wp 5: progress on tasks 5.2, 5.3 and 5.4
DESCRIPTION
WP 5: Progress on tasks 5.2, 5.3 and 5.4. Olli Leino THL. Tasks. 5.2: Tiered methodology for risk benefit assessment 5.3: Review on available Methodology for validation of risk, benefit and risk-benefit assessment 5.4: Identification of common currency. http://en.opasnet.org/w/Opasnet - PowerPoint PPT PresentationTRANSCRIPT
WP 5: Progress on tasks 5.2, 5.3 and 5.4
Olli LeinoTHL
Tasks
5.2: Tiered methodology for risk benefit assessment
5.3: Review on available Methodology for validation of risk, benefit and risk-benefit assessment
5.4: Identification of common currency
http://en.opasnet.org/w/Opasnet
http://en.opasnet.org/w/Benefit-risk_assessment_of_plant-based_food_supplements
Task 5.2 descriptionBased on findings reported in the review (DWP5-1) and a preliminary conceptual workshop heldat the kick-off meeting (MWP5-1), a risk-benefit assessment methodology will be proposed andtested in selected case-studies. The methodology, to be developed in Mediawiki, should beorganized in tiers, allowing to identify risk-benefit scenarios and to address qualitativelyscenarios (e.g., through MOE, ADI) where risks or benefits are not overlapping. After preliminarytesting of the methodology on at least 5 case-studies drawn from the PlantLIBRA list of plants,the report will be submitted for review to partners and to the three advisory boards; theirfeedback will be discussed, aligned with preliminary outcomes of WP2 (benefits, specificallydefinition of benefits and integration of various types of evidence), WP3 (risks and otherapproaches for risk assessment already available), and integrated at the second project meeting.Uncertainty will be described and estimated when possible. The final report will be publishedalongside with a generic Analytica software tool to explore risk and benefits (DWP5-1).
http://en.opasnet.org/w/Opasnet
http://en.opasnet.org/w/Benefit-risk_assessment_of_plant-based_food_supplements
Task 5.2 descriptionBased on findings reported in the review (DWP5-1) and a preliminary conceptual workshop heldat the kick-off meeting (MWP5-1), a risk-benefit assessment methodology will be proposed and
tested in selected case-studies. The methodology, to be developed in Mediawiki, should be
organized in tiers, allowing to identify risk-benefit scenarios and to address qualitativelyscenarios (e.g., through MOE, ADI) where risks or benefits are not overlapping. After preliminarytesting of the methodology on at least 5 case-studies drawn from the PlantLIBRA list of plants,the report will be submitted for review to partners and to the three advisory boards; theirfeedback will be discussed, aligned with preliminary outcomes of WP2 (benefits, specificallydefinition of benefits and integration of various types of evidence), WP3 (risks and otherapproaches for risk assessment already available), and integrated at the second project meeting.Uncertainty will be described and estimated when possible. The final report will be publishedalongside with a generic Analytica software tool to explore risk and benefits (DWP5-1).
http://en.opasnet.org/w/Opasnet
http://en.opasnet.org/w/Benefit-risk_assessment_of_plant-based_food_supplements
Case studies
Suggested case-studies: • Bilberry • Ginkgo • Ginseng • Cinnamon • Sea buckthorn http://en.opasnet.org/w/Benefit-risk_assessment_of_food_supplements
Case studies: screenshot
http://en.opasnet.org/w/Benefit-risk_assessment_of_food_supplements
Task 5.2 descriptionBased on findings reported in the review (DWP5-1) and a preliminary conceptual workshop heldat the kick-off meeting (MWP5-1), a risk-benefit assessment methodology will be proposed andtested in selected case-studies. The methodology, to be developed in Mediawiki, should beorganized in tiers, allowing to identify risk-benefit scenarios and to address qualitativelyscenarios (e.g., through MOE, ADI) where risks or benefits are not overlapping. After preliminarytesting of the methodology on at least 5 case-studies drawn from the PlantLIBRA list of plants,the report will be submitted for review to partners and to the three advisory boards; theirfeedback will be discussed, aligned with preliminary outcomes of WP2 (benefits, specificallydefinition of benefits and integration of various types of evidence), WP3 (risks and otherapproaches for risk assessment already available), and integrated at the second project meeting.Uncertainty will be described and estimated when possible. The final report will be publishedalongside with a generic Analytica software tool to explore risk and benefits (DWP5-1).
http://en.opasnet.org/w/Opasnet
http://en.opasnet.org/w/Benefit-risk_assessment_of_plant-based_food_supplements
Task 5.2 descriptionBased on findings reported in the review (DWP5-1) and a preliminary conceptual workshop held
at the kick-off meeting (MWP5-1), a risk-benefit assessment methodology will be proposed and
tested in selected case-studies. The methodology, to be developed in Mediawiki, should be
organized in tiers, allowing to identify risk-benefit scenarios and to address qualitatively
scenarios (e.g., through MOE, ADI) where risks or benefits are not overlapping. After preliminarytesting of the methodology on at least 5 case-studies drawn from the PlantLIBRA list of plants,the report will be submitted for review to partners and to the three advisory boards; theirfeedback will be discussed, aligned with preliminary outcomes of WP2 (benefits, specificallydefinition of benefits and integration of various types of evidence), WP3 (risks and otherapproaches for risk assessment already available), and integrated at the second project meeting.Uncertainty will be described and estimated when possible. The final report will be publishedalongside with a generic Analytica software tool to explore risk and benefits (DWP5-1).
http://en.opasnet.org/w/Opasnet
http://en.opasnet.org/w/Benefit-risk_assessment_of_plant-based_food_supplements
Risk-benefit assessment methodology organized in tiers
• Tier I: Definition of the use purpose and scope of an assessment
• Tier II: Definition of the decision criteria
• Tier III: Information production
Tiered approach: screenshot
http://en.opasnet.org/w/Benefit-risk_assessment_of_food_supplements
Task 5.3 descriptionA review of the concepts of validation and fit-for purpose in the field of risk, benefit and risk-benefit assessment will be conducted by Hylo in peer-reviewed literature and reported (DWP5-1). Following review by partners and advisory boards, a protocol with requirements to assess fit for-purpose and to validate (potentially against unused data-sets) the different assessment methodologies will be prepared using a Mediawiki platform and reported by THL (MWP5-2).
http://en.opasnet.org/w/Opasnet
http://en.opasnet.org/w/Benefit-risk_assessment_of_plant-based_food_supplements
Task 5.3 descriptionA review of the concepts of validation and fit-for purpose in the field of risk, benefit and risk-benefit assessment will be conducted by Hylo in peer-reviewed literature and reported (DWP5-1). Following review by partners and advisory boards, a protocol with requirements to assess fit for-purpose and to validate (potentially against unused data-sets) the different assessment methodologies will be prepared using a Mediawiki platform and reported by THL (MWP5-2).
http://en.opasnet.org/w/Opasnet
http://en.opasnet.org/w/Benefit-risk_assessment_of_plant-based_food_supplements
Validating different assessment methodologies
• BEPRARIBEAN project meeting in May 30th in Maastrict, THL (Mikko Pohjola)
• Six scientific review articles on the state-of-the-art of benefit-risk analysis in the fields of:– food microbiology– economics and marketing-finance– environmental health (THL)– Medicine– consumer perception
• Manuscripts revised and resubmitted to journal in May– After final acceptance, the information will be openly available
BEPRARIBEAN = Best Practices for Risk Benefit Analysis of Foods
http://en.opasnet.org/w/Bepraribean
Task 5.4 descriptionThe identification of the common currency (e.g., QALYs, DALYs) will be informed by the review of task 1 (approaches used and applicability to PFS) by the conceptual definition of benefit of WP2 (T2.2) and in consultation with advisory boards. Measurement of benefits that do not involve reduction of disease risk (e.g., enhanced attention due to caffeine intake) will be achieved through a review of the literature and based on results of WP8 (consumers). Two alternative common currencies will be tested in at least one case study of task 5.2 and submitted to the scientific advisory board for review. The process of identification will be documented in DWP5-1.
http://en.opasnet.org/w/Opasnet
http://en.opasnet.org/w/Benefit-risk_assessment_of_plant-based_food_supplements
Task 5.4 descriptionThe identification of the common currency (e.g., QALYs, DALYs) will be informed by the review of task 1 (approaches used and applicability to PFS) by the conceptual definition of benefit of WP2 (T2.2) and in consultation with advisory boards. Measurement of benefits that do not involve reduction of disease risk (e.g., enhanced attention due to caffeine intake) will be achieved through a review of the literature and based on results of WP8 (consumers). Two alternative common currencies will be tested in at least one case study of task 5.2 and submitted to the scientific advisory board for review. The process of identification will be documented in DWP5-1.
http://en.opasnet.org/w/Opasnet
http://en.opasnet.org/w/Benefit-risk_assessment_of_plant-based_food_supplements
Demonstration of task 5.41) The wikipage (disability weights) above contains an
embedded R-software code2) Source data on the page ”disability weights” is
automatically stored in Opasnet base (data base of Opasnet)
3) ”disability weights” can be used together with other information on Opasnet pages to calculate desired results- e.g. Lung cancer cases due to Radon in Europe & disability weights = disability adjusted lifeyears due to Radon in Europe
http://en.opasnet.org/w/Disability_weights
http://en.opasnet.org/w/Lung_cancer_cases_due_to_radon_in_Europe
http://en.opasnet.org/w/Opasnet
http://en.opasnet.org/w/Benefit-risk_assessment_of_plant-based_food_supplements