service:    1  year    Where  do  you  work?  Front  Office  of  Goss  Lab    Recent  contribution  to  the  department:  Working  with  Dr.  Cianciolo  and  Texas  A&M  University  to  coordinate  shipping  for  The  International  Veterinary  Renal  Pathology  Service.  We’ve  helped  practices  in  Australia,  South  Korea,  the  UK,  and  Canada.    Best  Part  about  working  in  Biosciences:    Listening  to  researchers  talking  about  their  projects  and  actually  understanding  some  of  it  now  (from  being  surrounded  by  it  for  a  year).  And,  getting  to  –  hopefully!  –  maybe  see  the  inside  of  a  squid  someday.  

Contributing to our service and outreach mission

It is what we make of what we have, not what we are given, that separates one person from another.

- Nelson Mandela

Rosol Selected as HBA Mentor for Personal Branding Dr. Rosol has been selected as the only male mentor for the Healthcare Businesswomen’s Association (HBA) in-depth program on personal branding. Rosol will have 4 mentees selected by HBA and they will complete their program that includes two meetings a month with a market-

ready brand during a graduation ceremony in November. The program follows the book, ‘Branding Pays: The Five-Step System to Reinvent Your Personal Brand’ by branding expert, Karen Kang. www.hbanet.org  

 

Anne  Saulsbery    Title:  Lead  Histology  Technician    (although  we  are  all  pretty  self-­‐sufficient!)    Years  of  Service:    15  years    

Where  do  you  work?  The  Histology  Lab    Recent  contribution  to  the  department:    I  enjoy  adding  to  my  knowledge  of  special  stains  the  renal  panel  of  stains  that  I  had  to  acquire  when  Dr.  Cianciolo  came  on  board  with  the  renal  pathology  service.    Best  Part  about  working  in  Biosciences:      The  best  part  of  working  in  Biosciences  for  me  is  meeting  and  learning  from  all  the  researchers  and  graduate  students  that  come  though  the  histology  lab.  

 

 

Trainee Awards – Kudos!

Dreams are extremely important. You can’t do it unless you can imagine it. - George Lucas

 

Congratulations  current  &  alumni  trainees  for  successful  completion  of  Phase  I  of  the  ACVP  Certifying  Exam!  

 

Nadine  Bowden  Sarah  Chaney  Elizabeth  Clark  Laurie  Milward  

CVM Research Day Immunology & Infectious Diseases *

Tara Martin

Identification of cGAMP as an effective adjuvant for induction of mucosal IgA via sublingual immunization

Mentor: Dr. Prosper Boyaka  

* Sponsored by the Public Health Preparedness for Infectious Diseases Program

CVM Research Day Molecular & Cellular Biology

Dr. Lauren Himmel

Suppression of breast cancer stem cells in the MMTV-Her2/neu mouse model by the hdac inhibitor AR-42

Mentor: Dr. Ching-Shih Chen

Dr.  Michael  Martinez        

Received  the  Ohio  State  Excellence  in  Pathology  and  the  ACVP  Excellence  in  Veterinary  Pathology  Awards.  He  will  join  our  combined  anatomic  residency  /  PhD  program  in  June!  

Feifei  Wang  Hayes  Graduate  Research  Forum  

2nd  Place,  Oral  Presentation    

Effect  of  phosphorylation  of  mouse  SAMHD1  on  restriction  of  HIV-­‐1  and  murine  leukemia  virus  infections    

Mentor:  Dr.  Li  Wu  

EunSoo  Kim      

Chronic  ingestion  of  low  doses  of  cadmium  alters  the  gut  microbiome  and  immune  homeostasis  to  enhance  allergic  sensitization    

Selected  for  oral  presentation  &  travel  award  at  the  American  Association  of  Immunologists  meeting    

Mentors:  Drs.  Estelle  Cormet-­‐Boyaka  and  Prosper  Boyaka  

 

 

Impact starts with discovery!

Your success in life isn’t based on your ability to simply change. It is based on your ability to change faster than your competition.

– Mark Sanborn

 Engineering  protease-­‐resistant  A/B  foldamer  peptides  for  broad  spectrum  antivirals.  Stefan  Niewiesk;  Weill  Cornell  Medical  College.        

Mechanisms  underlying  influenza-­‐induced  CF  exacerbations.    Ian  Davis;  Cystic  Fibrosis  Foundation.  

     

Dissecting  the  role  of  miR-­‐9  in  normal  and  malignant  mast  cell  biology.  Joelle  Fenger  (Mentors:  Cheryl  London,  Guido  Marcucci);  National  Institutes  of  Health,  KO2.  

Accelerator  Award  Congratulations  to  Drs.  Yasuko  Rikihisa  and  Ian  

Davis,  their  internal  team,  Drs.  Jean  Schelhorn,  Kate  Hayes-­‐Ozello,  Tom  Rosol,  and  Melissa  Kelly,  and  external  partners  Dr.  David  Ralph  and  Mr.  John  Steele  on  winning  an  Ohio  State  University  

Accelerator  Award  for  their  proposal:      

Harnessing  Nature’s  Tick  to  Deliver  Drugs    

This  was  the  first  round  of  Accelerator  Awards  granted  at  The  Ohio  State  University.  The  primary  goal  of  the  new  Accelerator  Awards  is  to  provide  Ohio  State  researchers  with  awards  up  to  $50,000  to  develop  and  validate  inventions,  software,  and  technologies  and  to  make  early  inventions  more  marketable  to  potential  licensing  and/or  business  partners.  

 

 

People think focus means saying yes to the thing you’ve got to focus on. But that’s not what it means at all. It means saying no to the hundred other good ideas that there are. You have to pick carefully. – Steve Jobs

Publication  spotlight:  Cigarette  smoke  damages  channels  in  airway  cells  that  are  critical  for  mucous  clearance  

 

Over  90%  of  patients  who  develop  chronic  obstructive  pulmonary  disease  (COPD)  are  or  were  smokers  and  cigarette  smoke  has  been  shown  to  interfere  with  the  function  of  airway  cell  channels  that  are  critical  for  airway  cells  to  remove  mucous  and  other  material  from  the  lungs.  In  this  study,  the  lab  of  Dr.  Estelle  Cormet-­‐Boyaka  found  that  cigarette  smoke  activates  a  pathway  (MAPK/ERK)  which  is  responsible  for  communication  between  the  airway  cell’s  nucleus  and  the  channel  on  the  surface.  Activation  of  this  pathway  leads  to  increased  destruction  of  the  airway  channel  –  a  key  marker  associated  with  reduced  clearance  of  mucous,  bronchitis,  and  obstructive  airway  disease  in  people.  Importantly,  they  found  that  blocking  the  MAPK/ERK  pathway,  prevented  the  destruction  of  the  airway  channel  –  providing  potential  new  treatments  for  patients  with  COPD.    

Biochimica  et  Biophysica  Acta      http://www.ncbi.nlm.nih.gov/pubmed/25697727        

Publication  spotlight:  Newly  characterized  pig  virus  causes  major  economic  impact            

In  2014,  a  new  virus  emerged  in  pigs  in  the  Midwest  and  rapidly  spread  across  North  America  resulting  in  major  economic  losses.  Although  having  similarity  to  other  major  diseases  of  pigs  (transmissible  gastroenteritis  and  epidemic  diarrhea),  veterinarians  and  researchers  were  able  to  identify  a  novel  virus  (porcine  deltacoronovirus)  as  causing  the  disease.  The  labs  of  Drs.  Jianrong  Li,  Steve  Krakowka,  and  Mike  Oglesbee  teamed  up  to  study  this  virus.  They  analyzed  the  virus’s  genetic  structure  found  it  to  be  similar  to  coronoviruses  of  Asian  leopard  cats  and  Chinese  ferret-­‐badgers.  They  also  tested  the  virus  and  compared  it  to  other  coronoviruses  of  pigs  to  better  understand  the  disease  it  causes,  the  organs  it  affects,  how  it  is  transmitted  and  infects  other  pigs,  and  how  to  test  for  the  infection.  They  show  that  the  new  virus  causes  severe  diarrhea  and  vomiting  in  piglets,  replicates  strongly  in  the  gut  but  also  blood  and  multiple  organs  throughout  the  body.  Furthermore,  the  virus  was  found  to  be  highly  infectious  and  could  persist  in  pigs  for  a  long  period  of  time  –  making  it  a  challenge  to  clear  from  a  swine  facility.    

MBio        http://www.ncbi.nlm.nih.gov/pubmed/25759498      

Have something to contribute to BIOS? An interesting update? Someone we should highlight? A good quote or kudos you’d like to share? Please contact Robyn Luce at luce.73@osu.edu

 

 

Ideas are cheap – making something of them is difficult. - Anne Sigismund Huff

From our pathology and shared resource groups Comparative Pathology & Mouse Phenotyping Shared Resource • Bolon, B (Editor). Pathology of the Developing Mouse; a systematic approach. CRC Press • Coble DJ, Shoemaker M, Harrington B, Dardenne AD, Bolon B. Histiocytic Sarcoma and Bilateral

Facial Vein Thrombosis in a Siberian Hamster (Phodopus sungorus). Comp Med http://www.ncbi.nlm.nih.gov/pubmed/25926398

• Gressel KL, Duncan FJ, Oberyszyn TM, La Perle KM, Everts HB. Endogenous Retinoic Acid Required to Maintain the Epidermis Following Ultraviolet Light Exposure in SKH-1 Hairless Mice. Photochem Photobiol http://www.ncbi.nlm.nih.gov/pubmed/25715879

International Veterinary Renal Pathology Service • Cianciolo RE, Mohr FC, Aresu L, Brown CA, James C, Jansen JH, Spangler WL, van der Lugt JJ,

Kass PH, Brovida C, Cowgill LD, Heiene R, Polzin DJ, Syme H, Vaden SL, Dongen AM, Lees GE. World Small Animal Veterinary Association Renal Pathology Initiative: Classification of Glomerular Diseases in Dogs. Vet Pathol http://www.ncbi.nlm.nih.gov/pubmed/25957358

• Holm LP, Hawkins I, Robin C, Newton RJ, Jepson R, Stanzani G, McMahon LA, Pesavento P, Carr T, Cogan T, Couto CG, Cianciolo R, Walker DJ. Cutaneous and renal glomerular vasculopathy as a cause of acute kidney injury in dogs in the UK. Vet Rec http://www.ncbi.nlm.nih.gov/pubmed/25802439

Pathology • Pieczarka EM, Russell DS, Santangelo KS, Aeffner F, Burkhard MJ. Osseous metaplasia within a

canine insulinoma. Vet Clin Pathol http://www.ncbi.nlm.nih.gov/pubmed/24446791

From our research and clinical trial groups

Boyaka lab • Xu X, Balsiger R, Tyrrell J, Boyaka PN, Tarran R, Cormet-Boyaka E. Cigarette smoke exposure

reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR. Biochim Biophys Acta http://www.ncbi.nlm.nih.gov/pubmed/25697727

Cormet-Boyaka lab • Abdelaziz DH, Khalil H, Cormet-Boyaka E, Amer AO. The cooperation between the autophagy

machinery and the inflammasome to implement an appropriate innate immune response: do they regulate each other? Immunol Rev http://www.ncbi.nlm.nih.gov/pubmed/25879294

• Gorr MW, Youtz DJ, Eichenseer CM, Smith KE, Nelin TD, Cormet-Boyaka E, Wold LE. In vitro particulate matter exposure causes direct and lung-mediated indirect effects on cardiomyocyte function. Am J Physiol Heart Circ Physiol http://www.ncbi.nlm.nih.gov/pubmed/25957217

• Qian Z, Xu X, Amacher JF, Madden DR, Cormet-Boyaka E, Pei D. Intracellular Delivery of Peptidyl Ligands by Reversible Cyclization: Discovery of a PDZ Domain Inhibitor that Rescues CFTR Activity. Angew Chem Int Ed Engl http://www.ncbi.nlm.nih.gov/pubmed/25785567

• Xu X, Balsiger R, Tyrrell J, Boyaka PN, Tarran R, Cormet-Boyaka E. Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR. Biochim Biophys Acta http://www.ncbi.nlm.nih.gov/pubmed/25697727

Sharing new knowledge

 

 

A good head and a good heart are always a formidable combination. But when you add to that a literate tongue or pen, then you have something very special.

- Nelson Mandela

Davis lab • Woods PS, Tazi MF, Chesarino NM, Amer AO, Davis IC. TGF-β-induced IL-6 prevents development of

acute lung injury in influenza A virus-infected F508del CFTR-heterozygous mice. Am J Physiol Lung Cell Mol Physiol http://www.ncbi.nlm.nih.gov/pubmed/25840995

Hamlin lab • Authier S, Curtis MJ, Soloviev M, Redfern WS, Kallman MJ, Hamlin RL, Leishman DJ, Valentin JP,

Koerner JE, Vargas HM, Botchway A, Correll K, Pugsley MK. The Diplomate in Safety Pharmacology (DSP) certification scheme. J Pharmacol Toxicol Methods http://www.ncbi.nlm.nih.gov/pubmed/25959882

Krakowka lab • Ma Y, Zhang Y, Liang X, Lou F, Oglesbee M, Krakowka S, Li J. Origin, evolution, and virulence of

porcine deltacoronaviruses in the United States. MBio http://www.ncbi.nlm.nih.gov/pubmed/25759498 Li lab • Cai H, Zhang Y, Ma Y, Sun J, Liang X, Li J. Zinc binding activity of human metapneumovirus M2-1

protein is indispensable for viral replication and pathogenesis in vivo. J Virol http://www.ncbi.nlm.nih.gov/pubmed/25855728

• Liu C, Tang J, Ma Y, Liang X, Yang Y, Peng G, Qi Q, Jiang S, Li J, Du L, Li F. Receptor usage and cell entry of porcine epidemic diarrhea coronavirus. J Virol http://www.ncbi.nlm.nih.gov/pubmed/25787280

• DiCaprio E, Purgianto A, Li J. The Effect of Abiotic and Biotic Stress on the Internalization and Dissemination of Human Norovirus Surrogates in Growing Romaine Lettuce. Appl Environ Microbio http://www.ncbi.nlm.nih.gov/pubmed/25956773

• Lou F, Neetoo H, Chen H, Li J. High hydrostatic pressure processing: a promising nonthermal technology to inactivate viruses in high-risk foods. Annu Rev Food Sci Technol http://www.ncbi.nlm.nih.gov/pubmed/25884283

• Ma Y, Zhang Y, Liang X, Lou F, Oglesbee M, Krakowka S, Li J. Origin, evolution, and virulence of porcine deltacoronaviruses in the United States. MBio http://www.ncbi.nlm.nih.gov/pubmed/25759498

London lab • London CA, Gardner HL, Mathie T, Stingle N, Portela R, Pennell ML, Clifford CA, Rosenberg MP, Vail

DM, Williams LE, Cronin KL, Wilson-Robles H, Borgatti A, Henry CJ, Bailey DB, Locke J, Northrup NC, Crawford-Jakubiak M, Gill VL, Klein MK, Ruslander DM, Thamm DH, Phillips B, Post G. Impact of Toceranib/Piroxicam/Cyclophosphamide Maintenance Therapy on Outcome of Dogs with Appendicular Osteosarcoma following Amputation and Carboplatin Chemotherapy: A Multi-Institutional Study. PLoS One http://www.ncbi.nlm.nih.gov/pubmed/25923466

Oglesbee lab • Ma Y, Zhang Y, Liang X, Lou F, Oglesbee M, Krakowka S, Li J. Origin, evolution, and virulence of

porcine deltacoronaviruses in the United States. MBio http://www.ncbi.nlm.nih.gov/pubmed/25759498  Rikihisa lab • Cheng Z, Lin M, Rikihisa Y. Erratum for Cheng et al., Ehrlichia chaffeensis proliferation begins with

NtrY/NtrX and PutA/GlnA upregulation and CtrA degradation induced by proline and glutamine uptake. MBio http://www.ncbi.nlm.nih.gov/pubmed/25784699

Impact through scholarship

 

 

 

Rosol lab • Byrd RA, Sorden SD, Ryan T, Pienkowski T, LaRock R, Quander R, Wijsman JA, Smith HW,

Blackbourne JL, Rosol TJ, Long GG, Martin JA, Vahle JL. Chronic Toxicity and Carcinogenicity Studies of the Long-Acting GLP-1 Receptor Agonist Dulaglutide in Rodents. Endocrinology http://www.ncbi.nlm.nih.gov/pubmed/25860029

• Parviainen S, Autio K, Vähä-Koskela M, Guse K, Pesonen S, Rosol TJ, Zhao F, Hemminki A. Incomplete but infectious vaccinia virions are produced in the absence of oncolysis in feline SCCF1 cells. PLoS One http://www.ncbi.nlm.nih.gov/pubmed/25799430

• Vahle JL, Byrd RA, Blackbourne JL, Martin JA, Sorden SD, Ryan T, Pienkowski T, Wijsman JA, Smith HW, Rosol TJ. Effects of Dulaglutide on Thyroid C-Cells and Serum Calcitonin in Male Monkeys. Endocrinology http://www.ncbi.nlm.nih.gov/pubmed/25860028

Wu lab • de Silva S, St. Gelais C, Nagaraja T, and Wu L. Counteraction of SAMHD1 by Vpx. In Hope T,

Richman D, Stevenson M. (Ed.) Encyclopedia of AIDS • St Gelais C, Roger J, Wu L. Non-POU Domain-Containing Octamer-Binding Protein Negatively

Regulates HIV-1 Infection in CD4+ T Cells. AIDS Res Hum Retroviruses http://www.ncbi.nlm.nih.gov/pubmed/25769457

• Wong HK, de Silva S, Mishra A, Wu L, and Porcu P. Cutaneous T Cell Lymphoma: Mycosis Fungoides and Sézary Syndrome. In Lu, Q., Chang CC, and Richardson BC (Eds) Epigenetics & Dermatology  

Scholarship and Excellence

Noteworthy news!

 Drs.  Jean  Schelhorn  and  Tom  Rosol,  with  Dr.  Joan  Herbers  and  members  of  the  NSF  funded  CEOS  (Comprehensive  Equity  at  Ohio  State)  project,  were  part  of  the  Organizing  Committee  for  the  National  Summit  on  Innovation  &  Entrepreneurship  –  A  Roadmap  for  Inclusion  held  April  30,  2015  in  Washington  DC.  This  partnership  between  the  Association  for  Women  in  Science  (AWIS)  and  Ohio  State,  was  designed  to  bring  together  experts  in  innovation  and  entrepreneurship  from  industry,  academia,  and  government  to  develop  a  roadmap  for  engaging  women  as  well  as  men  in  STEM  (science,  technology,  engineering,  and  mathematics)  entrepreneurship.  

 

Science is simply common sense at its best, that is, rigidly accurate in observation and merciless to fallacy in logic. - Thomas Henry Huxley