barcelona september 2013 oxygen therapy in normobarism trophic injuries of the lower limbs the...
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Barcelona September 2013
Oxygen therapy in normobarism
Trophic injuries of the lower limbs
The reasoning
for the therapy
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Barcelona September 2013
Oxygen therapy in normobarism
Trophic injuries of the lower limbs
•Epidemiology
•It is estimated that this pathology affects
•1.5% of the population
• 5% of the population over 65 years
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Barcelona September 2013
Oxygen therapy in normobarism
Trophic injuries of the lower limbs
•Problem for the patient
•The sick person with such injuries, which by definiton are
chronic, is often incapable, suffering, malodorous, depressed
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Barcelona September 2013
Oxygen therapy in normobarism
Trophic injuries of the lower limbs
•Problem for society. The costs
•Direct costs
•Treatment, material, departments
•Public services and within the national health service
•insurance
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Barcelona September 2013
Oxygen therapy in normobarism
Trophic injuries of the lower limbs
•Problem for society. The costs
•Indirect costs
•Working days lost both by the patient and by family members involved and eventual costs for
insurance
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•Social health consequences of inadequate treatment
•For the Patient
•infections, gangrene, amputation and in any case complications of
health and relationship .
Oxygen therapy in normobarism
Trophic injuries of the lower limbs
Barcelona September 2013
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•Social health consequences of
• inadequate treatment
•For the family
•infections, gangrene, amputation and in any case complications of
health and relationships .
Oxygen therapy in normobarism
Trophic injuries of the lower limbs
Barcelona September 2013
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•Social health consequences of inadequate treatment
Oxygen therapy in normobarism
Trophic injuries of the lower limbs
Barcelona September 2013
•For the national health system
• greater costs for complications
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Definition of ulcerLoss of substances linked to hemodynamic, hemorheologic
and coagulative modifications: in its genesis the use of microcirculation and consequent impairment of tissue
trophism is fundamental. It represents the epiphenomenon of various pathologies which have at their base an
insufficient hematic supply with consequent hypoxia and infection (Bimonte).
Madeyski’s Normobaric Chamber
Barcelona September 2013
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Classification
1) Ulcers of venous stasis
2) Arterial ulcers
3) Traumatic ulcers
4) Collagen ulcers
5) Diabetic ulcers (Diabetic foot)
Madeyski’s Normobaric Chamber
Barcelona September 2013
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Physiopathology of the ulcer
Transcutaneous oximetry has shown at the level of the vasculopathic injuries a pO2 of 5-10 mm of Hg.
This value is incompatible with the life of the cells and impedes the proliferation and the action of the
leukocytes which require values of pO2 of 30-40 mm of Hg: from this derives the danger of infection.
Madeyski’s Normobaric Chamber
Barcelona September 2013
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Physiopathology of the ulcer Even the synthesis of the collagen starting from the
fibroblasts cannot disregard the oxygen.
In conditions of relative hypoxia an immature and not very stable collagen will be formed with
inevitable healing problems
Madeyski’s Normobaric Chamber
Barcelona September 2013
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For the re-epithelialization of the ulcera
a) An optimal supply of oxygen
b) Complete cleansing of the injury
c) Good perfusion of blood
Barcelona September 2013
Madeyski’s Normobaric Chamber
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POSSIBLE THERAPIES
Ulcer therapy concerns local and systemic factors.
1) Medical therapies 2) Surgical therapies 3) Therapy with hyperbaric chamber4) Therapy with normobaric oxygen5) Therapy with oxygen-ozone
Barcelona September 2013
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Reasoning for oxygen hyperbaric therapy
Restores the distribution of O2 from the capillaries to the cells where this is impeded or to reduce the hematic
perfusion or for thickening of the means of transit (edema, pyogenic membrane, necrotic tissues)
Barcelona September 2013
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Hyperbaric chamber Local chamber
The concentration of oxygen reaches 22%
The concentration of oxygen reaches 95%
Oxygen dissolved in the blood equal to 6 cc %
Oxygen dissolved in the blood equal to 2 cc %
DIFFERENCES BETWEEN THE HYPERBARIC AND LOCAL CHAMBERS
Barcelona September 2013
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DIFFERENCES BETWEEN HYPERBARIC AND LOCAL
CHAMBERS
Substantially the hyperbaric chamber actsthanks to the increase in oxygen dissolved while the
local chamber acts thanks to the high concen-tration of oxygen at the level of the trophic injuries
Madeyski’s Normbaric Chamber
Barcelona September 2013
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Advantages Disadvantages
Increase of O2 dissolved
Bactericidal action
Anti-edema action
Healing action
-Not borne by many patients.
-Cardiac,vestibular, psychological problems,etc.
-Limited number of centres.
-Transport problems.
-High costs
Hyperbaric Chamber
Barcelona September 2013
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So called for the “similarity” with
the hyperbaric chamber
.
Madeyski’s Normobaric Chamber
Barcelona September 2013
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Madeyski’s Normobaric Chamber
PORTABLE VERSION (HOME)
Barcelona September 2013
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Advantages Disadvantages
High concentration of oxygen at the level of the
injury
Minor or no increase of oxygen dissolved in the
plasma
NO LOCAL OR SYSTEMIC SIDE EFFECTS
Madeyski’s normobaric chamber
Barcelona September 2013
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CASE HISTORIES 2012
Casa di Cura Rizzola
Patients treated : 156Phlebostatic ulcers: 86
Diabetic ulcers: 42Arterial ulcers: 11Mixed ulcers: 07
Transplant ulcers 10
Barcelona September 2013
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Methodology
Patients underwent daily sittings of one or two hours.
The number of sittings was variable with healing between 2 and 4 months on
average. Self medication only took place with saline solution
Barcelona September 2013
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Subjective results
1) Reduction of secretion and cleansing of the injuries.
2) Improvement in the subjective symptomatology (pains, burns, itching,).
Barcelona September 2013
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Objective results
1) Precocious appearance of a good tissue of granulation.2) Reduction of the diameter of the injury until complete closure in 70% of cases.3) Effect favouring subsequent transplants taking root in 85% of the sick people. 4) Result null in 15% of cases
Barcelona September 2013
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Overview of ulcers treated
Casa di Cura Rizzola 2012
Barcelona september 2013
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Overview of ulcers treated
Casa di Cura Rizzola 2012
Barcelona september 2013
•before therapy
•After 1 month of therapy
•After 2 months of therapy
•After 3 months of therapy
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Conclusion
High compliance
Effectiveness documented
Low cost of purchase and of use Social cost
Easy availability
Absence of side effects
Rapid training of personnel
Barcelona September 2013