Ganesh Kishore

Chief Biotechnology Officer

December 4 2006

DuPontTranslating science to societal

value

DuPont’s Vision

To be the world’s most dynamic science company, creating sustainable solutions essential

to a better, safer, healthier life for people everywhere.

1802 1830 1850 1900 1925 1945 1990 2000 2050 2090

Birth

Growth

Maturity

Birth

Growth

Maturity

Birth

Growth

Explosives

Chemistry,Energy

Chemistry, Biology. . .Knowledge -Intensive

Solutions

MaturityE. I. du Pont

1802 1830 1850 1900 1925 1945 1990 2000 2050 2090

Birth

Growth

Maturity

Birth

Growth

Maturity

Birth

Growth

Explosives

Chemistry,Energy

Chemistry, Biology. . .Knowledge -Intensive

Solutions

MaturityE. I. du Pont

Birth

Growth

Maturity

Birth

Growth

Maturity

Birth

Growth

Explosives

Chemistry,Energy

Chemistry, Biology. . .Knowledge -Intensive

Solutions

MaturityE. I. du Pont

Electronic &Communication

Technologies

PerformanceMaterials

Safety &Protection

Agriculture& Nutrition

Coatings& Color

Technologies

Electronic &Communication

Technologies

PerformanceMaterials

Safety &Protection

Agriculture& Nutrition

Coatings& Color

Technologies

2010 Goals …• 25% of revenues from businesses not

requiring depletable raw materialsToday at 17%

• 10% of energy needs derived from renewable sources

Today at 5 ½ %

The 5 Platforms of DuPont

• Safety & Health• Environmental Stewardship• Ethics• Respect for People

Our Core ValuesThe Foundation …

DuPont – A 204 Year History of Innovation

$6.4B

$6.8B

$3.5B

$6.2B

$5.2B

Total Revenue$28B

Driving Productivity in R&D

More technical effort on growth.- Clear technology goals- Install a disciplined innovation process- Shift business unit resources from

“sustain” to “grow”- Focus on critical few

More patents; more end use patents.

Faster product development cycles.

Market RelevanceTechnology UniquenessCommercialization Feasibility

Continuously validated through life of projectSpecial emphasis on Market Relevance prior to project

initiation

Project Selection and Execution Criteria

Global R&D Accelerates GrowthWuppertal, Germany

1999Taiwan Technical Center

2004

Utsunomiya, Japan

2000

China R&D Center,Shanghai

2005Korea TechnicalCenter, Seoul

(Located at Korean Institute of Science & Technology)

2005

Value Chain

CONSUMER

CornSoyRice

Canola...

Farm & Feed

ChemicalsEnergyLabor

Non-Plant BasedIngredients

Crop

Processing

Farm

and

Feed

Food and Fitness

Fuel and Fiber

Health, Wellness, Flavor & Texture

Biotechnology Offers Significant Growth Potential Throughout the Crop and Value Chain

‘Omics (Geno, Transcripto, Proteo, Metabolo, Pheno) – Informatics - Transformation Enabling Competencies

Chemicals, Enzymes, Microbes

Traits & Germplasm – Cost Effective IntrogressionProcesses & Products

DuPont Businesses in Agriculture and Nutrition

Genetics

Chemistry

HealthScience

Food &Nutrition

Fungicides$0.4B

Pioneer $2.7B

InputProviders Growers Food

Mfg.FoodSales

Grain Processors

The Solae Company $1.1B

QualiconBunge Biotech Alliance

8th Continent$0.3B

Herbicides$1.5B

Insecticides$0.4B

Soy Protein & Lecithin Ingredients

Corn Seed$2.0B

Soy Seed$0.5B

Other Seeds$0.3B

Fungicides$0.4B

Pioneer $2.7B

InputProviders Growers Food

Mfg.FoodSales

Grain Processors

The Solae Company $1.1B

QualiconBunge Biotech Alliance

8th Continent$0.3B

Herbicides$1.5B

Insecticides$0.4B

Soy Protein & Lecithin Ingredients

Corn Seed$2.0B

Soy Seed$0.5B

Other Seeds$0.3B

Gene Gun

Our Crop Genetics Businesses are Leveraging Advancements in Biotech

BiotechBiotech

TraitsTraits

• ↑ productivity• ↑ reliability• ↑ quality

• Pest protection• Stress alleviation• Superior nutrient use • Enhanced nutrient density• Elevated safety• Processor friendly

0

20

40

60

80

100

120

140

160

180

1920 1925 1930 1935 1940 1945 1950 1955 1960 1965 1970 1975 1980 1985 1990 1995 2000 2005

b=1.52

b = 2.85Open Pollinated

Open Pollinated

b = -0.67b = 1.17

Double Cross Hybrids

Double Cross Hybrids

Single Cross Hybrids

Single Cross Hybrids

1988

1983

19701974

1993

1936

1947

0

20

40

60

80

100

120

140

160

180

1920 1925 1930 1935 1940 1945 1950 1955 1960 1965 1970 1975 1980 1985 1990 1995 2000 2005

b=1.52

b = 2.85Open Pollinated

Open Pollinated

b = -0.67b = 1.17

Double Cross Hybrids

Double Cross Hybrids

Single Cross Hybrids

Single Cross Hybrids

1988

1983

19701974

1993

1936

1947

Corn YieldsU.S. Average Bu/Ac

Pioneer has been breeding corn since 1926

Pioneer has been breeding Pioneer has been breeding corn since 1926corn since 1926

BreedingBreeding Agrobacterium

Biotech

Biotech

DuPont’s Current Biotechnology Business is Built Chiefly on Licensed and Co-Developed Traits

Unsprayed SprayedUnsprayed Sprayed

Roundup Ready Soybeans & Corn

Benefits …

U.S. Conservation Tillage Adoption

(MM Acres)

Insect Resistant Corn

European Corn Borer Extending the BenefitsFurther Protection

Western

Northern

Mexican

• Simple & flexible weed management

• Reduced pesticide application

• Conservation or no-tillage

Bt Corn Non-Bt Corn

ControlChemicalInsecticide

Biotech TraitProtected

European Corn Borer

SouthwesternCorn Borer

FallArmyworm

Black Cutworm

CornEarworm

Stacking Exponentially

Increases Value

3.5

3

2.5

2

1.5

1

1 = Indexed Value of Single Trait

DOUBLESTACK

TRIPLESTACK

Trait Retail Value Added per Acre

1.59

3.42

• Reduced labor• Reduced energy• Greater resource efficiency• Higher yield• Improved quality• Favorable economic returns

Licensed (Monsanto) Co-Developed (Dow)

(1997)

(1999)

(2006)

(2004)

(2004)

Drought exacerbates weed-disease-insect pressure

and chemical injury

Drought exacerbates weed-disease-insect pressure

and chemical injury

Delivering Now, Positioning for the Future

2006 Regulatory 2006 Regulatory submissionsubmission> $100> $100High Oleic SoyHigh Oleic Soy

2006 Regulatory 2006 Regulatory SubmissionSubmission> $200> $200RynaxypyrRynaxypyr™™ (E2Y) (E2Y)

InsecticideInsecticide

Field trialsField trials> $50> $50Seed Production Seed Production TechnologyTechnology

DevelopmentDevelopment> $100> $100Soy Protein TasteSoy Protein Taste

Field trialsField trials> $25 > $25 Stalk Rot Resistance Stalk Rot Resistance

2006 Regulatory 2006 Regulatory submissionsubmission

2006 Launch2006 Launch

2/3 of 2006 N.A. sales2/3 of 2006 N.A. sales

StatusStatus

AnnualAnnualOpportunityOpportunity

Revenue Revenue $ MM$ MM

> $200> $200OptimumOptimum™™ GATGAT™™SoySoy

> $150> $150HerculexHerculex®® RW + RW + StacksStacks

> $1100> $1100New GeneticsNew Genetics

Herculex insect protection technology by Dow AgroSciences and Pioneer Hi-Bred. Herculex is a registered trademark of Dow AgroSciences LLC.2001* 2002 2003 2004 2005

in Ag & Nutrition

PTOI

$0

$150

$300

$450

$600

$750

$900

2006 Rich Crop Genetics PipelineFarmer Consumer Processor Enabling Technology

Target Markets Phase 3Advanced

Development

Phase 2Early

Development

Phase 1Proof of Concept

Phase 4Pre-Launch

DiscoveryGene/Trait

IdentificationAnthracnose Stalk Rot Resistance

Fungal Disease Resistance

Drought Tolerance

Corn Rootworm Resistance II

Nitrogen Use EfficiencyIncreased Yield IIncreased Yield II

Increased Ethanol Production II

Improved Feed II

Seed Production Technology

Optimum™ GAT™*

Corn Borer Resistance II

Increased Ethanol Production III

Improved Feed III

Corn Rootworm Resistance III

Corn Borer Resistance III

Corn

Glyphosate ALS Tolerant Cotton

Insect Resistant RiceNematode Resistant Cotton

Glyphosate Tolerant Cotton

Insect Resistant Cotton

Glyphosate Tolerant CanolaOthe

r Cro

psSo

ybea

ns

Asian Soybean Rust ResistanceOptimum™ GAT™*

Glyphosate ALS Tolerance II

Cyst Nematode ResistanceIncreased Yield I

Improved Feed I

Insect Resistance

Increased Yield II

Improved Feed IIHigh Oleic + High Stearic Acid Oil

High Oleic Acid OilOmega-3 Oil

Improved FlavorImproved Functionality

* Proprietary Pioneer Glyphosate ALS Tolerant trait * Proprietary Pioneer Glyphosate ALS Tolerant trait

High

LowLow High

Alzheimer’s

MacularDegeneration

Parkinson’s

ProstrateCancer

CognitiveDysfunction

ColonCancer

BreastCancer

InfantNutrition

Enteral/ParentalNutrition

AgedMalnutrition

Joint Health

Inflammation

GlucoseManagement

Cardiovascular

Women’s Health

Weight Management

SCIENTIFIC OPPORTUNITY

MA

RK

ET

OPP

OR

TU

NIT

Y(s

ize

and

grow

th, u

nmet

nee

ds)

FUTURE NOW

Red = Metabolic Syndrome

Nutrition – Opportunities in Nutrition Create a Critical, Major Growth Wave for Next Generation Products

Prevention vs. TreatmentProgression of Symptoms vs. Age

Sym

ptom

s

Cos

t

Years

Prevention

ProgressionDelay

DiseaseManagement

DrugsNutrientsBehavior

NutrientsBehavior

Progression of Symptoms vs. Age

Sym

ptom

s

Cos

t

Years

Prevention

ProgressionDelay

DiseaseManagement

DrugsNutrientsBehavior

NutrientsBehavior

Major Areas of Opportunity

Solae Soy ProteinCurrent Products

Corn Seed

• Isolated soy protein• Meat Emulsifiers• Bars & Shakes• Beverages

Qualified Health Claim“Heart Health”

Taste Improvements

Low Linolenic Soybean Oil• Trans fat free• Eliminates chemical

hydrogenation• Protects HDL level

White Corn • High oleic sunflower• Oil-modified canola• Cardio friendly oils

Solae Soy ProteinFuture

Nutrium• Superior tasting• Improved texture• Consistent health efficacy

• High oleic soy oil• High oleic / high stearate

soy oil• Omega-3 soy oils

Omega-3 Intake of EPA-DHA

(Grams per Day)

0.00.20.40.60.81.0

IdealCurrent

0.90

0.15

Deficiency

"Let thy food be thy medicine and thy

medicine be thy food.”

Hippocrates (460-377 BC)

Taste – Texture – Nutrition – Convenience – Cost - PersonalizationTaste – Texture – Nutrition – Convenience – Cost - Personalization

Also in Solae pipeline:SoleCinaHigh 7SMixes with other

proteinsPeptides

Bio Based Materials – The Right Science at the Right Time

Bio Based Materials

Enabling Technology and IP Leverage in All Four Areas

Bio-Based Materials – Bio-PDO™ (1,3 Propanediol, 3G)

Cell Factory

Genome

Economic Production of 3G

E.coli has been programmed to

increase Bio-PDO™production 500-fold

In Nature:two microorganisms convert glucose to 3G stepwise

YeastYeast BacteriumBacterium

Glucose Glycerol 3GStarch

Biotech Application:a single microorganism to effect the conversion

OH OHOH OHGlucose Programmed E. coli

OC

CC

O

OC

OC

OC

CC

O

OC

OHO

CC

COH C

O

OHC

HO

OC

O

OHC

HO

O++1,3-Propanediol

(3G)1,3-Propanediol

(3G)Polypropylene terephthalate

(3GT)Polypropylene terephthalate

(3GT)Terephthalic AcidTerephthalic Acid

3GT (Sorona®)

Superior PropertiesStretch & Recovery

SoftnessVibrant ColorStain ResistanceUV & Chlorine ResistanceEasy Care

Sorona® (3GT) – An Advanced Polymer/Fiber

390 Gal/Acre@ 150 bu/ac grain yield

100 Gal/Acre

18 Gal/Acre

Corn has Significant Potential for Biofuels

Gal

lons

per

Acr

e

The Potential: 30 - 50 Billion GallonsThe Potential: 30 The Potential: 30 -- 50 Billion Gallons50 Billion Gallons

Grain - Endosperm

Stover

Grain - Pericarp

0

200

400

600

800

1000

1200

2005 2010 2015 2020

Ethanol Productivity

0

10

20

30

40

50

60

2005 2010 2015 2020

Corn Acres AvailableMillion Acres

Corn Ethanol ProducedBillion Gallons

30-50B gal

Stover

FeedstockProduction

FeedstockHarvest & Transport

FeedstockConversion

FermentationProduction

Separate,RefineProduceProduce

Chemicals & FuelsChemicals & Fuels

Sustainable Materials, Chemicals & Energy

Integrated Corn Biorefinery Strategy

DuPont Vision

To be the world’s most dynamicscience company, creating

sustainable solutionsessential to a better, safer, healthier

life for people everywhere.

Biotechnology Vision

Unlocking genetic secrets to meet societal needs in a sustainable manner

To Summarize … An Expectation is Set that Makes the Biotechnology Vision Strategically Critical for DuPont

Put Scienceto Work

Power ofOne

DuPont

Go Where the

Growth is

The best way to predict the future is to invent it.--- Peter Drucker

Plant Sciences, an important building block of the future

Agriculture is a major strength of US economy – traditionally $45 B + trade surplusUS is not only a producer of 25% of worlds grain but also a leading technology developerPlant sciences will migrate from food and feed to include fuel, fiber and fitness – tremendous value additionEco Agriculture can be effectively delivered through plant sciences

Several aspects of plant science research are critical

Pest control through geneticsStress resistance to reduce variabilityNutrient and energy assimilation and transformation (N, Water, Light, C)Biomass distribution (architecture)Metabolic partitioning and distributionProcess friendlyEnvironmental and eco safetyHuman safety and nutrition

Traditionally, plant sciences has been a poor cousin of human sciences

Most investments for scientific and technological development by the private sectorTools borrowed from human and microbial sciencesFood availability not a main stream issuePoor appreciation of the potentialNo National Institute of Plant SciencesLittle funding in the competitive granting arena in relationship to health

Global competition in Plant Sciences is intensifying

China has made plant sciences a strategic national prioritySubstantial commitment to Plant Science Centers at Beijing, ShanghaiFocus on rice as a model and commercial cropLarge US, Europe trained personnelState of art facilitiesIntegrated basic and applied research

Expanded investments in plant sciences has broad societal and global impact

Hunger Sustainability and eco enhancementDisease prevention and better managementRural economic development and industrializationNew paradigms for new industries (tech providers, value chain)Global trade harmonization

To accelerate returns on investments, a number of breakthroughs are neededTechnology (current timeframe: 8-15 years)- molecular understanding of key physiological processes @ cell, tissue, organism and ecosystems- early identification of fruitful pursuits- transparent, science-based regulatory processesSignificant private/public sector interactionGreater participation of academic community in Translation researchNovel ways of approaching the research component of training and educationSeed money for early stage commercial workPeople – leadership and execution capabilities in multi-disciplinary environmentSocial Acceptance and Freedom to practice