dr. b ch 19_lecture_presentation
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Dr. B Week 4TRANSCRIPT
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19The Endocrine System
PowerPoint® Lecture Presentations prepared bySteven BassettSoutheast Community College Lincoln, Nebraska
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Introduction
• The nervous system and the endocrinesystem work together to monitor thebody’s activities
• The nervous system: produces short-term, very specific responses
• The endocrine system: many times it produces long-term, general responses
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Introduction
• The endocrine system releases chemicalscalled hormones
• Hormones leave a gland or gland-like structure• The hormone enters into the bloodstream• Hormones are organized into four groups
based on chemical structure: • Amino acid derivatives • Peptide hormones• Steroid hormones• Eicosanoids
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An Overview of the Endocrine System
• The main endocrine organs are:• Pituitary gland• Hypothalamus • Thyroid gland• Thymus gland• Suprarenal glands• Pineal gland• Parathyroid glands• Pancreas• Reproductive glands
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Endocrine activity Endocrine activity is controlled by endocrine reflexes that are triggered by:
Humoral stimuli Hormonal stimuli Neural stimuli
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Figure 19.1 The Endocrine System
KEY TO PITUITARY HORMONES
ACTHTSHGHPRLFSHLHMSHADH
Adrenocorticotropic hormoneThyroid-stimulating hormoneGrowth hormoneProlactinFollicle-stimulating hormoneLuteinizing hormoneMelanocyte-stimulating hormoneAntidiuretic hormone
Each suprarenal gland issubdivided into:Medulla: Epinephrine (E) Norepinephrine (NE)Cortex: Cortisol, corticosterone, aldosterone, androgens
Thymosins
Testis
Thyroxine (T4)Triiodothyronine (T3)Calcitonin (CT)
Pars distalis (anterior lobe): ACTH, TSH, GH, PRL, FSH, LH, and MSHNeurohypophysis(posterior lobe): Release of oxytocin and ADH
Suprarenal Glands
Thymus(Undergoes atrophyduring adulthood)
Thyroid Gland
Pituitary Gland
HypothalamusProduction of ADH,oxytocin, and regulatoryhormones
Pineal GlandMelatonin
Parathyroid Glands(on posterior surface ofthyroid gland)
Parathyroid hormone (PTH)
HeartNatriuretic peptides: Atrial natriuretic peptide (ANP) Brain natriuretic peptide (BNP)
Erythropoietin (EPO)Calcitriol(Chapters 19 and 26)
Kidney
Adipose Tissue
Digestive Tract
Pancreatic Islets
Gonads
LeptinResistin
Numerous hormones(detailed in Chapter 25)
Insulin, glucagon
Testes (male): Androgens (especially testosterone), inhibinOvaries (female): Estrogens, progestins, inhibinOvary
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An Overview of the Endocrine System
• The Hypothalamus and Endocrine Regulation
• Hypothalamus functions via three mechanisms• Secretes regulatory hormones
• Secretes releasing hormones (RH)• Secretes inhibiting hormones (IH)
• Acts as an endocrine organ• Releases antidiuretic hormone and oxytocin to
the pituitary gland• Contains autonomic nervous system centers
• Exerts control over the suprarenal medulla
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Figure 19.2 Hypothalamic Control over Endocrine Organs
HYPOTHALAMUS
Secretion ofregulatory hormonesto control activity ofpars distalis (anteriorlobe) of pituitary gland
Productionof ADH andoxytocin
Control of sympatheticoutput to suprarenalmedullae
Pars distalis(anterior lobe)
of pituitary gland
Neurohypophysis(posterior lobe)of pituitary gland
Medulla
Hormones secretedby pars distalis ofpituitary glandcontrol otherendocrine organs
Release ofADH andoxytocin
Secretion ofepinephrine andnorepinephrine
Suprarenal gland
Preganglionicmotor fibers
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The Pituitary Gland
The pituitary gland, or hypophysis Neurohypophysis (posterior lobe)
ADH: is secreted in response to low blood volume or high electrolyte concentration in blood. It will raise the blood pressure and lower the electrolyte concentration.
Lack of ADH secretion will cause diabetes insipidus. Oxytocin
Adenohypophysis (anterior lobe) ACTH — adrenocorticotropic hormone TSH — thyroid-stimulating hormone GH — growth hormone PRL — prolactin FSH — follicle-stimulating hormone: stimulates egg development
and estrogen production in female. LH — luteinizing hormone
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Figure 19.3a Gross Anatomy and Histological Organization of the Pituitary Gland and Its Subdivisions
Relationship of the pituitarygland to the hypothalamus
Medianeminence
Thirdventricle
Mamillarybody
HYPOTHALAMUS
Optic chiasm
Infundibulum
Diaphragmasellae
Parstuberalis
Parsdistalis
Parsintermedia
Neurohypophysis(posterior lobe)
Sphenoid(sella turcica)
Adenohypophysis(anterior lobe)
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Figure 19.5 The Pituitary Gland and the Hypophyseal Portal System
ADENOHYPOPHYSISOF PITUITARY GLAND
NEUROHYPOPHYSISOF PITUITARY GLAND
MEDIAN
EMINENCE
HYPOTHALAMUS
Hypophyseal veins
Endocrine cells
Inferior hypophyseal artery
Infundibulum
Superior hypophyseal artery
Portal veins
Mamillarybody
Paraventricularnuclei
Supraopticnuclei
Opticchiasm
CapillaryBeds
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Table 19.1 The Pituitary Hormones
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Figure 19.4 Pituitary Hormones and Their Targets
HypothalamusDirect Release
of HormonesIndirect Control Through Release
of Regulatory HormonesDirect Controlby NervousSystem Sensory
stimulationOsmoreceptor
stimulationRegulatory hormones are released intothe hypophyseal portal system for delivery
to the anterior lobe of the pituitary
Posterior lobeof pituitary gland
Adenohypophysis ofpituitary glandMedulla
Cortex
Suprarenalgland
Thyroidgland
Epinephrine andnorepinephrine
Liver
Glucocorticoids(cortisol,
corticosterone)
Thyroidhormones (T3, T4)
Bone, muscle,other tissues Mammary
glands
Testesof male
Ovariesof female
TestosteroneInhibin Estrogen Progesterone Inhibin
Melanocytes (uncertainsignificance in healthyadults)
Females: Uterinesmooth muscle andmammary glands
Males: Smoothmuscle in ductusdeferens andprostate gland
Kidneys
KEY TO PITUITARY HORMONES
ACTHTSH
GH
PRL
FSHLH
MSH
ADH
Adrenocorticotropic hormone
Thyroid-stimulating hormone
Growth hormone
Prolactin
Follicle-stimulating hormone
Luteinizing hormone
Melanocyte-stimulating hormone
Antidiuretic hormone
ADH
Oxytocin
MSH
LHFSHPRL
GHTSH
ACTH
Somatomedins
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The Thyroid Gland
Sits on thyroid cartilage of larynx Butterfly-like appearance Consists of two main lobes connected by the isthmusThe only endocrine gland that stores its hormone extracellularly. Controls metabolism
Thyroxine (T4) Triiodothyronine (T3)
Involved in calcium homeostasis Calcitonin: decreases the concentration of
calcium in blood.
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Figure 19.6a Anatomy and Histological Organization of the Thyroid Gland
Location and anatomy of the thyroid gland
Isthmus ofthyroid gland
Left lobe ofthyroid gland
Internaljugular vein
Cricoid cartilageof larynx
Inferiorthyroid artery
Inferiorthyroidveins
Superiorthyroid artery
Hyoid bone
Middle thyroid vein
Thyrocervical trunk
Trachea
Outline of clavicle
Outline of sternum
Thyroid cartilageof larynx
Superiorthyroid vein
Commoncarotid artery
Right lobe ofthyroid gland
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Table 19.2 Hormones of the Thyroid Gland, Parathyroid Glands, and Thymus (Part 1 of 2)
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Figure 19.7 The Regulation of Thyroid Secretion
Hypothalamusreleases TRH
Pituitarygland
Anteriorlobe
Anteriorlobe
TRH
TSH
Thyroidgland
Adenohypophysisreleases TSH
Thyroid folliclesrelease T3 and T4
Normal T3 and T4
concentrations,normal bodytemperature
Decreased T3 and T4 concentrations
in blood or lowbody temperature
Increased T3 and T4 concentrationsin blood
HomeostasisDisturbed
HomeostasisRestored
HOMEOSTASIS
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The Parathyroid Glands
Located on the back of the thyroid glandTwo types of cells:
Parathyroid cells, or principal cells (Chief Cells)— glandular cells that produce the hormone PTH, which raises the blood calcium
Oxyphil cells and transitional cells— likely immature or inactive principal cells
Regulates calcium homeostasis PTH— parathyroid hormone
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Figure 19.8 Anatomy and Histological Organization of the Parathyroid Glands
The location and size of the parathyroidglands on the posterior surface of thethyroid lobes
The histology of the parathyroidand thyroid glands
A histological section showing parathyroid cellsand oxyphil cells of the parathyroid gland
LM 600Parathyroid gland
Oxyphilcells
Parathyroid(chief) cells
LM 100Parathyroid and thyroid gland
Connectivetissue capsuleof parathyroid
gland
Thyroidfollicles
Blood vessel
Left lobe ofthyroid gland
Parathyroidglands
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Table 19.2 Hormones of the Thyroid Gland, Parathyroid Glands, and Thymus (Part 1 of 2)
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The Thymus Gland
Located on top of the heart Secretes many chemicals that help T
cells of the immune system develop Thymosins
Atrophies as one ages
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Figure 19.1 The Endocrine System
KEY TO PITUITARY HORMONES
ACTHTSHGHPRLFSHLHMSHADH
Adrenocorticotropic hormoneThyroid-stimulating hormoneGrowth hormoneProlactinFollicle-stimulating hormoneLuteinizing hormoneMelanocyte-stimulating hormoneAntidiuretic hormone
Each suprarenal gland issubdivided into:Medulla: Epinephrine (E) Norepinephrine (NE)Cortex: Cortisol, corticosterone, aldosterone, androgens
Thymosins
Testis
Thyroxine (T4)Triiodothyronine (T3)Calcitonin (CT)
Pars distalis (anterior lobe): ACTH, TSH, GH, PRL, FSH, LH, and MSHNeurohypophysis(posterior lobe): Release of oxytocin and ADH
Suprarenal Glands
Thymus(Undergoes atrophyduring adulthood)
Thyroid Gland
Pituitary Gland
HypothalamusProduction of ADH,oxytocin, and regulatoryhormones
Pineal GlandMelatonin
Parathyroid Glands(on posterior surface ofthyroid gland)
Parathyroid hormone (PTH)
HeartNatriuretic peptides: Atrial natriuretic peptide (ANP) Brain natriuretic peptide (BNP)
Erythropoietin (EPO)Calcitriol(Chapters 19 and 26)
Kidney
Adipose Tissue
Digestive Tract
Pancreatic Islets
Gonads
LeptinResistin
Numerous hormones(detailed in Chapter 25)
Insulin, glucagon
Testes (male): Androgens (especially testosterone), inhibinOvaries (female): Estrogens, progestins, inhibinOvary
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The Suprarenal Glands
Located on top of kidneys Manages stress levels Can be divided into two regions:
Suprarenal cortex. Yellow in color due to presence of steroid lipids. The Zona Glomerulosa produces
mineralocorticoids. The Zona Fasciculata produces glucocorticoids. The Zona Reticularis produces androgens.
Suprarenal medulla Chromaffin cells produce epinephrine (adrenaline)
and norephinephrine (noradrenaline).
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Figure 19. 9ab Anatomy and Histological Organization of the Suprarenal Gland
A suprarenal glandcut to show both the cortex and themedulla. Note theorientation of thesection for part (c).
Medulla
Cortex
Sectional planefor part (b)Left suprarenal(adrenal) gland
Left middlesuprarenal arteryLeft inferiorsuprarenal arteries
Left suprarenal vein
Superior mesentericartery
Left renal vein
Left renal artery
Right and left inferiorphrenic arteries
Inferiorvena cava
Abdominalaorta
Anterior view of the kidney and suprarenalgland. Note the sectional plane for part (b).
Right superiorsuprarenal arteries
Celiac trunk
Right suprarenal(adrenal) gland
Right middlesuprarenal artery
Right inferiorsuprarenal artery
Right renalartery
Right renalvein
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Figure 19. 9bc Anatomy and Histological Organization of the Suprarenal Gland
A suprarenal glandcut to show both the cortex and themedulla. Note theorientation of thesection for part (c).
Medulla
Cortex
Histology of the suprarenal gland showingidentification of the major regions
Capsule
Zonaglomerulosa
Zonafasciculata
Zonareticularis
Cortex
Medulla
Suprarenal gland LM 140
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Table19.3 The Suprarenal Hormones
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Endocrine Functions of the Kidneys and Heart
The kidneys Renin, an enzyme that regulates the blood pressure
and blood volume. Erythropoietin, a peptide hormone that stimulates the
RBC production in red bone marrow. Calcitriol, a steroid hormone
The heart Atrial natriuretic peptide (ANP) Brain natriuretic peptide (BNP)
Both produce hormones involved with the regulation of blood pressure and blood volume
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The Pancreas and Other Endocrine Tissues
The Pancreas — located under stomach Alpha cells — glucagon Beta cells — insulin Delta cells — somatostatin (growth-hormone
inhibiting hormone) F cells — pancreatic polypeptide (PP)
Other digestive hormones discussed in digestive chapter
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Figure 19.1 The Endocrine System
KEY TO PITUITARY HORMONES
ACTHTSHGHPRLFSHLHMSHADH
Adrenocorticotropic hormoneThyroid-stimulating hormoneGrowth hormoneProlactinFollicle-stimulating hormoneLuteinizing hormoneMelanocyte-stimulating hormoneAntidiuretic hormone
Each suprarenal gland issubdivided into:Medulla: Epinephrine (E) Norepinephrine (NE)Cortex: Cortisol, corticosterone, aldosterone, androgens
Thymosins
Testis
Thyroxine (T4)Triiodothyronine (T3)Calcitonin (CT)
Pars distalis (anterior lobe): ACTH, TSH, GH, PRL, FSH, LH, and MSHNeurohypophysis(posterior lobe): Release of oxytocin and ADH
Suprarenal Glands
Thymus(Undergoes atrophyduring adulthood)
Thyroid Gland
Pituitary Gland
HypothalamusProduction of ADH,oxytocin, and regulatoryhormones
Pineal GlandMelatonin
Parathyroid Glands(on posterior surface ofthyroid gland)
Parathyroid hormone (PTH)
HeartNatriuretic peptides: Atrial natriuretic peptide (ANP) Brain natriuretic peptide (BNP)
Erythropoietin (EPO)Calcitriol(Chapters 19 and 26)
Kidney
Adipose Tissue
Digestive Tract
Pancreatic Islets
Gonads
LeptinResistin
Numerous hormones(detailed in Chapter 25)
Insulin, glucagon
Testes (male): Androgens (especially testosterone), inhibinOvaries (female): Estrogens, progestins, inhibinOvary
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Figure 19.10a Anatomy and Histological Organization of the Pancreas
The gross anatomy of the pancreas
Pancreaticduct
Body ofpancreas
Lobule Tail
Accessorypancreatic
duct
Head ofpancreas
Smallintestine
(duodenum)
Commonbile duct
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Table 19.4 Hormones of the Pancreas
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Endocrine Tissues of the Reproductive System
Testes Interstitial cells produce androgens (testosterone)
Promotes production of functional sperms, maintains secretory glands, influences secondary sexual characteristics, and stimultes muscle growth
Nurse cells (or sustentabular cells) secrete inhibin
Ovaries Follicular cells produce estrogens and secrete inhibin Corpus luteum releases progestins and relaxin
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Table 19.6 Hormones of the Reproductive System
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The Pineal Gland
Part of the epithalamus Contains neurons, glial cells, and special
secretary cells called pinealocytes Pinealocytes synthesizes the hormone,
melatonin Melatonin
Slows the maturation of sperm, oocytes, and reproductive organs
Production rate rises at night and declines during the day
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Hormones and Aging
Exhibits relatively few changes with advancing ageOne can expect
The changes in reproduction hormone levels at puberty
The decline in the concentration of reproductive hormones at menopause in women
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