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© 2007 STEP Consortium
STEPSTEP::
A Strategy for the EuroPhysiomeA Strategy for the EuroPhysiome
Coordination Action 027642
Final Review MeetingFinal Review Meeting Brussels, 18 April 2007
© 2007 STEP Consortium
Overview of Project, Overview of Project, Workpackages & Workpackages &
DeliverablesDeliverablesGordon Clapworthy (BED)
© 2007 STEP Consortium
Context• the physiome is the quantitative and integrated
description of the functional behaviour of the physiological state of an individual or species
– it includes integrated models of components of organisms, such as particular organs or cell systems, biochemical, or endocrine systems
– multiscale modelling is critical in this context
• IUPS Physiome Project running for many years
– IUPS = International Union for Physiological Sciences
– worldwide, “grass-roots” initiative of loosely coupled actions
– leading figures: Peter Hunter (NZ), James Bassingthwaighte (US)
© 2007 STEP Consortium
Virtual Physiological Human (VPH)
• the VPH started from an initiative of the ICT Health team in the summer of 2005
– White Paper completed in the autumn of 2005
• independently and simultaneously, the STEP proposal was submitted to Call 6 of FP6
• the term VPH indicates a shared resource formed by a federation of:
– disparate but integrated computer models
– of the mechanical, physical, and biochemical functions of living human body
– in both physiological and pathological conditions
© 2007 STEP Consortium
VPH and the Physiome Project• the goals of the VPH are entirely coherent with those of the
Physiome Project
– VPH not exclusive
– links with other international efforts encouraged
• VPH has a stronger emphasis on industrial and clinical applications
– early industrial and clinical uptake is critical
• “EuroPhysiome” coined to describe:
– integrated European approach aiming to:
• avoid redundancy, duplication
• increase coherence & momentum of European work
© 2007 STEP Consortium
STEP – the beginnings
• European activity within the Physiome Project was increasing
• little contact between teams at the time
• teams known to us were contacted
• Peter Hunter supplied other names
• the STEP consortium was born
© 2007 STEP Consortium
The STEP Consortium• BED - University of Bedfordshire (UK)
–Project Coordinator, Gordon Clapworthy
• IOR - Istituti Ortopedici Rizzoli (I)
–Scientific Coordinator, Marco Viceconti
• ULB - Université Libre de Bruxelles (B)
• USFD - University of Sheffield (UK)
• AAS - Aalborg Sygehus (DK)
• UOXF - University of Oxford (UK)
• NOT - University of Nottingham (UK)
• CNRS - CNRS/IBISC (F)
• UCL - University College London (UK)
© 2007 STEP Consortium
EuroPhysiome Projects• Cardiome
– heart structure & function, based at Oxford
• Epitheliome
– epithelial tissue, based at Sheffield
• Giome
– gastroenterology, based in Aalborg
• Living Human
– musculo-skeletal, based at IOR & BED
• ULB Virtual Human
– musculo-skeletal, based at ULB
• Renal Physiome
– kidney, based at CNRS-LaMI in Evry
• Physiological Flow Network
– physiological flows, based at Nottingham
© 2007 STEP Consortium
STEP Objectives• to bring together all current Physiome-related
projects in Europe
• to create a roadmap that will ensure that future European work will be coherent, integrated and internationally competitive
• this implies that European work:– develops a broader perspective
– moves from a project-based outlook to a Physiome-based outlook
• to provide the opportunity for all relevant work in Europe to participate in the above process
© 2007 STEP Consortium
Boundaries• attempting to consider the whole body is too ambitious
for a simple CA:
– exclude brain and perceptual/cognitive aspects of the sensorial apparatus
– concentrate on subsystems for which physics-based modelling is a fundamental aspect
• cardiovascular, musculoskeletal, respiratory, digestive, skin (within restrictions noted)
• this represents a broad, relatively homogeneous, domain
– European work in this area is already recognised as being strong
© 2007 STEP Consortium
The Scope of the Roadmap• identify the Grand Challenges that we must overcome to
achieve the VPH objective
• provide to the European Commission and to other grant agencies:
– a research roadmap for the VPH to be used for strategic planning of research funding
• evangelise research, clinical and industrial stakeholders on the concepts of:
– the Physiome, VPH and VPH Technology
• inform the citizens of Europe of:
– the potential impact that VPH research may have on their daily lives
© 2007 STEP Consortium
Project Structure
WP1 M0–M15
Co-ordination & management
WP1 M0–M15
Co-ordination & management
WP2 M0–M4
Organisation of the First
Conference
WP2 M0–M4
Organisation of the First
Conference
WP3 M1–M15
Discussion Groups & Mailing Lists
WP3 M1–M15
Discussion Groups & Mailing Lists
WP4 M3–M12
Organisation of the Second Conference
WP4 M3–M12
Organisation of the Second Conference
WP6 M0–M15
Dissemination
WP6 M0–M15
Dissemination
WP5 M12–M15
Production of the Road Map
WP5 M12–M15
Production of the Road Map
© 2007 STEP Consortium
Project Phases
WP2 M0–M4
Organisation of the First
Conference
WP2 M0–M4
Organisation of the First
Conference
WP4 M3–M12
Organisation of the Second Conference
WP4 M3–M12
Organisation of the Second Conference
WP5 M12–M15
Production of the Road Map
WP5 M12–M15
Production of the Road Map
Phase 1 Phase 3Phase 2
Conf 1 Conf 2
© 2007 STEP Consortium
Phase 1 Activities
• setting up the project
• creating the infrastructure to support the Internet-based discussions
– based on Biomed Town
• appointing the Advisory Board and Expert Panel
• organising the first conference
– Brussels, 15-16 May 2006
– open only to the consortium and invited experts
• ensuring that STEP was widely disseminated from the outset
© 2007 STEP Consortium
Strands• moving directly from a project-based outlook to a Physiome-based
outlook appeared difficult, so:
– we broke down the large problem into a number of smaller problems
• STEP defined a set of Strands suited to the domain defined for the project
• the strands defined covered tissue types:
– hard tissue (coordinator IOR)
– soft tissue (coordinator AAS)
– fluids (coordinator USFD)
• they also covered aspects common across all tissue types:
– anatomy & physiology (coordinator ULB)
– Multiscale modelling (coordinator UOXF)
– VPH Technology (coordinator UCL/BED)
© 2007 STEP Consortium
Phase 2 Activities• consolidating the outcomes of Conference 1
• opening up the discussions to the widest possible audience
– these were previously closed to the Consortium, the Advisory Board and the Expert Panel
– this allowed the major issues of concern to be identified ahead of Conference 2
• organising Conference 2
– Brussels 5-7 November 2006
– open to the public (no registration fee)
• devising a suitable programme for Conference 2 to allow the major issues to be fully aired
© 2007 STEP Consortium
Strands to Panel
• the Strands from Phase 1 produced similar reports
• the movement to the physiome approach was completed by merging the Strands into a single Expert Panel
• additional experts were added to broaden formal participation
• a draft Roadmap was produced ahead of schedule to provide a focus for the on-going discussions
© 2007 STEP Consortium
Phase 3 Activities
• feed the results of Conference 2 into the draft Roadmap
• encourage further contributions from all relevant stakeholders and interest groups
• continue the draft/circulate/edit cycle
• submit the final version of the Roadmap for printing
© 2007 STEP Consortium
Deliverables
No Title By Date
D1.1, D1.3, D1.4 Progress Reports BED M3, M9, M12
D1.2, D1.5 Periodic Report (inc. cost statements) BED M6, M15
D1.6 Final Report BED M15
D2.1 Report on Logistic Organisation of 1st Conf BED M6
D3.1 Internet Mailing Lists and Discussion Groups IOR M1
D4.1 Report on Logistic Organisation of 2nd Conf ULB M14
D5.1 The Final Road Map IOR M15
D6.1 Project Web site IOR M2
D6.2 Scientific Report on 1st Conf. for Web site IOR M6
D6.3 Scientific Report on 2nd Conf. for Web site IOR M14
© 2007 STEP Consortium
Dissemination & Inclusivity• dissemination was considered critical and a huge number of
dissemination activities have taken place
– journal & conference papers
– special journal issues, conference sessions
– various media: national press, local press, general magazines, specialist magazines, radio
– political figures
– support for EC activities:• ICT-BIO, IST2006, concertation meetings
• STEP continuously encouraged participation by ALL interested parties
– actively pursued links with other projects worldwide
© 2007 STEP Consortium
Summary
• the project progressed smoothly with only very minor problems
– none of these caused a significant change in the project schedule
• all deliverables were submitted on time
• liaison with the ICT for Health team has been consistently strong throughout the project
• all partners have acted energetically in pursuit of the project objectives
© 2007 STEP Consortium
Detailed description of Detailed description of work undertaken in work undertaken in
individual individual workpackagesworkpackages
Marco Viceconti (IOR)
© 2007 STEP Consortium
Synopsis
• Chronological outline
• Conference #2 results
• Dissemination and lobbying
© 2007 STEP Consortium
Where it all begin
Final document of the Workshop:
“Towards virtual physiological human: Multilevel modelling and simulation of the human anatomy and physiology”
Barcelona, 1-2 June 2005
© 2007 STEP Consortium
STEPSTEP: : A Strategy for the EuroPhysiomeA Strategy for the EuroPhysiome
Coordination Action # 027642Coordination Action # 027642
© 2007 STEP Consortium
Definition of the Physiome
• The physiome is the quantitative and integrated description of the functional behavior of the physiological state of an individual or species.
– The physiome describes the physiological dynamics of the normal intact organism and is built upon information and structure (genome, proteome, and morphome). The term comes from "physio-" (life) and "-ome" (as a whole). In its broadest terms, it should define relationships from genome to organism and from functional behavior to gene regulation. In context of the Physiome Project, it includes integrated models of components of organisms, such as particular organs or cell systems, biochemical, or endocrine systems.
© 2007 STEP Consortium
The Physiome Goals
• aims to provide a computational framework:
– to facilitate the understanding of
• human physiology
• the integrative function of cells, organs and organisms
– multiscale in silico model of human physiology
• it is an international effort:
– loosely coupled actions of individual labs
– “grass roots” approach
• noticeably gaining momentum
© 2007 STEP Consortium
The EuroPhysiome initiative
• All Physiome-related projects managed by European researchers have been recently coordinated under the STEP Coordination action
• STEP: a Strategy for The EuroPhysiome aims to coordinate European efforts toward the development of the Virtual Physiological Human
• This effort will materialise into a VPH roadmap document, written through a running consensus process that will involve all European stakeholders
© 2007 STEP Consortium
The Consortium• LUT - University of Luton (UK)
– Project Coordinator, Gordon Clapworthy
• IOR - Istituti Ortopedici Rizzoli (I)
– Scientific Coordinator, Marco Viceconti
• ULB - Université Libre de Bruxelles (B)
• SHE - University of Sheffield (UK)
• AAS - Aalborg and Aarhus University Hospitals (DK)
• OXF - University of Oxford (UK)
• NOT - University of Nottingham (UK)
• CNRS – CNRS/LaMI (F)
• UCL - University College London (UK)
© 2007 STEP Consortium
The scope of the Roadmap• Identify the Grand Challenges that we must overcome to
achieve the VPH objective
• Provide to the European Commission and to other grant agencies a research roadmap for the Virtual Physiological Human, to be used for strategic planning of research funding
• Evangelise research, clinical and industrial stakeholders on the concepts of Physiome, VPH and VPH Technology
• Inform the citizens of Europe of the potential impact that VPH research may have of their daily lives
STEP
consortium
Core Definitions
Strand Panels
Experts
Advisory Board
Experts
Multiscale
modelling Panel
Hard Tissue
Panel
Soft Tissue
Panel
Fuilds Panel
Anatomy &
Physiology
Panel
VPH
Technology
Panel
STEP
Conference #1
STEP Roadmap
Draft #1
The road to the Roadmap /1
The road to the Roadmap /2
STEP Roadmap
Draft #1
Biomed
Town
Biomch-l
list
Trade
associatio
Clinical
Societies
STEP Roadmap
Draft #2
STEP
Conference #2
STEP Roadmap
© 2007 STEP Consortium
The Consortium Surname Name Affiliation
1 Aranov Vladik Université Libre de Bruxelles
2 Bandieri Annalisa Istituti Ortopedici Rizzoli
3 Betik Nilufer University College London
4 Brook Bindi University of Nottingham
5 Clapworthy Gordon University of Bedfordshire
6 Coveney Peter University College London
7 De Fabriitis Gianni University College London
9 Feipel Véronique Université Libre de Bruxelles
10 Fenner John University of Sheffield
11 Gale Catherine University College London
12 Garny Alan University of Oxford
13 Gregersen Hans Aalborg Hospital
14 Hose Rod University of Sheffield
15 Kamat Prajay University of Bedfordshire
16 Kohl Peter University of Oxford
17 Lawford Pat University of Sheffield
18 Leardini Alberto Istituti Ortopedici Rizzoli
19 Liao Donghua Aalborg Hospital
20 Lufimpadio Jean-Louis Université Libre de Bruxelles
21 McCormack Keith University of Sheffield
22 McFarlene Nigel University of Bedfordshire
23 Moiseev Fedor Université Libre de Bruxelles
24 Nilsson Dan Aalborg Hospital
25 Pinney David University of Sheffield
26 Sholukha Victor Université Libre de Bruxelles
27 Snoeck Olivier Université Libre de Bruxelles
28 Taddei Fulvia Istituti Ortopedici Rizzoli
29 Tahi Fariza Centre de la Recherche Scientifique
30 Thomas Randall S. Centre de la Recherche Scientifique
31 Van Sint Jan Serge Université Libre de Bruxelles
32 Viceconti Marco Istituti Ortopedici Rizzoli
33 Waters Sarah University of Nottingham
34 Whiteley Jonathan University of Oxford
35 Wu Fuli University of Bedfordshire
Surname Name Affiliation
1 Aranov Vladik Université Libre de Bruxelles
2 Bandieri Annalisa Istituti Ortopedici Rizzoli
3 Betik Nilufer University College London
4 Brook Bindi University of Nottingham
5 Clapworthy Gordon University of Bedfordshire
6 Coveney Peter University College London
7 De Fabriitis Gianni University College London
9 Feipel Véronique Université Libre de Bruxelles
10 Fenner John University of Sheffield
11 Gale Catherine University College London
12 Garny Alan University of Oxford
13 Gregersen Hans Aalborg Hospital
14 Hose Rod University of Sheffield
15 Kamat Prajay University of Bedfordshire
16 Kohl Peter University of Oxford
17 Lawford Pat University of Sheffield
18 Leardini Alberto Istituti Ortopedici Rizzoli
19 Liao Donghua Aalborg Hospital
20 Lufimpadio Jean-Louis Université Libre de Bruxelles
21 McCormack Keith University of Sheffield
22 McFarlene Nigel University of Bedfordshire
23 Moiseev Fedor Université Libre de Bruxelles
24 Nilsson Dan Aalborg Hospital
25 Pinney David University of Sheffield
26 Sholukha Victor Université Libre de Bruxelles
27 Snoeck Olivier Université Libre de Bruxelles
28 Taddei Fulvia Istituti Ortopedici Rizzoli
29 Tahi Fariza Centre de la Recherche Scientifique
30 Thomas Randall S. Centre de la Recherche Scientifique
31 Van Sint Jan Serge Université Libre de Bruxelles
32 Viceconti Marco Istituti Ortopedici Rizzoli
33 Waters Sarah University of Nottingham
34 Whiteley Jonathan University of Oxford
35 Wu Fuli University of Bedfordshire
• Major involvement of all partner institutions:
• 45 Researchers from the partner institutions actively contributed to the action
• > 90 Researchers from the partner institutions contributed to the Panel discussions
© 2007 STEP Consortium
The Europhysiome Identity
• Europhysiome is a new term used to indicate the European contribution to the international initiative called Physiome.
• The term is also used to indicate collectively all Europe-based Physiome projects such as the Renal Physiome Project, the Giome Project, the Epitheliome Project, the Living Human Project, the Cardiome Project, and the Physiological Flows Initiative.
• www.europhysiome.org registered as domain
© 2007 STEP Consortium
Biomed Town /1• Home of the STEP action
• Private Consortium Floor
• Private Experts Floor
• Public Reception
•VPH Community Home
• Events & News (RSS Feed)
• Public Discussion forums
• Want / offer Board
© 2007 STEP Consortium
Biomed Town /2Biomed Town Citizens
0
100
200
300
400
500
600
700
07-2005 11-2005 02-2006 05-2006 09-2006 12-2006 03-2007 06-2007
Date
Number of Citizens
© 2007 STEP Consortium
Biomed Town /3
0
50.000
100.000
150.000
200.000
250.000
300.000
350.000
Number of requests
Jan2006
Feb2006
Mar2006
Apr2006
May2006
Jun2006
Jul 2006
Aug2006
Sep2006
Oct2006
Nov2006
Dec2006
Jan2007
Feb2007
Mar2007
Month
Biomed Town accesses
© 2007 STEP Consortium
Biomed Town /4
Site URL Number of requests http://www.biomedtown.org/ 1,231,707 http://www.google.com/ 10,975 http://www.europhysiome.org/ 2,615 http://www.google.co.uk/ 1,699
Site URL Number of requests http://www.biomedtown.org/ 1,231,707 http://www.google.com/ 10,975 http://www.europhysiome.org/ 2,615 http://www.google.co.uk/ 1,699
© 2007 STEP Consortium
Advisory Board# Surname Name Affiliation Country Stakeholder
1 Bassingthwaighte James University of Washington USA Research
2 Bedlington Nicola European Patient Forum CH EU liason
3 Beglinger Christoph United European Gastroenterology Federation A EU liasion
4 Coatrieux Jean-Louis Inserm – University Rennes 1 FR Research
5 Delp Scott Stanford University USA Research
6 Hunter Peter University of Auckland NZ Research
7 Kamm Roger Massachussetts Institute of Technology USA Research
8 Kurachi Yoshi Osaka University JP Research
9 Mackay Andrew Insights International UK Industry
10 Mosekilde Erik Technical University of Denmark DK Research
11 Read Isabell e Chacma UK Industry
12 Van der Helm Frans TU Delft NL Research
13 Van der Sloten Jos KU Leuven BE Research
14 Zlotta Alex European Association of Urologist NL EU Liason
# Surname Name Affiliation Country Stakeholder
1 Bassingthwaighte James University of Washington USA Research
2 Bedlington Nicola European Patient Forum CH EU liason
3 Beglinger Christoph United European Gastroenterology Federation A EU liasion
4 Coatrieux Jean-Louis Inserm – University Rennes 1 FR Research
5 Delp Scott Stanford University USA Research
6 Hunter Peter University of Auckland NZ Research
7 Kamm Roger Massachussetts Institute of Technology USA Research
8 Kurachi Yoshi Osaka University JP Research
9 Mackay Andrew Insights International UK Industry
10 Mosekilde Erik Technical University of Denmark DK Research
11 Read Isabell e Chacma UK Industry
12 Van der Helm Frans TU Delft NL Research
13 Van der Sloten Jos KU Leuven BE Research
14 Zlotta Alex European Association of Urologist NL EU Liason
© 2007 STEP Consortium
DefinitionsThe Virtual Physiological Human is a methodological and technological
framework that once established will enable the investigation of the human body as a single complex system.
The Virtual Physiological Human is a methodological and technological framework that once established will enable the investigation of the
human body as a single complex system.
© 2007 STEP Consortium
STEP Conference #1• 15-16 May 2006 - Solbosh campus, ULB, Brussels
• Nearly 100 participants from most EU countries
– Kick-off presentations by Alex Frangi, Marco Viceconti and Gordon Clapworthy
– The Clinical Need presentations by Marcel Rooze, Daniel A. Ruefenacht and Odd Helge Gilja
– Parallel sessions for the Strands discussion
– Roundtable: The Virtual Physiological Human: An opportunity for a European Industry
– Consensus meeting: from strands to the Road Map
• Main output: Road Map index and consensus on scope
© 2007 STEP Consortium
Road Map• 30 internal revisions
• 10 versions submitted to the Advisory Committee for extensive review
• 5 versions submitted to public debate
• Link to draft sent to more than 18,000 unique contacts:
– All UK NHS providers (flyers to 1542 companies)
– BIOMCH-L (> 5500 members)
– EAMBES (> 8000 members)
– Biomed Town (> 400 members)
– ESB (> 500 members)
– GNB (> 300 members)
– Direct personal contacts (10 x 200 = 2000 personal contacts)
© 2007 STEP Consortium
STEP Conference #2• 5-7 November 2007, Solbosh campus, ULB
• More than 250 participants from 28 countries, including delegates from USA, China, Japan, New Zealand, Russia, Israel. Largest group from UK (57 delegates)
• Complex conference structure including breakout sessions, Electronic voting, Want/offer, Open spaces, Capture sheets
• Speakers: James Bassingthwaighte, Ilias Iakovidis, Stephane Hogan, Brian Goodwin, Denis Noble, Victor Alessandrini, Johan Montagnat, Peter Coveney, Jessica Wright, Jean Herveg, Andrew Mackay, Peter Kohl, Alex Bangs, Renè Rizzoli, Peter Hunter
© 2007 STEP Consortium
Question A 2 resultsQuestion A 2 results
16%4%
18%3%
37%34%
22%49%
7%10%
1. low
2.
3. medium
4.
5. high
of the Euro Physiome road map ?What is my level of understanding
Before After
© 2007 STEP Consortium
Question B 2 resultsQuestion B 2 results
0%0%
1%0%
7%9%
34%39%
58%52%
1. low
2.
3. medium
4.
5. high
to overcome in order to be successful?What level of challenge does this project have
Before After
© 2007 STEP Consortium
Question C 2 ResultsQuestion C 2 Results
5%5%
24%18%
48%47%
21%25%
2%5%
1. low
2.
3. medium
4.
5. high
the challanges of the VPH?How well does the current draft of the roadmap reflect
Before After
© 2007 STEP Consortium
Question D 2 resultsQuestion D 2 results
1%0%
3%4%
18%10%
38%37%
40%49%
1. low
2.
3. medium
4.
5. high
of the VPH to do good?What is the potential impact
Before After
© 2007 STEP Consortium
Question E 2 resultsQuestion E 2 results
7%4%
25%12%
22%30%
19%22%
27%32%
1. bystander
2.
3.
4.
5. active participant
What is my own commitment to this work?
Before After
© 2007 STEP Consortium
Dissemination: support material
• Targeted PowerPoint presentations for Researchers, Industry, Clinicians, public at large
• Flyers, brochures, Roadmap summaries, etc
• Press releases
• High quality images related to VPH
• Popular sciences cartoon
© 2007 STEP Consortium
Dissemination: researchers• Conference presentations
– Special session at ISBI 2006, ICT-BIO 2006, WCB 2006 and HealthGrid 2007
– Keynote presentation at ISBMDA 2006 and at the Cocoon conference 2007
• Direct communication
– Monthly VPH newsletter started on 1-9-2006, become weekly on 23-1-2007
– Flyers distributed at WCB and at Inforsalud 2007
• Info Days
– VPH Info day, CNR Rome 22-9-2006, Sheffield 13-10-2006, Paris 23-11-2006
• Papers
– Special Issue of IEEE Proceedings on Physiome research
– Special issue of Clinical Biomechanics on Early Clinical Applications of the Virtual Physiological Human in Musculoskeletal Biomechanics
– Special issue of ERCIM News on Digital Patient, including a chapter on the VPH and STEP
– Paper on Ansys News
© 2007 STEP Consortium
Dissemination: public at large• Press releases:
– English, French, Italian, Russian, Dutch, Polish
• Radio:
– Italian Radio Network 105 Live, program “Mouse to Mouse”
• Printed press:
– English: Daily Telegraph, Russian SININ, The House, Financial Times, Wired
– Danish: Nordjyllands radio
– Italian: Quark, La Stampa, Il Sole 24 Ore
– French: La Soir
• News Agencies:
– ANSA, AreaPress, MarkPress, AlphaGalileo, PuntoInformatico
• Internet media coverage:
– www.hesmagazine.com, punto-informatico.it, www.simel.it, www.folmall.it, www.marketpress.info, www.molecularlab.it, www.eurochina-it.org, del.icio.us, first.aster.it, cordis.europa.eu, www.intermib.com, www.healthgrid.org, www.bioinfogrid.eu, www.hoise.com/vmw, www.lastampa.it, www.ehealthnews.eu, www.telegraph.co.uk,
© 2007 STEP Consortium
Road Map Index
• 1. Scope (IOR)
• 2. Rationale (BED)
• 3. Motivation (ULB)
• 4. International context (IOR)
• 5. Common Objectives (OXF)
• 6. Research Challenges (NOT)
• 7. Impact Analysis (CNRS)
• 8. Success stories (AAS)
• 9. Ethical, Legal and Gender Issues (USFD)
• 10. Dissemination Models (BED)
• 11. Exploitation Models & Long-term Sustainability (UCL)
• 12. Concrete Implementation: recommendations (IOR)
© 2007 STEP Consortium
Multilevel document
• 200 words executive summary
• 850 words Scope chapter
• 4500 Recommendations chapter
• > 50000 words detailed document
© 2007 STEP Consortium
Chapter #1: Scope• Defines the scope of the road map
• Clarify what is the VPH
• Identify its main features:– descriptive: the framework should allow observations made in laboratories, in hospitals
and in the field, at a variety of locations situated anywhere in the world, to be collected, catalogued, organised, shared and combined in any possible way;
– integrative: the framework should enable experts to analyse these observations collaboratively and to develop systemic hypotheses that involve the knowledge of multiple scientific disciplines;
– predictive: the framework should make it possible to interconnect predictive models defined at different scales, with different methods, and with different levels of detail, into systemic networks that solidify those systemic hypotheses; it should also make it possible to verify their validity by comparison with other clinical or laboratory observations.
© 2007 STEP Consortium
Chapter #12: Final recommendations
• The Infrastructure
• The Data
• The Models
• The Validation
• Long term sustainability models
• The People
© 2007 STEP Consortium
Chapter #12: The Infrastructure
• The VPH needs
• Community infrastructures
• Physical infrastructures
• Technological infrastructures
• Commercial, Legal and Ethical frameworks
© 2007 STEP Consortium
Chapter #12: The Data
• Accumulating clinical observations
– It is necessary to favour projects that aim to collect relevant experimental data with respect to cell to cell and cell to tissue interaction
• Challenges in data collection
– Curation, quality assurance
© 2007 STEP Consortium
Chapter #12: The Models
• Challenges in VPH modelling
• Accumulating models
– Separating models from solvers
– Separating models from numerical solutions
• Interconnecting models
– Models as web services
– Supermodels
• Model verification
© 2007 STEP Consortium
Chapter #12: The Validation
• Challenges in validation
– Validation with controlled experiments
– Confirmation of independent observations
• Validating for the clinic
– Quality assurance for models
• Validating for the industry
– models in medical devices certification
© 2007 STEP Consortium
Chapter #12: Long term sustainability
models• Barter model
• E-Commerce model
• Subscription support
© 2007 STEP Consortium
Chapter #12: The People
• A major problem in the sustainable implementation of the ideas behind VPH, and the realisation of the corresponding benefits with respect to scientific development and public health, is the attraction of this field to younger scientists.
• Currently, it is much more promising for gifted young researchers to go directly into fields such as molecular biology and medicine.
• Efforts in interdisciplinary fields are usually under-rewarded, so it will be necessary to develop around VPH research a comprehensive career support and incentive system.
• The most talented young people facing fundamental career decisions have to see a real chance for their own scientific development when entering VPH-related activities.
• Only then, will we be able to recruit top quality people and to achieve fast and sustained scientific development.
© 2007 STEP Consortium
The Future
• Biomed Town will continue to operate in 2007 through LHDL Financial support
• IOR will continue to steer the WIRI Agreement, and would be happy to serve as news concentration for all VPH-related initiatives
• General VPH dissemination in 2007 is not funded; EC news services should use the VPH News feed as a basis for targeted dissemination actions
• IOR will closely monitor (but not participate in the core consortium) the forthcoming NoE, to maintain the highest possible level of momentum
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