© 2007 step consortium step : a strategy for the europhysiome final review meeting step : a...

© 2007 STEP Consortium

STEPSTEP::

A Strategy for the EuroPhysiomeA Strategy for the EuroPhysiome

Coordination Action 027642

Final Review MeetingFinal Review Meeting Brussels, 18 April 2007


Overview of Project, Overview of Project, Workpackages & Workpackages &

DeliverablesDeliverablesGordon Clapworthy (BED)


Context• the physiome is the quantitative and integrated

description of the functional behaviour of the physiological state of an individual or species

– it includes integrated models of components of organisms, such as particular organs or cell systems, biochemical, or endocrine systems

– multiscale modelling is critical in this context

• IUPS Physiome Project running for many years

– IUPS = International Union for Physiological Sciences

– worldwide, “grass-roots” initiative of loosely coupled actions

– leading figures: Peter Hunter (NZ), James Bassingthwaighte (US)


Virtual Physiological Human (VPH)

• the VPH started from an initiative of the ICT Health team in the summer of 2005

– White Paper completed in the autumn of 2005

• independently and simultaneously, the STEP proposal was submitted to Call 6 of FP6

• the term VPH indicates a shared resource formed by a federation of:

– disparate but integrated computer models

– of the mechanical, physical, and biochemical functions of living human body

– in both physiological and pathological conditions


VPH and the Physiome Project• the goals of the VPH are entirely coherent with those of the

Physiome Project

– VPH not exclusive

– links with other international efforts encouraged

• VPH has a stronger emphasis on industrial and clinical applications

– early industrial and clinical uptake is critical

• “EuroPhysiome” coined to describe:

– integrated European approach aiming to:

• avoid redundancy, duplication

• increase coherence & momentum of European work


STEP – the beginnings

• European activity within the Physiome Project was increasing

• little contact between teams at the time

• teams known to us were contacted

• Peter Hunter supplied other names

• the STEP consortium was born


The STEP Consortium• BED - University of Bedfordshire (UK)

–Project Coordinator, Gordon Clapworthy

• IOR - Istituti Ortopedici Rizzoli (I)

–Scientific Coordinator, Marco Viceconti

• ULB - Université Libre de Bruxelles (B)

• USFD - University of Sheffield (UK)

• AAS - Aalborg Sygehus (DK)

• UOXF - University of Oxford (UK)

• NOT - University of Nottingham (UK)

• CNRS - CNRS/IBISC (F)

• UCL - University College London (UK)


EuroPhysiome Projects• Cardiome

– heart structure & function, based at Oxford

• Epitheliome

– epithelial tissue, based at Sheffield

• Giome

– gastroenterology, based in Aalborg

• Living Human

– musculo-skeletal, based at IOR & BED

• ULB Virtual Human

– musculo-skeletal, based at ULB

• Renal Physiome

– kidney, based at CNRS-LaMI in Evry

• Physiological Flow Network

– physiological flows, based at Nottingham


STEP Objectives• to bring together all current Physiome-related

projects in Europe

• to create a roadmap that will ensure that future European work will be coherent, integrated and internationally competitive

• this implies that European work:– develops a broader perspective

– moves from a project-based outlook to a Physiome-based outlook

• to provide the opportunity for all relevant work in Europe to participate in the above process


Boundaries• attempting to consider the whole body is too ambitious

for a simple CA:

– exclude brain and perceptual/cognitive aspects of the sensorial apparatus

– concentrate on subsystems for which physics-based modelling is a fundamental aspect

• cardiovascular, musculoskeletal, respiratory, digestive, skin (within restrictions noted)

• this represents a broad, relatively homogeneous, domain

– European work in this area is already recognised as being strong


The Scope of the Roadmap• identify the Grand Challenges that we must overcome to

achieve the VPH objective

• provide to the European Commission and to other grant agencies:

– a research roadmap for the VPH to be used for strategic planning of research funding

• evangelise research, clinical and industrial stakeholders on the concepts of:

– the Physiome, VPH and VPH Technology

• inform the citizens of Europe of:

– the potential impact that VPH research may have on their daily lives


Project Structure

WP1 M0–M15

Co-ordination & management

WP1 M0–M15

Co-ordination & management

WP2 M0–M4

Organisation of the First

Conference

WP2 M0–M4


Conference

WP3 M1–M15

Discussion Groups & Mailing Lists

WP3 M1–M15

Discussion Groups & Mailing Lists

WP4 M3–M12

Organisation of the Second Conference

WP4 M3–M12


WP6 M0–M15

Dissemination

WP6 M0–M15

Dissemination

WP5 M12–M15

Production of the Road Map

WP5 M12–M15



Project Phases

WP2 M0–M4


Conference

WP2 M0–M4


Conference

WP4 M3–M12


WP4 M3–M12


WP5 M12–M15


WP5 M12–M15


Phase 1 Phase 3Phase 2

Conf 1 Conf 2


Phase 1 Activities

• setting up the project

• creating the infrastructure to support the Internet-based discussions

– based on Biomed Town

• appointing the Advisory Board and Expert Panel

• organising the first conference

– Brussels, 15-16 May 2006

– open only to the consortium and invited experts

• ensuring that STEP was widely disseminated from the outset


Strands• moving directly from a project-based outlook to a Physiome-based

outlook appeared difficult, so:

– we broke down the large problem into a number of smaller problems

• STEP defined a set of Strands suited to the domain defined for the project

• the strands defined covered tissue types:

– hard tissue (coordinator IOR)

– soft tissue (coordinator AAS)

– fluids (coordinator USFD)

• they also covered aspects common across all tissue types:

– anatomy & physiology (coordinator ULB)

– Multiscale modelling (coordinator UOXF)

– VPH Technology (coordinator UCL/BED)


Phase 2 Activities• consolidating the outcomes of Conference 1

• opening up the discussions to the widest possible audience

– these were previously closed to the Consortium, the Advisory Board and the Expert Panel

– this allowed the major issues of concern to be identified ahead of Conference 2

• organising Conference 2

– Brussels 5-7 November 2006

– open to the public (no registration fee)

• devising a suitable programme for Conference 2 to allow the major issues to be fully aired


Strands to Panel

• the Strands from Phase 1 produced similar reports

• the movement to the physiome approach was completed by merging the Strands into a single Expert Panel

• additional experts were added to broaden formal participation

• a draft Roadmap was produced ahead of schedule to provide a focus for the on-going discussions


Phase 3 Activities

• feed the results of Conference 2 into the draft Roadmap

• encourage further contributions from all relevant stakeholders and interest groups

• continue the draft/circulate/edit cycle

• submit the final version of the Roadmap for printing


Deliverables

No Title By Date

D1.1, D1.3, D1.4 Progress Reports BED M3, M9, M12

D1.2, D1.5 Periodic Report (inc. cost statements) BED M6, M15

D1.6 Final Report BED M15

D2.1 Report on Logistic Organisation of 1st Conf BED M6

D3.1 Internet Mailing Lists and Discussion Groups IOR M1

D4.1 Report on Logistic Organisation of 2nd Conf ULB M14

D5.1 The Final Road Map IOR M15

D6.1 Project Web site IOR M2

D6.2 Scientific Report on 1st Conf. for Web site IOR M6

D6.3 Scientific Report on 2nd Conf. for Web site IOR M14


Dissemination & Inclusivity• dissemination was considered critical and a huge number of

dissemination activities have taken place

– journal & conference papers

– special journal issues, conference sessions

– various media: national press, local press, general magazines, specialist magazines, radio

– political figures

– support for EC activities:• ICT-BIO, IST2006, concertation meetings

• STEP continuously encouraged participation by ALL interested parties

– actively pursued links with other projects worldwide


Summary

• the project progressed smoothly with only very minor problems

– none of these caused a significant change in the project schedule

• all deliverables were submitted on time

• liaison with the ICT for Health team has been consistently strong throughout the project

• all partners have acted energetically in pursuit of the project objectives


Detailed description of Detailed description of work undertaken in work undertaken in

individual individual workpackagesworkpackages

Marco Viceconti (IOR)


Synopsis

• Chronological outline

• Conference #2 results

• Dissemination and lobbying


Where it all begin

Final document of the Workshop:

“Towards virtual physiological human: Multilevel modelling and simulation of the human anatomy and physiology”

Barcelona, 1-2 June 2005


STEPSTEP: : A Strategy for the EuroPhysiomeA Strategy for the EuroPhysiome

Coordination Action # 027642Coordination Action # 027642


Definition of the Physiome

• The physiome is the quantitative and integrated description of the functional behavior of the physiological state of an individual or species.

– The physiome describes the physiological dynamics of the normal intact organism and is built upon information and structure (genome, proteome, and morphome). The term comes from "physio-" (life) and "-ome" (as a whole). In its broadest terms, it should define relationships from genome to organism and from functional behavior to gene regulation. In context of the Physiome Project, it includes integrated models of components of organisms, such as particular organs or cell systems, biochemical, or endocrine systems.


The Physiome Goals

• aims to provide a computational framework:

– to facilitate the understanding of

• human physiology

• the integrative function of cells, organs and organisms

– multiscale in silico model of human physiology

• it is an international effort:

– loosely coupled actions of individual labs

– “grass roots” approach

• noticeably gaining momentum


The EuroPhysiome initiative

• All Physiome-related projects managed by European researchers have been recently coordinated under the STEP Coordination action

• STEP: a Strategy for The EuroPhysiome aims to coordinate European efforts toward the development of the Virtual Physiological Human

• This effort will materialise into a VPH roadmap document, written through a running consensus process that will involve all European stakeholders


The Consortium• LUT - University of Luton (UK)

– Project Coordinator, Gordon Clapworthy

• IOR - Istituti Ortopedici Rizzoli (I)

– Scientific Coordinator, Marco Viceconti

• ULB - Université Libre de Bruxelles (B)

• SHE - University of Sheffield (UK)

• AAS - Aalborg and Aarhus University Hospitals (DK)

• OXF - University of Oxford (UK)

• NOT - University of Nottingham (UK)

• CNRS – CNRS/LaMI (F)

• UCL - University College London (UK)


The scope of the Roadmap• Identify the Grand Challenges that we must overcome to

achieve the VPH objective

• Provide to the European Commission and to other grant agencies a research roadmap for the Virtual Physiological Human, to be used for strategic planning of research funding

• Evangelise research, clinical and industrial stakeholders on the concepts of Physiome, VPH and VPH Technology

• Inform the citizens of Europe of the potential impact that VPH research may have of their daily lives

STEP

consortium

Core Definitions

Strand Panels

Experts

Advisory Board

Experts

Multiscale

modelling Panel

Hard Tissue

Panel

Soft Tissue

Panel

Fuilds Panel

Anatomy &

Physiology

Panel

VPH

Technology

Panel

STEP

Conference #1

STEP Roadmap

Draft #1

The road to the Roadmap /1

The road to the Roadmap /2

STEP Roadmap

Draft #1

Biomed

Town

Biomch-l

list

Trade

associatio

Clinical

Societies

STEP Roadmap

Draft #2

STEP

Conference #2

STEP Roadmap


The Consortium Surname Name Affiliation

1 Aranov Vladik Université Libre de Bruxelles

2 Bandieri Annalisa Istituti Ortopedici Rizzoli

3 Betik Nilufer University College London

4 Brook Bindi University of Nottingham

5 Clapworthy Gordon University of Bedfordshire

6 Coveney Peter University College London

7 De Fabriitis Gianni University College London

9 Feipel Véronique Université Libre de Bruxelles

10 Fenner John University of Sheffield

11 Gale Catherine University College London

12 Garny Alan University of Oxford

13 Gregersen Hans Aalborg Hospital

14 Hose Rod University of Sheffield

15 Kamat Prajay University of Bedfordshire

16 Kohl Peter University of Oxford

17 Lawford Pat University of Sheffield

18 Leardini Alberto Istituti Ortopedici Rizzoli

19 Liao Donghua Aalborg Hospital

20 Lufimpadio Jean-Louis Université Libre de Bruxelles

21 McCormack Keith University of Sheffield

22 McFarlene Nigel University of Bedfordshire

23 Moiseev Fedor Université Libre de Bruxelles

24 Nilsson Dan Aalborg Hospital

25 Pinney David University of Sheffield

26 Sholukha Victor Université Libre de Bruxelles

27 Snoeck Olivier Université Libre de Bruxelles

28 Taddei Fulvia Istituti Ortopedici Rizzoli

29 Tahi Fariza Centre de la Recherche Scientifique

30 Thomas Randall S. Centre de la Recherche Scientifique

31 Van Sint Jan Serge Université Libre de Bruxelles

32 Viceconti Marco Istituti Ortopedici Rizzoli

33 Waters Sarah University of Nottingham

34 Whiteley Jonathan University of Oxford

35 Wu Fuli University of Bedfordshire

Surname Name Affiliation

1 Aranov Vladik Université Libre de Bruxelles

2 Bandieri Annalisa Istituti Ortopedici Rizzoli

3 Betik Nilufer University College London

4 Brook Bindi University of Nottingham

5 Clapworthy Gordon University of Bedfordshire

6 Coveney Peter University College London

7 De Fabriitis Gianni University College London

9 Feipel Véronique Université Libre de Bruxelles

10 Fenner John University of Sheffield

11 Gale Catherine University College London

12 Garny Alan University of Oxford

13 Gregersen Hans Aalborg Hospital

14 Hose Rod University of Sheffield

15 Kamat Prajay University of Bedfordshire

16 Kohl Peter University of Oxford

17 Lawford Pat University of Sheffield

18 Leardini Alberto Istituti Ortopedici Rizzoli

19 Liao Donghua Aalborg Hospital

20 Lufimpadio Jean-Louis Université Libre de Bruxelles

21 McCormack Keith University of Sheffield

22 McFarlene Nigel University of Bedfordshire

23 Moiseev Fedor Université Libre de Bruxelles

24 Nilsson Dan Aalborg Hospital

25 Pinney David University of Sheffield

26 Sholukha Victor Université Libre de Bruxelles

27 Snoeck Olivier Université Libre de Bruxelles

28 Taddei Fulvia Istituti Ortopedici Rizzoli

29 Tahi Fariza Centre de la Recherche Scientifique

30 Thomas Randall S. Centre de la Recherche Scientifique

31 Van Sint Jan Serge Université Libre de Bruxelles

32 Viceconti Marco Istituti Ortopedici Rizzoli

33 Waters Sarah University of Nottingham

34 Whiteley Jonathan University of Oxford

35 Wu Fuli University of Bedfordshire

• Major involvement of all partner institutions:

• 45 Researchers from the partner institutions actively contributed to the action

• > 90 Researchers from the partner institutions contributed to the Panel discussions


The Europhysiome Identity

• Europhysiome is a new term used to indicate the European contribution to the international initiative called Physiome.

• The term is also used to indicate collectively all Europe-based Physiome projects such as the Renal Physiome Project, the Giome Project, the Epitheliome Project, the Living Human Project, the Cardiome Project, and the Physiological Flows Initiative.

• www.europhysiome.org registered as domain

http://www.europhysiome.org/



The Europhysiome Logo


Biomed Town /1• Home of the STEP action

• Private Consortium Floor

• Private Experts Floor

• Public Reception

•VPH Community Home

• Events & News (RSS Feed)

• Public Discussion forums

• Want / offer Board


Biomed Town /2Biomed Town Citizens

0

100

200

300

400

500

600

700

07-2005 11-2005 02-2006 05-2006 09-2006 12-2006 03-2007 06-2007

Date

Number of Citizens


Biomed Town /3

0

50.000

100.000

150.000

200.000

250.000

300.000

350.000

Number of requests

Jan2006

Feb2006

Mar2006

Apr2006

May2006

Jun2006

Jul 2006

Aug2006

Sep2006

Oct2006

Nov2006

Dec2006

Jan2007

Feb2007

Mar2007

Month

Biomed Town accesses


Biomed Town /4

Site URL Number of requests http://www.biomedtown.org/ 1,231,707 http://www.google.com/ 10,975 http://www.europhysiome.org/ 2,615 http://www.google.co.uk/ 1,699

Site URL Number of requests http://www.biomedtown.org/ 1,231,707 http://www.google.com/ 10,975 http://www.europhysiome.org/ 2,615 http://www.google.co.uk/ 1,699


Advisory Board# Surname Name Affiliation Country Stakeholder

1 Bassingthwaighte James University of Washington USA Research

2 Bedlington Nicola European Patient Forum CH EU liason

3 Beglinger Christoph United European Gastroenterology Federation A EU liasion

4 Coatrieux Jean-Louis Inserm – University Rennes 1 FR Research

5 Delp Scott Stanford University USA Research

6 Hunter Peter University of Auckland NZ Research

7 Kamm Roger Massachussetts Institute of Technology USA Research

8 Kurachi Yoshi Osaka University JP Research

9 Mackay Andrew Insights International UK Industry

10 Mosekilde Erik Technical University of Denmark DK Research

11 Read Isabell e Chacma UK Industry

12 Van der Helm Frans TU Delft NL Research

13 Van der Sloten Jos KU Leuven BE Research

14 Zlotta Alex European Association of Urologist NL EU Liason

# Surname Name Affiliation Country Stakeholder

1 Bassingthwaighte James University of Washington USA Research

2 Bedlington Nicola European Patient Forum CH EU liason

3 Beglinger Christoph United European Gastroenterology Federation A EU liasion

4 Coatrieux Jean-Louis Inserm – University Rennes 1 FR Research

5 Delp Scott Stanford University USA Research

6 Hunter Peter University of Auckland NZ Research

7 Kamm Roger Massachussetts Institute of Technology USA Research

8 Kurachi Yoshi Osaka University JP Research

9 Mackay Andrew Insights International UK Industry

10 Mosekilde Erik Technical University of Denmark DK Research

11 Read Isabell e Chacma UK Industry

12 Van der Helm Frans TU Delft NL Research

13 Van der Sloten Jos KU Leuven BE Research

14 Zlotta Alex European Association of Urologist NL EU Liason


DefinitionsThe Virtual Physiological Human is a methodological and technological

framework that once established will enable the investigation of the human body as a single complex system.

The Virtual Physiological Human is a methodological and technological framework that once established will enable the investigation of the

human body as a single complex system.


Discussion Strands


STEP Conference #1• 15-16 May 2006 - Solbosh campus, ULB, Brussels

• Nearly 100 participants from most EU countries

– Kick-off presentations by Alex Frangi, Marco Viceconti and Gordon Clapworthy

– The Clinical Need presentations by Marcel Rooze, Daniel A. Ruefenacht and Odd Helge Gilja

– Parallel sessions for the Strands discussion

– Roundtable: The Virtual Physiological Human: An opportunity for a European Industry

– Consensus meeting: from strands to the Road Map

• Main output: Road Map index and consensus on scope


ICT-BIO conferenceCharlemagne Building, Brussels

29-30 June 2006


Road Map• 30 internal revisions

• 10 versions submitted to the Advisory Committee for extensive review

• 5 versions submitted to public debate

• Link to draft sent to more than 18,000 unique contacts:

– All UK NHS providers (flyers to 1542 companies)

– BIOMCH-L (> 5500 members)

– EAMBES (> 8000 members)

– Biomed Town (> 400 members)

– ESB (> 500 members)

– GNB (> 300 members)

– Direct personal contacts (10 x 200 = 2000 personal contacts)


STEP Conference #2• 5-7 November 2007, Solbosh campus, ULB

• More than 250 participants from 28 countries, including delegates from USA, China, Japan, New Zealand, Russia, Israel. Largest group from UK (57 delegates)

• Complex conference structure including breakout sessions, Electronic voting, Want/offer, Open spaces, Capture sheets

• Speakers: James Bassingthwaighte, Ilias Iakovidis, Stephane Hogan, Brian Goodwin, Denis Noble, Victor Alessandrini, Johan Montagnat, Peter Coveney, Jessica Wright, Jean Herveg, Andrew Mackay, Peter Kohl, Alex Bangs, Renè Rizzoli, Peter Hunter


Question A 2 resultsQuestion A 2 results

16%4%

18%3%

37%34%

22%49%

7%10%

1. low

2.

3. medium

4.

5. high

of the Euro Physiome road map ?What is my level of understanding

Before After


Question B 2 resultsQuestion B 2 results

0%0%

1%0%

7%9%

34%39%

58%52%

1. low

2.

3. medium

4.

5. high

to overcome in order to be successful?What level of challenge does this project have

Before After


Question C 2 ResultsQuestion C 2 Results

5%5%

24%18%

48%47%

21%25%

2%5%

1. low

2.

3. medium

4.

5. high

the challanges of the VPH?How well does the current draft of the roadmap reflect

Before After


Question D 2 resultsQuestion D 2 results

1%0%

3%4%

18%10%

38%37%

40%49%

1. low

2.

3. medium

4.

5. high

of the VPH to do good?What is the potential impact

Before After


Question E 2 resultsQuestion E 2 results

7%4%

25%12%

22%30%

19%22%

27%32%

1. bystander

2.

3.

4.

5. active participant

What is my own commitment to this work?

Before After


Dissemination: support material

• Targeted PowerPoint presentations for Researchers, Industry, Clinicians, public at large

• Flyers, brochures, Roadmap summaries, etc

• Press releases

• High quality images related to VPH

• Popular sciences cartoon


Dissemination: researchers• Conference presentations

– Special session at ISBI 2006, ICT-BIO 2006, WCB 2006 and HealthGrid 2007

– Keynote presentation at ISBMDA 2006 and at the Cocoon conference 2007

• Direct communication

– Monthly VPH newsletter started on 1-9-2006, become weekly on 23-1-2007

– Flyers distributed at WCB and at Inforsalud 2007

• Info Days

– VPH Info day, CNR Rome 22-9-2006, Sheffield 13-10-2006, Paris 23-11-2006

• Papers

– Special Issue of IEEE Proceedings on Physiome research

– Special issue of Clinical Biomechanics on Early Clinical Applications of the Virtual Physiological Human in Musculoskeletal Biomechanics

– Special issue of ERCIM News on Digital Patient, including a chapter on the VPH and STEP

– Paper on Ansys News


Dissemination: public at large• Press releases:

– English, French, Italian, Russian, Dutch, Polish

• Radio:

– Italian Radio Network 105 Live, program “Mouse to Mouse”

• Printed press:

– English: Daily Telegraph, Russian SININ, The House, Financial Times, Wired

– Danish: Nordjyllands radio

– Italian: Quark, La Stampa, Il Sole 24 Ore

– French: La Soir

• News Agencies:

– ANSA, AreaPress, MarkPress, AlphaGalileo, PuntoInformatico

• Internet media coverage:

– www.hesmagazine.com, punto-informatico.it, www.simel.it, www.folmall.it, www.marketpress.info, www.molecularlab.it, www.eurochina-it.org, del.icio.us, first.aster.it, cordis.europa.eu, www.intermib.com, www.healthgrid.org, www.bioinfogrid.eu, www.hoise.com/vmw, www.lastampa.it, www.ehealthnews.eu, www.telegraph.co.uk,


Internet media

We have been blogged!!


La StampaLa Stampa


23/11/200623/11/2006


La Soir, 6/11/2006La Soir, 6/11/2006


The Roadmap and the The Roadmap and the futurefuture

Marco Viceconti (IOR)


Road Map Index

• 1. Scope (IOR)

• 2. Rationale (BED)

• 3. Motivation (ULB)

• 4. International context (IOR)

• 5. Common Objectives (OXF)

• 6. Research Challenges (NOT)

• 7. Impact Analysis (CNRS)

• 8. Success stories (AAS)

• 9. Ethical, Legal and Gender Issues (USFD)

• 10. Dissemination Models (BED)

• 11. Exploitation Models & Long-term Sustainability (UCL)

• 12. Concrete Implementation: recommendations (IOR)


Multilevel document

• 200 words executive summary

• 850 words Scope chapter

• 4500 Recommendations chapter

• > 50000 words detailed document


Chapter #1: Scope• Defines the scope of the road map

• Clarify what is the VPH

• Identify its main features:– descriptive: the framework should allow observations made in laboratories, in hospitals

and in the field, at a variety of locations situated anywhere in the world, to be collected, catalogued, organised, shared and combined in any possible way;

– integrative: the framework should enable experts to analyse these observations collaboratively and to develop systemic hypotheses that involve the knowledge of multiple scientific disciplines;

– predictive: the framework should make it possible to interconnect predictive models defined at different scales, with different methods, and with different levels of detail, into systemic networks that solidify those systemic hypotheses; it should also make it possible to verify their validity by comparison with other clinical or laboratory observations.


Chapter #12: Final recommendations

• The Infrastructure

• The Data

• The Models

• The Validation

• Long term sustainability models

• The People


Chapter #12: The Infrastructure

• The VPH needs

• Community infrastructures

• Physical infrastructures

• Technological infrastructures

• Commercial, Legal and Ethical frameworks


Chapter #12: The Data

• Accumulating clinical observations

– It is necessary to favour projects that aim to collect relevant experimental data with respect to cell to cell and cell to tissue interaction

• Challenges in data collection

– Curation, quality assurance


Chapter #12: The Models

• Challenges in VPH modelling

• Accumulating models

– Separating models from solvers

– Separating models from numerical solutions

• Interconnecting models

– Models as web services

– Supermodels

• Model verification


Chapter #12: The Validation

• Challenges in validation

– Validation with controlled experiments

– Confirmation of independent observations

• Validating for the clinic

– Quality assurance for models

• Validating for the industry

– models in medical devices certification


Chapter #12: Long term sustainability

models• Barter model

• E-Commerce model

• Subscription support


Chapter #12: The People

• A major problem in the sustainable implementation of the ideas behind VPH, and the realisation of the corresponding benefits with respect to scientific development and public health, is the attraction of this field to younger scientists.

• Currently, it is much more promising for gifted young researchers to go directly into fields such as molecular biology and medicine.

• Efforts in interdisciplinary fields are usually under-rewarded, so it will be necessary to develop around VPH research a comprehensive career support and incentive system.

• The most talented young people facing fundamental career decisions have to see a real chance for their own scientific development when entering VPH-related activities.

• Only then, will we be able to recruit top quality people and to achieve fast and sustained scientific development.


The Future

• Biomed Town will continue to operate in 2007 through LHDL Financial support

• IOR will continue to steer the WIRI Agreement, and would be happy to serve as news concentration for all VPH-related initiatives

• General VPH dissemination in 2007 is not funded; EC news services should use the VPH News feed as a basis for targeted dissemination actions

• IOR will closely monitor (but not participate in the core consortium) the forthcoming NoE, to maintain the highest possible level of momentum


Thank You!Thank You!

© 2007 step consortium step : a strategy for the europhysiome final review meeting step : a...

Documents

step consortium vph

step consortium context

step proposal

physiome project vph

nottingham slide

context iups physiome

term vph

integrated european