Eric Green, M.D., Ph.D. Director, NHGRI

Welcome and Setting a Context

Past Future

Genomics Landscape

Present

Human Genome Project Begins

October, 1990

Human Genome Project

Model Organisms

Multicellular Biology

Unicellular Biology

Human Biology

Mammalian Biology

500 Myr

80 Myr

1,000 Myr

Nature 387:1-105, 1997

First Eukaryotic Genome Sequence

Science 282:1012-2018, 1998

First Animal Genome Sequence

Science 287:2185-2195, 2000

Second Animal Genome Sequence

Draft Human Genome Sequence Published

First Mammalian Genome Sequence

Nature 420:520-562, 2002

Second Mammalian Genome Sequence

Human Genome Project Ends

April, 2003

Myriad Applications of Genomics

Health, Disease, & Medicine

Genomic Medicine

Healthcare tailored to the individual based on genomic information

Base Pairs to Bedside

Helix to Health

Nature

2003

Function of the Human Genome Sequence

The ENCODE Portfolio: Elucidating Genome Function

TGCCGCGGAACTTTTCGGCTCTCTAAGGCTGTATTTTGATATACGAAAGGCACATTTTCCTTCCCTTTTCAAAATGCACCTTGCAAACGTAACAGGAACCCGACTAGGATCATCGGGAAAAGGAGGAGGAGGAGGAAGGCAGGCTCCGGGGAAGCTGGTGGCAGCGGGTCCTGGGTCTGGCGGACCCTGACGCGAAGGAGGGTCTAGGAAGCTCTCCGGGGAGCCGGTTCTCCCGCCGGTGGCTTCTTCTGTCCTCCAGCGTTGCCAACTGGACCTAAAGAGAGGCCGCGACTGTCGCCCACCTGCGGGATGGGCCTGGTGCTGGGCGGTAAGGACACGGACCTGGAAGGAGCGCGCGCGAGGGAGGGAGGCTGGGAGTCAGAATCGGGAAAGGGAGGTGCGGGGCGGCGAGGGAGCGAAGGAGGAGAGGAGGAAGGAGCGGGAGGGGTGCTGGCGGGGGTGCGTAGTGGGTGGAGAAAGCCGCTAGAGCAAATTTGGGGCCGGACCAGGCAGCACTCGGCTTTTAACCTGGGCAGTGAAGGCGGGGGAAAGAGCAAAAGGAAGGGGTGGTGTGCGGAGTAGGGGTGGGTGGGGGGAATTGGAAGCAAATGACATCACAGCAGGTCAGAGAAAAAGGGTTGAGCGGCAGGCACCCAGAGTAGTAGGTCTTTGGCATTAGGAGCTTGAGCCCAGACGGCCCTAGCAGGGACCCCAGCGCCCGAGAGACCATGCAGAGGTCGCCTCTGGAAAAGGCCAGCGTTGTCTCCAAACTTTTTTTCAGGTGAGAAGGTGGCCAACCGAGCTTCGGAAAGACACGTGCCCACGAAAGAGGAGGGCGTGTGTATGGGTTGGGTTTGGGGTAAAGGAATAAGCAGTTTTTAAAAAGATGCGCTATCATTCATTGTTTTGAAAGAAAATGTGGGTATTGTAGAATAAAACAGAAAGCATTAAGAAGAGATGGAAGAATGAACTGAAGCTGATTGAATAGAGAGCCACATCTACTTGCAACTGAAAAGTTAGAATCTCAAGACTCAAGTACGCTACTATGCACTTGTTTTATTTCATTTTTCTAAGAAACTAAAAATACTTGTTAATAAGTACCTAAGTATGGTTTATTGGTTTTCCCCCTTCATGCCTTGGACACTTGATTGTCTTCTTGGCACATACAGGTGCCATGCCTGCATATAGTAAGTGCTCAGAAAACATTTCTTGACTGAATTCAGCCAACAAAAATTTTGGGGTAGGTAGAAAATATATGCTTAAAGTATTTATTGTTATGAGACTGGATATATCTAGTATTTGTCACAGGTAAATGATTCTTCAAAAATTGAAAGCAAATTTGTTGAAATATTTATTTTGAAAAAAGTTACTTCACAAGCTATAAATTTTAAAAGCCATAGGAATAGATACCGAAGTTATATCCAACTGACATTTA

The Human Genome Sequence

Nature Nature

2003 2011

New NHGRI Vision for Genomics Published

genome.gov/sp2011

February, 2011

Five Domains of Genomics Research

Alternate Routes Among Domains

Understanding the Structure of

Genomes

Understanding the Biology of

Genomes

Understanding the Biology of

Disease

Advancing the Science of

Medicine

Improving the Effectiveness of Healthcare

1990-2003 Human Genome Project

2004-2010

2011-2020

Beyond 2020

Genomic Accomplishments Across Domains

Sequencing a Human Genome

HGP (1st Sequence) Today

~6-8 years ~2-3 days

~$1B ~$4-8K

Immediate Post-HGP

~3-4 months

~$10-50M

Continued Key Role of Model Systems

Caroline Kelly Mike Pazin Leslie Adams Elise Feingold Kurd Ali Jory Barone

Special Thanks!

Improving human health through genomics research