ECM Health Concept MapCaitlin Hamilton04/18/2014

This Quarter So FarCollagen Type I

Structural component of all tissues except cartilage (e.g. bone, dermis) Gelse et al., 2003,

Collagen Type I

Structural component of all tissues except

vessel wall

Katsuda et al., 1992

Collagen Type I

Structural component of all tissues except

vessel wall

Rauterberg et al., 1993,

Collagen Type I

Structural component of all tissues except

heart

Marijianowski et al., 1994

Collagen Type Iassociated with genetic disease classic type Ehlers-Danlos syndrome Nuytinck et al., 2000

Collagen Type Iassociated with genetic disease Osteogenesis imperfecta Bonadio and Byers, 1985

Collagen Type I

associated with disease Atherosclerosis Katsuda et al., 1992; Rauterberget al., 1993

Collagen Type I

associated with disease hypertensive heart disease Lópezet al., 2001; Díez et al., 2005

Collagen Type I

associated with disease fibrotic diseases including chronic kidney diseases Alexakis et al., 2006

Collagen Type IIPredominant component of cartilage Bruckner and van der Rest, 1994

Collagen Type IImediates interactions with proteoglycans Mayne, 1989

Collagen Type IIassociated with genetic disease Stickler syndrome type I

Maumenee, 1979; Ahmadet al., 1991

Collagen Type IIassociated with genetic disease spondyloepiphyseal dysplasia Tiller et al., 1995

Collagen Type IIassociated with genetic disease achondrogenesis Eyre et al., 1986

Collagen Type IIassociated with genetic disease Kniest dysplasia Winterpacht et al., 1993

Collagen Type II

associated with disease Osteoarthritis Nelson et al., 1998

Collagen Type IIIDominant collagen type of granulation tissue Katsuda et al., 1992

Next Steps

• Integrate table into a concept map linking:• Nutrient effects on ECM• Drug effects on ECM• Diseases related to specific ECM components