constructing s.t.e.a.m.: a physicsian scientist’s perspective
TRANSCRIPT
Constructing S.T.E.A.M.Constructing S.T.E.A.M.: : aa PHYSICSian scientist’s perspective PHYSICSian scientist’s perspectiveSherry-Ann Brown, MD, PhD@drbrowncares, [email protected]
www.myschoolhouse.com
S.T.E.A.M.www.myschoolhouse.com
Star Trek: The Next Generation sixth season episode "Second Chances"
The Cerebellum
• Latin, little brain
• Constitutes only 10% of the total volume of the brain, but contains more than half of all its neurons
• Coordinates posture, gaze, speech, handwriting, and other motor functions
The Cerebellum, Principles of Neural Science. 2000 McGraw Hill.
ATAXIAATAXIAnn. . GreekGreek. Loss of motor coordination.. Loss of motor coordination.
Climbing Fiber Stimulus Depolarization throughout PN Extracellular Calcium entry into cell!
Parallel Fiber Stimulus IP3 Production Calcium mobilization from ER!ER = endoplasmic reticulum
Cerebellar Purkinje Neuron Cerebellar Purkinje Neuron (PN)(PN)
Hernjak et al, Biophysical Journal 2005
Parallel fiber stimulus
Climbing fiber stimulus
Calcium Pathways In The Cell
Hernjak et al, Biophysical Journal 2005
Parallel fiber stimulus
Climbing fiber stimulus
Calcium Pathways In The Cell
Aim 1:3D Model
Purkinje neuronReconstructed Experimental 3D Geometry of
Purkinje Cell Dendrite Branchlet
Hernjak et al, Biophysical Journal 2005
Parallel fiber stimulus
Climbing fiber stimulus
Calcium Pathways In The Cell
Aim 1:3D Model
Hernjak et al, Biophysical Journal 2005
Parallel fiber stimulus
Climbing fiber stimulus
Calcium Pathways In The Cell
Aim 1:3D Model
Aim 2:Electric Model
Simplification of Purkinje Neuronal Morphology
Miyasho et al., Brain Research, 2001@drbrowncares
Comparison of Electrical Activity in the Full and Reduced Models - soma
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Full model Reduced model
Hernjak et al, Biophysical Journal 2005@drbrowncares
Calcium Pathways In The Cell
Aim 3:Ataxia Model
Aim 1:3D Model
Aim 2:Electric Model
S.T.E.A.M. CollectionS.T.E.A.M. Collection© 2010 Sherry-Ann Brown
Coincident IncidentHow Will I Dance?
Just One More Step
My Thesis CommitteeMy Thesis CommitteeCCAM, MD/PhD ProgramCCAM, MD/PhD Program
University of Connecticut Health CenterUniversity of Connecticut Health CenterNIHNIH
Primary Investigator:Primary Investigator:Dr. Leslie M. Loew Dr. Ion Moraru
Dr. James Schaff
Dr. Ann Cowan
Dr. Raquell Holmes
Dr. James WatrasDr. James WatrasMr. Frank MorganMr. Frank Morgan
Ed & ElenaEd & Elena
Karen, Donna, Karen, Donna, DebbieDebbie
Anu, Fei, Li Ye; Boris, Igor, Pavel
Sofya, Jon, Stacy
Dr. Art HandDr. Art HandDr. Bill LyttonDr. Bill Lytton
Dr. Marja HurleyDr. Marja Hurley
Stepping In & Out
Sherry-Ann Brown, MD, PhDCI Planning Meeting 2015
Thesis reception: S.T.E.A.M. poetry collection poster, art & photography@drbrowncares
Sherry-Ann Brown, MD, PhD@drbrowncares, [email protected]
www.myschoolhouse.com
Constructing S.T.E.A.M.Constructing S.T.E.A.M.: : aa PHYSICSian scientist’s perspective PHYSICSian scientist’s perspective
Ohm’s Law & Blood Circulation
Ohms Law Darcy’s Law V = I x R BP = Q x VR
"The heart is the only organ of all organs that can not endure injury. This is expected because when the main power source is destroyed, no additional force can be brought by the organs that depend on it" (Aristotle - 384 BC).
www.slideshare.net, http://www.scielo.br/scielo.php?pid=S0102-76382010000100006&script=sci_arttext&tlng=enwww.slideshare.net, http://www.scielo.br/scielo.php?pid=S0102-76382010000100006&script=sci_arttext&tlng=en @[email protected]
• In a noncompressible fluid system, flow is the same at any given point
• Flow = area x velocity
• area x velocity = area x velocity
• F V r∝ ⋅ 2
cm³ ► cm² cmx
Conservation of Mass Principle
Compliments of Dr. Hector Michelena, Mayo Clinic
Heart Murmurs
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w.cv
phys
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Heart
Aorta
Aorta
Heart
Normal Narrow
www.cvphysiology.comwww.cvphysiology.com
Heart Murmurs
http://www.boxerbreedcouncil.co.uk/as.htmhttp://www.boxerbreedcouncil.co.uk/as.htm
Sherry-Ann Brown, MD, PhD@drbrowncares, [email protected]
www.myschoolhouse.com
Constructing S.T.E.A.M.Constructing S.T.E.A.M.: : aa PHYSICSian scientist’s perspective PHYSICSian scientist’s perspective