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    CONTENTSCONTENTS

    Introduction Apexogenesis

    a)Defnition

    b)Objectivec) Indirect pulp capping

    d)Direct pulp capping

    e)Apical closure

    pulpotomy- Calcium hydroxide

    pulpotomy

    - MA pulpotomy

    Apexifcation 

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    INTRODUCTIONINTRODUCTION

    OPEN APEX: Probe!sProbe!s

    - Canals have larger apical diametervs smaller coronal canal diameter

      ma!es debridement di"cult

    - #ac! o$ an apical stop ma!esobturation impossible%

    - he thin root canal &alls becomeprone to $racture

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     Soution " Surgery? 

    Dra#bac$s:Dra#bac$s:

    '% Inade(uate cro&nroot ratio

    *% +hysically and psychologically traumatic

    to the patient,% oung patients are not very cooperative%

    .% Apical &alls are thin and could shatter&hen touched by a rotating bur

    /% hin &alls &ould ma!e condensation o$ aretrograde flling di"cult

    0% 1urgery &ould remove the root sheathand prevent any possibility o$ $urther root

    development% 2Morse et al)

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    APEXO%ENESIS & 'ITA(APEXO%ENESIS & 'ITA(

    PU(P T)ERAP*+PU(P T)ERAP*+Defnition:

    1.  “ The physiologic root enddevelopment and formation.”  3

     American Association of Endodontists

    *% 'ita Pup t,erap-: 4Treatment of

    a vital pulp in an immature tooth to permit continued dentin formationand apical closure” - Walton and

    Torabinejad

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    Ob.ecti/e:

    Maintain the vitality o$ radicular pulp

     Achieved through:

    '% Indirect pulp capping

    *% Direct pulp capping

    ,% Apical closure pulpotomy

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    INDIRECT PULP CAPPING

    Defnition: 

    4Application o$ a medicament over a

    thin layer o$ remaining carious dentina$ter deep excavation5 &ith no

    exposure o$ the pulp6 3 Ingle

    Rationae:

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    DIRECT PULP CAPPING

    Defnition: 4+lacement o$ a biocompatible agent

      on healthy pulp tissue that has been

    inadvertently exposed $rom cariesexcavation or traumatic injury%6 - Ingle

     Ob.ecti/e:

     Indication:  1mall traumatic exposures o$ less than 'mm

    diameter and only a $e& hours duration%

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    Contraindication:

      Carious exposures in an immaturetooth as the extent o$ in7ammationand contamination cannot be

    determined clinically% (Seltzer andBender)

    0aterias Used:'%Calcium hydroxide

    *%MA

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    APICAL CLOSURE PULPOTOMY

    Defnition:

      4 8emoval o$ damaged and in7amedtissue to the level o$ a clinically healthy

    pulp5 $ollo&ed by a calcium hydroxidedressing6 (Anderson)

    Indication:

    '%An immature permanent tooth &ith anopen apex and reversible pulpitis su9ers acarious exposure

    *%#arge diameter 2more than 'mm)traumatic pulpal exposure5 o$ any duration

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    T-pes:

    1.Partial pulpotomy  2 shallo&5 lo&-level or Cveks pulpotomy!

    .!ervical pulpotom y  2deep5 high-

    level5 total or conventional pulpotomy)0aterias used:

    '%Calcium :ydroxide

    *%MA

    ,%;one gro&th $actors

    .%;one morphogenic proteins

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    Caciu! ,-droxide

    pupoto!-Partia pupoto!-:

    '%Anestheti

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    Ad/antages:

    '% Minor injury to the pulp and undisturbed

    physiologic apposition o$ dentin5 especiallyin the critical cervical area o$ the tooth%

    *%  he limited loss o$ coronal pulp allo&s $orvitality testing%

    ,% #imited loss o$ cro&n precludes need $orpost and core%

    Co!pared #it, pup capping it

    i!pies: ;etter &ound control%

    ;etter sealing against micro lea!age%

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    0TA Pupoto!-

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    Disad/antage: @xpensive

    #ong setting time5 re(uiring anadditional appointment in certain cases

    Di"culty in manipulation

    Ad/antage o/er Ca&o,+1

    '%?ood seal

    *%?ood 1trength

    ,%:as cell inductive potential

    .%+roduces signifcantly more dentinalbridging in a shorter period o$ time &ithsignifcantly less in7ammation

    (!ohen).

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    Reca 2or Apexogenesis

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    Treat!ent 2aiure Cessation o$ root gro&th

    Development o$ signs and symptoms orperiapical lesion%

    Calcifc metamorphosis 2i%e% calcifcobliteration) o$ canal or internalresorption

    %oas:'%1ustaining a viable :ert&igs epithelial

    root sheath*%Maintaining pulpal vitality,%+romoting root end closure.%?enerating a dentinal bridge at the site

    o$ pulpotomy

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    Restoration:

      Institute root canal therapy a$terapexogenesis (!ve"# $e%%er#Seltzer and Bender)

    Prognosis: "ulp capping 3 >*-BB

    "artial pulpotomy 3 .-0

    Cervical pulpotomy 3 >*->

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    APEXI3ICATIONAPEXI3ICATION

    #on-surgical approaches $discussed by%orse!& ;lunt end or rolled cone 2customi

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    Defnition:

      4%ethod of inducing apical closure by the

    formation of osteocementum or a similarhard tissue or the continued apicaldevelopment of the root of an incompletelyformed tooth in 'hich the pulp is no longer

    vital%6 & American Association o'ndodontics

    Root end cosure tec,ni4ue (ora%ine*ad)

      (The process of creating an environment

    'ithin the root canal and periapical tissues

    after pulp death that allo's a calci)c barrierto form across the open ape*” 

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    Indication 8estorable immature tooth &ith pulp

    necrosis%

    Contraindications :'%All vertical and un$avorable hori

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    Properties o2 CaO)1 reated to its,ig, p) (Andreasen):

      p, " &66"61+

    +.Capacity to dissolve necrotic pulpremnants&

    ,.trong antibacterial eect&

      % o$ bacteria $rom the common

    root canal 7ora are !illed &ithin a $e&minutes upon direct contact &ithCaO:*

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    Apexifcation using caciu!

    ,-droxide

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     Paste #oud need to be c,anged at t,irdreca &7 #ee$s+ i2 

    +aste is $ound to be &et in apical hal$ due to exudates%

    8adiographic evidence o$ dilution o$ paste +aste is overextended at second appointment% +atient develops sinus tract or symptoms

    6183ina fing o2 t,e cana: 1ymptomless tooth &ith healing o$ any sinus tract% 8adiographic observation o$ osseous deposition in the

    periapical o$ lateral de$ect 8adiographic observation o$ hard tissue deposition at

    the apex% Ginding the CaO:* paste to be dry &hen tested by

    probing% Confrmation o$ a calcifc barrier by probing &ith light

    fnger pressure &ith smaller 2*H-*/) fles% Drying o$ canal system &ith paper points elicits no

    hemorrhage or tissue 7uids%

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    T,ere can be f/e outco!es o2apexifcation procedure &$eine)

    '% Eo radiographic change is apparent but i$instrument is inserted5 a bloc!age at theapex is encountered%

    *% 8adiographic evidence o$ calcifed materialis seen at or near the apex%

    ,% Apex closes &ithout any change in canalspace%

    .% Apex continues to develop &ith closure o$the canal apace%

    /% Eo radiographic evidence o$ change is seen5and clinical symptom andJor development o$or the increase in si

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    Disad/antages o2 caciu! ,-droxide

    apexifcation:

    Cost o$ multiple visits

    +atient compliance &ith multipleappointments over 0-*. months

    +ossibility o$ root $racture during theextended period because o$ the thin roots andincidence o$ traumatic injuries in children%

     he dentin becoming more brittle as it

    continues to be in contact &ith CaO:*5 &hich5along &ith thin &alls &ill predispose to$ractures.(Ingle)

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    ONE 'ISIT APEXI3ICATION

    0aterias used:

    '% ricalcium phosphate

    *%8esorbable ceramic%,%Caph*

    .%Gree

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    One /isit apexifcation

    #it, 0TATec,ni4ue'% A$ter thorough debridement5 the canal is

    medicated &ith CaO:* $or ' &ee! $or disin$ection%

    *% On re-entry5 canal is cleansed and rinsed &ith

    EaOCl%,% he canal is dried and a ,-. mm plug o$ MA ispac!ed into the apical end &ith pluggers or paperpoints%

    .% he placement is confrmed radiographically and

    then a moist pellet is placed against the MA andaccess cavity is sealed $or .-0 hours to allo& thematerial to harden

    /% he canal is then obturated &ith gutta-percha orbonded composite%

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    Osteogenic Protein 9 6 $bone

    morphogenetic protein!'% Attract and recruit mononuclear

    phagocytes to sites bone $ormation%

    *%1timulates the proli$eration o$mesenchymal cells that subse(uentlydi9erentiate into osteogenic cells%

     Material is used &ith a collagen carrier

    &hich allo&s its release over a longperiod%

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    'itait- testing 2or i!!ature -oungper!anent teet,:

     hermal tests%@+

    Ot,er appications o2 apexifcation:'% #ateral per$oration

    *% Aggressive external resorption

    $Weine!

     Ape+ogenesis vs. Ape+i,cation

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    CONC(USION