ntp.niehs.nih.gov · f1_hsd ntp study number: c20006b lock date: 06/21/2010 cage range: all date...

F1_HSDNTP Study Number: C20006B

Lock Date: 06/21/2010

Cage Range: ALL

Date Range: ALL

Reasons For Removal: ALL

Removal Date Range: ALL

Treatment Groups: Include ALL

Study Gender: Both

TDMSE Version: 3.0.1.1_001

PWG Approval Date: NONE

Experiment Number: 20006 - 03 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 04/16/2013Test Type: CHRONIC Indole-3-carbinol Time Report Requested: 09:53:55

Route: GAVAGE CAS Number: 700-06-1 First Dose M/F: 03/14/07 / 03/15/07Species/Strain: RATS/HSD Lab: BAT

DAY ON TEST

HARLAN SPRAGUE DAWLEY RATSMALE

0727

0727

0634

0197

0727

0728

0728

0450

0689

0631

0666

0682

0438

0685

0685

0599

0695

0635

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0729

0505

0575

0645

0720

0681

0 mg/kgANIMAL ID

00001

00002

00003

00004

00005

00006

00007

00008

00009

00010

00011

00012

00013

00014

00015

00016

00017

00018

00019

00020

00021

00022

00023

00024

00025

males(cont...)

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +Necrosis 3

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +Erosion

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +

Intestine Small, Duodenum + + A + + + + A + A + + + + + + + A A + + + + + A

Intestine Small, Ileum + + A + + + + A + A + A + A + + + A A + A + + A A

Intestine Small, Jejunum + + A + + + + A + A + A + + + + + A A + + + + + A

Liver + + + + + + + + + + + + + + + + + + + + + + + + +AngiectasisBasophilic Focus XClear Cell Focus X X X X XEosinophilic Focus X X X X X XHepatodiaphragmatic Nodule XMixed Cell Focus X X XNecrosis 1 3Bile Duct, Fibrosis 3Bile Duct, Hyperplasia 1 2Periportal, Inflammation, Chronic Active 2



* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:X .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

DAY ON TEST


0727

0727

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0727

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0689

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0682

0438

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0599

0695

0635

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0729

0505

0575

0645

0720

0681

0 mg/kgANIMAL ID

00001

00002

00003

00004

00005

00006

00007

00008

00009

00010

00011

00012

00013

00014

00015

00016

00017

00018

00019

00020

00021

00022

00023

00024

00025

males(cont...)

Mesentery + +Artery, Inflammation, Chronic Active 4Fat, Necrosis 3

Oral Mucosa + + + + + + + + + + + + + + + + + + + + + + + + +

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +Acinus, AtrophyAcinus, Hyperplasia 2 2 2 1 2 1 2 1 1 1 1Artery, Inflammation, Chronic Active 3 2 3 2 2 3 3 2 2 3 1

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 2 1 2 2 1 2 2 1 2 1 1Inflammation 1 3Necrosis 4Ulcer 1 2

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +Epithelium, Hyperplasia 1Epithelium, Inflammation, Chronic Active 1 1 1Epithelium, Mineralization 3 2 3 2Epithelium, Necrosis 1

Tooth +Necrosis 3

CARDIOVASCULAR SYSTEM




DAY ON TEST


0727

0727

0634

0197

0727

0728

0728

0450

0689

0631

0666

0682

0438

0685

0685

0599

0695

0635

0575

0729

0505

0575

0645

0720

0681

0 mg/kgANIMAL ID

00001

00002

00003

00004

00005

00006

00007

00008

00009

00010

00011

00012

00013

00014

00015

00016

00017

00018

00019

00020

00021

00022

00023

00024

00025

males(cont...)

Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +Dilatation 3Inflammation, Chronic Active 2 2 2 2 3 2 3 3 2 1 2 2 2

Heart + + + + + + + + + + + + + + + + + + + + + + + + +Cardiomyopathy 2 1 2 1 1 3 2 2 3 3 3 3 2 3 3 3 3 3 3 3 2 3 3 3Mineralization 2Atrium, Thrombosis 4Epicardium, Inflammation

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Degeneration, CysticDegeneration, Fatty 2 1 2 2 2Hyperplasia 2 3 3 3 2 2 3Necrosis 1

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +AngiectasisHyperplasia 2 4 1 2 3 1 2 1 1 1 1

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 2

Parathyroid Gland + + + + M + + + + + + + + + + + + + + + + + + M +Hyperplasia 3 4 2

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0727

0727

0634

0197

0727

0728

0728

0450

0689

0631

0666

0682

0438

0685

0685

0599

0695

0635

0575

0729

0505

0575

0645

0720

0681

0 mg/kgANIMAL ID

00001

00002

00003

00004

00005

00006

00007

00008

00009

00010

00011

00012

00013

00014

00015

00016

00017

00018

00019

00020

00021

00022

00023

00024

00025

males(cont...)

Pars Distalis, Hyperplasia 2 1 1 3 3 2 2 1 1 1

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +ThrombosisC-cell, Hyperplasia 2 2Follicular Cell, Hypertrophy 1 2 2 2 1 1 2 2 2 3

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +Cyst 2 3 2 3 3 2Fibrosis 1Inflammation 3

Prostate + + + + + + + + + + + + + + + + + + + + + + + + +AtrophyFibrosis 2Hyperplasia 1Inflammation, Acute 1Necrosis 3

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + A +

Testes + + + + + + + + + + + + + + + + + + + + + + + A +




DAY ON TEST


0727

0727

0634

0197

0727

0728

0728

0450

0689

0631

0666

0682

0438

0685

0685

0599

0695

0635

0575

0729

0505

0575

0645

0720

0681

0 mg/kgANIMAL ID

00001

00002

00003

00004

00005

00006

00007

00008

00009

00010

00011

00012

00013

00014

00015

00016

00017

00018

00019

00020

00021

00022

00023

00024

00025

males(cont...)

Atrophy 4 4 1 1 2 3 2 2 1 1 1 3Artery, Inflammation, Chronic Active 1 3 3 2 3 3 2 4 2 1 2 3Interstitial Cell, Hyperplasia

HEMATOPOIETIC SYSTEM

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 3

Lymph Node + +Mediastinal, Hemorrhage 3Renal, Ectasia 3Renal, Hemorrhage

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Plasma Cell

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Lymphoid

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Hematopoietic Cell Proliferation 2 3 2 2 2 1 2 3 2 2 2Inflammation 2

Thymus + + + + + + + + + + + + + + + + M M + + + + + + +Atrophy 3 3 3 2 2 3 3 4 1 4 1 3 2 3 3 1 3 2 4 2Epithelial Cell, Hyperplasia

INTEGUMENTARY SYSTEM




DAY ON TEST


0727

0727

0634

0197

0727

0728

0728

0450

0689

0631

0666

0682

0438

0685

0685

0599

0695

0635

0575

0729

0505

0575

0645

0720

0681

0 mg/kgANIMAL ID

00001

00002

00003

00004

00005

00006

00007

00008

00009

00010

00011

00012

00013

00014

00015

00016

00017

00018

00019

00020

00021

00022

00023

00024

00025

males(cont...)

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Skin + + + + + + + + + + + + + + + + + + + + + + + + +Cyst Epithelial Inclusion X X X XInflammation 1Epidermis, Ulcer 3

MUSCULOSKELETAL SYSTEM

Bone + + + + + + + + + + + + + + + + + + + + + + + + +Fibrous Osteodystrophy 3 3 3 3 3 3 3

NERVOUS SYSTEM

Brain + + + + + + + + + + + + + + + + + + + + + + + + +

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + + +Hemorrhage, Multifocal 1 2Inflammation, Chronic 1 1 2 1 1 1 1 3 1Necrosis 3Alveolar Epithelium, HyperplasiaAlveolus, Infiltration Cellular, Histiocyte 1 1 1 1 1 1 1 1 1 2Alveolus, Mineralization

Nose + + + + + + + + + + + + + + + + + + + + + + + + +Foreign Body XFungus XInflammation 2




DAY ON TEST


0727

0727

0634

0197

0727

0728

0728

0450

0689

0631

0666

0682

0438

0685

0685

0599

0695

0635

0575

0729

0505

0575

0645

0720

0681

0 mg/kgANIMAL ID

00001

00002

00003

00004

00005

00006

00007

00008

00009

00010

00011

00012

00013

00014

00015

00016

00017

00018

00019

00020

00021

00022

00023

00024

00025

males(cont...)

Inflammation, Chronic Active 2 1 2 1 1 1 3Respiratory Epithelium, Hyperplasia

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation 2

SPECIAL SENSES SYSTEM

Eye + + + + + + + + + + + + + + + + + + + + + + + + +Anterior Chamber, Inflammation, Acute 1 1Cornea, Inflammation, Acute 1 2 2 2 4 2 2 3 3

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Pigmentation, Porphyrin 3

Lacrimal Gland +Degeneration 2

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Nephropathy 3 3 3 1 3 3 3 3 4 4 3 4 2 4 4 4 4 3 3 3 3 4 3 3 3

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0727

0693

0729

0727

0685

0684

0188

0669

0728

0728

0421

0727

0728

0728

0728

0716

0729

0729

0727

0539

0728

0726

0729

0485

0444

0 mg/kgANIMAL ID

00026

00027

00028

00029

00030

00031

00032

00033

00034

00035

00036

00037

00038

00039

00040

00041

00042

00043

00044

00045

00046

00047

00048

00049

00050 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 50Necrosis 1 3.0

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50Erosion 3 1 3.0

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50

Intestine Small, Duodenum + + + + + + A + + + + + + + + + + + + + + + + + + 43

Intestine Small, Ileum + + + + + + A A + + + + + + + A + + + + + A + A + 35

Intestine Small, Jejunum + + + + + + A A + + + + + + + + + + + + + A + + + 40

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Angiectasis 3 1 3.0Basophilic Focus X X 3Clear Cell Focus X X X X X X X X X 14Eosinophilic Focus X X X X 10Hepatodiaphragmatic Nodule X 2Mixed Cell Focus X 4Necrosis 3 3 2.3Bile Duct, Fibrosis 1 2 2.0Bile Duct, Hyperplasia 1 1 1 1 1 7 1.1Periportal, Inflammation, Chronic Active 1 2.0




DAY ON TEST


0727

0693

0729

0727

0685

0684

0188

0669

0728

0728

0421

0727

0728

0728

0728

0716

0729

0729

0727

0539

0728

0726

0729

0485

0444

0 mg/kgANIMAL ID

00026

00027

00028

00029

00030

00031

00032

00033

00034

00035

00036

00037

00038

00039

00040

00041

00042

00043

00044

00045

00046

00047

00048

00049

00050 * TOTALS

Mesentery 2Artery, Inflammation, Chronic Active 1 4.0Fat, Necrosis 1 3.0

Oral Mucosa + + + + + + + + + + + + + + + + + + + + + + + + + 50

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50Acinus, Atrophy 1 1 1.0Acinus, Hyperplasia 1 2 1 1 2 16 1.4Artery, Inflammation, Chronic Active 2 2 2 2 2 2 2 1 3 2 2 22 2.2

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 2 1 1 2 2 3 2 2 19 1.7Inflammation 2 2.0Necrosis 1 4.0Ulcer 2 1.5

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50Epithelium, Hyperplasia 1 2 1.0Epithelium, Inflammation, Chronic Active 3 1.0Epithelium, Mineralization 3 2 2 7 2.4Epithelium, Necrosis 1 1.0

Tooth 1Necrosis 1 3.0





DAY ON TEST


0727

0693

0729

0727

0685

0684

0188

0669

0728

0728

0421

0727

0728

0728

0728

0716

0729

0729

0727

0539

0728

0726

0729

0485

0444

0 mg/kgANIMAL ID

00026

00027

00028

00029

00030

00031

00032

00033

00034

00035

00036

00037

00038

00039

00040

00041

00042

00043

00044

00045

00046

00047

00048

00049

00050 * TOTALS

Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 50Dilatation 1 3.0Inflammation, Chronic Active 2 2 3 2 2 2 1 2 2 1 2 2 1 2 2 2 2 30 2.0

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Cardiomyopathy 2 3 3 3 3 3 2 2 2 3 1 2 2 2 3 2 3 2 1 1 3 3 3 47 2.4Mineralization 1 2.0Atrium, Thrombosis 1 4.0Epicardium, Inflammation 2 1 2.0

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Degeneration, Cystic 2 2 2 2 4 2.0Degeneration, Fatty 2 3 2 8 2.0Hyperplasia 3 1 1 4 1 1 3 14 2.3Necrosis 1 1.0

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50Angiectasis 2 1 2.0Hyperplasia 3 2 2 3 4 2 4 18 2.2

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 2 2 3 2.0

Parathyroid Gland + + + M + + + + M M + + + + + + M + + + + + + M + 43Hyperplasia 3 3.0

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50




DAY ON TEST


0727

0693

0729

0727

0685

0684

0188

0669

0728

0728

0421

0727

0728

0728

0728

0716

0729

0729

0727

0539

0728

0726

0729

0485

0444

0 mg/kgANIMAL ID

00026

00027

00028

00029

00030

00031

00032

00033

00034

00035

00036

00037

00038

00039

00040

00041

00042

00043

00044

00045

00046

00047

00048

00049

00050 * TOTALS

Pars Distalis, Hyperplasia 2 4 2 1 1 4 3 17 2.0

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Thrombosis 2 1 2.0C-cell, Hyperplasia 1 3 3 2 6 2.2Follicular Cell, Hypertrophy 2 3 3 2 2 1 1 1 1 2 1 21 1.8

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 3 1 3.0

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst 3 7 2.6Fibrosis 1 1.0Inflammation 3 2 3.0

Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 2 1 2.0Fibrosis 1 2.0Hyperplasia 3 2 3 2.0Inflammation, Acute 1 1.0Necrosis 1 3.0

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 49

Testes + + + + + + + + + + + + + + + + + + + + + + + + + 49




DAY ON TEST


0727

0693

0729

0727

0685

0684

0188

0669

0728

0728

0421

0727

0728

0728

0728

0716

0729

0729

0727

0539

0728

0726

0729

0485

0444

0 mg/kgANIMAL ID

00026

00027

00028

00029

00030

00031

00032

00033

00034

00035

00036

00037

00038

00039

00040

00041

00042

00043

00044

00045

00046

00047

00048

00049

00050 * TOTALS

Atrophy 1 1 2 3 2 3 1 3 2 2 4 4 2 1 1 1 2 4 30 2.1Artery, Inflammation, Chronic Active 3 2 3 3 2 3 1 2 2 2 1 1 1 3 4 1 28 2.3Interstitial Cell, Hyperplasia 1 1 1.0


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 1 3.0

Lymph Node + + 4Mediastinal, Hemorrhage 1 3.0Renal, Ectasia 4 2 3.5Renal, Hemorrhage 3 1 3.0

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia, Plasma Cell 2 1 2.0

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia, Lymphoid 3 1 3.0

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50Hematopoietic Cell Proliferation 3 2 2 2 3 3 3 2 2 2 2 2 2 2 2 1 2 28 2.1Inflammation 1 2.0

Thymus + + + + + + + + + + + + + + + + + + + + M M + + + 46Atrophy 3 2 1 2 1 1 1 1 2 3 2 1 2 2 1 2 2 3 2 1 3 41 2.2Epithelial Cell, Hyperplasia 2 1 2.0





DAY ON TEST


0727

0693

0729

0727

0685

0684

0188

0669

0728

0728

0421

0727

0728

0728

0728

0716

0729

0729

0727

0539

0728

0726

0729

0485

0444

0 mg/kgANIMAL ID

00026

00027

00028

00029

00030

00031

00032

00033

00034

00035

00036

00037

00038

00039

00040

00041

00042

00043

00044

00045

00046

00047

00048

00049

00050 * TOTALS

Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst Epithelial Inclusion X 5Inflammation 3 3 3 2.3Epidermis, Ulcer 1 3.0


Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50Fibrous Osteodystrophy 3 3 3 3 3 12 3.0

NERVOUS SYSTEM

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + + 49Hemorrhage, Multifocal 1 3 1.3Inflammation, Chronic 4 1 2 1 3 1 1 2 17 1.6Necrosis 1 3.0Alveolar Epithelium, Hyperplasia 4 1 4.0Alveolus, Infiltration Cellular, Histiocyte 1 1 1 1 1 2 2 1 1 19 1.2Alveolus, Mineralization 3 1 3.0

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50Foreign Body X X X 4Fungus 1Inflammation 1 2.0




DAY ON TEST


0727

0693

0729

0727

0685

0684

0188

0669

0728

0728

0421

0727

0728

0728

0728

0716

0729

0729

0727

0539

0728

0726

0729

0485

0444

0 mg/kgANIMAL ID

00026

00027

00028

00029

00030

00031

00032

00033

00034

00035

00036

00037

00038

00039

00040

00041

00042

00043

00044

00045

00046

00047

00048

00049

00050 * TOTALS

Inflammation, Chronic Active 1 1 2 1 11 1.5Respiratory Epithelium, Hyperplasia 2 2 2 2.0

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation 1 2.0


Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50Anterior Chamber, Inflammation, Acute 2 1.0Cornea, Inflammation, Acute 1 2 3 1 2 2 1 2 2 2 3 20 2.1

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Pigmentation, Porphyrin 1 3.0

Lacrimal Gland 1Degeneration 1 2.0

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Nephropathy 3 4 4 4 4 3 3 3 3 4 2 3 3 3 3 2 3 4 3 2 3 4 4 4 4 50 3.2

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50




DAY ON TEST


0692

0729

0637

0382

0441

0727

0689

0680

0569

0357

0695

0617

0728

0727

0728

0671

0648

0454

0728

0571

0703

0650

0191

0559

0602

75 mg/kgANIMAL ID

00051

00052

00053

00054

00055

00056

00057

00058

00059

00060

00061

00062

00063

00064

00065

00066

00067

00068

00069

00070

00071

00072

00073

00074

00075

males(cont...)

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +InflammationEpithelium, Hyperplasia

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, LymphoidNecrosis

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +


Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +

Intestine Small, Ileum A + + + + + + A + + + + + + + + + + + + + + + + A

Intestine Small, Jejunum A + + A + + + + + + + + + + + A + + + + A + + + ALymphatic, Ectasia 1 1

Liver + + + + + + + + + + + + + + + + + + + + + + + + +CholangiofibrosisClear Cell Focus X X X X XEosinophilic Focus X X X X X XMixed Cell FocusNecrosis 1 2Artery, Inflammation, Chronic ActiveBile Duct, Hyperplasia 1 1




DAY ON TEST


0692

0729

0637

0382

0441

0727

0689

0680

0569

0357

0695

0617

0728

0727

0728

0671

0648

0454

0728

0571

0703

0650

0191

0559

0602

75 mg/kgANIMAL ID

00051

00052

00053

00054

00055

00056

00057

00058

00059

00060

00061

00062

00063

00064

00065

00066

00067

00068

00069

00070

00071

00072

00073

00074

00075

males(cont...)

Mesentery +Artery, Mineralization

Oral Mucosa + + + + + + + + + + + + + + + + + + + + + + + + +Foreign Body XHyperplasia, Squamous 2

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +ThrombosisAcinus, Atrophy 1Acinus, Hyperplasia 1 1 1 1Artery, Inflammation, Chronic Active 1 3 2 2 3 2 2 1 2 1 2 3 1 2 2 4 2

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Metaplasia 2

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 1 2 1 2 1 2 4 1 3 1Ulcer

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +Epithelium, HyperplasiaEpithelium, Inflammation 3Epithelium, Inflammation, Chronic Active 2 1Epithelium, Mineralization 2 1 2 3Epithelium, Ulcer 1Epithelium, Muscularis, Hyperplasia, Focal 2





DAY ON TEST


0692

0729

0637

0382

0441

0727

0689

0680

0569

0357

0695

0617

0728

0727

0728

0671

0648

0454

0728

0571

0703

0650

0191

0559

0602

75 mg/kgANIMAL ID

00051

00052

00053

00054

00055

00056

00057

00058

00059

00060

00061

00062

00063

00064

00065

00066

00067

00068

00069

00070

00071

00072

00073

00074

00075

males(cont...)

Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Chronic Active 2 3 2 2 2 2 3 1 1 1 1 2 2 2 2 2 3 2 3 2Mineralization 3

Heart + + + + + + + + + + + + + + + + + + + + + + + + +Cardiomyopathy 1 2 3 3 3 3 3 1 3 2 3 3 3 3 3 3 2 2 3 3 2 3 3Atrium, Thrombosis 4 3Epicardium, Inflammation

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Degeneration, Cystic 1 3Degeneration, Fatty 2 1 2 2 1 2 2 1Hyperplasia 1 2 2 3 3Thrombosis 2

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +Degeneration, Fatty 1Hyperplasia 4 1 2 3 3 2 3 3 3 2 3


Parathyroid Gland + + + + + + + + + + + + + + + + + + + M M + M M +Hyperplasia 1 3 2 2

Pituitary Gland + + + + M + + + + + + + + + + + + + + + + + + + +Pars Distalis, Hyperplasia 3 2 2 2 4 4 2 4 3 2




DAY ON TEST


0692

0729

0637

0382

0441

0727

0689

0680

0569

0357

0695

0617

0728

0727

0728

0671

0648

0454

0728

0571

0703

0650

0191

0559

0602

75 mg/kgANIMAL ID

00051

00052

00053

00054

00055

00056

00057

00058

00059

00060

00061

00062

00063

00064

00065

00066

00067

00068

00069

00070

00071

00072

00073

00074

00075

males(cont...)

Thyroid Gland + + + A + + + A + + + + + + + + + + + + + + + + +C-cell, Hyperplasia 2 2Follicular Cell, Hyperplasia 4Follicular Cell, Hypertrophy 3 2 2 3 2 2 4 3 2 2 2 3 1 1 2 1 2 1

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Prostate + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 2Fibrosis 2 1 2Hyperplasia 2Inflammation, Acute 1 3

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +

Testes + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 1 1 2 2 2 2 3 1 1 1 3 1 1 2 1 2 3 3 2Artery, Inflammation, Chronic Active 1 2 3 3 2 3 3 1 1 1 1 1 3 3 3 3 1


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0692

0729

0637

0382

0441

0727

0689

0680

0569

0357

0695

0617

0728

0727

0728

0671

0648

0454

0728

0571

0703

0650

0191

0559

0602

75 mg/kgANIMAL ID

00051

00052

00053

00054

00055

00056

00057

00058

00059

00060

00061

00062

00063

00064

00065

00066

00067

00068

00069

00070

00071

00072

00073

00074

00075

males(cont...)

Hyperplasia 2

Lymph Node + + + +Bronchial, Hemorrhage 3Deep Cervical, HemorrhageDeep Cervical, Hyperplasia, Plasma Cell 3Deep Cervical, Inflammation 4Mediastinal, EctasiaMediastinal, Hemorrhage 3Mediastinal, Hyperplasia, LymphoidMediastinal, Infiltration Cellular, Histiocyte 3Pancreatic, HemorrhageRenal, Hemorrhage 3 3

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +Ectasia 3

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +EctasiaHemorrhage

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Hematopoietic Cell Proliferation 2 2 3 2 3 3 2 2 1 2 1 2 3 2 2

Thymus + + + + + + + + + + + + + + + + + + + + + + + + MAtrophy 1 1 2 4 2 4 1 3 2 3 3 3 4 4 1 1 3 2


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0692

0729

0637

0382

0441

0727

0689

0680

0569

0357

0695

0617

0728

0727

0728

0671

0648

0454

0728

0571

0703

0650

0191

0559

0602

75 mg/kgANIMAL ID

00051

00052

00053

00054

00055

00056

00057

00058

00059

00060

00061

00062

00063

00064

00065

00066

00067

00068

00069

00070

00071

00072

00073

00074

00075

males(cont...)

Skin + + + + + + + + + + + + + + + + + + + + + + + + +Cyst Epithelial Inclusion XInflammation 3Necrosis


Bone + + + + + + + + + + + + + + + + + + + + + + + + +Fibrous Osteodystrophy 3 3 3 3 3 3 3 3 3 3 3

NERVOUS SYSTEM

Brain + + + + + + + + + + + + + + + + + + + + + + + + +Gliosis 1 1

Spinal Cord + +Degeneration 3 2

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + + +Foreign Body XHemorrhage, Multifocal 1 1Inflammation, Chronic 1 1 1 1 3 3 3 2 3 1 1 2 1Alveolus, Infiltration Cellular, Histiocyte 1 1 1 1 1 1 2 2 1 1Alveolus, Mineralization 2 3

Nose + + + + + + + + + + + + + + + + + + + + + + + + +Foreign Body X X X X X X XInflammation, Chronic Active 1 1 1 1 1 1 1 1




DAY ON TEST


0692

0729

0637

0382

0441

0727

0689

0680

0569

0357

0695

0617

0728

0727

0728

0671

0648

0454

0728

0571

0703

0650

0191

0559

0602

75 mg/kgANIMAL ID

00051

00052

00053

00054

00055

00056

00057

00058

00059

00060

00061

00062

00063

00064

00065

00066

00067

00068

00069

00070

00071

00072

00073

00074

00075

males(cont...)

Thrombosis 1Respiratory Epithelium, Hyperplasia 1 1

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation 2


Eye + + + + + + + + + + + + + + + + + + + + + + + + +Anterior Chamber, Inflammation, AcuteCornea, Inflammation, Acute 2 2 2 2 2 2 2 2 1 1 3 2 2 2

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +

Lacrimal GlandDegeneration

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Metaplasia, OsseousNephropathy 3 2 3 3 2 4 4 4 2 4 3 3 2 3 4 3 4 3 3 4 4 3 4 4

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0637

0617

0623

0516

0727

0729

0728

0448

0616

0456

0505

0655

0533

0651

0597

0728

0489

0661

0679

0582

0685

0727

0614

0728

0729

75 mg/kgANIMAL ID

00076

00077

00078

00079

00080

00081

00082

00083

00084

00085

00086

00087

00088

00089

00090

00091

00092

00093

00094

00095

00096

00097

00098

00099

00100 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation 2 1 2.0Epithelium, Hyperplasia 1 1 1.0

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia, Lymphoid 3 1 3.0Necrosis 4 1 4.0

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50


Intestine Small, Duodenum + + A + + + + + A + + + + + + + + + + + + + + + + 48

Intestine Small, Ileum + + A A + + + + A + + A + + + + + + + + + + + + + 43

Intestine Small, Jejunum + + A + + + + + A A + A + A + + + + A + + + + + + 39Lymphatic, Ectasia 2 1.0

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Cholangiofibrosis 2 1 2.0Clear Cell Focus X X X X X X X X 13Eosinophilic Focus X X X X X X 12Mixed Cell Focus X X 2Necrosis 1 3 1.3Artery, Inflammation, Chronic Active 1 1 1.0Bile Duct, Hyperplasia 1 1 4 1.0




DAY ON TEST


0637

0617

0623

0516

0727

0729

0728

0448

0616

0456

0505

0655

0533

0651

0597

0728

0489

0661

0679

0582

0685

0727

0614

0728

0729

75 mg/kgANIMAL ID

00076

00077

00078

00079

00080

00081

00082

00083

00084

00085

00086

00087

00088

00089

00090

00091

00092

00093

00094

00095

00096

00097

00098

00099

00100 * TOTALS

Mesentery + 2Artery, Mineralization 2 1 2.0

Oral Mucosa + + + + + + + + + + + + + + + + + + + + + + + + + 50Foreign Body 1Hyperplasia, Squamous 1 2.0

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50Thrombosis 3 1 3.0Acinus, Atrophy 1 1.0Acinus, Hyperplasia 3 1 1 2 1 1 10 1.3Artery, Inflammation, Chronic Active 2 1 1 3 3 1 3 1 1 1 1 2 1 1 1 32 1.8

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50Metaplasia 1 2.0

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 2 1 1 2 3 3 1 1 1 19 1.7Ulcer 3 1 3.0

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50Epithelium, Hyperplasia 3 2 2 2 1 5 2.0Epithelium, Inflammation 1 3.0Epithelium, Inflammation, Chronic Active 2 3 4 2.0Epithelium, Mineralization 3 3 3 4 1 3 3 2 12 2.5Epithelium, Ulcer 1 1.0Epithelium, Muscularis, Hyperplasia, Focal 1 2.0





DAY ON TEST


0637

0617

0623

0516

0727

0729

0728

0448

0616

0456

0505

0655

0533

0651

0597

0728

0489

0661

0679

0582

0685

0727

0614

0728

0729

75 mg/kgANIMAL ID

00076

00077

00078

00079

00080

00081

00082

00083

00084

00085

00086

00087

00088

00089

00090

00091

00092

00093

00094

00095

00096

00097

00098

00099

00100 * TOTALS

Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation, Chronic Active 2 2 2 2 2 3 3 2 3 2 1 2 2 2 3 2 2 2 38 2.1Mineralization 3 2 3.0

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Cardiomyopathy 3 3 3 3 2 3 3 3 3 2 3 3 3 3 1 1 2 3 3 3 3 2 2 3 1 48 2.6Atrium, Thrombosis 3 3 3.3Epicardium, Inflammation 3 1 3.0

ENDOCRINE SYSTEM

Adrenal Cortex M + + + + + + + + + + + + + + + + + + + + + + + + 49Degeneration, Cystic 3 3 2.3Degeneration, Fatty 1 2 2 2 3 13 1.8Hyperplasia 2 3 2 3 2 2 2 2 1 1 2 2 3 2 19 2.1Thrombosis 1 2.0

Adrenal Medulla M + + + + + + + + + + + + + + + + + + + + + + + + 49Degeneration, Fatty 1 1.0Hyperplasia 2 3 2 1 1 1 1 4 1 1 2 22 2.2

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 3 2 2 1 2 6 2.0

Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 46Hyperplasia 2 1 3 2 3 3 10 2.2

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49Pars Distalis, Hyperplasia 2 3 1 1 3 3 4 2 18 2.6




DAY ON TEST


0637

0617

0623

0516

0727

0729

0728

0448

0616

0456

0505

0655

0533

0651

0597

0728

0489

0661

0679

0582

0685

0727

0614

0728

0729

75 mg/kgANIMAL ID

00076

00077

00078

00079

00080

00081

00082

00083

00084

00085

00086

00087

00088

00089

00090

00091

00092

00093

00094

00095

00096

00097

00098

00099

00100 * TOTALS

Thyroid Gland + + + + + + + + + + + A + + + + + + + + A + + + + 46C-cell, Hyperplasia 2 2 4 2.0Follicular Cell, Hyperplasia 1 4.0Follicular Cell, Hypertrophy 3 2 1 1 1 2 2 2 1 1 1 2 2 1 1 2 34 1.9

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 1 2.0Fibrosis 3 1.7Hyperplasia 3 2 2 4 2.3Inflammation, Acute 1 1 2 1 6 1.5

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50

Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 2 2 1 1 2 2 2 3 3 2 4 3 2 4 1 1 1 3 37 2.0Artery, Inflammation, Chronic Active 2 3 2 2 3 3 4 3 2 2 1 2 2 1 1 3 2 34 2.1


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50




DAY ON TEST


0637

0617

0623

0516

0727

0729

0728

0448

0616

0456

0505

0655

0533

0651

0597

0728

0489

0661

0679

0582

0685

0727

0614

0728

0729

75 mg/kgANIMAL ID

00076

00077

00078

00079

00080

00081

00082

00083

00084

00085

00086

00087

00088

00089

00090

00091

00092

00093

00094

00095

00096

00097

00098

00099

00100 * TOTALS

Hyperplasia 2 2 2.0

Lymph Node + + + + 8Bronchial, Hemorrhage 1 3.0Deep Cervical, Hemorrhage 3 1 3.0Deep Cervical, Hyperplasia, Plasma Cell 1 3.0Deep Cervical, Inflammation 1 4.0Mediastinal, Ectasia 3 1 3.0Mediastinal, Hemorrhage 2 2 2.5Mediastinal, Hyperplasia, Lymphoid 4 1 4.0Mediastinal, Infiltration Cellular, Histiocyte 1 3.0Pancreatic, Hemorrhage 2 1 2.0Renal, Hemorrhage 2 3.0

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 50Ectasia 1 3.0

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50Ectasia 3 1 3.0Hemorrhage 1 1 1.0

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50Hematopoietic Cell Proliferation 3 2 2 2 2 2 2 2 2 3 2 3 2 2 3 1 2 2 33 2.2

Thymus + + + + + + + + + + + + + + + + + + + + + + + + + 49Atrophy 3 4 2 1 2 2 2 3 4 3 3 4 4 2 3 3 3 4 1 3 1 4 1 41 2.6


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50




DAY ON TEST


0637

0617

0623

0516

0727

0729

0728

0448

0616

0456

0505

0655

0533

0651

0597

0728

0489

0661

0679

0582

0685

0727

0614

0728

0729

75 mg/kgANIMAL ID

00076

00077

00078

00079

00080

00081

00082

00083

00084

00085

00086

00087

00088

00089

00090

00091

00092

00093

00094

00095

00096

00097

00098

00099

00100 * TOTALS

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst Epithelial Inclusion X X 3Inflammation 3 2 3.0Necrosis 4 3 2 3.5


Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50Fibrous Osteodystrophy 3 3 3 3 3 3 3 3 19 3.0

NERVOUS SYSTEM

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50Gliosis 2 1.0

Spinal Cord 2Degeneration 2 2.5

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Foreign Body 1Hemorrhage, Multifocal 1 3 1.0Inflammation, Chronic 3 2 1 2 2 3 2 1 21 1.9Alveolus, Infiltration Cellular, Histiocyte 2 1 1 1 1 1 1 1 1 1 1 1 22 1.1Alveolus, Mineralization 2 2.5

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50Foreign Body X X X X X 12Inflammation, Chronic Active 1 2 1 3 2 2 1 15 1.3




DAY ON TEST


0637

0617

0623

0516

0727

0729

0728

0448

0616

0456

0505

0655

0533

0651

0597

0728

0489

0661

0679

0582

0685

0727

0614

0728

0729

75 mg/kgANIMAL ID

00076

00077

00078

00079

00080

00081

00082

00083

00084

00085

00086

00087

00088

00089

00090

00091

00092

00093

00094

00095

00096

00097

00098

00099

00100 * TOTALS

Thrombosis 1 1.0Respiratory Epithelium, Hyperplasia 2 1.0

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation 1 2.0


Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50Anterior Chamber, Inflammation, Acute 3 1 3.0Cornea, Inflammation, Acute 2 3 2 1 3 2 3 3 2 2 2 25 2.1

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

Lacrimal Gland + + 2Degeneration 3 3 2 3.0

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Metaplasia, Osseous 2 1 2.0Nephropathy 4 4 3 3 3 3 3 3 3 3 4 4 4 4 3 3 3 4 4 3 4 3 3 3 3 49 3.3

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50




DAY ON TEST


0693

0728

0587

0709

0727

0500

0657

0594

0503

0624

0713

0727

0727

0486

0729

0727

0709

0727

0616

0729

0423

0727

0367

0570

0706

150 mg/kgANIMAL ID

00101

00102

00103

00104

00105

00106

00107

00108

00109

00110

00111

00112

00113

00114

00115

00116

00117

00118

00119

00120

00121

00122

00123

00124

00125

males(cont...)

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +



Intestine Small, Duodenum + + + + + + + A + + + + + + + + + + + + + + + + +Lymphatic, Ectasia 1 1 3 1 2 2 1 1 1 1 3

Intestine Small, Ileum + + + + + + + A + A + + + + + + + + + + + + + + +

Intestine Small, Jejunum + + A A + + + + + + + + + A + + + + + + + + + + ALymphatic, Ectasia 2 3 1 3 1 2 1 1 2 2 3 1 2 2 2 2 2 2

Liver + + + + + + + + + + + + + + + + + + + + + + + + +Basophilic Focus X X XCholangiofibrosis 2 4Clear Cell Focus X X X X X X X X X X XDegeneration, Cystic 3Eosinophilic Focus X X X X XHepatodiaphragmatic NoduleMixed Cell FocusNecrosis 1 3 1Bile Duct, Cyst 2Bile Duct, Cyst, Multiple 2Bile Duct, Fibrosis 3




DAY ON TEST


0693

0728

0587

0709

0727

0500

0657

0594

0503

0624

0713

0727

0727

0486

0729

0727

0709

0727

0616

0729

0423

0727

0367

0570

0706

150 mg/kgANIMAL ID

00101

00102

00103

00104

00105

00106

00107

00108

00109

00110

00111

00112

00113

00114

00115

00116

00117

00118

00119

00120

00121

00122

00123

00124

00125

males(cont...)

Bile Duct, Hyperplasia 2 1

Mesentery +

Oral Mucosa + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Squamous 3

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +Acinus, Hyperplasia 3 1 3 2 1 2 1 1 1Artery, Inflammation, Chronic Active 2 2 2 3 2 2 2 2 2 2 2 1

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +Erosion 1Hyperplasia 3 3 3 2 2 1 2 2 2Inflammation 1 1Ulcer 3

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +Epithelium, Amyloid Deposition 3Epithelium, Hyperplasia 2 2Epithelium, Inflammation, Chronic Active 1Epithelium, Mineralization 3 1 2

Tooth +Malformation 3





DAY ON TEST


0693

0728

0587

0709

0727

0500

0657

0594

0503

0624

0713

0727

0727

0486

0729

0727

0709

0727

0616

0729

0423

0727

0367

0570

0706

150 mg/kgANIMAL ID

00101

00102

00103

00104

00105

00106

00107

00108

00109

00110

00111

00112

00113

00114

00115

00116

00117

00118

00119

00120

00121

00122

00123

00124

00125

males(cont...)

Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Chronic Active 2 2 3 2 1 3 4 3 2 2 2 3 3 2 2 2MineralizationThrombosis X

Heart + + + + + + + + + + + + + + + + + + + + + + + + +Cardiomyopathy 3 3 3 3 2 1 3 3 2 3 3 3 2 2 1 1 3 2 3 2 2 1 2 3Atrium, Thrombosis 3 4Pericardium, Inflammation 3

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Degeneration, Cystic 2 1 2Degeneration, Fatty 1 2 2Hematopoietic Cell Proliferation 2Hemorrhage 3Hyperplasia 3 2 1 2 4 2 2 1

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 2 2 1 2 3


Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 1 3 1 3 2 2 2

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0693

0728

0587

0709

0727

0500

0657

0594

0503

0624

0713

0727

0727

0486

0729

0727

0709

0727

0616

0729

0423

0727

0367

0570

0706

150 mg/kgANIMAL ID

00101

00102

00103

00104

00105

00106

00107

00108

00109

00110

00111

00112

00113

00114

00115

00116

00117

00118

00119

00120

00121

00122

00123

00124

00125

males(cont...)

Pars Distalis, Hyperplasia 3 4 1 4 1 2 2 1

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +C-cell, Hyperplasia 4 2 2Follicular Cell, Hypertrophy 1 2 2 2 2 1 3 3 2 3 1 2 2 1 4

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +

Preputial Gland + + + + + + + + + + + + + + + M + + + + + + + + +Cyst 3 3 4

Prostate + + + + + + + + + + + + + + + + + + + + + + + + +Fibrosis 2 2Hyperplasia 3 3 3 2

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +Hypoplasia 2

Testes + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 3 1 3 1 3 1 2 3 1 3 2 2 1 2Pigmentation, HemosiderinArtery, Inflammation, Chronic Active 1 4 3 4 1 2 2 3 2 2 3 2 2 2Interstitial Cell, Hyperplasia




DAY ON TEST


0693

0728

0587

0709

0727

0500

0657

0594

0503

0624

0713

0727

0727

0486

0729

0727

0709

0727

0616

0729

0423

0727

0367

0570

0706

150 mg/kgANIMAL ID

00101

00102

00103

00104

00105

00106

00107

00108

00109

00110

00111

00112

00113

00114

00115

00116

00117

00118

00119

00120

00121

00122

00123

00124

00125

males(cont...)


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 3 2 3

Lymph Node + + + +Bronchial, Hemorrhage 3Iliac, Infiltration Cellular, HistiocyteLumbar, Hemorrhage 3 3Mediastinal, EctasiaMediastinal, Hemorrhage 3 3

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +EctasiaHemorrhage 3

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +Lymphatic, Ectasia 3

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Hematopoietic Cell Proliferation 3 2 1 1 2 2 2 3 1 1 1 2 2 2 3 3 1Necrosis 3

Thymus + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 3 1 4 1 2 4 3 2 4 2 2 3 3 3 4 4 2 1 1 3 2 3Hemorrhage 3


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0693

0728

0587

0709

0727

0500

0657

0594

0503

0624

0713

0727

0727

0486

0729

0727

0709

0727

0616

0729

0423

0727

0367

0570

0706

150 mg/kgANIMAL ID

00101

00102

00103

00104

00105

00106

00107

00108

00109

00110

00111

00112

00113

00114

00115

00116

00117

00118

00119

00120

00121

00122

00123

00124

00125

males(cont...)

Fibrosis 2

Skin + + + + + + + + + + + + + + + + + + + + + + + + +Cyst Epithelial Inclusion X


Bone + + + + + + + + + + + + + + + + + + + + + + + + +Fibrous Osteodystrophy 3 3 3 3 3 3Maxilla, Fracture 2

NERVOUS SYSTEM

Brain + + + + + + + + + + + + + + + + + + + + + + + + +

Spinal CordDegeneration

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + + +EdemaForeign BodyHemorrhage 1Hemorrhage, Multifocal 2 2 1 1 2Inflammation, GranulomatousInflammation, Chronic 2 2 3 1 2 3 1 1Alveolar Epithelium, Hyperplasia 1Alveolus, Infiltration Cellular, Histiocyte 1 1 1 1 1 1 1 3 2 2 1 1 1Alveolus, Mineralization




DAY ON TEST


0693

0728

0587

0709

0727

0500

0657

0594

0503

0624

0713

0727

0727

0486

0729

0727

0709

0727

0616

0729

0423

0727

0367

0570

0706

150 mg/kgANIMAL ID

00101

00102

00103

00104

00105

00106

00107

00108

00109

00110

00111

00112

00113

00114

00115

00116

00117

00118

00119

00120

00121

00122

00123

00124

00125

males(cont...)

Nose + + + + + + + + + + + + + + + + + + + + + + + + +Foreign Body X X X XInflammation, Chronic Active 1 2 2 1 1 3 3 1Respiratory Epithelium, HyperplasiaRespiratory Epithelium, Metaplasia, Squamous

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation


Ear +External Ear, Hyperplasia, Squamous 3

Eye + + + + + + + M + + + + + + + + + + + + + + + + +Anterior Chamber, Inflammation, Acute 3 2 2Cornea, Inflammation, Acute 2 3 2 3 2 2 2 3 3 3

Harderian Gland + + + + + + + M + + + + + + + + + + + + + + + + +

Lacrimal Gland + +Degeneration 3 2

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Nephropathy 3 3 4 4 3 3 3 4 3 4 4 3 3 3 3 3 4 4 4 3 1 3 3 4Renal Tubule, Dilatation

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0729

0729

0482

0593

0728

0558

0583

0623

0499

0729

0690

0664

0468

0546

0697

0549

0727

0711

0727

0531

0666

0712

0611

0727

0727

150 mg/kgANIMAL ID

00126

00127

00128

00129

00130

00131

00132

00133

00134

00135

00136

00137

00138

00139

00140

00141

00142

00143

00144

00145

00146

00147

00148

00149

00150 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 50



Intestine Small, Duodenum + + + + + A + + + + + + + + + + + + + A + + + + + 47Lymphatic, Ectasia 1 2 1 2 15 1.5

Intestine Small, Ileum + + + + + A + A + + A A + + + + + + + A + A + + + 42

Intestine Small, Jejunum + + + + + A + A + + A + + + A + + + + A + A + + + 40Lymphatic, Ectasia 1 1 2 2 1 1 2 2 1 27 1.7

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Basophilic Focus 3Cholangiofibrosis 2 3 2.7Clear Cell Focus X X X X X X X 18Degeneration, Cystic 1 3.0Eosinophilic Focus X X X X X 10Hepatodiaphragmatic Nodule X 1Mixed Cell Focus X 1Necrosis 3 2 5 2.0Bile Duct, Cyst 1 2.0Bile Duct, Cyst, Multiple 1 2.0Bile Duct, Fibrosis 1 3.0




DAY ON TEST


0729

0729

0482

0593

0728

0558

0583

0623

0499

0729

0690

0664

0468

0546

0697

0549

0727

0711

0727

0531

0666

0712

0611

0727

0727

150 mg/kgANIMAL ID

00126

00127

00128

00129

00130

00131

00132

00133

00134

00135

00136

00137

00138

00139

00140

00141

00142

00143

00144

00145

00146

00147

00148

00149

00150 * TOTALS

Bile Duct, Hyperplasia 2 3 1.7

Mesentery 1

Oral Mucosa + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia, Squamous 2 2 2.5

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50Acinus, Hyperplasia 3 1 1 1 4 14 1.8Artery, Inflammation, Chronic Active 2 3 1 3 1 3 2 2 1 2 1 2 2 1 2 27 1.9

Salivary Glands + + + + + + + + + + + + + + M + + + + + + + + + + 49

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50Erosion 1 1.0Hyperplasia 2 2 3 2 2 2 2 3 3 2 19 2.3Inflammation 2 1 4 1.3Ulcer 1 3.0

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50Epithelium, Amyloid Deposition 1 3.0Epithelium, Hyperplasia 2 1 2 2 3 7 2.0Epithelium, Inflammation, Chronic Active 2 2 1.5Epithelium, Mineralization 3 2 3 6 2.3

Tooth 1Malformation 1 3.0





DAY ON TEST


0729

0729

0482

0593

0728

0558

0583

0623

0499

0729

0690

0664

0468

0546

0697

0549

0727

0711

0727

0531

0666

0712

0611

0727

0727

150 mg/kgANIMAL ID

00126

00127

00128

00129

00130

00131

00132

00133

00134

00135

00136

00137

00138

00139

00140

00141

00142

00143

00144

00145

00146

00147

00148

00149

00150 * TOTALS

Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation, Chronic Active 2 2 3 2 2 2 2 2 2 4 2 2 2 2 30 2.3Mineralization 3 1 3.0Thrombosis 1

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Cardiomyopathy 3 2 1 3 1 3 3 3 3 2 3 3 2 3 3 2 3 2 2 3 3 3 3 3 3 49 2.5Atrium, Thrombosis 3 3 3.3Pericardium, Inflammation 1 3.0

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Degeneration, Cystic 2 2 5 1.8Degeneration, Fatty 2 1 5 1.6Hematopoietic Cell Proliferation 1 2.0Hemorrhage 1 3.0Hyperplasia 1 4 2 1 2 2 2 1 3 1 3 19 2.1

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 2 2 3 1 2 2 1 2 2 4 1 1 1 1 2 20 1.9

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 1 2.0

Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 1 2 2 1 2 4 13 2.0

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50




DAY ON TEST


0729

0729

0482

0593

0728

0558

0583

0623

0499

0729

0690

0664

0468

0546

0697

0549

0727

0711

0727

0531

0666

0712

0611

0727

0727

150 mg/kgANIMAL ID

00126

00127

00128

00129

00130

00131

00132

00133

00134

00135

00136

00137

00138

00139

00140

00141

00142

00143

00144

00145

00146

00147

00148

00149

00150 * TOTALS

Pars Distalis, Hyperplasia 2 2 1 2 1 3 3 2 2 1 1 19 2.0

Thyroid Gland + + + + + + + + + + A + + + + + + + + A + + + + + 48C-cell, Hyperplasia 3 4 2.8Follicular Cell, Hypertrophy 2 2 2 3 3 1 2 1 2 2 1 3 3 2 3 3 2 2 33 2.1

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49Cyst 3 3.3

Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50Fibrosis 2 2.0Hyperplasia 3 2 3 7 2.7

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50Hypoplasia 1 2.0

Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 2 2 2 2 2 3 35 1.7Pigmentation, Hemosiderin 1 1 1.0Artery, Inflammation, Chronic Active 3 2 1 3 2 2 2 2 1 2 3 2 3 2 3 2 2 3 3 33 2.3Interstitial Cell, Hyperplasia 1 1 1.0




DAY ON TEST


0729

0729

0482

0593

0728

0558

0583

0623

0499

0729

0690

0664

0468

0546

0697

0549

0727

0711

0727

0531

0666

0712

0611

0727

0727

150 mg/kgANIMAL ID

00126

00127

00128

00129

00130

00131

00132

00133

00134

00135

00136

00137

00138

00139

00140

00141

00142

00143

00144

00145

00146

00147

00148

00149

00150 * TOTALS


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 1 4 2.3

Lymph Node + + + + 8Bronchial, Hemorrhage 1 3.0Iliac, Infiltration Cellular, Histiocyte 2 1 2.0Lumbar, Hemorrhage 2 3.0Mediastinal, Ectasia 3 1 3.0Mediastinal, Hemorrhage 3 3 3.0

Lymph Node, Mandibular + + + + + + + + + + + + + + M + + + + + + + + + + 49Ectasia 3 1 3.0Hemorrhage 1 3.0

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphatic, Ectasia 1 3.0

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50Hematopoietic Cell Proliferation 2 2 1 2 2 2 3 3 2 2 2 28 2.0Necrosis 1 3.0

Thymus + + + + + + + + + + + + + + + + + + + M + + + + + 49Atrophy 1 1 1 2 3 1 3 2 2 3 3 2 3 3 1 4 2 4 2 2 42 2.4Hemorrhage 1 3.0


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50




DAY ON TEST


0729

0729

0482

0593

0728

0558

0583

0623

0499

0729

0690

0664

0468

0546

0697

0549

0727

0711

0727

0531

0666

0712

0611

0727

0727

150 mg/kgANIMAL ID

00126

00127

00128

00129

00130

00131

00132

00133

00134

00135

00136

00137

00138

00139

00140

00141

00142

00143

00144

00145

00146

00147

00148

00149

00150 * TOTALS

Fibrosis 1 2.0

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst Epithelial Inclusion X 2


Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50Fibrous Osteodystrophy 3 3 3 4 3 3 3 13 3.1Maxilla, Fracture 1 2.0

NERVOUS SYSTEM

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50

Spinal Cord + 1Degeneration 2 1 2.0

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Edema 3 1 3.0Foreign Body X 1Hemorrhage 1 1.0Hemorrhage, Multifocal 2 1 7 1.6Inflammation, Granulomatous 2 1 2.0Inflammation, Chronic 1 3 3 3 1 2 1 3 1 1 1 1 1 3 2 2 24 1.8Alveolar Epithelium, Hyperplasia 1 1.0Alveolus, Infiltration Cellular, Histiocyte 1 3 1 1 2 2 19 1.4Alveolus, Mineralization 3 1 3.0




DAY ON TEST


0729

0729

0482

0593

0728

0558

0583

0623

0499

0729

0690

0664

0468

0546

0697

0549

0727

0711

0727

0531

0666

0712

0611

0727

0727

150 mg/kgANIMAL ID

00126

00127

00128

00129

00130

00131

00132

00133

00134

00135

00136

00137

00138

00139

00140

00141

00142

00143

00144

00145

00146

00147

00148

00149

00150 * TOTALS

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50Foreign Body X X X X X X X 11Inflammation, Chronic Active 1 2 2 1 2 1 2 2 16 1.7Respiratory Epithelium, Hyperplasia 2 2 2 1 4 1.8Respiratory Epithelium, Metaplasia, Squamous 1 1 2 1.0

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation 2 1 2.0


Ear 1External Ear, Hyperplasia, Squamous 1 3.0

Eye + + + + + + + + + + + + + + + + + + + + + + + + + 49Anterior Chamber, Inflammation, Acute 2 4 2.3Cornea, Inflammation, Acute 2 1 2 2 1 3 3 17 2.3

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49

Lacrimal Gland + + 4Degeneration 3 2 4 2.5

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Nephropathy 3 3 3 3 2 4 3 4 4 3 4 4 4 4 4 4 4 3 4 4 3 3 4 3 3 49 3.4Renal Tubule, Dilatation 3 1 3.0

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50




DAY ON TEST


0673

0727

0629

0477

0575

0498

0597

0615

0617

0589

0727

0727

0727

0728

0640

0412

0658

0306

0683

0659

0727

0658

0401

0651

0712

300 mg/kgANIMAL ID

00151

00152

00153

00154

00155

00156

00157

00158

00159

00160

00161

00162

00163

00164

00165

00166

00167

00168

00169

00170

00171

00172

00173

00174

00175

males(cont...)

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +



Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +Fibrosis 1

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +Lymphatic, Ectasia 1 2 1 1 2 1 1 1 2 1 1

Intestine Small, Ileum + + + + A + + A + + + + + + A + + A A + + + + A +

Intestine Small, Jejunum A + + + A + + + + + + + + + A + A + A A + + + A +Lymphatic, Ectasia 1 2 2 1 3 2 3 3 3 1 2 2 3 3 3 2 3 3

Liver + + + + + + + + + + + + + + + + + + + + + + + + +Basophilic FocusCholangiofibrosisClear Cell Focus X X XEosinophilic Focus X XHepatodiaphragmatic Nodule XMixed Cell Focus X XNecrosis 1 3 2Bile Duct, Cyst 2 2Bile Duct, FibrosisBile Duct, Hyperplasia 1 1




DAY ON TEST


0673

0727

0629

0477

0575

0498

0597

0615

0617

0589

0727

0727

0727

0728

0640

0412

0658

0306

0683

0659

0727

0658

0401

0651

0712

300 mg/kgANIMAL ID

00151

00152

00153

00154

00155

00156

00157

00158

00159

00160

00161

00162

00163

00164

00165

00166

00167

00168

00169

00170

00171

00172

00173

00174

00175

males(cont...)

Oval Cell, Hyperplasia 1

Oral Mucosa + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, SquamousSebaceous Gland, Ectopic Tissue X

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +AngiectasisAcinus, Atrophy 1 1Acinus, Hyperplasia 1 4 2Artery, Inflammation, Chronic Active 2 3 1 2 2 2 2 3 2

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Metaplasia 1

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 2 2 2 2 2 3 3 2 2 2 1 1InflammationUlcer

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +Epithelium, Hyperplasia 2 2Epithelium, Inflammation, Chronic ActiveEpithelium, Mineralization 2 2 2 2 2 1

Tongue +


Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0673

0727

0629

0477

0575

0498

0597

0615

0617

0589

0727

0727

0727

0728

0640

0412

0658

0306

0683

0659

0727

0658

0401

0651

0712

300 mg/kgANIMAL ID

00151

00152

00153

00154

00155

00156

00157

00158

00159

00160

00161

00162

00163

00164

00165

00166

00167

00168

00169

00170

00171

00172

00173

00174

00175

males(cont...)

Inflammation, Chronic Active 2 3 1 2 2 1 2 1 2 2 2 1Mineralization 3

Heart + + + + + + + + + + + + + + + + + + + + + + + + +Cardiomyopathy 3 3 1 3 1 2 3 3 2 2 2 1 2 3 3 3 3 3 3 1 2 1 2 1Mineralization 3Atrium, Thrombosis

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 3Degeneration, Cystic 2 1Degeneration, Fatty 2 2 2 1 2 1Hyperplasia 2 2 2Necrosis 2

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 1 2 3 1 1 1 2 2 1 1 1 1

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 1 4

Parathyroid Gland + + + + + + + + M + + + + + + + + + + + + + + + +Hyperplasia 2 2 2 3 4 1

Pituitary Gland + + + + + + + + + + + + + + + + M + + + + + + + +Pars Distalis, Hyperplasia 2 3 1 1

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0673

0727

0629

0477

0575

0498

0597

0615

0617

0589

0727

0727

0727

0728

0640

0412

0658

0306

0683

0659

0727

0658

0401

0651

0712

300 mg/kgANIMAL ID

00151

00152

00153

00154

00155

00156

00157

00158

00159

00160

00161

00162

00163

00164

00165

00166

00167

00168

00169

00170

00171

00172

00173

00174

00175

males(cont...)

C-cell, HyperplasiaC-cell, HypertrophyFollicular Cell, Hypertrophy 3 3 3 4 3 2 4 3 2 3 1 2 2 2 3 2 3 2 1

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +Cyst 3 3 3Inflammation

Prostate + + + + + + + + + + + + + + + + + + + + + + + + +FibrosisHyperplasia 2 2Inflammation, Acute 2 3 1 1Inflammation, Chronic Active

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Acute 4

Testes + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 2 1 2 1 2 1 1 2 2 1 1 1 1 1 1Artery, Inflammation, Chronic Active 2 2 2 2 2 3 3 2 3 2 1 3 2 2Interstitial Cell, Hyperplasia




DAY ON TEST


0673

0727

0629

0477

0575

0498

0597

0615

0617

0589

0727

0727

0727

0728

0640

0412

0658

0306

0683

0659

0727

0658

0401

0651

0712

300 mg/kgANIMAL ID

00151

00152

00153

00154

00155

00156

00157

00158

00159

00160

00161

00162

00163

00164

00165

00166

00167

00168

00169

00170

00171

00172

00173

00174

00175

males(cont...)


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 2

Lymph Node + + +AngiectasisMediastinal, Hemorrhage 2Mediastinal, Infiltration Cellular, Lipocyte 3Mediastinal, Pigmentation, HemosiderinPancreatic, Hemorrhage 3Renal, Pigmentation, Hemosiderin

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +Ectasia

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Lymphoid 2Lymphatic, Ectasia 1 1

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +AtrophyHematopoietic Cell Proliferation 1 3 3 2 2 3 2 2 1 1 2 3 2

Thymus + + + M + + + + + + + + + + + + + + + + + + + + +Atrophy 3 3 2 3 2 2 3 3 3 2 2 3 3 2 2 2 4 2 1 3


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0673

0727

0629

0477

0575

0498

0597

0615

0617

0589

0727

0727

0727

0728

0640

0412

0658

0306

0683

0659

0727

0658

0401

0651

0712

300 mg/kgANIMAL ID

00151

00152

00153

00154

00155

00156

00157

00158

00159

00160

00161

00162

00163

00164

00165

00166

00167

00168

00169

00170

00171

00172

00173

00174

00175

males(cont...)

Inflammation

Skin + + + + + + + + + + + + + + + + + + + + + + + + +Cyst Epithelial Inclusion XInflammation 4 3Sebaceous Gland, Hyperplasia


Bone + + + + + + + + + + + + + + + + + + + + + + + + +Fibrous Osteodystrophy 3 4 3 3 3 3

NERVOUS SYSTEM

Brain + + + + + + + + + + + + + + + + + + + + + + + + +Cyst Epithelial Inclusion XNecrosis

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + + +Edema 2FibrosisHemorrhageHemorrhage, Multifocal 1 3 2 1Inflammation, Chronic 1 1 2 2 3 2 3 2 2 1 1 1 1Mineralization 4Alveolar Epithelium, HyperplasiaAlveolus, Infiltration Cellular, Histiocyte 2 1 1 1 1 1Alveolus, Mineralization 2




DAY ON TEST


0673

0727

0629

0477

0575

0498

0597

0615

0617

0589

0727

0727

0727

0728

0640

0412

0658

0306

0683

0659

0727

0658

0401

0651

0712

300 mg/kgANIMAL ID

00151

00152

00153

00154

00155

00156

00157

00158

00159

00160

00161

00162

00163

00164

00165

00166

00167

00168

00169

00170

00171

00172

00173

00174

00175

males(cont...)

Nose + + + + + + + + + + + + + + + + + + + + + + + + +Foreign Body X X X X X XInflammation, Chronic Active 2 1 2 2 1 1 1 1Respiratory Epithelium, Hyperplasia 1 1 2 2

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +


Eye + + + + + + + + + + + + + + + + + + + + + + + + +Cataract 2Anterior Chamber, Inflammation, Acute 2Cornea, Inflammation, Acute 1 2 2 2 1 2 1 3 2 2Retina, Fibrosis

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Angiectasis 2

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +CystNephropathy 4 3 4 3 4 4 3 3 4 4 3 4 2 4 4 4 3 2 4 4 3 3 3 3 3

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +HemorrhageInflammation




DAY ON TEST


0462

0727

0710

0727

0190

0258

0611

0722

0720

0729

0729

0645

0519

0706

0729

0701

0661

0496

0534

0719

0612

0532

0727

0621

0531

300 mg/kgANIMAL ID

00176

00177

00178

00179

00180

00181

00182

00183

00184

00185

00186

00187

00188

00189

00190

00191

00192

00193

00194

00195

00196

00197

00198

00199

00200 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50



Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50Fibrosis 1 1.0

Intestine Small, Duodenum + + + + + A + + + + + + + A + + + + + + + + + + + 48Lymphatic, Ectasia 1 3 1 14 1.4

Intestine Small, Ileum + + A + + A + + + + + + + A + + + + + A + + A A + 38

Intestine Small, Jejunum + + A + + + + + + + + + + + + + + + + + + + + + + 42Lymphatic, Ectasia 1 1 1 4 2 2 3 1 1 1 2 2 1 1 3 1 2 1 3 2 2 2 1 41 2.0

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Basophilic Focus X 1Cholangiofibrosis 2 1 2.0Clear Cell Focus X X X X X X 9Eosinophilic Focus X X X X 6Hepatodiaphragmatic Nodule 1Mixed Cell Focus 2Necrosis 3 2 3 2 7 2.3Bile Duct, Cyst 2 3 3 5 2.4Bile Duct, Fibrosis 1 1 1.0Bile Duct, Hyperplasia 1 3 1.0




DAY ON TEST


0462

0727

0710

0727

0190

0258

0611

0722

0720

0729

0729

0645

0519

0706

0729

0701

0661

0496

0534

0719

0612

0532

0727

0621

0531

300 mg/kgANIMAL ID

00176

00177

00178

00179

00180

00181

00182

00183

00184

00185

00186

00187

00188

00189

00190

00191

00192

00193

00194

00195

00196

00197

00198

00199

00200 * TOTALS

Oval Cell, Hyperplasia 1 1.0

Oral Mucosa + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia, Squamous 3 1 3.0Sebaceous Gland, Ectopic Tissue 1

Pancreas + + + + + A + + + + + + + + + + + + + + + + + + + 49Angiectasis 1 1 1.0Acinus, Atrophy 2 1.0Acinus, Hyperplasia 1 3 2 4 1 2 2 10 2.2Artery, Inflammation, Chronic Active 1 2 2 3 2 2 2 2 2 2 2 2 21 2.0

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50Metaplasia 1 2 1.0

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 2 2 2 1 3 1 1 1 1 1 22 1.8Inflammation 1 1 1.0Ulcer 1 1 1.0

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50Epithelium, Hyperplasia 2 3 2.0Epithelium, Inflammation, Chronic Active 2 1 2.0Epithelium, Mineralization 1 2 3 1 10 1.8

Tongue 1


Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 50




DAY ON TEST


0462

0727

0710

0727

0190

0258

0611

0722

0720

0729

0729

0645

0519

0706

0729

0701

0661

0496

0534

0719

0612

0532

0727

0621

0531

300 mg/kgANIMAL ID

00176

00177

00178

00179

00180

00181

00182

00183

00184

00185

00186

00187

00188

00189

00190

00191

00192

00193

00194

00195

00196

00197

00198

00199

00200 * TOTALS

Inflammation, Chronic Active 1 2 2 2 2 2 2 3 2 2 2 2 3 2 2 2 2 29 1.9Mineralization 1 3.0

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Cardiomyopathy 3 2 3 1 2 2 2 3 3 3 3 3 3 3 3 3 3 2 2 3 1 1 3 3 48 2.4Mineralization 1 3.0Atrium, Thrombosis 3 3 4 3 3.3

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 1 3.0Degeneration, Cystic 2 3 4 2.0Degeneration, Fatty 2 1 2 2 3 1 2 3 1 1 16 1.8Hyperplasia 2 2 2 6 2.0Necrosis 1 2 1.5

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 1 2 3 1 3 1 1 19 1.5

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 1 3 2.0

Parathyroid Gland + + + + + M + + + + + + + + + + + + + + + + + M + 47Hyperplasia 3 3 8 2.5

Pituitary Gland + + + + + + I + + + + + + + + + + + + + + + + + M 47Pars Distalis, Hyperplasia 1 1 4 1 2 2 2 1 12 1.8

Thyroid Gland + + A + + A + + + + + + + + + + + + + + + A + + + 47




DAY ON TEST


0462

0727

0710

0727

0190

0258

0611

0722

0720

0729

0729

0645

0519

0706

0729

0701

0661

0496

0534

0719

0612

0532

0727

0621

0531

300 mg/kgANIMAL ID

00176

00177

00178

00179

00180

00181

00182

00183

00184

00185

00186

00187

00188

00189

00190

00191

00192

00193

00194

00195

00196

00197

00198

00199

00200 * TOTALS

C-cell, Hyperplasia 3 3 4 4 2 5 3.2C-cell, Hypertrophy 2 1 2.0Follicular Cell, Hypertrophy 2 2 3 3 2 3 3 2 4 2 4 2 3 2 3 1 4 36 2.6

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM

Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50

Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst 2 3 5 2.8Inflammation 3 1 3.0

Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50Fibrosis 2 1 2.0Hyperplasia 1 3 1.7Inflammation, Acute 3 3 6 2.2Inflammation, Chronic Active 1 1 1.0

Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation, Acute 4 2 4.0

Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 2 1 1 1 1 2 2 2 1 4 1 2 4 3 1 2 1 1 33 1.6Artery, Inflammation, Chronic Active 1 1 3 1 3 2 2 3 2 3 1 3 2 3 2 3 3 2 1 33 2.2Interstitial Cell, Hyperplasia 1 4 2 2.5




DAY ON TEST


0462

0727

0710

0727

0190

0258

0611

0722

0720

0729

0729

0645

0519

0706

0729

0701

0661

0496

0534

0719

0612

0532

0727

0621

0531

300 mg/kgANIMAL ID

00176

00177

00178

00179

00180

00181

00182

00183

00184

00185

00186

00187

00188

00189

00190

00191

00192

00193

00194

00195

00196

00197

00198

00199

00200 * TOTALS


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 2 2 3 2.0

Lymph Node + + + 6Angiectasis 2 1 2.0Mediastinal, Hemorrhage 1 2.0Mediastinal, Infiltration Cellular, Lipocyte 1 3.0Mediastinal, Pigmentation, Hemosiderin 3 1 3.0Pancreatic, Hemorrhage 1 3.0Renal, Pigmentation, Hemosiderin 3 1 3.0

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 50Ectasia 3 1 3.0

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia, Lymphoid 1 2.0Lymphatic, Ectasia 2 1 2 5 1.4

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 3 1 3.0Hematopoietic Cell Proliferation 2 1 2 2 2 1 2 2 1 2 2 2 2 2 3 2 29 2.0

Thymus + + + + + + + + M + + + + + + + + + + + + + M + + 47Atrophy 3 1 1 1 1 4 2 2 3 3 2 2 2 3 2 4 4 4 2 2 4 41 2.5


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50




DAY ON TEST


0462

0727

0710

0727

0190

0258

0611

0722

0720

0729

0729

0645

0519

0706

0729

0701

0661

0496

0534

0719

0612

0532

0727

0621

0531

300 mg/kgANIMAL ID

00176

00177

00178

00179

00180

00181

00182

00183

00184

00185

00186

00187

00188

00189

00190

00191

00192

00193

00194

00195

00196

00197

00198

00199

00200 * TOTALS

Inflammation 3 1 3.0

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst Epithelial Inclusion X 2Inflammation 2 3.5Sebaceous Gland, Hyperplasia 3 1 3.0


Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50Fibrous Osteodystrophy 3 3 8 3.1

NERVOUS SYSTEM

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst Epithelial Inclusion 1Necrosis 2 3 2 2.5

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Edema 1 2.0Fibrosis 2 1 2.0Hemorrhage 1 1 1.0Hemorrhage, Multifocal 1 2 3 7 1.9Inflammation, Chronic 3 3 3 3 1 3 1 1 1 1 23 1.8Mineralization 1 4.0Alveolar Epithelium, Hyperplasia 1 1 1.0Alveolus, Infiltration Cellular, Histiocyte 1 1 1 1 2 1 1 13 1.2Alveolus, Mineralization 1 2.0




DAY ON TEST


0462

0727

0710

0727

0190

0258

0611

0722

0720

0729

0729

0645

0519

0706

0729

0701

0661

0496

0534

0719

0612

0532

0727

0621

0531

300 mg/kgANIMAL ID

00176

00177

00178

00179

00180

00181

00182

00183

00184

00185

00186

00187

00188

00189

00190

00191

00192

00193

00194

00195

00196

00197

00198

00199

00200 * TOTALS

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50Foreign Body X X X X 10Inflammation, Chronic Active 2 2 1 2 1 2 2 15 1.5Respiratory Epithelium, Hyperplasia 2 1 3 7 1.7

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50


Eye + + M + + + + + + + + + + + + + + + + + + + + + + 49Cataract 1 2.0Anterior Chamber, Inflammation, Acute 2 2 3 2.0Cornea, Inflammation, Acute 2 2 3 1 2 2 3 1 1 2 2 21 1.9Retina, Fibrosis 3 1 3.0

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Angiectasis 1 2.0

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst 2 1 2.0Nephropathy 4 3 3 3 2 2 4 3 3 3 3 4 3 3 3 4 3 4 4 4 4 3 3 4 4 50 3.4

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemorrhage 2 1 2.0Inflammation 1 1 1.0




*** END OF MALE DATA ***




DAY ON TEST

HARLAN SPRAGUE DAWLEY RATSFEMALE

0509

0730

0729

0729

0614

0729

0645

0642

0730

0719

0681

0730

0729

0730

0729

0632

0642

0373

0730

0729

0719

0730

0719

0538

0422

0 mg/kgANIMAL ID

00201

00202

00203

00204

00205

00206

00207

00208

00209

00210

00211

00212

00213

00214

00215

00216

00217

00218

00219

00220

00221

00222

00223

00224

00225

females(cont...)

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +




Intestine Small, Duodenum + + + + A + + + + + + + + + + + + + + + + + + + +

Intestine Small, Ileum + + + + A + + + + + + + + + + + + + + + + + + + +

Intestine Small, Jejunum + + + + A + + + + + + + + + + + + + + + + + + + +

Liver + + + + + + + + + + + + + + + + + + + + + + + + +AngiectasisBasophilic Focus X X X X X X X XClear Cell Focus X X X XMixed Cell Focus X X XNecrosis 2Pigmentation 3Bile Duct, Cyst 2 3Bile Duct, Cyst, Multiple 2 3Bile Duct, Hyperplasia 1 2

Oral Mucosa + + + + + + + + + + + + + + + + + + + + + + + + +

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0509

0730

0729

0729

0614

0729

0645

0642

0730

0719

0681

0730

0729

0730

0729

0632

0642

0373

0730

0729

0719

0730

0719

0538

0422

0 mg/kgANIMAL ID

00201

00202

00203

00204

00205

00206

00207

00208

00209

00210

00211

00212

00213

00214

00215

00216

00217

00218

00219

00220

00221

00222

00223

00224

00225

females(cont...)

Acinus, HyperplasiaArtery, Inflammation, Chronic Active

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 1Inflammation 1Ulcer 2

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +Ulcer 2Epithelium, Hyperplasia

TongueErosion


Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Chronic Active

Heart + + + + + + + + + + + + + + + + + + + + + + + + +Cardiomyopathy 1 1 1 1 1 1 1 1 1 2 1 1Epicardium, Inflammation 2

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Degeneration, Cystic 2 3 2 2




DAY ON TEST


0509

0730

0729

0729

0614

0729

0645

0642

0730

0719

0681

0730

0729

0730

0729

0632

0642

0373

0730

0729

0719

0730

0719

0538

0422

0 mg/kgANIMAL ID

00201

00202

00203

00204

00205

00206

00207

00208

00209

00210

00211

00212

00213

00214

00215

00216

00217

00218

00219

00220

00221

00222

00223

00224

00225

females(cont...)

Degeneration, Fatty 2 3 2Hyperplasia 1 1 3 2 2 3Hypertrophy 1Bilateral, Degeneration, Cystic

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 1 1 1 1 1 1 1

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +

Parathyroid Gland + M + + M + + + + + + + + + + + + + + M + + + + +

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +Pars Distalis, Hyperplasia 3 1 4 1 2 3 2 4 1 2

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +C-cell, Hyperplasia 3 2 2 1Follicular Cell, HyperplasiaFollicular Cell, Hypertrophy 2 1 1 2 1 2 1 1 1 2 2 2 3 3 1

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +Cyst 3Inflammation 1

Ovary + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0509

0730

0729

0729

0614

0729

0645

0642

0730

0719

0681

0730

0729

0730

0729

0632

0642

0373

0730

0729

0719

0730

0719

0538

0422

0 mg/kgANIMAL ID

00201

00202

00203

00204

00205

00206

00207

00208

00209

00210

00211

00212

00213

00214

00215

00216

00217

00218

00219

00220

00221

00222

00223

00224

00225

females(cont...)

Atrophy 2 3 3 1 1 2 2 1 1 1 2 3 4 3 2 2 1 2 1 1 2Cyst 3 2 2 1 2 1 1 2 2 3 1 1Inflammation, Chronic Active 2

Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Dilatation 3 4 3 1 3 2Inflammation, Histiocytic, Focal 1Inflammation, Acute 1 1 2Endometrium, Hyperplasia, Cystic 1 1 1 1 2 2 1 3 2 2 3 3 3 2 2Endometrium, Metaplasia, Squamous 1 3 2 2 3 1

Vagina +


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 3 3 3 2 2 2 3 3 3 3

Lymph Node + + + +Inguinal, Hyperplasia, LymphoidLumbar, Hemorrhage 3 3Lumbar, Hyperplasia, LymphoidMediastinal, Hemorrhage 4 3Mediastinal, Infiltration Cellular, Histiocyte

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +Pigmentation, Hemosiderin




DAY ON TEST


0509

0730

0729

0729

0614

0729

0645

0642

0730

0719

0681

0730

0729

0730

0729

0632

0642

0373

0730

0729

0719

0730

0719

0538

0422

0 mg/kgANIMAL ID

00201

00202

00203

00204

00205

00206

00207

00208

00209

00210

00211

00212

00213

00214

00215

00216

00217

00218

00219

00220

00221

00222

00223

00224

00225

females(cont...)

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Hematopoietic Cell Proliferation 3 2 3 2 3 4 2 2 2 3 2 2 3 3 2 3 3 1 3 1

Thymus + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 2 2 4 3 4 2 3 1 3 1 3 2 2 2 1 2 2 1Epithelial Cell, Hyperplasia 3


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +GalactoceleHyperplasia 1 2 1 1InflammationInflammation, Chronic 3Duct, Dilatation 3

Skin + + + + + + + + + + + + + + + + + + + + + + + + +


Bone + + + + + + + + + + + + + + + + + + + + + + + + +

Skeletal Muscle

NERVOUS SYSTEM

Brain + + + + + + + + + + + + + + + + + + + + + + + + +Necrosis

RESPIRATORY SYSTEM




DAY ON TEST


0509

0730

0729

0729

0614

0729

0645

0642

0730

0719

0681

0730

0729

0730

0729

0632

0642

0373

0730

0729

0719

0730

0719

0538

0422

0 mg/kgANIMAL ID

00201

00202

00203

00204

00205

00206

00207

00208

00209

00210

00211

00212

00213

00214

00215

00216

00217

00218

00219

00220

00221

00222

00223

00224

00225

females(cont...)

Lung + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Granulomatous 1Inflammation, Chronic 1 2 2 3 2 3 2 3 3 1 2 3 3 3 3 2 2Alveolus, Infiltration Cellular, Histiocyte 2 3 1 1

Nose + + + + + + + + + + + + + + + + + + + + + + + +Foreign Body XInflammation, Chronic Active 1 1 1Olfactory Epithelium, Degeneration

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +


Eye + + + + + + + + + + + + + + + + + + + + + + + + +Cataract 2

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Nephropathy 2 1 1 2 1 2 1 1 2 2 1 1 2 3 1 1 2 2 2 2 1 1 2

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0688

0611

0488

0730

0558

0729

0729

0617

0425

0389

0607

0288

0552

0446

0645

0730

0729

0730

0502

0729

0730

0695

0730

0656

0513

0 mg/kgANIMAL ID

00226

00227

00228

00229

00230

00231

00232

00233

00234

00235

00236

00237

00238

00239

00240

00241

00242

00243

00244

00245

00246

00247

00248

00249

00250 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50




Intestine Small, Duodenum + + + + + + + + A + + + + + + + + + + + + + + + + 48

Intestine Small, Ileum + + + + + + + + A A + + + + + + + + + + + + + + + 47

Intestine Small, Jejunum + + + + + + + + A A + + + + + + + + + + + + + + + 47

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Angiectasis 1 1 1.0Basophilic Focus X X X X X X 14Clear Cell Focus X X 6Mixed Cell Focus X X 5Necrosis 1 2.0Pigmentation 1 3.0Bile Duct, Cyst 2 2.5Bile Duct, Cyst, Multiple 2 2.5Bile Duct, Hyperplasia 2 1.5

Oral Mucosa + + + + + + + + + + + + + + + + + + + + + + + + + 50

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50




DAY ON TEST


0688

0611

0488

0730

0558

0729

0729

0617

0425

0389

0607

0288

0552

0446

0645

0730

0729

0730

0502

0729

0730

0695

0730

0656

0513

0 mg/kgANIMAL ID

00226

00227

00228

00229

00230

00231

00232

00233

00234

00235

00236

00237

00238

00239

00240

00241

00242

00243

00244

00245

00246

00247

00248

00249

00250 * TOTALS

Acinus, Hyperplasia 2 1 2.0Artery, Inflammation, Chronic Active 3 1 3.0

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation 2 1 2.0

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 3 2 2.0Inflammation 1 1.0Ulcer 1 2.0

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50Ulcer 1 2.0Epithelium, Hyperplasia 2 1 2.0

Tongue + 1Erosion 3 1 3.0


Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation, Chronic Active 3 1 3.0

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Cardiomyopathy 1 1 1 1 2 1 1 2 2 2 1 1 24 1.2Epicardium, Inflammation 1 2.0

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Degeneration, Cystic 1 2 2 2 2 2 3 3 2 4 3 2 16 2.3




DAY ON TEST


0688

0611

0488

0730

0558

0729

0729

0617

0425

0389

0607

0288

0552

0446

0645

0730

0729

0730

0502

0729

0730

0695

0730

0656

0513

0 mg/kgANIMAL ID

00226

00227

00228

00229

00230

00231

00232

00233

00234

00235

00236

00237

00238

00239

00240

00241

00242

00243

00244

00245

00246

00247

00248

00249

00250 * TOTALS

Degeneration, Fatty 2 3 5 2.4Hyperplasia 2 3 2 4 4 1 1 1 2 1 4 4 18 2.3Hypertrophy 1 1.0Bilateral, Degeneration, Cystic 4 1 4.0

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 1 1 1 2 1 1 1 1 15 1.1

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50

Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 47

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Pars Distalis, Hyperplasia 1 4 2 2 4 3 3 3 3 19 2.5

Thyroid Gland + + + + + + + + A + + + + + + + + + + + + + + + + 49C-cell, Hyperplasia 3 2 1 7 2.0Follicular Cell, Hyperplasia 2 1 2.0Follicular Cell, Hypertrophy 1 2 3 2 1 2 1 1 1 1 1 1 27 1.6

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst 3 3 2 3 5 2.8Inflammation 1 1.0

Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 50




DAY ON TEST


0688

0611

0488

0730

0558

0729

0729

0617

0425

0389

0607

0288

0552

0446

0645

0730

0729

0730

0502

0729

0730

0695

0730

0656

0513

0 mg/kgANIMAL ID

00226

00227

00228

00229

00230

00231

00232

00233

00234

00235

00236

00237

00238

00239

00240

00241

00242

00243

00244

00245

00246

00247

00248

00249

00250 * TOTALS

Atrophy 2 1 2 3 1 1 1 3 3 1 3 2 1 1 2 3 4 3 1 40 2.0Cyst 1 2 4 2 4 17 2.0Inflammation, Chronic Active 1 2.0

Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50Dilatation 4 1 2 9 2.6Inflammation, Histiocytic, Focal 1 1.0Inflammation, Acute 1 1 5 1.2Endometrium, Hyperplasia, Cystic 1 1 1 1 2 2 1 2 1 1 3 3 2 2 29 1.8Endometrium, Metaplasia, Squamous 1 3 1 2 3 1 12 1.9

Vagina + 2


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 2 2 1 3 2 2 3 3 2 1 3 21 2.4

Lymph Node + + + 7Inguinal, Hyperplasia, Lymphoid 3 1 3.0Lumbar, Hemorrhage 2 3.0Lumbar, Hyperplasia, Lymphoid 3 1 3.0Mediastinal, Hemorrhage 2 3.5Mediastinal, Infiltration Cellular, Histiocyte 2 1 2.0

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 50

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50Pigmentation, Hemosiderin 2 1 2.0




DAY ON TEST


0688

0611

0488

0730

0558

0729

0729

0617

0425

0389

0607

0288

0552

0446

0645

0730

0729

0730

0502

0729

0730

0695

0730

0656

0513

0 mg/kgANIMAL ID

00226

00227

00228

00229

00230

00231

00232

00233

00234

00235

00236

00237

00238

00239

00240

00241

00242

00243

00244

00245

00246

00247

00248

00249

00250 * TOTALS

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50Hematopoietic Cell Proliferation 1 3 3 2 3 3 3 3 3 3 2 3 2 3 2 3 36 2.5

Thymus + + M + + + + + M + + + + + + M + + + + + + + + + 47Atrophy 4 2 4 2 2 1 2 1 2 3 3 1 2 4 1 1 1 2 2 2 38 2.2Epithelial Cell, Hyperplasia 1 3.0


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Galactocele X 1Hyperplasia 2 1 1 1 8 1.3Inflammation 4 1 4.0Inflammation, Chronic 1 3.0Duct, Dilatation 1 3.0

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50


Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50

Skeletal Muscle + 1

NERVOUS SYSTEM

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50Necrosis 3 1 3.0

RESPIRATORY SYSTEM




DAY ON TEST


0688

0611

0488

0730

0558

0729

0729

0617

0425

0389

0607

0288

0552

0446

0645

0730

0729

0730

0502

0729

0730

0695

0730

0656

0513

0 mg/kgANIMAL ID

00226

00227

00228

00229

00230

00231

00232

00233

00234

00235

00236

00237

00238

00239

00240

00241

00242

00243

00244

00245

00246

00247

00248

00249

00250 * TOTALS

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation, Granulomatous 1 1.0Inflammation, Chronic 2 3 2 2 2 3 2 3 2 1 2 3 2 1 3 2 3 34 2.3Alveolus, Infiltration Cellular, Histiocyte 1 1 1 2 1 1 2 2 1 13 1.5

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 49Foreign Body X X 3Inflammation, Chronic Active 2 2 5 1.4Olfactory Epithelium, Degeneration 1 1 1.0

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50


Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50Cataract 1 2.0

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Nephropathy 1 1 1 2 1 1 2 1 2 3 1 2 3 2 2 2 3 2 3 2 1 2 45 1.7

Urinary Bladder + + + + + + + + + + + + + + + + + + M + + + + + + 49




DAY ON TEST


0719

0729

0719

0730

0622

0621

0531

0622

0633

0713

0665

0379

0665

0730

0729

0730

0710

0730

0730

0729

0705

0313

0719

0729

0509

75 mg/kgANIMAL ID

00251

00252

00253

00254

00255

00256

00257

00258

00259

00260

00261

00262

00263

00264

00265

00266

00267

00268

00269

00270

00271

00272

00273

00274

00275

females(cont...)

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation 1




Intestine Small, Duodenum + + + + + A + + + + + + + + + + + + + + + A + + +

Intestine Small, Ileum + + + + + A + + + + + + + + + + + + + + + A + + +

Intestine Small, Jejunum + + + + + A + + + + + + + + + + + + + + A A + + +

Liver + + + + + + + + + + + + + + + + + + + + + + + + +Basophilic Focus X X X X XCholangiofibrosisClear Cell Focus X X X X X XEosinophilic Focus X XMixed Cell Focus XNecrosis 3ThrombosisBile Duct, CystBile Duct, Cyst, MultipleCentrilobular, Degeneration 3

Mesentery




DAY ON TEST


0719

0729

0719

0730

0622

0621

0531

0622

0633

0713

0665

0379

0665

0730

0729

0730

0710

0730

0730

0729

0705

0313

0719

0729

0509

75 mg/kgANIMAL ID

00251

00252

00253

00254

00255

00256

00257

00258

00259

00260

00261

00262

00263

00264

00265

00266

00267

00268

00269

00270

00271

00272

00273

00274

00275

females(cont...)

Artery, Inflammation, Chronic Active

Oral Mucosa + + + + + + + + + + + + + + + + + + + + + + + + +

Pancreas + + + + + + + + + + + + + + + + + + + + + A + + +Acinus, Hyperplasia 1Artery, Inflammation, Chronic Active 2 1

Salivary Glands + + + + + + + + + + + + + + + + + + + + + M + + +

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 1 1Pigmentation, Melanin

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + A + + +

TongueInflammation

Tooth +


Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Chronic Active 1

Heart + + + + + + + + + + + + + + + + + + + + + + + + +Cardiomyopathy 3 1 1 2 2 1 2 3 2Atrium, ThrombosisEpicardium, Inflammation 1 3




DAY ON TEST


0719

0729

0719

0730

0622

0621

0531

0622

0633

0713

0665

0379

0665

0730

0729

0730

0710

0730

0730

0729

0705

0313

0719

0729

0509

75 mg/kgANIMAL ID

00251

00252

00253

00254

00255

00256

00257

00258

00259

00260

00261

00262

00263

00264

00265

00266

00267

00268

00269

00270

00271

00272

00273

00274

00275

females(cont...)

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Degeneration, Cystic 2 2 1 1 3 2 3Degeneration, Fatty 3Hyperplasia 1 2 2Inflammation 1Thrombosis

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 2 2 1 2 1


Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 1 1

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +Pars Distalis, Hyperplasia 3 2 3 2 1 2 4

Thyroid Gland + + + + + + + + + + + + + + + + + + + + A + + + +C-cell, Hyperplasia 2 1Follicular Cell, Hypertrophy 2 1 3 2 1 1 3 2 2 1 3 1 2

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM




DAY ON TEST


0719

0729

0719

0730

0622

0621

0531

0622

0633

0713

0665

0379

0665

0730

0729

0730

0710

0730

0730

0729

0705

0313

0719

0729

0509

75 mg/kgANIMAL ID

00251

00252

00253

00254

00255

00256

00257

00258

00259

00260

00261

00262

00263

00264

00265

00266

00267

00268

00269

00270

00271

00272

00273

00274

00275

females(cont...)

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +Cyst 3

Ovary + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 2 3 3 2Cyst 1 3 1 4 3 2 3 3Inflammation, Chronic Active

Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Dilatation 3 2 4Inflammation, Acute 2 1 2Endometrium, Hyperplasia, Cystic 3 3 1 1 1 1 2 1 2 2 1 2 2Endometrium, Metaplasia, Squamous 1 1 2 3 3 2

Vagina +


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +AtrophyHyperplasia 2 2 2 2 1 2 3 2 1 3 3

Lymph Node + + +Iliac, Hyperplasia, LymphoidInguinal, Hemorrhage 3Lumbar, HemorrhageLumbar, Hyperplasia, LymphoidLumbar, Infiltration Cellular, Histiocyte 2




DAY ON TEST


0719

0729

0719

0730

0622

0621

0531

0622

0633

0713

0665

0379

0665

0730

0729

0730

0710

0730

0730

0729

0705

0313

0719

0729

0509

75 mg/kgANIMAL ID

00251

00252

00253

00254

00255

00256

00257

00258

00259

00260

00261

00262

00263

00264

00265

00266

00267

00268

00269

00270

00271

00272

00273

00274

00275

females(cont...)

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + M + + +

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Hematopoietic Cell Proliferation 2 3 2 2 3 1 3 3 1 2 3 2 3 2 3 2 2

Thymus + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 3 2 3 2 1 2 1 2 3 3 1 1 3 4 2InflammationEpithelial Cell, Hyperplasia 2 4


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 1 1Inflammation

Skin + + + + + + + + + + + + + + + + + + + + + + + + +Cyst Epithelial Inclusion X


Bone + + + + + + + + + + + + + + + + + + + + + + + + +Fibrous Osteodystrophy

NERVOUS SYSTEM

Brain + + + + + + + + + + + + + + + + + + + + + + + + +Gliosis




DAY ON TEST


0719

0729

0719

0730

0622

0621

0531

0622

0633

0713

0665

0379

0665

0730

0729

0730

0710

0730

0730

0729

0705

0313

0719

0729

0509

75 mg/kgANIMAL ID

00251

00252

00253

00254

00255

00256

00257

00258

00259

00260

00261

00262

00263

00264

00265

00266

00267

00268

00269

00270

00271

00272

00273

00274

00275

females(cont...)

InflammationMeninges, Pigmentation, Lipofuscin 1

Peripheral Nerve +

Spinal Cord +Hemorrhage 2Necrosis 2

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + + +AtelectasisForeign Body XInflammation, Chronic 3 3 2 3 3 2 2 1 1 1 2 1 3 3 1 2 2Alveolus, Infiltration Cellular, Histiocyte 1 1 1 2 1 1Bronchiole, HyperplasiaMediastinum, Inflammation 3Pleura, Inflammation, Chronic Active

Nose + + + + + + + + + + + + + + + + + + + + + + + + +Foreign Body X XInflammation, Chronic Active 2 1Glands, Olfactory Epithelium, Hyperplasia 1

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +Epithelium, Necrosis 2





DAY ON TEST


0719

0729

0719

0730

0622

0621

0531

0622

0633

0713

0665

0379

0665

0730

0729

0730

0710

0730

0730

0729

0705

0313

0719

0729

0509

75 mg/kgANIMAL ID

00251

00252

00253

00254

00255

00256

00257

00258

00259

00260

00261

00262

00263

00264

00265

00266

00267

00268

00269

00270

00271

00272

00273

00274

00275

females(cont...)

Eye + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Nephropathy 2 2 1 2 2 2 3 1 3 3 2 1 2 1 2 3 2 3 2 2 2 2

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0729

0645

0730

0730

0616

0670

0730

0645

0492

0611

0388

0729

0481

0420

0730

0669

0463

0706

0730

0664

0335

0730

0187

0730

0730

75 mg/kgANIMAL ID

00276

00277

00278

00279

00280

00281

00282

00283

00284

00285

00286

00287

00288

00289

00290

00291

00292

00293

00294

00295

00296

00297

00298

00299

00300 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation 3 2 2.0




Intestine Small, Duodenum + + + + A + + + + + + + + + + + + + + + + + + + + 47

Intestine Small, Ileum + + + + + + + + + + + + + + + + + A + + + + + + + 47

Intestine Small, Jejunum + + + + + + + + + + + + + + + A + + + + + + + + + 46

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Basophilic Focus X 6Cholangiofibrosis 1 1 1.0Clear Cell Focus X 7Eosinophilic Focus X X 4Mixed Cell Focus 1Necrosis 4 2 3.5Thrombosis 2 1 2.0Bile Duct, Cyst 2 1 2.0Bile Duct, Cyst, Multiple 2 1 2.0Centrilobular, Degeneration 1 3.0

Mesentery + + 2




DAY ON TEST


0729

0645

0730

0730

0616

0670

0730

0645

0492

0611

0388

0729

0481

0420

0730

0669

0463

0706

0730

0664

0335

0730

0187

0730

0730

75 mg/kgANIMAL ID

00276

00277

00278

00279

00280

00281

00282

00283

00284

00285

00286

00287

00288

00289

00290

00291

00292

00293

00294

00295

00296

00297

00298

00299

00300 * TOTALS

Artery, Inflammation, Chronic Active 3 1 3.0

Oral Mucosa + + + + + + + + + + + + + + + + + + + + + + + + + 50

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 49Acinus, Hyperplasia 2 1 3 1.3Artery, Inflammation, Chronic Active 2 1 4 1.5

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 49

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 3 4 3 5 2.4Pigmentation, Melanin 2 1 2.0

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 49

Tongue + 1Inflammation 3 1 3.0

Tooth 1


Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation, Chronic Active 1 2 3 1.3

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Cardiomyopathy 1 2 2 2 1 1 1 1 1 2 3 2 1 2 1 24 1.7Atrium, Thrombosis 4 1 4.0Epicardium, Inflammation 3 3 2.3




DAY ON TEST


0729

0645

0730

0730

0616

0670

0730

0645

0492

0611

0388

0729

0481

0420

0730

0669

0463

0706

0730

0664

0335

0730

0187

0730

0730

75 mg/kgANIMAL ID

00276

00277

00278

00279

00280

00281

00282

00283

00284

00285

00286

00287

00288

00289

00290

00291

00292

00293

00294

00295

00296

00297

00298

00299

00300 * TOTALS

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Degeneration, Cystic 2 2 2 3 2 12 2.1Degeneration, Fatty 1 2 3 2.0Hyperplasia 1 3 2 2 2 3 2 2 11 2.0Inflammation 1 1.0Thrombosis 2 1 2.0

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 2 2 1 2 3 1 1 3 13 1.8


Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + M + + + 49Hyperplasia 2 1.0

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Pars Distalis, Hyperplasia 1 3 2 1 2 1 2 14 2.1

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49C-cell, Hyperplasia 2 2 3 5 2.0Follicular Cell, Hypertrophy 1 1 1 1 1 1 2 4 1 2 23 1.7

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM




DAY ON TEST


0729

0645

0730

0730

0616

0670

0730

0645

0492

0611

0388

0729

0481

0420

0730

0669

0463

0706

0730

0664

0335

0730

0187

0730

0730

75 mg/kgANIMAL ID

00276

00277

00278

00279

00280

00281

00282

00283

00284

00285

00286

00287

00288

00289

00290

00291

00292

00293

00294

00295

00296

00297

00298

00299

00300 * TOTALS

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst 2 2 2.5

Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 3 3 3 2 1 2 1 2 1 2 1 1 2 3 2 1 1 3 3 23 2.0Cyst 2 2 3 3 1 13 2.4Inflammation, Chronic Active 3 1 3.0

Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50Dilatation 4 3 3 4 4 4 9 3.4Inflammation, Acute 3 3 3 2 2 2 3 1 1 12 2.1Endometrium, Hyperplasia, Cystic 1 1 1 2 1 2 2 1 1 2 2 1 3 1 3 28 1.6Endometrium, Metaplasia, Squamous 3 3 2 2 2 3 2 1 1 3 2 3 18 2.2

Vagina 1


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 3 1 3.0Hyperplasia 2 1 1 2 2 1 2 2 3 20 2.0

Lymph Node + + + 6Iliac, Hyperplasia, Lymphoid 2 1 2.0Inguinal, Hemorrhage 1 3.0Lumbar, Hemorrhage 3 1 3.0Lumbar, Hyperplasia, Lymphoid 3 1 3.0Lumbar, Infiltration Cellular, Histiocyte 1 2.0




DAY ON TEST


0729

0645

0730

0730

0616

0670

0730

0645

0492

0611

0388

0729

0481

0420

0730

0669

0463

0706

0730

0664

0335

0730

0187

0730

0730

75 mg/kgANIMAL ID

00276

00277

00278

00279

00280

00281

00282

00283

00284

00285

00286

00287

00288

00289

00290

00291

00292

00293

00294

00295

00296

00297

00298

00299

00300 * TOTALS


Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50Hematopoietic Cell Proliferation 2 3 3 2 3 4 2 2 3 2 1 3 3 2 2 32 2.4

Thymus + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 3 1 4 2 3 4 2 4 1 3 1 3 2 2 3 1 31 2.3Inflammation 3 1 3.0Epithelial Cell, Hyperplasia 3 4 4 3.3


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 1 3 1.0Inflammation 3 1 3.0

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst Epithelial Inclusion 1


Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50Fibrous Osteodystrophy 3 1 3.0

NERVOUS SYSTEM

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50Gliosis 2 1 2.0




DAY ON TEST


0729

0645

0730

0730

0616

0670

0730

0645

0492

0611

0388

0729

0481

0420

0730

0669

0463

0706

0730

0664

0335

0730

0187

0730

0730

75 mg/kgANIMAL ID

00276

00277

00278

00279

00280

00281

00282

00283

00284

00285

00286

00287

00288

00289

00290

00291

00292

00293

00294

00295

00296

00297

00298

00299

00300 * TOTALS

Inflammation 2 1 2.0Meninges, Pigmentation, Lipofuscin 1 1.0

Peripheral Nerve + 2

Spinal Cord 1Hemorrhage 1 2.0Necrosis 1 2.0

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Atelectasis X 1Foreign Body X 2Inflammation, Chronic 3 1 1 2 4 2 3 1 3 3 3 2 3 30 2.2Alveolus, Infiltration Cellular, Histiocyte 3 1 1 1 3 1 1 2 1 3 16 1.5Bronchiole, Hyperplasia 3 1 3.0Mediastinum, Inflammation 1 3.0Pleura, Inflammation, Chronic Active 2 1 2.0

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50Foreign Body 2Inflammation, Chronic Active 3 1 4 1.8Glands, Olfactory Epithelium, Hyperplasia 1 1.0

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50Epithelium, Necrosis 1 2.0





DAY ON TEST


0729

0645

0730

0730

0616

0670

0730

0645

0492

0611

0388

0729

0481

0420

0730

0669

0463

0706

0730

0664

0335

0730

0187

0730

0730

75 mg/kgANIMAL ID

00276

00277

00278

00279

00280

00281

00282

00283

00284

00285

00286

00287

00288

00289

00290

00291

00292

00293

00294

00295

00296

00297

00298

00299

00300 * TOTALS

Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation 3 1 3.0

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation 2 1 2.0

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Nephropathy 2 3 2 3 1 3 2 1 2 1 1 2 2 4 2 2 1 1 3 41 2.0

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50




DAY ON TEST


0611

0446

0615

0730

0730

0730

0548

0639

0730

0516

0730

0729

0329

0688

0688

0727

0596

0729

0608

0645

0526

0645

0631

0393

0729

150 mg/kgANIMAL ID

00301

00302

00303

00304

00305

00306

00307

00308

00309

00310

00311

00312

00313

00314

00315

00316

00317

00318

00319

00320

00321

00322

00323

00324

00325

females(cont...)

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +



Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +Metaplasia 2

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +Lymphatic, Ectasia 1 1 1 1 1 1 1 1

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + +

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + +Lymphatic, Ectasia 2 1 1 1 2 3 1 2 3 1 2 1 2

Liver + + + + + + + + + + + + + + + + + + + + + + + + +Angiectasis 2Basophilic Focus X X X X X XClear Cell Focus X X XEosinophilic Focus X X X XHepatodiaphragmatic Nodule XMixed Cell Focus X X X XBile Duct, Cyst 4 2Bile Duct, Cyst, Multiple 2 2

Mesentery +




DAY ON TEST


0611

0446

0615

0730

0730

0730

0548

0639

0730

0516

0730

0729

0329

0688

0688

0727

0596

0729

0608

0645

0526

0645

0631

0393

0729

150 mg/kgANIMAL ID

00301

00302

00303

00304

00305

00306

00307

00308

00309

00310

00311

00312

00313

00314

00315

00316

00317

00318

00319

00320

00321

00322

00323

00324

00325

females(cont...)

Oral Mucosa + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Squamous

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +Artery, Inflammation, Chronic Active 3 1 4

Salivary Glands + + + + + + + + + M + + + + + + + + + + + + + + +

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 3 2 2 2 2

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +Erosion 3Epithelium, Hyperplasia 2Epithelium, Mineralization 1


Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +Degeneration, FocalInflammation, Chronic Active 2 3 2 3Thrombosis 3

Heart + + + + + + + + + + + + + + + + + + + + + + + + +Cardiomyopathy 1 2 1 1 3 3 1 1 1 2 2 1Pericardium, Inflammation 2

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0611

0446

0615

0730

0730

0730

0548

0639

0730

0516

0730

0729

0329

0688

0688

0727

0596

0729

0608

0645

0526

0645

0631

0393

0729

150 mg/kgANIMAL ID

00301

00302

00303

00304

00305

00306

00307

00308

00309

00310

00311

00312

00313

00314

00315

00316

00317

00318

00319

00320

00321

00322

00323

00324

00325

females(cont...)

Degeneration, Cystic 2 2 2 2 3 3Hyperplasia 3 3 3 2 2 2 1 2 1NecrosisThrombosis

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 1 2 2 2 3 1


Parathyroid Gland + + + + + + + + + M + + + + + + + M + + + + + + +

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +Pars Distalis, Hyperplasia 4 2 3 4 3 4 4 2 4

Thyroid Gland + + + + + + + + + M + + + + + + + + + + + + + + +C-cell, Hyperplasia 1 4 2 1Follicular Cell, Hyperplasia 2Follicular Cell, Hypertrophy 2 1 2 1 3 1 3 2 1

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +Cyst 3

Ovary + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 1 1 3 2 2 1 3 2 1 1 1 1 1 1 3 2 3 3




DAY ON TEST


0611

0446

0615

0730

0730

0730

0548

0639

0730

0516

0730

0729

0329

0688

0688

0727

0596

0729

0608

0645

0526

0645

0631

0393

0729

150 mg/kgANIMAL ID

00301

00302

00303

00304

00305

00306

00307

00308

00309

00310

00311

00312

00313

00314

00315

00316

00317

00318

00319

00320

00321

00322

00323

00324

00325

females(cont...)

Cyst 3 2 2 2 2 2 3 4Inflammation, AcuteNecrosis, Fibrinoid 4

Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Cyst 2 3Dilatation 4 3 3 4Inflammation, Acute 1 1ThrombosisEndometrium, Hyperplasia, Cystic 2 1 1 3 3 2 2 2 2 1 1 3 1 2 2Endometrium, Metaplasia, Squamous 1 3 3 1 3 3 2 1 3 3


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +AtrophyHyperplasia 1 3 2 3 2 2 1 2 3 3 1 2

Lymph Node + +Inguinal, Hyperplasia, LymphoidLumbar, Infiltration Cellular, HistiocyteMediastinal, Ectasia 3Mediastinal, Hemorrhage 3

Lymph Node, Mandibular + + + + + + + + + M + + + + + + + + + + + + + + +

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +Lymphatic, Ectasia 1

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0611

0446

0615

0730

0730

0730

0548

0639

0730

0516

0730

0729

0329

0688

0688

0727

0596

0729

0608

0645

0526

0645

0631

0393

0729

150 mg/kgANIMAL ID

00301

00302

00303

00304

00305

00306

00307

00308

00309

00310

00311

00312

00313

00314

00315

00316

00317

00318

00319

00320

00321

00322

00323

00324

00325

females(cont...)

Hematopoietic Cell Proliferation 3 2 1 3 2 3 3 2 2 2 3 2 3 4 2 2 3 2 3 2 3 2

Thymus + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 2 2 2 3 3 3 3 2 2 1 1 3 3 3 3 1 2 2 1 2InflammationEpithelial Cell, Hyperplasia 2 2 2


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 2 1 2 1

Skin + + + + + + + + + + + + + + + + + + + + + + + + +


Bone + + + + + + + + + + + + + + + + + + + + + + + + +Fibrous Osteodystrophy 3

Skeletal Muscle +Degeneration 1

NERVOUS SYSTEM

Brain + + + + + + + + + + + + + + + + + + + + + + + + +

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Chronic 3 2 2 3 3 3 3 3 2 3 1 1 2 2 3 1 3 3 3 1 2 2Alveolus, Infiltration Cellular, Histiocyte 1 1 1




DAY ON TEST


0611

0446

0615

0730

0730

0730

0548

0639

0730

0516

0730

0729

0329

0688

0688

0727

0596

0729

0608

0645

0526

0645

0631

0393

0729

150 mg/kgANIMAL ID

00301

00302

00303

00304

00305

00306

00307

00308

00309

00310

00311

00312

00313

00314

00315

00316

00317

00318

00319

00320

00321

00322

00323

00324

00325

females(cont...)

Bronchiole, Hyperplasia

Nose + + + + + + + + + + + + + + + + + + + + + + + + +AngiectasisForeign Body XInflammation, Chronic Active 1 3 1Olfactory Epithelium, Atrophy 1Olfactory Epithelium, Degeneration 1Respiratory Epithelium, Hyperplasia 3 2Respiratory Epithelium, Metaplasia, Squamous

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +


Eye + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation 3

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Focal

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Nephropathy 2 3 2 3 3 3 3 3 1 3 2 2 1 2 2 3 1 2 3 3 2 3

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia




DAY ON TEST


0730

0730

0730

0729

0664

0646

0646

0729

0729

0590

0730

0730

0688

0189

0631

0719

0730

0643

0730

0160

0646

0307

0614

0397

0730

150 mg/kgANIMAL ID

00326

00327

00328

00329

00330

00331

00332

00333

00334

00335

00336

00337

00338

00339

00340

00341

00342

00343

00344

00345

00346

00347

00348

00349

00350 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50



Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50Metaplasia 1 2.0

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + A + A + 48Lymphatic, Ectasia 1 1 2 2 1 1 1 2 16 1.2

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + A A + 48

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + A A + 48Lymphatic, Ectasia 1 1 1 2 1 1 1 2 2 3 2 2 3 3 1 2 1 30 1.7

Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Angiectasis 2 2 2.0Basophilic Focus X X X X X 11Clear Cell Focus X 4Eosinophilic Focus X 5Hepatodiaphragmatic Nodule X X 3Mixed Cell Focus X 5Bile Duct, Cyst 2 2 4 2.5Bile Duct, Cyst, Multiple 2 2.0

Mesentery + 2




DAY ON TEST


0730

0730

0730

0729

0664

0646

0646

0729

0729

0590

0730

0730

0688

0189

0631

0719

0730

0643

0730

0160

0646

0307

0614

0397

0730

150 mg/kgANIMAL ID

00326

00327

00328

00329

00330

00331

00332

00333

00334

00335

00336

00337

00338

00339

00340

00341

00342

00343

00344

00345

00346

00347

00348

00349

00350 * TOTALS


Pancreas + + + + + + + + + + + + + + + + + + + + + + + A + 49Artery, Inflammation, Chronic Active 3 2.7

Salivary Glands + + + + + + + + + + + + + + + + + + + M + + + + + 48

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 2 2 7 2.1

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50Erosion 1 3.0Epithelium, Hyperplasia 1 2.0Epithelium, Mineralization 1 1.0


Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 50Degeneration, Focal 2 1 2.0Inflammation, Chronic Active 4 2.5Thrombosis 1 3.0

Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Cardiomyopathy 1 2 3 2 3 3 2 1 2 2 1 1 24 1.8Pericardium, Inflammation 3 2 2.5

ENDOCRINE SYSTEM

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50




DAY ON TEST


0730

0730

0730

0729

0664

0646

0646

0729

0729

0590

0730

0730

0688

0189

0631

0719

0730

0643

0730

0160

0646

0307

0614

0397

0730

150 mg/kgANIMAL ID

00326

00327

00328

00329

00330

00331

00332

00333

00334

00335

00336

00337

00338

00339

00340

00341

00342

00343

00344

00345

00346

00347

00348

00349

00350 * TOTALS

Degeneration, Cystic 1 3 2 4 2 11 2.4Hyperplasia 2 4 1 1 1 1 1 1 3 18 1.9Necrosis 2 1 2.0Thrombosis 3 1 3.0

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 1 3 3 1 2 11 1.9


Parathyroid Gland + + + + M + + + + + + + + + + + M + + + + + + + + 46

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Pars Distalis, Hyperplasia 4 3 3 4 2 2 4 4 3 18 3.3

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + A + 48C-cell, Hyperplasia 3 3 6 2.3Follicular Cell, Hyperplasia 1 2.0Follicular Cell, Hypertrophy 3 1 1 2 1 1 2 2 2 3 1 2 1 1 1 24 1.7

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst 3 3 3 3.0

Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 2 3 1 1 3 2 3 3 2 2 1 3 3 3 2 2 2 2 2 37 2.0




DAY ON TEST


0730

0730

0730

0729

0664

0646

0646

0729

0729

0590

0730

0730

0688

0189

0631

0719

0730

0643

0730

0160

0646

0307

0614

0397

0730

150 mg/kgANIMAL ID

00326

00327

00328

00329

00330

00331

00332

00333

00334

00335

00336

00337

00338

00339

00340

00341

00342

00343

00344

00345

00346

00347

00348

00349

00350 * TOTALS

Cyst 3 3 1 2 3 3 2 3 16 2.5Inflammation, Acute 3 1 3.0Necrosis, Fibrinoid 1 4.0

Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst 2 2.5Dilatation 4 4 3 7 3.6Inflammation, Acute 3 2 2 2 6 1.8Thrombosis 2 1 2.0Endometrium, Hyperplasia, Cystic 3 2 3 2 1 2 1 2 3 1 2 3 3 2 29 2.0Endometrium, Metaplasia, Squamous 1 3 2 1 2 1 1 2 3 2 20 2.1


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 2 1 2.0Hyperplasia 2 2 2 3 3 2 2 3 3 2 2 23 2.2

Lymph Node + + 4Inguinal, Hyperplasia, Lymphoid 2 1 2.0Lumbar, Infiltration Cellular, Histiocyte 3 1 3.0Mediastinal, Ectasia 1 3.0Mediastinal, Hemorrhage 1 3.0


Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphatic, Ectasia 1 1.0

Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50




DAY ON TEST


0730

0730

0730

0729

0664

0646

0646

0729

0729

0590

0730

0730

0688

0189

0631

0719

0730

0643

0730

0160

0646

0307

0614

0397

0730

150 mg/kgANIMAL ID

00326

00327

00328

00329

00330

00331

00332

00333

00334

00335

00336

00337

00338

00339

00340

00341

00342

00343

00344

00345

00346

00347

00348

00349

00350 * TOTALS

Hematopoietic Cell Proliferation 3 1 1 2 2 2 3 2 2 3 2 1 1 3 3 3 2 2 40 2.3

Thymus + + + + + + + + + + + + + + + + + + + + + + + + M 49Atrophy 1 2 2 2 2 1 3 4 1 2 2 3 3 2 34 2.2Inflammation 2 1 2.0Epithelial Cell, Hyperplasia 3 2.0


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 1 2 1 7 1.4

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50


Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50Fibrous Osteodystrophy 1 3.0

Skeletal Muscle 1Degeneration 1 1.0

NERVOUS SYSTEM

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation, Chronic 2 3 3 2 2 2 3 3 2 1 3 3 2 3 1 2 38 2.3Alveolus, Infiltration Cellular, Histiocyte 1 1 2 2 1 2 3 2 11 1.5




DAY ON TEST


0730

0730

0730

0729

0664

0646

0646

0729

0729

0590

0730

0730

0688

0189

0631

0719

0730

0643

0730

0160

0646

0307

0614

0397

0730

150 mg/kgANIMAL ID

00326

00327

00328

00329

00330

00331

00332

00333

00334

00335

00336

00337

00338

00339

00340

00341

00342

00343

00344

00345

00346

00347

00348

00349

00350 * TOTALS

Bronchiole, Hyperplasia 1 1 1.0

Nose + + + + + + + + + + + + + + + + + + + + + + + A + 49Angiectasis 2 1 2.0Foreign Body X X 3Inflammation, Chronic Active 2 1 5 1.6Olfactory Epithelium, Atrophy 1 2 1.0Olfactory Epithelium, Degeneration 1 1.0Respiratory Epithelium, Hyperplasia 1 3 2.0Respiratory Epithelium, Metaplasia, Squamous 1 1 1.0

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50


Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation 1 3.0

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia, Focal 1 1 1.0

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Nephropathy 1 1 2 2 2 2 3 3 3 2 2 1 2 2 2 2 2 3 2 1 42 2.2

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 3 1 3.0




DAY ON TEST


0622

0175

0729

0730

0356

0729

0730

0630

0729

0730

0176

0730

0729

0416

0692

0719

0729

0730

0701

0688

0665

0729

0730

0729

0730

300 mg/kgANIMAL ID

00351

00352

00353

00354

00355

00356

00357

00358

00359

00360

00361

00362

00363

00364

00365

00366

00367

00368

00369

00370

00371

00372

00373

00374

00375

females(cont...)

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +Perforation X




Intestine Small, Duodenum + + + + + + + + + + + + + A + + + + + + + + + + +Lymphatic, Ectasia 2 4 1 1 1 2 1 1 3 1 2 1 2 2 3 2 1 2 1

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + +

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + +Lymphatic, Ectasia 3 3 2 2 2 2 2 3 3 3 4 2 3 3 2 3 2 3 3 3 3 2 3 2 2

Liver + + + + + + + + + + + + + + + + + + + + + + + + +AngiectasisBasophilic Focus X X X X X X X X X X XClear Cell Focus X X X X X X X X X X XEosinophilic Focus X X XHepatodiaphragmatic Nodule XInflammation, Chronic 2Mixed Cell Focus X X X XBile Duct, Cyst 3Bile Duct, Cyst, Multiple 2 3




DAY ON TEST


0622

0175

0729

0730

0356

0729

0730

0630

0729

0730

0176

0730

0729

0416

0692

0719

0729

0730

0701

0688

0665

0729

0730

0729

0730

300 mg/kgANIMAL ID

00351

00352

00353

00354

00355

00356

00357

00358

00359

00360

00361

00362

00363

00364

00365

00366

00367

00368

00369

00370

00371

00372

00373

00374

00375

females(cont...)

Mesentery

Oral Mucosa + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Squamous 1

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +Acinus, HyperplasiaArtery, Inflammation, Chronic Active 1 3

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +HyperplasiaInflammation

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +

TongueCyst


Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Chronic Active 1 3 1

Heart + + + + + + + + + + + + + + + + + + + + + + + + +Cardiomyopathy 2 1 1 2 2 1 2 1 2 1Epicardium, Inflammation

ENDOCRINE SYSTEM




DAY ON TEST


0622

0175

0729

0730

0356

0729

0730

0630

0729

0730

0176

0730

0729

0416

0692

0719

0729

0730

0701

0688

0665

0729

0730

0729

0730

300 mg/kgANIMAL ID

00351

00352

00353

00354

00355

00356

00357

00358

00359

00360

00361

00362

00363

00364

00365

00366

00367

00368

00369

00370

00371

00372

00373

00374

00375

females(cont...)

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Degeneration, Cystic 2 2 3 3 3 2 3 1 2Degeneration, Fatty 2Hyperplasia 1 1 2 2 1 2 4 2 1Inflammation 1Necrosis 3

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 1 4 1 4 1 1 2 1 1


Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + M + +

Pituitary Gland + + + + + + + + + + + + + + + + + + + + M + + + +Pars Distalis, Hyperplasia 3 1 1 2 3 2 3 1 1

Thyroid Gland + + + + + + + + + + + + + A + + + + + + + + + + +C-cell, Hyperplasia 4 4 1 2Follicular Cell, HyperplasiaFollicular Cell, Hypertrophy 1 3 1 2 2 2 3 2 3 2 1 2 1 3 1 2

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +Cyst




DAY ON TEST


0622

0175

0729

0730

0356

0729

0730

0630

0729

0730

0176

0730

0729

0416

0692

0719

0729

0730

0701

0688

0665

0729

0730

0729

0730

300 mg/kgANIMAL ID

00351

00352

00353

00354

00355

00356

00357

00358

00359

00360

00361

00362

00363

00364

00365

00366

00367

00368

00369

00370

00371

00372

00373

00374

00375

females(cont...)

Inflammation 3

Ovary + + + + + + + + + + + + + + + + + + + + + + + + +Angiectasis 3Atrophy 1 3 1 3 1 3 2 1 3 1 3 1 2 2 3Cyst 2 3 3 1 2 3 1 2 3 4 3Inflammation, Acute 2Inflammation, Chronic 2Inflammation, Chronic Active

Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Dilatation 2 1 3Inflammation, Acute 2ThrombosisEndometrium, Hyperplasia, Cystic 1 2 2 1 2 3 3 1 2 1Endometrium, Metaplasia, Squamous 2 3 2 1 2

Vagina + +


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 3 1 3 2 2 3 3 2 3 1 2

Lymph Node + + +Axillary, Hyperplasia, Lymphoid 3Iliac, Infiltration Cellular, Histiocyte 3

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0622

0175

0729

0730

0356

0729

0730

0630

0729

0730

0176

0730

0729

0416

0692

0719

0729

0730

0701

0688

0665

0729

0730

0729

0730

300 mg/kgANIMAL ID

00351

00352

00353

00354

00355

00356

00357

00358

00359

00360

00361

00362

00363

00364

00365

00366

00367

00368

00369

00370

00371

00372

00373

00374

00375

females(cont...)

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +Hemorrhage 3Lymphatic, Ectasia 1 1 1 3 3 1 2 1 1 2

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Hematopoietic Cell Proliferation 3 1 2 3 3 3 3 1 2 3 3 2 3 2 3 2 2

Thymus + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 3 4 4 2 2 2 2 1 1 1 2 2 3 2 2 1 3 4 1 2 3Hemorrhage 2


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia 1 2 2 1

Skin + + + + + + + + + + + + + + + + + + + + + + + + +Cyst Epithelial Inclusion 1Fibrosis


Bone + + + + + + + + + + + + + + + + + + + + + + + + +

Skeletal Muscle

NERVOUS SYSTEM

Brain + + + + + + + + + + + + + + + + + + + + + + + + +Hemorrhage 2




DAY ON TEST


0622

0175

0729

0730

0356

0729

0730

0630

0729

0730

0176

0730

0729

0416

0692

0719

0729

0730

0701

0688

0665

0729

0730

0729

0730

300 mg/kgANIMAL ID

00351

00352

00353

00354

00355

00356

00357

00358

00359

00360

00361

00362

00363

00364

00365

00366

00367

00368

00369

00370

00371

00372

00373

00374

00375

females(cont...)

Necrosis 2

RESPIRATORY SYSTEM

Lung + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Chronic 2 2 2 3 3 3 1 2 3 3 3 3 3 3 3 1 2 2 1Alveolar Epithelium, HyperplasiaAlveolar Epithelium, Metaplasia, SquamousAlveolus, Infiltration Cellular, Histiocyte 1 1

Nose + + + + + + + + + + + + + + + + + + + + + + + + +Foreign Body X XInflammation, Chronic Active 1 1 2 1Olfactory Epithelium, Atrophy 2Respiratory Epithelium, HyperplasiaRespiratory Epithelium, Metaplasia, Squamous 1

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +


Eye + + + + + + + + + + + + + + + + + + + + + + + + +

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +

URINARY SYSTEM

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Nephropathy 2 3 2 2 1 2 3 2 2 1 2 3 3 3 1 3 1 2 2 2 3Pelvis, Inflammation 3




DAY ON TEST


0622

0175

0729

0730

0356

0729

0730

0630

0729

0730

0176

0730

0729

0416

0692

0719

0729

0730

0701

0688

0665

0729

0730

0729

0730

300 mg/kgANIMAL ID

00351

00352

00353

00354

00355

00356

00357

00358

00359

00360

00361

00362

00363

00364

00365

00366

00367

00368

00369

00370

00371

00372

00373

00374

00375

females(cont...)

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +




DAY ON TEST


0197

0730

0592

0730

0184

0730

0730

0730

0563

0729

0729

0605

0729

0730

0571

0729

0730

0730

0729

0645

0674

0729

0645

0729

0730

300 mg/kgANIMAL ID

00376

00377

00378

00379

00380

00381

00382

00383

00384

00385

00386

00387

00388

00389

00390

00391

00392

00393

00394

00395

00396

00397

00398

00399

00400 * TOTALS

ALIMENTARY SYSTEM

Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50Perforation 1

Intestine Large, Cecum M + + + M + + + + + + + + + + + + + + + + + + + + 48

Intestine Large, Colon M + + + M + + + + + + + + + + + + + + + + + + + + 48


Intestine Small, Duodenum M + + + M + + + + + + + + + + + + + + + + + + + + 47Lymphatic, Ectasia 1 1 2 1 1 1 2 1 1 3 1 1 3 1 1 1 1 1 1 38 1.5

Intestine Small, Ileum M + + + M + + + A + + + + + + + + + + + + + + + + 47

Intestine Small, Jejunum M + + + M + + + + + + + + + + + + + + + + + + + + 48Lymphatic, Ectasia 3 3 3 2 2 2 3 3 1 2 3 1 2 3 2 2 2 3 3 2 1 3 47 2.5

Liver M + + + M + + + + + + + + + + + + + + + + + + + + 48Angiectasis 1 2 2 3 1.7Basophilic Focus X X X 14Clear Cell Focus X X X X X X X 18Eosinophilic Focus X X X 6Hepatodiaphragmatic Nodule X 2Inflammation, Chronic 1 2.0Mixed Cell Focus 4Bile Duct, Cyst 2 2 3 4 2.5Bile Duct, Cyst, Multiple 2 2.5




DAY ON TEST


0197

0730

0592

0730

0184

0730

0730

0730

0563

0729

0729

0605

0729

0730

0571

0729

0730

0730

0729

0645

0674

0729

0645

0729

0730

300 mg/kgANIMAL ID

00376

00377

00378

00379

00380

00381

00382

00383

00384

00385

00386

00387

00388

00389

00390

00391

00392

00393

00394

00395

00396

00397

00398

00399

00400 * TOTALS

Mesentery + 1


Pancreas M + + + M + + + + + + + + + + + + + + + + + + + + 48Acinus, Hyperplasia 1 1 1.0Artery, Inflammation, Chronic Active 1 4 1 3 6 2.2

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50

Stomach, Forestomach + + + + M + + + + + + + + + + + + + + + + + + + + 49Hyperplasia 2 2 3 3 2.3Inflammation 3 1 3.0

Stomach, Glandular + + + + M + + + + + + + + + + + + + + + + + + + + 49

Tongue + 1Cyst 3 1 3.0


Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 50Inflammation, Chronic Active 2 2 2 2 7 1.9

Heart + + + + M + + + + + + + + + + + + + + + + + + + + 49Cardiomyopathy 1 1 1 2 2 2 1 1 1 2 1 1 1 1 24 1.4Epicardium, Inflammation 3 1 3.0

ENDOCRINE SYSTEM




DAY ON TEST


0197

0730

0592

0730

0184

0730

0730

0730

0563

0729

0729

0605

0729

0730

0571

0729

0730

0730

0729

0645

0674

0729

0645

0729

0730

300 mg/kgANIMAL ID

00376

00377

00378

00379

00380

00381

00382

00383

00384

00385

00386

00387

00388

00389

00390

00391

00392

00393

00394

00395

00396

00397

00398

00399

00400 * TOTALS

Adrenal Cortex M + + + M + + + + + + + + + + + + + + + + + + + + 48Degeneration, Cystic 3 2 3 1 2 3 15 2.3Degeneration, Fatty 1 2.0Hyperplasia 3 1 1 3 4 1 15 1.9Inflammation 1 1.0Necrosis 1 3.0

Adrenal Medulla M + + + M + + + + + + + + + + + + + + + + + + + + 48Hyperplasia 1 2 1 12 1.7


Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49Pars Distalis, Hyperplasia 2 1 1 1 4 1 1 1 2 4 2 2 1 3 4 24 2.0

Thyroid Gland + + A + A + + + + + + + + + + + + + + + + + + + + 47C-cell, Hyperplasia 2 5 2.6Follicular Cell, Hyperplasia 3 1 3.0Follicular Cell, Hypertrophy 2 1 1 2 2 3 4 2 1 3 3 2 3 1 30 2.0

GENERAL BODY SYSTEM

NONE

GENITAL SYSTEM

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst 3 3 3 3 4 3.0




DAY ON TEST


0197

0730

0592

0730

0184

0730

0730

0730

0563

0729

0729

0605

0729

0730

0571

0729

0730

0730

0729

0645

0674

0729

0645

0729

0730

300 mg/kgANIMAL ID

00376

00377

00378

00379

00380

00381

00382

00383

00384

00385

00386

00387

00388

00389

00390

00391

00392

00393

00394

00395

00396

00397

00398

00399

00400 * TOTALS

Inflammation 3 2 3.0

Ovary + + + + M + + + + + + + + + + + + + + + + + + + + 49Angiectasis 1 3.0Atrophy 3 2 1 2 1 3 1 1 3 1 2 2 2 2 2 30 1.9Cyst 2 2 1 2 2 16 2.3Inflammation, Acute 1 2.0Inflammation, Chronic 1 2.0Inflammation, Chronic Active 1 1 1.0

Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50Dilatation 4 4 5 2.8Inflammation, Acute 2 2 1 2 2 1 2 2 9 1.8Thrombosis 3 1 3.0Endometrium, Hyperplasia, Cystic 3 2 1 1 3 2 1 2 2 3 1 21 1.9Endometrium, Metaplasia, Squamous 2 2 2 2 1 1 11 1.8

Vagina 2


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 1 2 1 2 1 1 17 1.9

Lymph Node 3Axillary, Hyperplasia, Lymphoid 1 3.0Iliac, Infiltration Cellular, Histiocyte 1 3.0





DAY ON TEST


0197

0730

0592

0730

0184

0730

0730

0730

0563

0729

0729

0605

0729

0730

0571

0729

0730

0730

0729

0645

0674

0729

0645

0729

0730

300 mg/kgANIMAL ID

00376

00377

00378

00379

00380

00381

00382

00383

00384

00385

00386

00387

00388

00389

00390

00391

00392

00393

00394

00395

00396

00397

00398

00399

00400 * TOTALS

Lymph Node, Mesenteric M + + + M + + + + + + + + + + + + + + + + + + + + 48Hemorrhage 1 3.0Lymphatic, Ectasia 3 2 1 3 1 15 1.7

Spleen M + + + M + + + + + + + + + + + + + + + + + + + + 48Hematopoietic Cell Proliferation 3 2 2 3 1 1 2 2 2 1 2 2 1 3 3 3 33 2.2

Thymus + + + + + + + + + + + + + + + + + + + + + + + + + 50Atrophy 1 2 2 3 1 4 2 4 2 3 1 3 2 2 3 2 3 38 2.3Hemorrhage 1 2.0


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Hyperplasia 2 1 1 7 1.4

Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Cyst Epithelial Inclusion 1 1.0Fibrosis 1 1 1.0


Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50

Skeletal Muscle + 1

NERVOUS SYSTEM

Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemorrhage 1 2.0




DAY ON TEST


0197

0730

0592

0730

0184

0730

0730

0730

0563

0729

0729

0605

0729

0730

0571

0729

0730

0730

0729

0645

0674

0729

0645

0729

0730

300 mg/kgANIMAL ID

00376

00377

00378

00379

00380

00381

00382

00383

00384

00385

00386

00387

00388

00389

00390

00391

00392

00393

00394

00395

00396

00397

00398

00399

00400 * TOTALS

Necrosis 1 2.0

RESPIRATORY SYSTEM

Lung + + + + M + + + + + + + + + + + + + + + + + + + + 49Inflammation, Chronic 1 2 2 1 3 2 3 1 3 3 2 3 3 3 2 3 35 2.3Alveolar Epithelium, Hyperplasia 1 1 1.0Alveolar Epithelium, Metaplasia, Squamous 1 1 1.0Alveolus, Infiltration Cellular, Histiocyte 1 2 1 1 1 1 1 9 1.1

Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50Foreign Body X 3Inflammation, Chronic Active 1 2 6 1.3Olfactory Epithelium, Atrophy 2 1 2 1 5 1.6Respiratory Epithelium, Hyperplasia 1 1 2 1.0Respiratory Epithelium, Metaplasia, Squamous 1 1.0

Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50


Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50

URINARY SYSTEM

Kidney M + + + M + + + + + + + + + + + + + + + + + + + + 48Nephropathy 2 2 1 1 1 3 1 1 3 2 2 3 1 3 2 2 3 1 1 3 1 2 43 2.0Pelvis, Inflammation 1 3.0




DAY ON TEST


0197

0730

0592

0730

0184

0730

0730

0730

0563

0729

0729

0605

0729

0730

0571

0729

0730

0730

0729

0645

0674

0729

0645

0729

0730

300 mg/kgANIMAL ID

00376

00377

00378

00379

00380

00381

00382

00383

00384

00385

00386

00387

00388

00389

00390

00391

00392

00393

00394

00395

00396

00397

00398

00399

00400 * TOTALS

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50

*** END OF REPORT ***




ntp.niehs.nih.gov · f1_hsd ntp study number: c20006b lock date: 06/21/2010 cage range: all date...

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