44,4346a4LiTilsa4.865sAmiiI‘ithteialaoliasiktiitt

wiiialoot>hdiasp4hisiLdialgaiiir Crocus satin's L. (Saffron) in the Treatment of Premenstrual Syndrome

.,,A double-blind, Randomized and Placebrrolled Trial

hitanmono leurnsiolastana end Gynkiv2008) ries

3'

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se/vas

23 Completed trial 24 Completed trial

Figure 1. Trial profile

1 Discontinued: due to consent withdra

—12 Discontinued: due to consent withdrawn

J.C.0( ,..);?t4)

.11S.

iii•J'Olt A uJf J44SJC

.J•u‘r

10.5 0

j.1‘1.1.aj cac..z.k (LW)

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J.)-1).-.»OW.5 31 Lur.P.-n.rr " .4"

J.C.r ,ort 4,z)

t • ._)))6. „se

P.)14o'S )))1 student's Test With a Two) ctIfl vo...)(Sided P Value

.0) ji Lt. Pc0.05-Lt 0=0.21.050—i,f jla). ja1H

kir ja v." &lo:Lf-uL-ro.7

,A;•10 JiL-"13.1.) r)1.=‘,:j1 5

4411. .,:)X•A • °jai S =

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rt,zus.t j

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tj ajw.

ubth A' -tiC.+1J5

Assigned to saifro

ua Women ened

8 Excluded h e ru

50 Randomised

1 25 Assigned to placebo

Seffron group Placebo group CrarrgiggrratruSfa=ssing,r.r .( T069 gif=48 rP=0.48)

re Likr' V jLc ja a) j_.f .,:a7

is•jj_C)_7., j4S1._i s-'- -S (G real hmut-Gersser Correcte f=11.13 aP-0.002)

rriar

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rp<0.0001 Xr."

-01;Y=

36.)Lrlojg ri.rMg.g)Irrirr riar-gl-rrirs4-1.41.t.L.r if) mrol..S.

Greenhorm-GeisserGonected:

F-53.09 cdf=1.55 P<0.0001)

Age (mean ± SD) 35.10 ± 7,79 gears)

Moritalstatus Sin le• 20 Married: 8 Divorced: 2

Level of edam-lion under diploma: g Diploma: 10 Figgher diploma: 9

NS. nonsignificant

Table I. gageNne data

rse'rril (SrLr 24-ri orcar gri

.(t-1.24 df48 .13-0.21)

.g.r1;31.*“14.sa•-01./..C.isPrigrzrrilk

giulgrarmArt.rieggruCkurarrif Greathouse G...)g-rConated:

F87.36 zdf-1 r.P•0.001)

t.-44 ror .L2. tr. of

.XL• tr-rt,Lt.y rr-r.1 1•

rift) jg (Zg.) )7.210 gL-ri3

L.)) Jr) ..rf ig (if) )1)1 i

girr_z.)/VA rPg0.0001)

rOL,r 31.41

Green house-Geisser Corrected:

tdfrorl.63 1Pc0.001)!

))1:14...prg.) (01.3_.,"

31A.; re)l jijj

.(P<0.0001) ls

Post hoc s r—rtrr 3i r, ▪ glregH).

.31g gl_:.)r,1)c-..

ig jc.„.

.(P < 0.001) JAL

J J I f jc . )

.( 8.99 crif-48 arr<0.001)

33.45 rrr 7.61 NS (years)

Srngle 21 NS Mamed Dworred, Under diploma: 5 NS Diploma 10 Higher diploma: 10

VAL" ‘51•VJ if iS

p<0.001)

Lrg.i3

(Ng)",

(I-5.92 rdf-F48 (P<0.001)

-0- copal -V- Upstrat pl

T woggles asympturg. mtg. (mouth)

rev vvvvadv evali eyetta 1“...orfflun Ve15

Figure 1. Mean151)5[m.y of two 2,DUps of women pc the Metal PrenrerVILLII VaibiSympl0M5SCOVS. Ns, nork9Fikarrt end v`P <0 001-The 1Vniontal symbols ("V wervised to VV,V5 541151Xei signfficarree veryys thai, Vapective baline vaithe sni vertical rrnbgls (i) were used for betvg)err-graup comparison).

j_,115

r.>)g)i ) Jr 1).1 gift.) reirlakri•

( p<0 001)( I rl_r.; rig 015"

..L.3.y.L;Post hoc Lc .--!La•

J r „c“Jc...&e argg oar "'ill)!

p ▪ 3 ▪ :Ur:,

sk.0 AT „Isis)

Als ors

2M;. 22P oss•

-9- C2030 plpeau

Adverse effects

Saffron Placebo

Decreased appetite NS

Inaeased appetite N5

Sedation NS

Nausea

NS

Headache NS

Hypomenia NS

NS, nonsignificant

Table 2. Clinical complutions and adverse effects were reported as number per group

71 2

; 0

3 C0133 C Ir 4

3 mow orsympoms 1031055301

mc01.000PM5

Ng um Mean ± SO mores or two gratms of women on he HaMillOn DPrileSSI n Rating scale 344,33 NS nonsmnrficast and "' < D.00 The hop ontal sy1n1301$("•)Wete ihed to empress slatinic I significanCe 3005 theirTP5PeMP 4000 33134 and verstal symbols i3.430 used fOf betweervoroup comparsons

r, PMS 30054 ;4

"033 ;IP 04 P wiz 22,21 jU -

;1; 050 04 3 3 0LN frm—'

;Ural-JILL.'"

0▪ MIPP 0;4151-4• .3 014

000.35514 ; 4 000.630 34;13.5

.0m5 .00034 j,-C .0053

s_11

4540 PMS mus 2ir3

.22 Sus.r.M. 22. sir u ‘ILS._21

2"m-2;3.1,r .'-:•3 5.1 J.1_1.•

art, rs'alAjC..2e1 IP

i11....j 01, s jp

-1-11.!

00 4. 3•

1- 0 '0-014103 0 4-M0

312i.:÷SPS a,1523.'

34,545S 0_45 .;3445 T.u..m.

221S22MIL-- pMCA 4(2 ,S2271- P

4.300 0-444 0544-3130 4-01

.53 .00 1-5411 6..00131

oi“..1.1. L.5

u-s- Lul

J>.... jar rs,..

P

rsm, :Amp

..!'ulL1 .L.11 .14L2

r s ju

;AA.. 50,01;50 0550.331

-Nth 4-1 -1-4

us •J-.0 st.Use 'Llis‘s 441La.

jlesativuS sajjC

si sip .L.YX:..1 s-.3; PMS

arlpti .4-4j

„4;13; L0-0-01500 0 350-33

454.544i 0004-0

334.34 0;30 ,p0

'1C0.3} a?-,' ti aku p sp_s4J1-224s3iLi..'

aTy sPLuirjb ,,ii PMS

sm.2 222 0-* .5P

JLk;I

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PMS r

L.,MM ors6.,54

ri'"I SDI

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REFERENCES

menteleperences./ Women3 Meallh 199a 7 083-907

FU.plun A re•end rtaimentol preff eisinal•ndane and {amen-

srpionoVreistake inl•brtors • prenla•mt•al syndrure f]rsternalic

2•02.0•3013g•

senraire ralleveammtd IT•Onam.•••••••repanenarual opflorne

13

15 Nowbala PA. Athe•daidel) S Imaged-3min. laruhl•pry fr•drp-

:750ateRc::::::::: keg Ta:Ln6g

inx jan:mikedrrm,adrend:tplablo.:7:11d

C•artai F ON•perison Cn•ao siesta and me •••• - men rni node's., apistarie ••.••••-• •••••••El Inai DVCCestrment Apern 004.

X. 'andel. Crony, satk.• 'Dean. • mc••• 5.2.3•11 dcutit4,1 m

antic(

16 NOG 4Arnuican (depot Inattroans and cylvEcthr••• Premer,

I? WM0 NAtthe•IA•oaatan. Dularate, Of I-Debt EV•u•pr•••••5

arry-L960.3 63-6

!Tent Manna% 20D6 555547511

tom Ann Wen, R.IS1996.1.2939-111