elovera spf ss

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    Sales Training

    EloveraSPF Lotion

    UV Spectrum

    Divided into following key regions:

    UV-C (270 to 290 nm).UV-B (290 to 320 nm).

    UV-A (320 to 400 nm).

    UVA II (320340 nm)

    UVA I (340400 nm)

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    Ratio of UV-A to UV-B is approximately 20:1.

    UV-A is constant throughout the year.

    UV-B is greatest during summer.

    UV-B & UV-A reach earths surface in amountsaffected by altitude & season.

    UV-C does not normally reach earths surface

    because of filtration by ozone & atmospheric

    moisture.

    Atmosphere does not protect humans completely

    from damage by UV-B & UV-A

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    UV-B rays, have shorter wavelength

    Absorbed by superficial layers of skin, i.e. epidermis& cause visible damage.

    UV-A rays have longer wavelengthPenetrate deep into skin & cause invisible damage.

    UVA is a severe threat to skin health because of itscarcinogenic effect.

    Damage can be immediate & long-term, with effectsranging from sunburn, rashes, cell & tissue damage topremature wrinkling.

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    Visible damageis reaction which is seen immediately

    after sun exposure e.g. immediate pigmentation,

    actinic erythema (sunburn), hyperkeratinisation &tanning.

    Invisible damageof skin are those which cause

    damage to immune system, harms cell membranes,making it a favorite site for attack by free radicals. UV

    light can also destroy DNA & thereby cause cell

    death.

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    Sunscreensare sun protective lotions/ creams whenapplied to skin, absorbs UV radiation.

    Made of chemical absorbers, physical reflectors or

    mixture of both.

    There are few chemicals that absorb both UV-A & UV-

    B radiations. Hence combination sunscreens are

    formulated as they are enriched with both UV-A &UV-B absorbing chemicals to provide broad spectrum

    protection.

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    UV-A chemical sunscreencompounds include

    benzophenones (oxybenzone), avobenzone &

    mexoryl X.

    UV-B chemical sunscreencompounds include

    para-aminobenzoic acid (PABA) & its

    derivatives, cinnamates, salicylates,octocrylene, ensilozole & camphor derivatives.

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    Sun Protection Factor (SPF)

    SPF is defined as the amount of UV radiation required to produce1 minimal erythema dose (MED) on protected skin afterapplication of 2 mg.cm of sunscreen product divided by theamount of UV radiation required to produce 1 MED on

    unprotected skin.

    MED (Minimal Erythema Dose) is the dose of radiation at aspecific wavelength which will produce a delayed erythemaresponse.

    MED with Photoprotection

    SPF = ---------------------------------

    MED without Photoprotection

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    It is recommended that broad-spectrum products withSPF of at least 15 be used. Broad-spectrum or full-

    spectrum sunscreen provides UV-B & UV-A

    protection.

    For children 6 months to 2 years, it is recommended to

    use sunscreen with SPF of at least 4, although 15 or

    higher is considered best.

    Because babys bodies may not be developed enough

    to handle sunscreen chemicals, they should not be

    used on babies younger than 6 months of age.

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    Criteria for an ideal sunscreen & how is EloveraSPF

    closer to it?

    High Sun Protection Factor: Therapeutic

    concentration of effective UV absorbing agents

    ensures effective protection.

    Broad Spectrum Sunscreen: Both UVA & UVB

    absorbing sunactive agents have been included.

    Protect against Visible & Invisible damages

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    EloveraSPF Lotion

    Criteria for an ideal sunscreen & how is EloveraSPF

    closer to it?

    Photo stability of formulation : After absorption of UV radiations

    sunscreen agents get converted into byproducts, which might

    prove allergic. Such allergic reactions are not reported with the

    sunactive agents in Elovera - SPF. All the ingredients arephotostable.

    Waterproof : Sunscreen formulation with water proof property so

    that after application though patient might sweat but still the

    product will be retained on skin for longer time. Secondly

    sunscreens are widely prescribed to swimmers where they are

    exposed to more amount of reflected light so sun damages are

    common.

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    EloveraSPF Lotion

    Criteria for an ideal sunscreen & how is EloveraSPFcloser to it?

    Diffusion of Sunactive agents at dermis : The sunactive

    agents of Elovera - SPF are lipophilic so they easily diffuse

    at the level of dermis thus protecting from deeper penetrating

    UVA radiations.

    Non-Comedogenic: Sunscreens are often applied on face &

    are prescribed to teens, where acne is a concern. In suchsituations comedogenic formulation might worsen acne. Thus

    it is essential that product should be noncomedogenic.

    Elovera-SPF is noncomedogenic.

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    Therapeutic applications of sunscreens

    Apart from photoprotection to normal skin sunscreens

    can also be applied in the following conditions to

    prevent further damage & improve condition of the skin.

    Photocarcinogenesis

    Skin cancer because of excessive exposure to UV

    radiation.DNA can absorb UV radiation directly leading to

    characteristic mutations that apparently result in

    altered DNA quality control.

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    Therapeutic applications of sunscreens

    Photoaging

    Skin aging because of excessive exposure toUV radiation.

    Photoallergy

    Involves interaction of immune system & solar

    radiation resulting in damage to skin.

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    SunlightTissue InteractionUV Radiation

    (Photons)

    DNA

    NADH, NADPH, Tryptophan, Riboflavin,Melanin (Chromophores*)

    Release ROS

    Oxidation of Lipids & Proteins

    Affect DNA repair

    Dyspigmentation

    Photoaging

    Carcinogenesis

    NADH-Nicotinamide Adenine Dinucleotide,NADPH- Nicotinamide Adenine

    Dinucleotide Phosphate, *Atomic grouping on which colour depends.

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    Therapeutic applications of sunscreens

    Polymorphous light eruption (PMLE)

    Idiopathic skin eruption that occurs in susceptible individuals on

    exposure to UV radiation that is more intense than usual. Seen

    most commonly at the beginning of summer.

    Porphyrias

    Caused by an inherited or acquired abnormality in the heme

    metabolic pathway.

    Solar urticaria

    It is a rare rapidly developing reaction to UV exposure.

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    Therapeutic applications of sunscreens

    Xeroderma pigmentosum

    Stems from a genetic defect in the

    ability to repair DNA. Skin neoplasms,

    including malignant melanoma as wellas basal cell & squamous cell

    carcinoma.

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    Therapeutic applications of sunscreens

    Drug photosensitivity skin reactionsPhotosensitivity can occur in any individual

    exposed to photosensitive agents. Many

    anticancer drugs, antidepressants,

    antihistamines, antifungals, doxycycline,tetracycline, antiparasitic drugs, psoralens can

    cause photosensitivity.

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    EloveraSPF Lotion: Composition & Role

    of Ingredients

    VITAMIN E ACETATE 0.5 %: Antioxidant &Photoprotection

    ALOE EXTRACT 10 % : Protects morphology & number

    of Langerhans cells, Photoprotection, Reduces

    production of ILs. AVOBENZONE 3 %: Photoprotection against UVA I

    OXYBENZONE 3 %: Photoprotection against UVA II &

    UVB Boosts SPF value in combination with other UV B

    absorbers OCTYL METHOXYCINNAMATE 7.5 %: Photoprotection

    against UV B

    CREAM BASE

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    EloveraSPF Lotion Mode of application

    Sufficient quantity should be applied to exposed

    areas 20 to 30 minutes before exposure to sunlight.

    AVAILABILITY

    60 ML FLIP-TOP PLASTIC BOTTLE IN A CARTON.

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    Elovera - SPF : Competition

    Shade (Fulford) : OCTYL METHOXYCINNAMATE 7.5 %

    OXYBENZONE 3 % & AVOBENZONE 3 %.

    Sunset (Merck) : OCTYL METHOXYCINNAMATE 7.5 %&

    OXYBENZONE 3 %

    Spectraban (Stifel)

    Sunban (H & H)

    Umrella (Le Sante)

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    Elovera - SPF : Competition

    Suncross lotion (Ranbaxy) :OCTINOXATE 7.5 %

    OXYBENZONE 3 %,

    AVOBENZONE 2 %

    ZINC OXIDE 2 %.

    SPF-26, 100 ml- Rs.219/30

    Sunban Forte cream (H & H) :

    OCTYL METHOXYCINNAMATE 8.5 %

    OXYBENZONE 3 %

    Titanium Dioxide 6 % (In micronised silica coated)UVA/ UVB ratio 0.51

    CWL 370 nm

    SPF-50, 60 gm- Rs.274/95