Global Research to Local Practice

Hilary EvansChief Executive, Alzheimer’s Research UK

Dementia – a global crisis

ARUK Defeat Dementia Report 2014

“I can think of no other disease where

innovation, including breakthrough

discoveries to develop a cure, is so badly

needed”

Dr Margaret Chan OBE

Director-General, World Health Organisation

Alzheimer’s Research UK

Increase awareness and provide information

Research strategy

Increasing awareness

Less than 1 in 4 people are aware that dementia is caused by brain diseases

People with dementia are at the centre of our work

People at the centre

Drug Discovery Alliance

Dementia Consortium

Accelerating access to treatmentsChallenge on Dementia

2020 Implementation Plan

ARUK Drug

Discovery AllianceDementia Consortium

Global Clinical

Trials Fund

International Dementia

Advisory Platform

Accelerating access to

treatments

ARUK

Ste

m C

ell

Rese

arch

Cen

treAR

UK fu

ndin

g

for b

asic

sci

ence

Improving our scientific

understanding

Translating scientific understanding into

promising treatments

Testing and trialling

promising treatments

Delivering outcomesthat matter most to people living with dementia and their

carers

Public health –

risk reduction and

awareness

START

Boosting drug discovery

• De-risking novel targets: applications from academics around the world for DC Pharma partners to adopt if successful

• Four current awards (UK, US, Italy, Luxembourg), one pending (UK)

Global Investment fund, managed by SV Life Sciences to discover and develop new treatments for dementia

UK Department of Health, ARUK, GSK, Lilly, Pfizer, J&J, Biogen, Takeda

Prime Minister’s challenge on dementia 2020

Dementia Research Institute

• Alzheimer’ Research UK is a founding partner of the DRI with the Medical Research Council and the Alzheimer’s Society

• The joint investment of £250M will create a national Institute that will bring together world-leading expertise in biomedical, care, public health and translational dementia research

Prime Minister’s challenge on dementia 2020

Funded 55 research projects at the Universities of Aberdeen, Dundee, Edinburgh and St Andrews

Over £5.6m research funded in Scotland

Research Network Centre in Scotland

Research funded in ScotlandResearch Network

DISCOVERY PRECLINICAL CLINICAL TRIALS (PHASE I-III) REIMBURSEMENTLICENSING COMMISSIONING ADOPTION

AND UPTAKE

Gaps in basic science

Accelerated Access Review

Accelerating access – looking at the path ahead

International Dementia Advisory Platform

14 -15 March 2017, Aberdeen

Thank you