pecoraro research group - university of...

Dendrimers (BLB)

Pecoraro Research GroupVincent L. Pecoraro: vlpec@umich.edu

Webpage: https://sites.lsa.umich.edu/pecoraro-lab

Synthetic Method (BS / BLB)

MC (large MC image)

Toxic Metal Binding Sites

Molecular MagnetismLanthanide Luminescence

Hydroxamic

acid

derivatives

Metal salts M = Ring Metal

M = Center Metal

Dendrimers

16Cys

19Leu

12Leu

N terminus

C terminus

GRAND-CSL16CL30Ha site

X-ray crystallography

NMR structural determination

Molecular Recognition/Catalysis

Ru or Rh style catalyst

Rational design to improve NiR activity

Gated NiR Catalysis

Carbonic

Anhydrase(PDB 3PBJ)

Spectroscopy

2 4 6 8 10 12

-3

-1

1

3

k/Å-1

k3 ´ E

XAFS

0 1 2 3 4 5 60.0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

R/Å

FT m

agnit

ude

A B

C

8960 8990 9020 90500

1

2

3

E/eV

Norm

alize

d In

tens

ity

Superoxide Dismutase

Asymmetric

3SCC

PECTIDES(large pymol) Enzyme Design

ab

(c)de

fg

a’

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Outside the Lab