The University of British ColumbiaDepartment of Medicine

31st Annual Resident Research Day

Wednesday, May 20, 2015Sutton Place Hotel

845 Burrard Street, Vancouver

PODIUM ADJUDICATORSMark Tyndall, MD, ScD, FRCPC

Dr. Mark Tyndall is the Executive Medical Director of the BC Centre for Disease Control, a deputy Provincial Health Officer for British Columbia, the Director of the UBC Centre for Disease Control Research Institute, and a Professor at the UBC School of Population and Public Health. Prior to coming to Vancouver, he was the Chief of the Division of Infectious Diseases at the University of Ottawa and a Senior Scientist at the Ottawa Hospital Research Institute. He received a doctoral degree in epidemiology from Harvard University with a focus on health and human rights. He has conducted international research and consultation in a number of countries and resided in Kenya for 4 years as part of the WHO collaborative research group on HIV. From 1999 to 2010 he was the Program Director for Epidemiology at the BC Centre for Excellence in HIV/AIDS and was co-lead investigator on the evaluation of Insite, North America’s first supervised injection site. Dr. Tyndall is a strong advocate and leader for public health in Canada and has fostered a number of community-based collaborations that have led to health policy changes. He was the co-founder of Physicians for Refugee Health and has advocated for enhanced harm-reduction interventions and the de-criminalization of drug use.

Diego Villa, MD, MPH, FRPCP

Diego Villa is Clinical Assistant Professor at the University of British Columbia and a medical oncologist at the British Columbia Cancer Agency – Vancouver Cancer Center.  He is involved in the care of patients with lymphoid malignancies and breast cancer.  His research interests include the management of transformed indolent lymphomas, CNS relapse of aggressive lymphoma, and the role of staging PET/CT in diffuse large B-cell lymphoma.  Dr. Villa has ongoing research collaborations with Canadian, Danish, and Australian lymphoma groups.  He is also the local principal investigator for various international lymphoma and breast cancer clinical trials open at BCCA, as well as a co-investigator in a randomized clinical trial of cardioprotection in early breast cancer being run in collaboration with VGH Cardiology.  He actively participates in the teaching of medical students, residents, and fellows at BCCA and VGH, and is the faculty coordinator for the medical oncology rotation at BCCA for the UBC Internal Medicine Residency Program.

Dr. Villa is a member of the UBC Medical Oncology Residency Training Program committee and its Promotions and Evaluations subcommittee.

POSTER ADJUDICATORSRichard Lester, MD, FRCPC

Dr. Richard Lester is the Director of the UBC Neglected Global Diseases Initiative and an Assistant Professor in Global Health in the Department of Medicine at UBC. He completed his research fellowship in HIV in Kenya at the University of Manitoba and University of Nairobi collaborative, where he initiated development of an innovative mobile phone health (mHealth) service that was demonstrated in a landmark trial, WelTel Kenya1 (Lancet 2010), to improve HIV outcomes. He is cofounder of the WelTel International mHealth Society, a nonprofit organization and Grand Challenges Canada $1M award winner for transitioning the mHealth service to scale in remote Kenya, and a Canadian software company. In a form of reverse innovation, Dr. Lester has introduced the WelTel service and model into the Canadian and other healthcare systems. His research has been published in top tier medical journals, including the Lancet, the New England Journal of Medicine, and Nature, and has been featured in nonacademic international and local media, such as CBC’s The National and The Economist. In addition to mHealth, Dr. Lester has been a spokesperson for emerging infectious diseases that affect the world’s poor and hosted an Ebola Symposium at UBC last fall. He has consulted globally on mHealth innovations, continues to conduct research in Canada and internationally, and is currently working toward developing a broad collaborative ‘centre of excellence’ for global health research and innovation in Kenya’s remote north.

Myp Sekhon, MD, FRCPC

Dr. Myp Sekhon, MD, is an intensive care physician and neurointensivist in the intensive care unit at Vancouver General Hospital. He is currently a Clinical Assistant Professor in the Division of Critical Care Medicine and Department of Medicine at the University of British Columbia. He completed his medical school training, internal medicine residency and critical care medicine subspecialty fellowship at the University of British Columbia, where he was chief resident.  Subsequently, he completed a neurocritical care fellowship at

Addenbrooke's Hospital at the University of Cambridge, United Kingdom under the guidance of Professors David Menon and Arun Gupta.  His clinical and research interests include multimodal neuromonitoring, cerebral autoregulation dysfunction and optimal cerebral perfusion identification / titration after traumatic brain injury and cardiac arrest.  He has recently published a textbook entitled "Neurocritical Care Essentials: A Practical Guide" with the Cambridge University Press and is the author of multiple peer reviewed articles and book chapters.  His non-academic interests include triathalons, beach volleyball and being a phenomenal big brother to Indy.

MODERATORDaniel Renouf, MD, MPH, FRCPC

Daniel Renouf is a medical oncologist at the British Columbia Cancer Agency, Vancouver Centre, and an Assistant Professor at the University of British Columbia, Department of Medicine.

He received his Doctor of Medicine from the University of Alberta and completed his internal medicine and medical oncology training at the University of British Columbia and British Columbia Cancer Agency. He undertook further training in early drug development and gastrointestinal oncology at Princess Margaret Hospital and the University of Toronto, and obtained a Masters of Public Health from Harvard University.

Daniel’s research interests include developmental therapeutics, genomics, and biomarker development within gastrointestinal cancers, with a focus on pancreatic cancer. He is the leader of the BC Cancer Agency Phase I program, the Co-Director of Pancreas Centre BC and is the Co-chair of the NCIC pancreatic cancer clinical trials group.

PRIZES & AWARDS The G.B. John Mancini Prize

Senior Resident/Fellow Award

The John H. Dirks PrizeBest Research Project by a Core Resident

The Stefan Grzybowski PrizeBest Research Project by a Fellow

Best Oral Presentation by a PGY1 Resident Best Oral Presentation by a PGY2 Resident

Best Oral Presentation by a PGY3 Resident Best Oral Presentation by an PGY4/5/6/7 Best Poster Project by a PGY1 Resident Best Poster Project by a PGY2 Resident Best Poster Project by a PGY3 Resident Best Poster Project by an PGY4/5/6

P O D I U M P R O G R A M

8:00 am Coffee8:15 am Opening Remarks – Dr. G. Meneilly

SESSION 18:24 am When does ST-depression predict

coronary occlusion after an out-of-hospital cardiac arrest?Dr. Chris Cheung – PGY2Sponsor: Dr. Krishnan Ramanathan

8:36 am VEGF Inhibition Reduces Luminal Narrowing In Heterotopic Heart Transplant Mouse ModelsDr. Safia Chatur – PGY1Sponsor: Dr. Bruce McManus

8:48 am Flecainide as monotherapy for Catecholaminergic Polymorphic Ventricular TachycardiaDr. Thomas Roston – PGY1Sponsor: Drs. A. Krahan & S. Sanatani

9:00 am Is it time to update how suspected angina is evaluated prior to use of specialized tests? A systematic reviewDr. Yashar Tashakkor – PGY2Sponsor: Dr. John Mancini

9:12 am The Impact of High PVC Burden in PregnancyDr. Calvin Tong – PGY1Sponsor: Dr. Jasmine Grewal

9:24 am Different ST-Segment Recovery Measures on Electrocardiograms Before and After Primary Percutaneous Coronary Intervention Predict In-

Hospital Adverse Outcomes in an ST-Elevation Myocardial Infarction PopulationDr. Annie Chou – PGY6 (Cardiology)Sponsor: Dr. Krishnan Ramanathan

9:36 am Spontaneous Coronary Artery Dissection Misdiagnosed as Takotsubo Cardiomyopathy – A Case SeriesDr. Annie Chou – PGY6 (Cardiology)Sponsor: Dr. Jacqueline Saw

10:00 am Poster Viewing & Coffee

SESSION 210:30 am Moral Distress and Burnout in Internal

Medicine ResidentsDr. Sharareh Sajjadi – PGYSponsor: Dr. Peter Dodek

10: 42am Outcomes in Primary AL Amyloidosis, A retrospective analysisDr. Hatem Al Ahwal – PGY2Sponsor: Dr. Kevin Song

10: 54 amDiagnosis and Management of Barrett's Esophagus: A Retrospective Study Comparing the Endoscopic Assessment of Early Esophageal Lesions in the Community versus a Specialized CenterDr. Erin Rayner-Hartley – PGY3Sponsor: Dr. Robert Enns

11:06 am Colonoscopy after CT diagnosed acute diverticulitis: is it really necessary?Dr. George Ou – PGY3

Sponsor: Dr. Brian Bressler11:18 am Upper Gastrointestinal Bleeding in the

Post Procedural Period in Patients Undergoing Transcatheter Aortic Valve Implantation: A Retrospective AnalysisDr. Dylan Stanger – PGY1Sponsor: Dr. Brian Bressler

11:30 am The impact of benzodiazepine use on mortality among polysubstance users in a Canadian settingDr. Tom Walton – PGY2Sponsor: Dr. Evan Wood

11:42 am Benzodiazepine use as a risk factor for hepatitis C infection in a prospective cohort of persons who inject drugsDr. Paxton Bach – PGY2Sponsor: Dr. Evan Wood

12:00 pm LUNCH

SESSION 31:00 pm Applying Indigenous methodologies to

compare HIV outcomes and mortality between Aboriginal Peoples and other ethnic groups in a Canadian multisite cohortDr. Denise Jaworsky – PGY4 (Medical Education)Sponsor: Dr. Mark Hull

1:12 pm Productivity Loss in Work-related Asthma:  a Preventable Burden?Dr. Alyson Wong – PGY2Sponsor: Dr. Mark Fitzgerald

1:24 pm Serum Bilirubin and disease progression in COPD Dr. Scott Apperley – PGY3Sponsor: Dr. Don Sin

1:36 pm Risk of active tuberculosis in chronic kidney disease: A systematic review and meta-analysisDr. Khalid Al-Efraij – PGY4 (Respirology)Sponsor: Dr. James Johnston

1:48 pm Survival of metastatic hormone receptor (HR) positive/HER2 negative; triple negative (TN); and HER2 positive breast cancer based on initial presentationDr. Wendie den Brok – PGY5 (Medical Oncology)Sponsor: Dr. Caroline Lohrisch

2:00 pm Impact of post-operative adjuvant fluoropyrimidine chemotherapy following pre-operative short course radiotherapy in stage II rectal cancerDr. Jonathan Loree – PGY4 (Medical Oncology)Sponsor: Dr. Winson Cheung

2:25 pm Poster Viewing & Coffee

SESSION 43:00 pm Empiric antimicrobial therapy with

vancomycin vs vancomycin plus beta-lactam in patients with methicillin-susceptible Staphylococcus aureus (MSSA) bacteremiaDr. Davie Wong – PGY4 (Infectious Disease)Sponsor: Dr. Victor Leung

3:12 pm Clinicians' acceptance pattern and perspectives on antimicrobial stewardship interventions at a major Canadian teaching hospitalDr. Clement Kwok – PGY5 (Infectious Disease)Sponsor: Dr. Jennifer Grant

3:24 pm Diabetes Medication Effectiveness in South Asian, Chinese, and White PatientsDr. Calvin Ke – PGY3Sponsor: Dr. Nadia Khan

3:36 pm Rate of Malignancy in Patients with the Diagnosis of Follicular Lesions of Undetermined Significance (FLUS) or Atypia of Undetermined Significance

(AUS) by Fine Needle Aspiration on Vancouver IslandDr. Xin Feng – PGY2Sponsor: Dr. David Miller

3:48 pm Smoke and (In)flame: risk of COPD in systemic sclerosisDr. Kun Huang – PGY2Sponsor: Dr. Antonio Avina-Zubieta

4:00pm In vivo imaging of disseminated intravascular coagulation in sepsis reveals a pathological role for neutrophil extracellular traps (NETs)Dr. Braedon McDonald – PGY2Sponsor: Drs. Craig Jenne & Paul Kubes

4:12pm Moral Distress in ICU Personnel Related to the Provision of Perceived Non-Beneficial CareDr. Sylvie Galindo – PGY3Sponsor: Dr. Peter Dodek

4:30 pm Concluding Remarks – Dr. G. Meneilly

6:30 pm Dinner and Prize/Award PresentationsUniversity Golf Club, 5185 University Boulevard

P O S T E R P R O G R A M8:00 am Coffee8:15 am Opening Remarks – Dr. G. Meneilly

SESSION 18:36 am Impact of elevated bilirubin on

eligibility of metastatic pancreatic cancer patients for nab-paclitaxel plus gemcitabineDr. Sally Lau – PGY2Sponsor: Dr. Winson Cheung

8:48 am A single-centre review of the use of solvent detergent treated plasmaDr. Lauren Lee – PGY3Sponsor: Dr. Paul Yenson

9:00 am Comparison of Outcomes in Chronic Lymphocytic Leukemia (CLL) with the Addition of Rituximab to Initial Treatment: A Comparative Effectiveness Analysis in the Province of British Columbia (BC), CanadaDr. Lauren Lee – PGY3Sponsor: Dr. Khaled Ramadan

9:12 am Autoimmune cytopenia in chronic lymphocytic leukemia: effect on outcome and survival, a population based analysis in British Columbia, CanadaDr. Alaa Al Zaki – PGY3Sponsor: Dr. Khaled Ramadan

9:24 am Time to endoscopy in patients with colorectal cancer: a retrospective analysis of the St Paul’s Hospital Division of Gastroenterology wait-timesDr. Renée Janssen King – PGY2Sponsor: Dr. Robert Enns

9:36 am When do trainees reach competency in performing endoscopic retrograde cholangiopancreatography (ERCP): A systematic reviewDr. Neal Shahidi – PGY2Sponsor: Dr. Robert Enns

9.48 am The utility of monitoring GGT levels post-liver transplantation: A longitudinal retrospective analysisDr. Neal Shahidi – PGY2Sponsor: Dr. Eric Yoshida

10:00 am Poster Viewing & Coffee

SESSION 210:42 am Autoimmunity in patients with primary

immunodeficiency in British ColumbiaDr. Jane Hsieh – PGY2Sponsor: Dr. Donald Stark

10:54 am Interdisciplinary Spasticity Management Clinic Outcomes Using the Goal Attainment Scale: A Retrospective Chart ReviewDr. Amy Hanlan – PGY4 (Physical Medicine & Rehabilitation)Sponsor: Dr. Heather Finlayson

11:06 am The risk of cardiovascular disease and systemic lupus erythematosus: a general population based studyDr. Fergus To – PGY2Sponsor: Dr. Antonio Avina-Zubieta

11:18 am Risk factors for Antibiotic Prescribing at the Level of the Patient, Prescriber and Environment: A Systematic ReviewDr. Allison Mah – PGY4 (Infectious Disease)Sponsor: Dr. David Patrick

11:30 am Methicillian-Resistant Staphylococcus aureus (MRSA) carriage is highly persistent in an inner-city, community-based populationDr. Thomas Roston – PGY1Sponsor: Dr. Mark Hull

11:42 am De Novo Development of Pulmonary Arterial Hypertension in Association with Pregnancy: A Retrospective Case SeriesDr. Lea Harper – PGY2Sponsor: Dr. Robert Levy

12:00 pm LUNCH

SESSION 31:12 pm Broken telephone: How do hospital-

based physicians communicate with patients’ outpatient care providers?

Drs. Daniel Ennis & Tony Wan – PGY2 & PGY3 Sponsor: Dr. Stephane Voyer

1:24 pm Risk factors of Diabetes in South Asian Population: A Systematic Review and Pooled Analysis of Observational StudiesDr. Behrouz Heidary – PGY2Sponsor: Dr. Nadia Khan

1:36 pm Microvascular Dysfunction in Patients with ST-Elevation Myocardial Infarction after Primary Percutaneous Coronary Intervention: No Sex DisparityDr. Annie Chou - PGY6 (Cardiology)Sponsor: Dr. Krishnan Ramanathan

1:48 pm Atrial Function for the Prediction of Success to Maintain Sinus Rhythm 6 Months Post Direct Current CardioversionDr. Christina Luong – PGY4 (Cardiology)Sponsor: Dr. Teresa S. M. Tsang

2:00 pm Recurrent chest pain in patients with a history of acute coronary syndrome: assessing the gestalt of Canadian cardiologistsDr. Laurie Cloutier – PGY1Sponsor: Dr. Krishnan Ramanathan

2:12 pm What is the relationship between low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B 100 in South Asians?Dr. Laura Fraser – PGY1Sponsor: Dr. Krishnan Ramanathan

2:25 pm Poster Viewing & Coffee

SESSION 43:12 pm Heart Failure Outcomes in British

ColumbiaDr. Chris Cheung – PGY2Sponsor: Dr. Mustafa Toma

3:24 pm Comparing Induction Immunosuppression with Basiliximab or Rabbit Anti-Thymocyte Globulin after Cardiac Transplantation: A Contemporary ExperienceDr. Omid Kiamanesh – PGY2Sponsor: Dr. Mustafa Toma

3:36 pm GI Bleeding in Cardiac Patients: What is the Threshold to Transfuse? Restrictive Versus Liberal Transfusion ThresholdsDr. Safia Chatur – PGY1Sponsor: Dr. Krishnan Ramanathan

3:48 pm What Proportion of Patients Admitted With Decompensated Heart Failure Have Predominantly Right Sided Failure? A Single Large Tertiary Referral Centre Retrospective Study

Dr. Safia Chatur – PGY1Sponsor: Drs. Patricia Campbell & Jonathan Howlett

4:00 pm STEMI and stent thrombosisDr. Mona Habibi – PGY1Sponsor: Drs. Krishnan Ramanathan & Anthony Fung

4:12 pm Clinical Approach to Acute Coronary SyndromesDrs. Thomas Roston & Laurie Cloutier

Sponsor: Dr. Krishnan Ramanathan

4:30 pm Concluding Remarks – Dr. G. Meneilly

6:30 pm Dinner and Prize/Award PresentationsUniversity Golf Club, 5185 University Boulevard